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Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats

World Journal of Gastroenterology 2007年第42期13卷 5605-5611页

作者： Ho-Lam Chung Grace Gar-Lee Yue ka-Fai To Ya-Lun Su Yu Huang Wing-Hung Ko Department of Physiology Faculty of MedicineThe Chinese University of Hong Kong Shatin Hong Kong China institute of Chinese medicine The ChineseUniversity of Hong Kong Shatin Hong Kong China Department of Anatomical and Cellular Pathology Faculty of Medicine The Chinese University of Hong KongShatin Hong Kong China institute of Materia Medica Chinese Academy ofMedical Sciences and Peking Union Medical College Beijing100050 China Department of Physiology and lika shing institute of Health Sciences Faculty of Medicine TheChinese University of Hong Kong Shatin Hong Kong China

AIM： To investigate the effect of Scutellariae Radix extract （SRE） on ulcerative colitis （UC） in rats induced by dextran-sulfate sodium （DSS）. METHODS： Colitis was induced in male Sprague-Dawley （SD） rats （170-180 g） by 4% dextran sulfate sodium （DSS, wt/v, MW 54000） in drinking water for 8 d. The treated rats received 4% DSS and SRE orally （100 mg/kg per day）. Control rats received either tap water or SRE only. Macroscopic assessment which included body weight changes, fecal occult blood and stool consistency were determined daily. At the appointed time, the rats were sacrificed and the entire colons were removed. The colon length and the myeloperoxidase （MPO） activity were measured. The severity of colitis was graded by morphological and histological assessments. The ion transport activity of the colonic mucosa was assessed by electrophysiological technique. RESULTS： Rats treated with oral administration of 4% DSS regularly developed clinical and macroscopic signs of colitis. Treatment with SRE relieved the symptoms, including the reduction in body weight, shortening 2nd ulceration of the colon. Administration of SRE also significantly reduced the histological damage induced by DSS. Moreover, the Isc responses of the colonic mucosa to forskolin, were suppressed after the induction of colitis. The stimulated ion transport activity of DSS-rats treated with SRE displayed significant improvement in the secretory responsiveness. CONCLUSION： SRE was effective in treating acute DSS- induced ulcerative colitis, as gauged by reduced clinical disease, improved macroscopic and histological damage scores, and enhanced recovery of normal colonic secretory function.

关键词： Ulcerative colitis Scutellariae Radix Inflammatory bowel disease Colonic ion transport Traditional Chinese medicine

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聚氨酯构建的慢性颈脊髓压迫模型早期炎症反应

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中国矫形外科杂志 2020年第20期28卷 1888-1892页

作者：于磊宋红星胡勇北京世纪坛医院脊柱外科北京市100038 首都医科大学研究生院北京市100069 香港大学李嘉诚医学院香港999077

[目的]采用聚氨酯构建慢性颈脊髓压迫动物模型,观察受压颈脊髓内早期炎症反应。[方法]SD大鼠随机均分为颈髓压迫模型(CSM)组和对照组。(CSM)组C6椎板下置入新型吸水性可膨胀生物材料聚氨酯,对照组不置入可膨胀性生物材料。建模14 d后行... 详细信息

[目的]采用聚氨酯构建慢性颈脊髓压迫动物模型,观察受压颈脊髓内早期炎症反应。[方法]SD大鼠随机均分为颈髓压迫模型(CSM)组和对照组。(CSM)组C6椎板下置入新型吸水性可膨胀生物材料聚氨酯,对照组不置入可膨胀性生物材料。建模14 d后行颈椎核磁共振检查,观察大鼠脊髓受压影像学表现。建模3、7、14 d后分别取大鼠受压颈脊髓组织,采用蛋白印迹方法检测受压颈脊髓组织p-MK2、炎症因子(NF-κB)、凋亡相关蛋白(caspase-8、Bax/Bcl-2)的变化。[结果]大鼠颈椎MRI检查提示CSM组矢状位、轴位MRI可见脊髓明显受压、局部变细。CSM组SD大鼠p-MK2、NF-κB、caspase-8和Bax表达较对照组显著增多(P2的表达则显著降低(P2可能参与了炎症反应。

