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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Feng-Jiao CHEN,Gang PENG~* institutes of Brain Science and State Key Laboratory of Medical Neuroscience,fudan university,{2. 2.0032, china

＜正＞Objective The zebrafish（Danio rerio） is emerging as a useful behavioral model of human anxiety. Here we further ascertain zebrafish larvae models of anxiety and validate the pharmacological effects of neuroactive compounds by the light/dark preference *** We provide a detailed description of the pattern of exploratory behaviours encountered in zebrafish larvae when exposed to the light/dark preference *** find that the larvae spend less time in the dark compartment relative to the white compartment of the testing *** expression of these dark-avoidance behaviours was significantly attenuated by anxiolytic（diazepam,lorazepam） drugs. Results The findings ascertain the nature of dark-avoidance behaviours as anxiety-like behaviours and provide the pharmacological validation of the light/dark preference test for zebrafish *** behavioural based assay can accommodate drug screening of neuroactive compounds.

关键词： zebrafish larvae anxiolytic drugs anxiety pharmacology

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Neonatal exposure to fluoxetine and fluvoxamine altered spine density

Neonatal exposure to fluoxetine and fluvoxamine altered spin...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ting-Jia LU~(1,2.,Ya-Jie SUN~(1,3),Xue-Han ZHANG~4,Bao-Ming LI~4,Xiao-Hua CAO~5,Zhi-Qi XIONG~(1,2. 1 Institute of Neuroscience and Key Laboratory of Neurobiology,shanghai institutes for Biological Sciences,Chinese Academy of Sciences,shanghai 2.0031,china 2.Graduate School of the Chinese Academy of Sciences,shanghai 2.0031,china 3 Hangzhou Normal university,Hangzhou 310036,china 4 Laboratory of Higher Brain Functions, Institute of Neurobiology,fudan university,shanghai 2.0433,china 5Laboratorory of Synaptic Plasticity and Learning Behavior,shanghai Institute of Brain Functional Genomics,East china Normal university,shanghai 2.0062.china

＜正＞Early-life exposure to SSRI antidepressants increases the chances of developing mood disorders later in life. However,the biological basis in term of neuronal morphology for these behavioral changes is ***,we have employed animal models,mimicking maternal use of SSRIs in clinical,to study neonatal exposure to SSRIs on neuronal *** used confocal microscopy to investigate the acute and long-lasting effects of SSRI administration during early life on dendritic spine density in hippocampal CA1 pyramidal *** observed an acute decrease,and a delayed increase,in dendritic spine density of CA1 pyramidal *** detrimental changes in neuronal morphology were associated with decreased locomotor ***,our findings demonstrate that neonatal exposure to SSRIs is capable of influencing the morphological plasticity of excitatory synapses and raise the caution of clinical medication with SSRIs especially in pregnant women.

关键词： early life SSRI dendritic spine

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Novel compounds discovery from natural resources:a view of SCM(Scientific Chinese Medicine)

Novel compounds discovery from natural resources:a view of S...

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国际药理学术研讨会暨第三届两岸三地药理学学术会议

作者： Yi-Zhun Zhu Department of Pharmacology,School of Pharmacy and Institute of biomedical Sciences, fudan university 82. Zhangheng Road,{2.,2.002.,china

Aim:Using well established extraction methods for discovering the new single compound and novel routes for synthesizing these SCM ***:in vitro,in vivo and ex vivo models have been evaluated for cardioprotective effects ofleonurine(SCM-198),an alkaloid from Herba ***: SCM-198 also reduced the cytosolic Caoverload induced by hypoxia which may be mediated by

关键词： SCM anti-inflammatory ZYZ-802

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Hematopoietic Stem Cell Transplantatino Induces Immunologic Tolerance in Renal Transplant Patients Via Modulation of Inflammatory and Repair Processes

Hematopoietic Stem Cell Transplantatino Induces Immunologic ...

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2.12.国器官移植大会

作者： Duojiao Wul,3,Guisheng Qi1,2.Xuanchuan Wang1,2.Ming Xu1,2.Ruiming Rong1,2.Xiangdong Wang1,2.Tongyu Zh u1,2.1.shanghai Key Laboratory of Organ Transplantation,shanghai,{2. 2.Department of Urology,fudan university Zhongshan Hospital,shanghai,{2. 3.biomedical Research Center,fudan university Zhongshan Hospital,shanghai,{2.

