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中国化学会第26届学术年会化学生物分会场

作者： Zhen Yang Laboratory of Chemical genomics, shenzhen Graduate School, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry, Peking University, beijing 100871

＜正＞Diversity-oriented synthesis （DOS） can be used to synthesize diversified molecules on a large scale. As with all large-scale experiments, this process requires a major investment in equipment, consumables and time. Therefore, careful careful design is critical. As the complexity of the libraries to be generated increases, additional considerations become important. What are the issues that should be considered when

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DETECTION OF THE BURROWING NEMATODE RADOPHOLUS SIMILIS USING PCR AND TAQMAN REAL-TIME FLUORESCENT PCR

DETECTION OF THE BURROWING NEMATODE RADOPHOLUS SIMILIS USING...

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International Congress on Biological Invasions

作者： Hai Long~1,Fang-Rong Li~1,De-Liang Peng~2,and Yi-Nong Li~1 1 shenzhen Entry-Exit Inspection and Quarantine Bureau,shenzhen 518001, china. 2 State Key Laboratory for Biology of Plant Diseases and Insect Pest,institute of Plant Protection,Chinese Academy of Agricultural Sciences,beijing 100094,china

The burrowing nematode Radopholus similis,a major pathogen of banana,plantains and other crops throughout the tropics,is listed as a quarantine pest by many countries and *** detect the ***,a single-step PCR and TAQMAN real-time fluorescent PCR diagnostic was *** specific primers,designed based on an alignment of ribosomal internal transcribed spacer(ITS) sequences of R. similis and relative species,were used to amplify the 387 bp product in *** Intercepted from different countries and regions and no product in native control and relative *** primers can be used for direct diagnosis of a single nematode and for detection of *** in mixed soil nematode *** the same time a TaqMan probe was designed to detect *** signal only appears in R. *** method can detect 1/20 of the nematode and is rapid and without contamination from PCR product.

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DRD1-Pol V-dependent Self-silencing of an Exogenous Silencer Restricts Non-cell-autonomous Silencing of an Endogenous Target Gene

DRD1-Pol V-dependent Self-silencing of an Exogenous Silencer...

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第十二届全国植物基因组学大会

作者： Li Dong,Huishan Guo~* State Key Laboratory of Plant genomics,institute of Microbiology,Chinese Academy of Sciences,beijing 100101,china

In plants,exogenous transgene transcribing inverted-repeat(exo-IR) sequences produces double-stranded RNAs that are processed by *** generated 21-nt siRNAs function as mobile signals to trigger non-cell-autonomous silencing of target endogene in neighboring 10-15 *** potential involvement of nuclear silencing pathway components in signal spreading or sensing in target cells is not ***,we demonstrate that the exo-IR silencer(exo-Pdsi) is negatively auto-regulated through methylation spreading, which acts in cis to reinforce self-silencing of the *** affecting nuclear proteins DRD1 and

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Interaction between Mnk2 and CBC^(VHL) ubiquitin ligase E3 complex

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Science china(Life Sciences) 2006年第3期49卷 265-273页

作者： WANG Pingzhang, WANG Xin, WANG Feng, CAI Tianjing & LUO Ying Chinese National Human Genome Center, beijing 100176, china institute of Basic Medical Sciences, Chinese Acadamy of Medical Sciences, beijing 100005, china Shanghai genomics Inc., Shanghai 201203, china Chinese National Human Genome Center Beijing 100176 China institute of Basic Medical Sciences Chinese Acadamy of Medical Sciences Beijing 100005 China Chinese National Human Genome Center Beijing 100176 China Shanghai genomics Inc. Shanghai 201203 China

