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Science china Chemistry 2009年第10期52卷 1711-1714页

作者： YU JianFang, WU GuangMing, HUANG Jing, SUN WeiLin & SHEN ZhiQuan Key Laboratory of Macromolecular Synthesis and Functionalization, Ministry of Education, Department of Polymer Science and Engineering, zhejiang university, Hangzhou 310027, china 1. Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

Discrete ion-pair complexes [Ln(EDBP)2(DME)Na(DME)3] [Ln=Er (1), Yb (2), Sm (3)] have been synthesized by the reaction between sodium salt of 2,2'-ethylidene-bis(4.6-di-tert-butylphenol)(EDBPH2) and Ln(BH4.3·3THF (Ln=Er, Yb, Sm) followed by centrifugation and recrystalization. The complexes were characterized by elemental analysis and FT-IR, and the bonding model of these compounds was confirmed by X-ray single crystal diffraction for complex 1. It was found that four O atoms in two biphenol ligands as well as two O atoms in one ethylene glycol dimethyl ether (DME) molecule connect to the center rare earth metal atom, while sodium exists as counterpart cation to balance the charge. Complexes 1―3 can all be used as single component initiators for the ring-opening polymerization of ε-caprolactone.

关键词： ring-opening polymerization ε-caprolactone X-ray single crystal biphenol

Functional distinction of rat liver natural killer cells from spleen natural killer cells under normal and acidic conditions in vitro

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Hepatobiliary & Pancreatic Diseases International 2012年第3期11卷 285-293页

作者： Li-Hong Lv, Jian-Dong Yu, Guo-Lin Li, Tian-Zhu Long, Wei Zhang, Ya-Jin Chen, Jun Min and Yun-Le Wan Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen university Department of Breast Surgery, Guangzhou Women and Children’s Medical center Guangzhou 510120, china Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, zhejiang university School of Medicine, Hangzhou 310003, china [a] Department of Hepatobiliary Surgery Sun Yat-Sen Memorial Hospital Sun Yat-Sen University (Lv LH Yu JD Li GL Chen YJ Min J and Wan YL) Guangzhou 510120 China [b] Department of Breast Surgery Guangzhou Women and Children's Medical Center (Long TZ) Guangzhou 510120 China [c] Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

BACKGROUND: The microenvironment within solid tumors has often been shown to exhibit an acidic extracellular pH. Although the morphologic and functional differences in natural killer (NK) cells of the liver and spleen have been reported previously under physiological conditions, the difference under acidic conditions is still unclear. This study was to investigate the differences in the morphological and functional characteristics between rat liver and spleen NK cells under normal and acidic conditions in vitro. METHODS: Liver and spleen NK cells were isolated and purified from Sprague-Dawley rats by density gradient centrifugation and the Dynabeads FlowComp TM Flexi system, and stimulated for 4.days with or without IL-2 or treated with low pH or control for different times. Morphology was examined by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), cell death and proliferation assays were performed by flow cytometry, IFN-γ production was tested by ELISA, and cytotoxic activity was evaluated by lactate dehydrogenase (LDH) release assay. RESULTS: Liver NK cells had significantly higher levels of cytotoxic activity than spleen NK cells under normal and acidic conditions, and the maximum difference was observed at pH 5.6. Further analysis revealed that the cytotoxic activity of NK cells was correlated with morphology, cell death, proliferative activity and IFN-γ production. By TEM, liver NK cells contained a greater number of electron-dense granules per cell at pH ***, a modest elevation of cell death and reduction of proliferation of liver NK cells occurred within a range of 5.6-7.2. Interestingly, an acidic extracellular pH only marginally, and not significantly, suppressed IFN-γ production by liver NK cells. CONCLUSION: The sharp morphological and functional differences shown by the two types of NK cells in vitro indicate that liver NK cells are unexpectedly resistant to pH shock.