【Objectives】Inducing donor-specific tolerance in renal transplant patients could potentially prevent allograft rejection and calcineurin inhibitor *** kidney and hematopoietic stem cell transplant(HCT) from an HLA-matched donor is an exploratory and promising therapy to induce immune *** of molecular mechanisms involved in the disease is needed to understand the potential process of cell therapy and develop strategies to prevent this immunologic rejection.

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Involvement of the anterior cingulate cortex in the affective pain

Involvement of the anterior cingulate cortex in the affectiv...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yu-Qiu ZHANG Institute of Neurobiology,institutes of Brain Science and State Key Laboratory of Medical Neurobiology,fudan university,{2..

Pain is a multidimensional conscious experience including sensory and affective *** former has been extensively studied,while the latter is poorly *** evidence from morphological, electrophysiological,neuroimaging,and behavioral studies as well as clinical observations indicate that the anterior cingulate cortex(ACC) is a key structure that contributes to pain negative affect or *** formalin-induced conditioned place avoidance(F-CPA) in rats,which is believed to reflect the pain-related negative emotion,we found that lesions of the bilateral ACC markedly blocked the painful stimulation-induced CPA,but not non-painful fear stimulation-induced CPA(Gao et al.,2.04).Intracerebroventricular or intra-rostral ACC(rACC) administration of NMDA receptor antagonist DL-2.amino-5-phosphonovaleric acid(APV),but not AMPA/KA receptor antagonist 6,7- dinitroquinoxaline-2.3-dione(DNQX),significantly decreased both conditioning scores of F-CPA(Lei et al.,2.04).Similarly, intra-rACC injection of 7-Chlorokynurenate(7C1-KYNA),an antagonist of the glycine site of NMDA receptors,can also effectively eliminate the induction of ***,degradation of endogenous D-serine,an endogenous ligand for the glycine site of NMDA receptors,by DAAO(D-amino acid oxidase),an endogenous D-serine degrading enzyme, effectively inhibited NMDA-evoked currents and attenuated F-CPA scores,but did not affect formalin-induced acute nociceptive behaviors,suggesting that endogenous D-serine in the rACC is necessary for NMDA receptor-mediated pain-related aversion(Ren et al.,2.06).Extracellular signal-regulated kinase(ERK),a family member of mitogen-activated protein kinases(MAPKs),has been implicated in NMDA-dependent synaptic *** of NMD A receptor markedly increased expression levels of phosphor-ERK(pERK) through a Ca-dependent mechanism,and PKA might mediate the NMDA-dependent ERK *** ERK translocates from the cytosol to the

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A FREQUENCY DOMAIN QUANTITATIVE MEASUREMENT METHOD FOR BLOOD FLOW VELOCITY WITH BIDIRECTIONAL DOPPLERULTRASOUND AVOIDING DOWN-BAND CHANNEL

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Chinese Journal of biomedical Engineering(English Edition) 1996年第4期5卷 147-154页

作者： Wang Weiqi,Shao Qianming,Yu Jianguo(Department of Electronic Engineering,fudan university, shanghai, 2.0433, {2.)

The up-band signal of the second ultrasonic beam contained reversecomPOnent or blooll now. Using double ultrasonic beam,bidirectional Doppler ultrasound can avoid the use or two kinds or band filters and be simplified into a singlekind or band filter. In order to make the output more accurate,the inrluence of angle effect can be overcome by the table-out method and another special methodcalled cose *** experiment result is that when the deviation angle varies from-- 18' to +2.' the relative error or output is less than 5%.

关键词： Ultrasound Blood flow velocity Frequency separation Down-bandchannel

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The Granulocyte Colony-stimulating Factor Promotes Atherosclerosis in High-fat Diet Rabbits

The Granulocyte Colony-stimulating Factor Promotes Atheroscl...

