Pharmacological study of the light/dark preference test in zebrafish larvae
会议名称：《中国神经科学学会第九届全国学术会议暨第五次会员代表大会》
会议日期：2011年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
关 键 词：zebrafish larvae anxiolytic drugs anxiety pharmacology
摘 要：正Objective The zebrafish（Danio rerio） is emerging as a useful behavioral model of human anxiety. Here we further ascertain zebrafish larvae models of anxiety and validate the pharmacological effects of neuroactive compounds by the light/dark preference *** We provide a detailed description of the pattern of exploratory behaviours encountered in zebrafish larvae when exposed to the light/dark preference *** find that the larvae spend less time in the dark compartment relative to the white compartment of the testing *** expression of these dark-avoidance behaviours was significantly attenuated by anxiolytic（diazepam,lorazepam） drugs. Results The findings ascertain the nature of dark-avoidance behaviours as anxiety-like behaviours and provide the pharmacological validation of the light/dark preference test for zebrafish *** behavioural based assay can accommodate drug screening of neuroactive compounds.