关键词： natural killer cells liver spleen tumor microenvironment extracellular pH

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气相色谱法测定口服液中神经酸的含量

色谱 1999年第3期17卷 306-307页

作者：周立勇侯镜德樊华浙江大学分析测试中心杭州310027 中美华东制药有限公司研究所杭州310011

提供了一种准确测定口服液中神经酸含量的方法。样品经预处理后，用BF3－CH3OH酯化，以邻苯二甲酸二壬酯为内标测定口服液中神经酸含量。所提供的方法线性范围为0．3～3g／L，平均回收率为97．04.，RSD为0．90％，经空白试验，对神经... 详细信息

提供了一种准确测定口服液中神经酸含量的方法。样品经预处理后，用BF3－CH3OH酯化，以邻苯二甲酸二壬酯为内标测定口服液中神经酸含量。所提供的方法线性范围为0．3～3g／L，平均回收率为97．04.，RSD为0．90％，经空白试验，对神经酸含量测定无干扰。

关键词：气相色谱神经酸口服液测定

The Construction and Evaluation of the Regional Innovation System of zhejiang Province

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The Construction and Evaluation of the Regional Innovation S...

2010 Second International Seminar On Business and Information Management (ISBIM 2010)

作者： Cai Ning College of Public Administration zhejiang university HangZhou china Huang Chun College of Public Administration zhejiang university HangZhou china

Concerning the economic development situation of zhejiang Province, a set of evaluation indicators urgently need to be established to reflect the regional development demand and fit for the regional innovation of the Province. Yet, since the economic and social development in zhejiang is unbalanced, there are still obvious differences in regional innovation among the 11 prefecture-level cities. Thus, how to objectively evaluate the creativity of one region and make countermeasures to raise the regional innovation in accordance with the differences among the regions has become an urgent theoretical problem and practical requirement. The paper constructs an evaluation system of zhejiang’s regional innovation by theoretical and empirical selection. Based on the evaluation indicator system and combined with the specific data material, the paper conducts practical measurement and horizontal comparative {4. to the regional innovation of the 11 prefecture-level cities of zhejiang Province.

关键词： regional innovation innovation system construction evaluation.

水平地震力作用下钢板桩围堰体系动力响应数值分析

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沈阳建筑大学学报（自然科学版） 2009年第6期25卷 1063-1068页

作者：崔春义黄建孙占琦魏超聂淼鑫大连海事大学道路与桥梁工程研究所辽宁大连116026 大连理工大学岩土工程研究所辽宁大连116024 深圳市市政设计研究院有限公司博士后创新基地深圳518029 浙江工贸职业技术学院浙江温州325003

目的针对水平地震力作用下钢板桩围堰体系的动力受力变形特性分别进行振型分解反应谱分析和动力时程分析,并将计算结果加以比较,为工程设计与实践提供参考依据.方法通过建立双排钢板桩围堰体系动力有限元数值模型,采用Lanczos特征值法... 详细信息

目的针对水平地震力作用下钢板桩围堰体系的动力受力变形特性分别进行振型分解反应谱分析和动力时程分析,并将计算结果加以比较,为工程设计与实践提供参考依据.方法通过建立双排钢板桩围堰体系动力有限元数值模型,采用Lanczos特征值法提取围堰体系自然频率与振型,利用Newmark逐步积分方法求解考虑几何非线性的动力平衡方程.结果双排钢板桩围堰体系振动固有周期较小,围堰体系正向平动刚度较负向平动刚度要小;在水平地震力作用下,围堰体系地震水平位移响应在围堰上部靠近外侧区域最为显著;外侧钢板桩受力变形响应较内侧钢板桩更为显著.结论内、外侧钢板桩水平位移分布均随着高度的增大而增大.相反的,内、外侧钢板桩广义剪应力分布均随着高度的增大而减小.

关键词：围堰体系反应谱分析时程分析水平地震力

measurement Equivalence in Cross-Culture Research:Concept,Bias Resource and Test Method

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Measurement Equivalence in Cross-Culture Research:Concept,Bi...

2009 Second International Workshop on Knowledge Discovery and Data Mining

作者： Xianfang Xue Department of Psychology zhejiang university Hangzhou 310028 china

＜正＞measurement equivalence（ME） is an important issue in cross-culture research,it’s critical for the interpretation and comparison of measured *** also has important meaning for human resource management and organizational behavior *** in cross-culture research can be reviewed from concept,bias resource and test *** measurement bias mainly comes from culture,language, organization and response *** present,there are two test methods:confirmative factor analysis（CFA） and item response theory（IRT）.

关键词： measurement equivalance bias resource test method

The measurement of Coordination Degree between Manufacturing and Logistics—Based on Gray Correlation System Model

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The Measurement of Coordination Degree between Manufacturing...