关键词：慢性脊髓压迫动物模型信号通路炎症因子凋亡蛋白

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Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells(ESPCs)-mediated articular cartilage repair

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Bioactive Materials 2023年第8期26卷 490-512页

作者： liangbin Zhou Jietao Xu Andrea Schwa Wenxue Tong Jiankun Xu lizhen Zheng Ye li Zhuo li Shunxiang Xu Ziyi Chen li Zou Xin Zhao Gerjo J.V.Mvan Osch Chunyi Wen ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics and Traumatology&Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory of li ka shing institute of Health Sciences Faculty of MedicineThe Chinese University of Hong Kong999077Hong Kong SARChina Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic University999077Hong Kong SARChina Department of Orthopaedics and Sports medicine Erasmus MCUniversity Medical Center Rotterdam3015 GDRotterdamthe Netherlands Department of Oral and Maxillofacial Surgery Erasmus MCUniversity Medical Center Rotterdam3015 GDRotterdamthe Netherlands Centre for Regenerative medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of Sciences-CRMH999077Hong Kong SARChina Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong Kong999077Hong Kong SARChina Department of Otorhinolaryngology Erasmus MCUniversity Medical Center Rotterdam3015 GDRotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritime and Materials EngineeringDelft University of Technology(TU Delft)2600 AADelftthe Netherlands Centre for Translational medicine Research and Development Shenzhen Institute of Advanced TechnologyThe Chinese Academy of Sciences518000ShenzhenChina

As a highly specialized shock-absorbing connective tissue,articular cartilage(AC)has very limited self-repair capacity after traumatic injuries,posing a heavy socioeconomic *** clinical therapies for small-to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies,including microfracture,mosaicplasty,autologous chondrocyte implantation(ACI),and matrix-induced ACI(MACI).However,these treatments frequently result in mechanically inferior fibrocartilage,low cost-effectiveness,donor site morbidity,and short-term *** prompts an urgent need for innovative approaches to pattern a pro-regenerative microenvironment and yield hyaline-like cartilage with similar biomechanical and biochemical properties as healthy native *** regenerative biomaterials can create a favorable local environment for AC repair without causing relevant regulatory and scientific concerns from cell-based treatments.A deeper understanding of the mechanism of endogenous cartilage healing is furthering the(bio)design and application of these ***,the utilization of regenerative biomaterials to magnify the repairing effect of joint-resident endogenous stem/progenitor cells(ESPCs)presents an evolving improvement for cartilage *** review starts by briefly summarizing the current understanding of endogenous AC repair and the vital roles of ESPCs and chemoattractants for cartilage *** several intrinsic hurdles for regenerative biomaterials-based AC repair are *** recent advances in novel(bio)design and application regarding regenerative biomaterials with favorable biochemical cues to provide an instructive extracellular microenvironment and to guide the ESPCs(***,migration,proliferation,differentiation,matrix production,and remodeling)for cartilage repair are ***,this review outlines the future directions of engineering the next-generation regenerative biomaterials toward ultim

关键词： Regenerative biomaterials Endogenous stem/progenitor cells(ESPCs) Articular cartilage(AC)repair Biochemical cues

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Sheng Jiang San, traditional multi-herb formulation, exerts anti-influenza effects in vitro and in vivo via neuraminidaseinhibition and immune regulation

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中国药理学与毒理学杂志 2019年第9期33卷 738-739页

作者： ZHANG Tian-bo XIAO Meng-jie Chun-Kwok WONG ka-Pun CHRIS MOK ZHAO Xin TI Hui-hui Pang-Chui SHAW State Key Laboratory of Respiratory Disease Guangdong Provincial Key Laboratory of Molecular Target&Clinical PharmacologySchool of Pharmaceutical Sciences and The Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina The School of life Sciences The Chinese University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