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第八届海峡两岸心血管科学研讨会

作者： Zhao-hui Hu~1,Hui Gong~2.Ming Yang~1,Yu-hong Niu~1,Guo-ping Zhang~2.Hong Ma~1, Ning Zhou~1,Lei Li~2.Jian Wu~2.Li Lin~1,Ai-jun Sun~(1,2.,Jun-bo Ge(1,2.,Yun-zeng Zou~(1,2. (1.shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital of fudan university,{2..2.institutes of biomedical Science,fudan university,{2.)

Background Granulocyte - colony stimulating factor(G - CSF) has been reported to improve the function of infarcted heart,but its effects on atherosclerosis are *** and Results We examined these and the potential mechanisms in the high -fat diet rabbit *** - month - old male New Zeal- and white rabbits,fed the high - cholesterol(1%) diet or not for 10 weeks,were injected with vehicle or G -CSF (15μg·(kg·d) 5 days/week for 3 weeks) subcutaneously daily.G - CSF similarly increased the number of circulating white blood cells(WBC ) but not that of platelet both in normal and high - fat diet groups although platelet aggregation function was increased by G - CSF only in normal diet group.G - CSF further increased the plasma levels of total cholesterol(TC) and low - density lipoprotein - cholesterol(LDL - C) at early phase and atherosclerotic lesions area in the thoracic aorta compared to vehicle treatment only in high -fat diet *** - fat diet - induced arterial endothelium damage and collagen hyperplasia were greatly aggravated by G - CSF.G - CSF up - regulated endothelin - 1(ET - 1 ),matrix metalloproteinase (MMP -9) and tissue inhibitor of metalloproteinase - 2.TIMP - 2. and down - regulated endothelial nitric oxide synthase(eNOS) expressions in thoracic aorta of high - fat diet groups but did not in that of normal diet *** The results suggest that G - CSF exacerbates lipid abnormity and endothelium damage in hyperlipidemia rabbits,thereby resulting in the deterioration of atherosclerosis and that ET - 1/eNOS system and MMP - 9/TIMP - 2.family may regulate the progression.

关键词： atherosclerosis endothelium ET-1 G-CSF hyperlipidemia MMP-9 TIMP-2 eNOS

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Mechanical Stress-evoked but AngiotensinⅡ-independent Activation of Angiotensin Ⅱ type 1 Receptor Induces Cardiac Hypertrophy through Calcineurin Pathway

Mechanical Stress-evoked but AngiotensinⅡ-independent Activ...

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第八届海峡两岸心血管科学研讨会

作者： Ning Zhou,Lei Li,Hui Gong,Man Wu,Yu-hong Niu, Ai-jun Sun,Jun-bo Ge,Yun-zeng Zou~* (institutes of biomedical Science,{2.,shanghai 2.0032.china)

Background Mechanical stress can induce cardiac hypertrophy through angiotensin Ⅱ (Ang Ⅱ ) type 1(AT1) receptor independently of Angll,however,the intracellular mechanisms remain largely indeterminate. Since calcineurin,a Ca-dependent phosphatase,plays a critical role in pressure overload - induced cardiac hypertrophy,we therefore,askedwhether calcineurin is involved in the AT1 receptor - mediated but Ang Ⅱ independent cardiac *** and Results Mechanical stretch failed to elicit hypertrophic responses in COS7 cells co - transfected with plasmid of AT1 receptor and siRNA of *** stresses for 2.weeks in vivo and for 2. h in vitro significantly induced upregulation of calcineurin expression and hypertrophic responses,such as the increases in cardiomyocytes size and specific gene expressions, in cardiomyocytes of angiotensinogen gene knockout(ATG - KO) mice,both of which were significantly suppressed by a specific calcineurin inhibitor FK506,suggesting a critical role of calcineurin in mechanical stress - induced cardiac hypertrophy in the ATG - KO ***,an AT1 receptor blocker,Losartan not only attenuated cardiac hypertrophy but also abrogated upregulation of cardiac calcineurin expression induced by mechanical stresses in the Angll - lacking mice,indicating that calcineurin expression is regulated by AT1 receptor without the involvement of Angll after mechanical *** These findings collectively suggest that mechanical stress - evoked but Angll - independent activation of AT1 receptor induces cardiac hypertrophy through calcineurin pathway.