MAP kinase-interacting kinase-2 (Mnk2) is one of the downstream kinasesactivated by MAP kinases. It phosphorylates the eukaryotic initiation factor 4E (elF4E), althoughthe role of elF4E phosphorylation and the role of Mnk2 in the process of proteintranslation are notwell understood. Except for elF4E, other physiological substrates of Mnk2 are still unidentified. Tolook for these unidentified substrates and to reveal the physiological function of Mnk2, weperformed a yeast two-hybrid screening with Mnk2 as the bait. The results demonstrated Mnk2 couldinteract with VHL (von Hippel-Lindau tumor suppressor), Rbx1 (ring-box1) and Cul2 (Cullin2) proteinsin yeast cells. Furthermore, we validated the interaction between Mnk2 and VHL proteins inmammalian cells by co-immunoprecipitation analysis. Because the three proteins VHL, Rbx1 and Cul2are all components of the CBC^(VHL) ubiquitin ligase E3 complex, it has been shown that Mnk2 caninteract with CBC^(VHL) complex, and is probably one of the newsubstrates of the CBC^(VHL) ***, during the interaction of Mnk2 with von Hippel-Lindau (VHL) tumor suppressor- bindingprotein 1 (VBP1), it appears that Mnk2 also joins to modulate cell shape as VBP1 plays an importantrole in the process of the maturation of the cytoskeleton and in the process of morphogenesis.

关键词： Mnk2, yeast two-hybrid, CBCVHL ubiquitin ligase E3 complex, VBP1.

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Allelic frequency distributions of 21 non-combined DNA index system STR loci in a Russian ethnic minority group from Inner Mongolia,china

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 533-540页

作者： Hong-dan WANG Chun-mei SHEN Wen-juan LIU Yu-dang ZHANG Guang YANG Jiang-wei YAN Hai-xia QIN Bo-feng ZHU School of Medicine Xi'an Jiaotong University People's Hospital of Zhengzhou University Medical Genetic institute of Henan Province People's Hospital of Henan Province Blood Center of Shaanxi Province Vascular Biology Center Georgia Health Sciences UniversityAugustaGA 30912USA beijing institute of genomics Chinese Academy of Science Department of Internal Medicine Morehouse School of MedicineAtlantaGA 30303USA

We studied the allelic frequency distributions and statistical forensic parameters of 21 new short tandem repeat(STR)loci and the amelogenin locus,which are not included in the combined DNA index system(CODIS),in a Russian ethnic minority group from the Inner Mongolia Autonomous Region,china.A total of 114 bloodstain samples from unrelated individuals were extracted and co-amplified with four fluorescence-labeled primers in a multiplex polymerase chain reaction(PCR)*** capillary electrophoresis,the PCR products of the 21 STR loci were separated and genotyped.A total of 161 alleles were observed in the Russian ethnic minority group,and corresponding allelic frequencies ranged from 0.0044 to *** 21 non-CODIS STR loci of the Russian ethnic minority group were characterized by high genetic diversity and therefore may be useful for elucidating the population's genetic background,for individual identification,and for paternity testing in forensic practice.

关键词： Short tandem repeat(STR) Russian population Genetic polymorphisms

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维普期刊数据库

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A Hybrid OCDMA Scheme with Variable Rate and QoS

A Hybrid OCDMA Scheme with Variable Rate and QoS

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2003 International Conference on Communication Technology

作者： Pu Tao Li Yu Quan Xu Ming Yang Shu Wen institute of Comm Eng PLA Univ of Scie&Tech Nanjing P.R.china Advanced Tech Research Center shenzhen University shenzhen P.R.china

We proposed a hybrid OCDMA system, in which users are divided into 3 categories: Frequency-Hop (FH), Time-Spread(TS) and FH-TS Codes’ users. Their address codes’ mathematical expression and codes’ car

关键词： OCDMA Algebraic Congruent Operator

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The proteomic responses in mouse plasma to sepsis generated from CLP model

The proteomic responses in mouse plasma to sepsis generated ...

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中国蛋白质组学第三届学术大会

作者： Yan Ren~(1,) Jiandong Wang~3, Ji Xia’ Kao Zhao’ Shaokun Shu~(1,) Ningzhi Xu~(1,) Yingxin Xu~3, Siqi Liu~(1,2) 1beijing genomics institute, CAS beijing, china 2beijing Proteomics institute, beijing, china 3The General Hospital of Military, beijing, china

It is estimated that over million individuals develop severe sepsis around the world. Because of problems with dysfunction of vital organs caused by sepsis, people with severe sepsis face 30 - 35% of mortality. Therefore a key issue for sepsis therapy is how to monitor and to control inflammation at early phase of sepsis. Herein we report an approach to define the candidates of biomarkers for

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River Boundaries Extraction in Mountain Areas for SAR Images with Fusing GIS Information

River Boundaries Extraction in Mountain Areas for SAR Images...