OBJECTIVE Sheng Jiang San(SJS),a multi-herb formulation,is used in treating high fever,thirsty and anxiety in ancient china and it is sometimes used to treat seasonal influenza in ***,there is no evidencebased investigation and mechanism research to support SJS′s anti-influenza *** study aims to investigate the anti-influenza effect of SJS and its possible *** In this study,we examined the inhibitory effect of SJS against different influenza viruses on Madin-Darby canine kidney *** virus infected BALB/c mice were employed as in vivo model to evaluate the *** challenged with A/pr/8/34(H1N1)were orally administrated SJS 1 g·kg^-1 daily for seven days and monitored for 14 *** survival rate,body mass changes,lung index,lung viral load,histopathologic changes and immune-regulation of the mice were *** underlying anti-influenza virus mechanisms were studied by a series of biological assays in vitro to determine if hemagglutinin,ribonucleoprotein complex or nerauminidase were targets of *** SJS exerted a broad spectrum of inhibitory effects on multiple influenza strains in a dose-dependent *** IC50 of SJS against A/WSN/33(H1N1)was lower than 35 mg·L^-*** also protected 50%of mice from influenza virus pr8 *** lung index and the lung viral load of SJS treated mice were signifi⁃cantly decrease compared with untreated *** 2 g·L^-1 inhibited 80%of neuraminidase enzymatic *** also up-regulated TNF-αand IFN-αand down-regulated IL-2 of influenza virus induced *** SJS is a useful formulation for treating influenza virus infection.

关键词： Sheng Jiang San anti-influenza activity neuraminidase inhibition immuno-regulation

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Photoperiodic diapause in a subtropical population of Aedes albopictus in Guangzhou,china:optimized fieldlaboratory-based study and statistical models for comprehensive characterization

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Infectious Diseases of Poverty 2018年第1期7卷 903-915页

作者： Dan Xia Xiang Guo Tian Hu li li Ping-Ying Teng Qing-Qing Yin Lei Luo Tian Xie Yue-hong Wei Qian Yang Shu-kai li Yu-Ji Wang Yu Xie Yi-Ji li Chun-Mei Wang Zhi-Cong Yang Xiao-Guang Chen Xiao-hong Zhou Department of Pathogen Biology Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher InstitutesGuangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongSpecial Administrative RegionChina Guangzhou Center for Disease Control and prevention Guangzhou 510515China

Background:Aedes albopictus is among the 100 most invasive species worldwide and poses a major risk to public *** diapause provides a crucial ecological basis for the adaptation of this species to adverse *** is the vital vector transmitting dengue virus in Guangzhou,but its diapause activities herein remain ***:In the laboratory,yeast powder and food slurry were compared for a proper diapause determination method,and the critical photoperiod(CPP)was tested at illumination times of 11,11.5,12,12.5,13,and 13.5 h.A 4-parameter logistic(4PL)regression model was selected to estimate the *** the field,the seasonal dynamics of the *** population,egg diapause,and hatching of overwintering eggs were investigated monthly,weekly,and daily,respectively.A distributed lag non-linear model(DLNM)was used to assess the associations of diapause with meteorological ***:In the laboratory,both the wild population and the Foshan strain of *** were induced to diapause at an incidence greater than 80%,and no significant difference(P>0.1)was observed between the two methods for identifying *** CPP of this population was estimated to be 12.312 h of *** the field,all of the indexes of the wild population were at the lowest levels from December to February,and the Route Index was the first to increase in *** incidence displayed pronounced seasonal *** was estimated that the day lengths of 12.111 h at week2016,43 and 12.373 h at week2017,41 contributed to diapause in 50%of the *** length was estimated to be the main meteorological factor related to ***:Photoperiodic diapause of *** in Guangzhou of china was confirmed and comprehensively elucidated in both the laboratory and the *** eggs are the main form for overwintering and begin to hatch in large quantities in March in ***,this study also established an optimized

关键词： Subtropical Aedes albopictus Critical photoperiod Photoperiodic diapause Distributed lag non-linear model

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Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?

