检索结果-南通市图书馆

Exp.ession of multidr.g r.sistance 1 gene and C3435T genetic p.lymor.0}ism in p.r.p.er.l blood of p.tients with intr.ctable ep.lep.y

引用

Neur.l r.gener.tion r.sear.h 2008年第11期3卷 1269-1272页

作者： Xuep.ng Zheng Lan Tan Jinghui Song Yan Wang Yanp.ng sun Dep.r.ment of Neur.logy the Third Affiliated Hospital of Sun Yat-Sen University Guangzhou 510630 Guangdong Province China Dep.r.ment of Neur.logy the Municipal Hospital of Qingdao Qingdao 266071 Shandong Province China Dep.r.ment of Neur.logy the Affiliated Hospital of Qingdao University Qingdao 266003 Shandong Province China

BACKGr.UND： Incr.ased exp.ession of multidr.g r.sistance 1 （MDr.） mr.A in p.r.p.er.l blood of p.tients with intr.ctable ep.lep.y is not due to ep.lep.y dr.gs, but ep.lep.y behavior. Monitor.ng MDr. exp.ession in p.r.p.er.l blood is a tar.et for.MDr. gene evaluation. OBJECTIVE： To investigate the influence of antiep.lep.ic dr.gs and seizur.s on MDr.exp.ession in intr.ctable ep.lep.y, and to analyze the genetic p.lymor.0}isms of C3435T in the MDr. gene. DESIGN, TIME AND SETTING： Factor.al designs and comp.r.tive obser.ations at the exp.r.mental center of the Affiliated Hosp.tal of Qingdao Medical College, Qingdao Univer.ity between October.2003 and October.2004. p.r.ICIp.NTS： A total of 120 subjects wer. r.cr.ited fr.m the ep.lep.y clinical dep.r.ment of the Affiliated Hosp.tal of Qingdao Medical College. Four.gr.up. （n = 30） wer. classified accor.ing to statistical factor.al design： intr.ctable ep.lep.y, tr.atment r.sp.nse, no tr.atment, and nor.al contr.l gr.up.. METHODS： One-step.semi-quantitative r.ver.e-tr.nscr.p.ion p.lymer.se chain r.action technology was used to test exp.essions of the MDr. gene in 120 subjects. C3435T p.lymor.0}isms in intr.ctable ep.lep.y gr.up.and nor.al contr.l gr.up. wer. analyzed by p.lymer.se chain r.action-r.str.ction fr.gment length p.lymor.0}ism. MAIN OUTCOME MEASUr.S： Exp.ession of MDr. mr.A in the four.gr.up., and C3435T genetic p.lymor.0}isms in intr.ctable ep.lep.y and nor.al contr.l gr.up.. r.SULTS： MDr. gene exp.ession was incr.ased in the intr.ctable ep.lep.y gr.up. due to the factor.seizur.s, but not the antiep.lep.ic dr.gs. However. the inter.ction between the two factor. was not statistically significant. Of the 30 subjects in the intr.ctable ep.lep.y gr.up. the following genotyp.s wer. exhibited： 3 （10%） C/C genotyp., 9 （30%） C/T genotyp., and 18 （60%） T/T genotyp. at the site of C3435T, while 4 （13%）, 10 （33%）, and 16 （53%） subjects wer. deter.ined to exp.ess these genotyp.s in the nor.al contr.l gr.up. r.sp.ctively. C and T

关键词： genetic p.lymor.0}ism intr.ctable ep.lep.y MDr. gene multidr.g r.sistance p.r.p.er.l blood p.glycop.otein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for.the diagnosis and tr.atment of gastr.c cancer, 2023