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2011 CIE International Conference on Radar(RADAR 2011)

作者： Wang Xiaoliang 1 2 Li Chunsheng 2 and Wu Renbiao 1 3 1 Tianjin Key Laboratory for Advanced Signal Processing Civil Aviation University of china Tianjin 300300 P.R.china 2 School of Electronics and Information Engineering Beihang University beijing 100191 china 3 Defence Key Laboratory for ATR shenzhen University shenzhen 518060 china

River boundaries extraction on SAR images is valuable for flood monitoring. Traditional methods usually failed in high relief areas. We proposed a river boundaries extraction method to conquer the difficulty to discri... 详细信息

关键词： SAR Information Fusion Segmentation Active Contour Model Level Set

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Establishment of the rapid gene targeting,RNAi and high content function analysis platform for reverse genetics investigation

Establishment of the rapid gene targeting,RNAi and high cont...

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2011国际基因组学大会

作者： Jiangjun Shengnang Sun Haili Guo and Shiyou Li CAS Key Laboratory of Genome Sciences and Information beijing institute of genomics Chinese Academy of Sciences beijing 100029 china

＜正＞Genetic factors are the most important causes on almost all diseases,whether inherited or resulting from the body’s response to environmental factors such as viruses,toxins or *** successes of the human genome ...

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Conditional and unconditional mapping of quantitative trait loci underlying plant height and tiller number in rice (Oryza sativa L.) grown at two nitrogen levels

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Progress in Natural Science:Materials International 2008年第12期18卷 1539-1547页

作者： Hua Jiang~(a,b) Liang Jiang~b Longbiao Guo~b Zhenyu Gao~b Dali Zeng~b Lihuang Zhu~c Guohua Liang~a Qian Qian~b a State Key Laboratory of Rice Biology/Key Laboratory of Plant Functional Genomies,Ministry of Education of china,Yangzhou University,Yangzhou 225009,china b State Key Laboratory of Rice Biology,china National Rice Research institute,Hangzhou 310006,china c institute of Genetics,Chinese Academy of Sciences,beijing 100101,china [a]State Key Laboratory of Rice Biology/Key Laboratory of Plant Functional genomics Ministry of Education of China Yangzhou University Yangzhou 225009 China [b]State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China [c]institute of Genetics Chinese Academy of Sciences Beijing 100101 China

In this study,we used 127 double haploid (DH) lines to analyze agricultural traits of *** DH lines,derived from a ZYQ8 (indica)/JX17 (japonica) cross by anther culture,contained 160 RFLP and 83 SSR *** and conditional quantitative trait loci (QTL) mapping was conducted to analyze plant height (PH) and tillers per plant (TP) at five growth stages that were grown at two nitrogen *** PH and 13 TP unconditional QTL were identified in the different growth stages,including 19 QTL from high-nitrogen (HN) and 14 QTL from low-nitrogen (LN) *** conditional QTL for 14 genomic regions under LN/HN con- ditions showed that there was a significant effect on PH and TP across the different *** one conditional QTL,ph2-3,was unable to be detected in unconditional *** QTL were detected in the first four rice growth stages than in the final ***- more,a line from the DH mapping population,DH78,was identified in extreme phenotypes of PH and TP that exhibited dwarfism and less-tiller (dft) *** gene dft1 was mapped to chromosome 2 using a backcrossed population of DH78/JX17 through a map- based cloning *** location of dft1 coincided with the mapping region of the small-LOD peak,QTL ph2 and tp2,which were identified in plants grown in low-nitrogen *** backcrossing and fine-mapping successfully delimited the dft1 locus to a 91 kb region.

关键词： Oryza sativa Quantitative trait loci Double haploid (DH) population Developmental behavior Nitrogen Map-based cloning

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