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Neural Regeneration Research 2015年第1期10卷 7-9页

作者： Suk Yu Yau Ang li Aimin Xu Kwok-fai So State Key Laboratory of Brain and Cognitive Sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong Division of Medical Sciences University of Victoria BCCanada Department of Anatomy The University of Hong Kong Department of medicine The University of Hong Kong Department of Pharmacology and Pharmacy The University of Hong Kong Research Centre of Heart BrainHormone and Healthy AgeingThe University of Hong Kong State Key Laboratory of Pharmaceutical Biotechnology Li Ka Shing Faculty of MedicineThe University of Hong Kong Department of Ophthalmology The University of Hong Kong Guangdong-hong kong-Macao institute of CNS Regeneration Jinan University Guangdong Key Laboratory of Brain Function and Diseases Jinan University

Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recog- nized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neuro- genesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counter- acting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.

关键词： hippocampus adult neurogenesis physical exercise voluntary wheel running depression neural progenitor cell adipocyte adiponectin adiponectin receptor AMP-activated protein kinase

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Photothermal-controlled sustainable degradation of protective coating modified Mg alloy using near-infrared light

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Rare Metals 2021年第9期40卷 2538-2551页

作者： Zhi-Xin Han Xiang-Mei liu Lei Tan Zhao-Yang li Yu-Feng Zheng Kelvin Wai-Kwok Yeung Zhen-Duo Cui Yan-Qin liang Sheng-li Zhu Shui-lin Wu Hubei Key Laboratory of Polymer Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhan 430062China The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of china School of Materials Science&EngineeringTianjin UniversityTianjin 300072China State Key Laboratory for Turbulence and Complex System Department of Materials Science and EngineeringCollege of EngineeringPeking UniversityBeijing 100871China Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam 999077Hong KongChina

Controlling the corrosion rate is critical for practical applications of Mg-based alloys. In this work, we constructed a protective coating of hybrid polycaprolactone(H-PCL)/indocyanine green(ICG) on AZ31 Mg alloy,whose degradation rate was controlled by 808-nm nearinfrared(NIR) light irradiation. The corrosion behaviors of H-PCL/ICG coated Mg alloys were systematically investigated by potentiodynamic polarization tests, electrochemical impedance spectroscopy(EIS) and hydrogen evolution experiments. The results disclosed that the H-PCL/ICG composite coating could effectively protect Mg alloy from corroding without NIR light irradiation. In contrast, under 808-nm NIR light irradiation, the corrosion resistance of this composite coating was decreased significantly, i.e., the corrosion current density(i_(corr))increasedfrom(8.81 ± 1.068) 9 10^(-8) to(1.22 ± 0.545) 9 10^(-6) A·cm^(-2). This is because the component of ICG in the coating was excited to produce heat locally, which triggered the glass transition temperature(T_(g)) of H-PCL in the coating, resulting in the motion of the molecular chain segment. Consequently, the electrolytes penetrated the coating and corroded the Mg substrate. In vitro biological experiment indicated that the synthesized coating exhibited good ***, these findings will provide a new strategy for designing novel photoresponsive coatings to remotely adjust the degradation rate of biodegradable metals for biomedical applications.