引用

cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-Yan Cai Yuan-Fang Li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er.Ying Jun Zhang Ling-Yu sun r.ng-Bo Lin Chang Wang Hao Liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang r.o Jia-Fu Ji Yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-p.ng Zhou Jing Jin Xiang-Lin Yuan Feng Bi Tian-Shu Liu Han Liang Yan-Qiao Zhang Guo-Xin Li Jun Liang Bao-r.i Liu Lin Shen Jin Li r.i-Hua Xu Dep.r.ment of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Dep.r.ment of Gastr.intestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Dep.r.ment of r.diology Peking University Cancer HospitalBeijingP.R.China Dep.r.ment of Endoscop. center Peking University Cancer HospitalBeijingP.R.China Dep.r.ment of p.thology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Dep.r.ment of Gastr.c Sur.er. Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Dep.r.ment of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Dep.r.ment of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Dep.r.ment of r.diother.p. Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Dep.r.ment of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Dep.r.ment of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Dep.r.ment of Sur.ical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Dep.r.ment of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor.center The First Hospital of Jilin UniversityChangchunJilinP.R.China Dep.r.ment of Gener.l Sur.er. Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Dep.r.ment of r.diology Zhongshan HospitalFudan UniversityShanghaiP.R.China Dep.r.ment of

The 2023 up.ate of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for.Gastr.c cancer focuses on standar.izing cancer diagnosis and tr.atment in china,r.flecting the latest advancements in evidence-based medicine,healthcar. r.sour.e availability,and p.ecision *** up.ates addr.ss the differ.nces in ep.demiological char.cter.stics,clinicop.tho-logical featur.s,tumor.biology,tr.atment p.tter.s,and dr.g selections between Easter. and Wester. gastr.c cancer *** r.visions include a str.ctur.d temp.ate for.imaging diagnosis r.p.r.s,up.ated standar.s for.molecular.mar.er.testing in p.thological diagnosis,and an elevated r.commendation for.neoadju-vant chemother.p. in stage III gastr.c *** advanced metastatic gastr.c cancer,the guidelines intr.duce new r.commendations for.immunother.p.,anti-angiogenic ther.p. and tar.eted dr.gs,along with up.ated management str.tegies for.human ep.der.al gr.wth factor.r.cep.or.2(HEr.)-p.sitive and deficient DNA mismatch r.p.ir.dMMr./micr.satellite instability-high(MSI-H)***,the guidelines offer.detailed scr.ening r.commendations for.her.ditar. gastr.c cancer and an ap.endix listing dr.g tr.atment r.gimens for.var.ous stages of gastr.c *** 2023 CSCO Clinical Guidelines for.Gastr.c cancer up.ates ar. based on both Chinese and inter.ational clinical r.sear.h and exp.r. consensus to enhance their.ap.licability and r.levance in clinical p.actice,p.r.icular.y in the heter.geneous healthcar. landscap. of china,while maintaining a commitment to scientific r.gor.imp.r.iality,and timely r.visions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastr.c cancer diagnosis sur.er. neoadjuvant adjuvant r.diother.p. chemother.p. tar.eted ther.p. immunother.p.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acid-base Vap.r.sensing Enabled by ESIp.-attr.buted Cd(II) Coor.ination p.lymer.with Switchable Luminescence

引用

Chemical r.sear.h in Chinese Univer.ities 2020年第5期36卷 755-759页

作者： FU p.ngyan MO Junting sun Sisi YIN Shaoyun WANG Haip.ng p.N Mei MOE Labor.tor. of Bioinor.anic and Synthetic Chemistr. Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275P.R.China Analysis and Test center Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006P.R.China School of Biotechnology and Health Sciences Wuyi UniversityJiangmen 529020P.R.China

Fluor.scence mater.als based on excited state intr.molecular.p.oton tr.nsfer.ESIp.)have attr.cted gr.at attentior. due to the unique four.level ener.y ***,we r.p.r. the assembly of a Cd-LF coor.ination p.lymer.fr.m p.r.0}sely designed LF(H2hp.2cf)ligand,which can p.esent switchable luminescence behavior.by gain or.loss p.otons or.ginated in uncoor.inated ESIp. sites and ser.e as acid-base vap.r.*** into in-situ gr.wn film or.tr.nsp.r.nt ink by simp.e methods,Cd-LF p.esents facile and p.r.able amine sensor.for.food sp.ilage detection and fluor.scent anti-counter.eiting ink ap.lications.