2010 Second International Seminar On Business and Information Management (ISBIM 2010)

作者： Jian-liang PENG College of Computer & Information Engineering zhejiang Gongshang university Hangzhou zhejiang Province china Kuai-juan ZHANG College of Computer & Information Engineering zhejiang Gongshang university Hangzhou zhejiang Province china

Coordinated growth of manufacturing and logistics industry has become an important issue in the sustainable development of a *** article firstly builds manufacturing and logistics system in index system,and then,with the application of gray model,makes a quantitative analysis of the degree of logistics coordination between manufacturing and logistics industry during 2000-2008 in *** finds that the coordinated development of manufacturing and logistics are in the critical state between coordination and lack of *** conclusions are of practical significance.

关键词： Coordination degree Grey Relational Model manufacturing industry logistics industry

Neural system encode information is in ordered space

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Neural system encode information is in ordered space

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Luping FANG~1,Hong ZHANG~(2,3),QinyeTONG~(1,2,3) 1 center of Neural Information Research zhejiang university 2 Department of Biomedical Engineering zhejiang university 3 Key Laboratory of Biomedical Engineering Ministry of Education zhejiang university Hangzhou 310027,{4.

＜正＞Up to now,many neural coding theories have been proposed,such as rate code,temporal code,population code,***,many of them contradict with each *** think that theoretical consideration is the basis to judge which proposal is more *** criteria are required for assessing neural coding *** the paper,four obligatory conditions are *** of all,we give the hypothesis that human’s neural system works in the ordered space,based on which the conclusion that neural coding takes the form of spike neural sequence can be drawn by computational analysis on the neuron ***,the signal process for the neural network in olfactory system is *** strength of various odors sensed by olfactory sensory neuron can be read directly from the output spike sequence of the mitral ***,what surprises us is the discovery that only single neuron is needed to perform Doppler measurement for the biological sonar system of bat,dolphin and *** implementation of echo-location requires one single neuron also,with high discerning *** other words,the subtle variation of Doppler signal or the small change of the sounding position can be discovered in high resolution from the output spike sequence of one *** spite that our theory has not been verified experimentally,it provides a new viewpoint.

关键词： neural code ordered space symbolic dynamics spike sequence

Comprehensive characterization of the small RNA transcriptomes of androgen dependent and independent prostate cancer

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Comprehensive characterization of the small RNA transcriptom...

2010’全国肿瘤分子标志及应用学术研讨会暨第五届中国中青年肿瘤专家论坛

作者： Gang Xu~(1,§),Jinyu Wu~(2,§),LingLin Zhou~2,Binghua Chen~1,Zhongsheng Sun~(2,3),Fangqing Zhao~(2,4.*) and Zhihua Tao~(1*) 1 center for Clinical Laboratory Diagnosis,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,china 2 Institute of Genomic Medicine/zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College,Wenzhou 325035,china 3 Behavioral Genetics center,Institute of Psychology,Chinese Academy of Science,Beijing 100101,china 4.center for Comparative Genomics and Bioinformatics,Department of Biochemistry and Molecular Biology,Pennsylvania State university,Pennsylvania 16802,USA

Given the important roles of miRNA in post-transcriptional regulation and its implications for cancer,comprehensive characterization of miRNA facilitates us to uncover molecular mechanisms underlying the progression of androgen-independent prostate cancer(PCa).The emergence of next-generation sequencing technologies has dramatically changed the speed of all aspects of sequencing in a rapid and

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The measurement of Technology Achievement Maturity Degree and Its Application in Value analysis

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The Measurement of Technology Achievement Maturity Degree an...

价值工程与技术创新国际会议

作者： Qingguo Ma Professor Business School zhejiang university Linfen Chen Ph.D student Business School zhejiang university Hangzhou 310027 {4.

中国科技成果转化为产品的比例很低,其原因之一,就是科技成果的成熟度较低。所以,研究可测量的科技成果成熟度的概念和测量方法,无论在实践上、理论上,都有重要意义。本文尝试性地做了这一工作,给出了可以测量的概念和测量方法,并研究... 详细信息

中国科技成果转化为产品的比例很低,其原因之一,就是科技成果的成熟度较低。所以,研究可测量的科技成果成熟度的概念和测量方法,无论在实践上、理论上,都有重要意义。本文尝试性地做了这一工作,给出了可以测量的概念和测量方法,并研究了它在科技成果购买的价值分析中的应用。

关键词：科技成果成熟度测量价值分析