关键词： Magnesium Corrosion Coating Photoresponsive Surface modification

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Clinical efficacies,underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2749-2767页

作者： Guoyi Tang Sha li Cheng Zhang Haiyong Chen Ning Wang Yibin Feng School of Chinese medicine Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SAR 999077China

Diabetic nephropathy(DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease,which causes serious health problems and great financial burden to human society *** strategies,such as renin-angiotensinaldosterone system blockade,blood glucose level control,and bodyweight reduction,may not achieve satisfactory outcomes in many clinical practices for DN ***,due to the multi-target function,Chinese medicine possesses promising clinical benefits as primary or alternative therapies for DN *** studies have emphasized identifying bioactive compounds and molecular mechanisms of reno-protective effects of Chinese *** pathways involved in glucose/lipid metabolism regulation,antioxidation,anti-inflammation,anti-fibrosis,and podocyte protection have been identified as crucial mechanisms of ***,we summarize the clinical efficacies of Chinese medicines and their bioactive components in treating and managing DN after reviewing the results demonstrated in clinical trials,systematic reviews,and meta-analyses,with a thorough discussion on the relative underlying mechanisms and molecular targets reported in animal and cellular *** aim to provide comprehensive insights into the protective effects of Chinese medicines against DN.

关键词： Chinese medicine Herbal medicine Diabetic nephropathy Diabetic kidney disease Signaling pathway Molecular target

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Neurovascular ageing:transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease

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Neural Regeneration Research 2021年第12期16卷 2411-2412页

作者： Zhongqi li Bonaventure Ip Vincent C.T.Mok Ho Ko Division of Neurology Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong Kong Special Administrative RegionChina li ka shing institute of Health Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina(Li ZKo H)Margaret K.L.Cheung Research Centre for Management of ParkinsonismThe Chinese University of Hong KongHong Kong Special Administrative RegionChina Chow Yuk Ho Technology Centre for Innovative medicine The Chinese University of Hong KongHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Centre School of Biomedical SciencesDepartment of PsychiatryPeter Hung Pain Research InstituteFaculty of MedicineThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

Ageing is one of the greatest risk factors for neurodegenerative *** the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely *** into neurodegenerative disorders has shifted from a neuron-centric approach,to the contributing roles of age-related neurovascular and glial cell dysfunction.

关键词： incomplete susceptibility ageing

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The novel male meiosis recombination regulator coordinates the progression of meiosis prophase Ⅰ

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Journal of Genetics and Genomics 2020年第8期47卷 449-464页

作者： Miao li Haiwei Feng Zexiong lin Jiahuan Zheng Dongteng liu Rui Guo Junshi li Raymond H.W.li Ernest H.Y.Ng Michael S.Y.Huen P.Jeremy Wang William S.B.Yeung Kui liu Shenzhen Key Laboratory of Fertility Regulation Center of Assisted Reproduction and EmbryologyThe University of Hong Kong-Shenzhen HospitalShenzhen518000China Department of Obstetrics and Gynecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China Department of Biomedical Sciences University of Pennsylvania School of Veterinary MedicinePhiladelphiaPA19104USA School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China

Meiosis is a specialized cell division for producing haploid gametes in sexually reproducing *** this study,we have independently identified a novel meiosis protein male meiosis recombination regulator(MAMERR)/4930432 K21 Rik and showed that it is indispensable for meiosis prophase I progression in male *** super-resolution structured illumination microscopy,we found that MAMERR functions at the same double-strand breaks as the replication protein A and meiosis-specific with OB domains/spermatogenesis associated 22 *** generated a Mamerr-deficient mouse model by deleting exons 3 e6 and found that most of Mamerrà/àspermatocytes were arrested at pachynema and failed to progress to diplonema,although they exhibited almost intact synapsis and progression to the pachytene stage along with XY body *** mechanistic studies revealed that the recruitment of DMC1/RAD51 and heat shock factor 2 ebinding protein in Mamerrà/àspermatocytes was only mildly impaired with a partial reduction in double-strand break repair,whereas a substantial reduction in ubiquitination on the autosomal axes and on the XY body appeared as a major phenotype in Mamerrà/à*** propose that MAMERR may participate in meiotic prophase I progression by regulating the ubiquitination of key meiotic proteins on autosomes and XY chromosomes,and in the absence of MAMERR,the repressed ubiquitination of key meiotic proteins leads to pachytene arrest and cell death.

关键词： Meiosis 4930432K21Rik Recombination Ubiquitination

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