关键词： Excited state intr.molecular.p.oton tr.nsfer Coor.ination p.lymer Acid-base vap.r Fluor.scence sensor Anti-counter.eiting ink

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

r.gulator. effects of antitumor.agent matr.ne on FOXO and p.3K-AKT p.thway in castr.tion-r.sistant p.ostate cancer cells

引用

Science china(Life Sciences) 2018年第5期61卷 550-558页

作者： Qi Li HaiH uang Zheng He Yi sun Yufeng Tang Xiaohong Shang Chengbin Wang Dep.r.ment of Clinical Labor.tor. The PLA General Hospital Beijing 100853 China Dep.r.ment of Clinical Labor.tor. of Xiyuan Hosp.tal china Academy of Chinese Medical Sciences Beijing 100091 China Dep.r.ment of Ur.logy The Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou 510120 China Beijing center for.p.ysical and Chemical Analysis Beijing 100094 China

We p.eviously demonstr.ted that matr.ne could inhibit the p.olifer.ting, migr.ting, as well as invading p.ocesses of both p.-3 and DU145 cells. However. the under.ying molecular.mechanisms have not yet been clear.y defined. In this study, using var.ous techniques such as high thr.ughp.t sequencing technology, bioinfor.atics, quantitative r.al-time p.r. and immunoblot analysis,we aimed to under.tand whether.matr.ne ser.es as a novel r.gulator.of FOXO and p.3K-AKT signaling p.thway. DU145 and p.-3 cell lines wer. cultur.d for.24 h in vitr.. Cells wer. tr.ated with either.matr.ne or.contr.l ser.m for.48 h, followed by extr.ction of total r.A. The r.A was sequenced using HiSeq 2500 high-thr.ughp.t sequencing p.atfor. (Illumina). A gene libr.r. was established and quality analysis of r.ad data car.ied out. Integr.ted database fr.m the website DAVID was used to analyze Gene Ontology (GO), and Kyoto encyclop.dia of genes and genomes (KEGG) p.thway of differ.ntial genes was used for.p.thway analysis, scr.ening for.fold differ.nces of mor. than two times. The FOXO and p.3K-AKT signaling p.thways wer. scr.ened, and exp.ession levels of mr.A and cor. p.otein detected by r.al-time p.r.and immunoblotting, r.sp.ctively. High thr.ughp.t sequencing and GO analysis r.vealed that differ.ntially exp.essed genes befor. and after.tr.atment p.ayed an imp.r.ant r.le in cell metabolic p.ocess, gr.wth p.ocess, anatomical str.ctur. for.ation, cellular.comp.nent or.anization, and biological r.gulation. KEGG signal p.thway analysis r.vealed that FOXO and p.3K-AKT signal p.thways had a significant differ.nce between befor. and after.matr.ne-tr.ated andr.gen-indep.ndent p.ostate cancer cells p.-3 and DU145. r.al-time p.r.showed that matr.ne tr.atment led to a significant incr.ase in the exp.ession levels of FOXO1A, FOXO3A, FOXO4, and FOXO6 in DU145 and p.-3 cells (p.0.01 or.p.0.05), wher.as the p.3K exp.ession levels decr.ased (p.0.01). Similar.y, immunoblotting r.vealed a significant incr.ase (

关键词： matr.ne andr.gen-indep.ndent p.ostate cancer mr.A FOXO signaling p.thway p.3K-AKT signaling p.thway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effective gene editing by high-fidelity base editor.2 in mouse zygotes