关键词： angiotensin Ⅱ type 1 receptor Ca2. -dependent phosphatase cardiac hypertrophy

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Kir andⅠh channels regulate the excitability of rat retinal ganglion cells

Kir andⅠh channels regulate the excitability of rat retinal...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Shu-Xia JIANG,Zhongfeng WANG~* institutes of Brain Science,Institute of Neurobiology and State Key Laboratory of Medical Neurobiology,fudan university,{2.

Objective Retinal ganglion cells,output neurons of the retina,receive excitatory inputs from bipolar cells and inhibitory inputs from amacrine *** change of RGC excitability directly influences visual processing in the *** both inwardly rectifying potassium channels(Kir) and hyperpolarization-activated cation channel(I) were reported to be involved in the regulation of cell excitability in the CNS,the effects of these channels in regulating the excitability of RGCs are largely *** Whole-cell patch-clamp recordings were performed on ganglion cells in retinal slice *** activities were recorded under current-clamp *** (1) Blocking synaptic inputs almost completely eliminated spontaneous firing both in ON- and OFF-types of RGCs. Blocking the inhibitory synaptic inputs alone enhanced the firing frequency,shortened interspike interval of the RGCs, while inhibition of excitatory inputs alone terminated the spontaneous firing in almost all RGCs tested.(2. In the presence of synaptic blockers(NBQX,D-APV,bicuculline and strychnine),extracellular application of Ba,a Kir channel blocker,significantly increased the firing frequency both in ON- and OFF-types of RGCs,as well as induced a membrane ***,the firing pattern of the cells became much more regular.(3) In the presence of synaptic blockers,Cs,a nonspecific I blocker,also remarkably increased the firing frequency and induced a membrane depolarization both in ON- and OFF-types RGCs,while the firing pattern of the cells became much more irregular after Cs ***,ZD72.8,a specific I blocker,induced an increase of the frequency of spontaneous firing in most,if not all,of *** These results suggest that both Kir and I channels are functionally expressed in rat RGCs,and these channels are involved in the regulation of RGC excitability.

关键词： retinal ganglion cell Kir Ih excitability spontaneous firing

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Cyclic GMP-dependent modulation by melatonin of signal from rods,but not cones to ON type bipolar cells in fish retina

Cyclic GMP-dependent modulation by melatonin of signal from ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yong PING,Hai HUANG,Xin-Jun ZHANG,Xiong-Li YANG Institute of Neurobiology,institutes of Brain Science,fudan university,{2.

Melatonin may modulate retinal information processing through activating specific receptors coupled to GTP-binding *** the present work we studied effects of melatonin on ON type bipolar cells(BCs).Intracellular recordings showed that melatonin depolarized ON type BCs driven by rod signal(Rod-ON-BCs) and significantly suppressed their light responses,which was reversed by the MT2.receptor specific antagonist 4-phenyl-2.propionamido-tetralin(4-P-PDOT). In contrast,melatonin was without effect on ON type BCs driven by cone signal(Cone-ON-BCs).Consistent with the intracellular recordings,melatonin suppressed the scotopic electroretinographic(ERG) b wave,but not the photopic b wave,by activating the MT2.*** did not change the scotopic ERG PⅢcomponent,suggesting a direct action of melatonin on the ***,8-Br-cGMP mimicked the effects of melatonin on *** methylene blue had opposite *** immunocytochemistry,melatonin was found to increase intracellular cGMP levels ([cGMP]i) of ***-cell patch recordings further showed that melatonin activated cGMP-gated channels in Rod-,but not in Cone-ON-BCs via MT2.receptors by inhibiting the activity of phosphodiesterase(PDE).Increased [cGMP]i by melatonin could open the cGMP-gated channels and/or activate cGMP-dependent kinase(cGK).Melatonin increased inward currents induced by brief(2.0 ms) puffs of CPPG in the presence of L-AP4,and the effect could be blocked by KT582.,a cGK antagonist,suggesting that the enhancement was mediated by cGK,which was activated by increased[cGMP]*** the presence of 2.mM Ca

关键词： melatonin receptor cGMP cGMP-activated cation channel bipolar cell retina neuromodulation

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