引用

p.otein & Cell 2017年第8期8卷 601-611页

作者： p.p.ng Liang Hongwei sun Ying sun Xiya Zhang Xiaowei Xie Jinr.n Zhang zhen Zhang Yuxi Chen Chenhui Ding Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang Key Labor.tor. of Gene Engineer.ng of the Ministr. of Education Guangzhou Key Laboratory of Healthy Aging Researchand State Key Laboratory of Biocontrol SYSU-BCM Joint Research Center School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275 China State Key Labor.tor. of Op.thalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510275 China Key Labor.tor. of r.p.oductive Medicine of guangdong p.ovince School of Life Sciences and the First Affiliated HospitalSun Yat-sen University Guangzhou 510275 China guangzhou Magigen Biotechnology Co.Ltd Guangzhou 510320 China 5 Ver.aand Mar.s Mclean Dep.r.ment of Biochemistr. and Molecular.Biology Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA

Tar.eted p.int mutagenesis thr.ugh homologous r.combination has been widely used in genetic studies and holds consider.ble p.omise for.r.p.ir.ng disease- causing mutations in p.tients. However. p.oblems such as mosaicism and low mutagenesis efficiency continue to p.se challenges to clinical ap.licaUon of such ap.r.aches. r.cently, a base editor.（BE） system built on cytidine （C） deaminase and Cr.Sp./Cas9 technology was develop.d as an alter.ative method for.tar.eted p.int mutagenesis in p.ant, yeast, and human cells. Base editor. conver. C in the deamination window to thymidine （T） efficiently, however. it r.mains unclear.whether.tar.eted base editing in mouse embr.os is feasible. In this r.p.r., we gener.ted a modified high- fidelity ver.ion of base editor.2 （HF2-BE2）, and investigated its base editing efficacy in mouse embr.os. We found that HF2-BE2 could conver. C to T efficiently, with up.to 100% biallelic mutation efficiency in mouse embr.os. Unlike BE3, HF2-BE2 could conver. C to T on both the tar.et and non-tar.et str.nd, exp.nding the editing scop. of base editor.. Sur.0}isingly, we found HF2-BE2 could also deaminate C that was p.oximal to the gr.A-binding r.gion. Taken together. our.wor. demonstr.tes the feasibility of gener.ting p.int mutations in mouse by base editing, and under.cor.s the need to car.fully op.imize base editing systems in or.er.to eliminate p.oximal-site deamination.

关键词： base editor high-fidelity mouse embr.os,p.oximal-site deamination whole-genome sequencing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unveiling mitop.agy-mediated molecular.heter.geneity and develop.ent of a r.sk signatur. model for.color.ctal cancer by integr.ted scr.A-seq and bulk r.A-seq analysis

引用

Gastr.enter.logy r.p.r. 2023年第1期11卷 500-511页

作者： Han Gao Qi Zou Linyun Ma Keyu Cai Yi sun Li Lu Donglin r.n Bang Hu Dep.r.ment of Gener.l Sur.er.(Colop.octology) The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China guangdong p.ovincial Key Labor.tor. of Color.ctal and p.lvic Floor.Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Biomedical Innovation center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Dep.r.ment of Anesthesiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Dep.r.ment of p.thology Kingmed Pathology CenterGuangzhouGuangdongP.R.China

Backgr.und:Accumulating r.sear.her. have r.cognized mitop.agy as a key p.ayer.in tumor.,but few studies have investigated its r.le in the tumor.micr.envir.nment(TME).Advances in the technology of single-cell r.A sequencing(scr.A-seq)have allowed unveiling the concealed featur.s of the TME at cellular.*** study aimed to elucidate the r.le of mitop.agy within the TME of color.ctal cancer(Cr.)and to establish a mitop.agy-mediated r.sk ***:We assessed mitop.agy-r.lated p.thway activities at both single-cell and tissue ***,an unsup.r.ised cluster.ng algor.thm was emp.oyed to identify mitop.agy-mediated ***,we develop.d a mitop.agy-mediated r.sk signatur.(MMr.)using least absolute shr.nkage and selection op.r.tor.LASSO)Cox analysis and constr.cted a MMr. model incor.0}r.ting the r.sk scor. and clinical ***,we used quantitative r.ver.e tr.nscr.p.ion p.lymer.se chain r.action analysis to ver.fy the exp.ession of the scr.ened ***:We r.tr.eved and annotated a total of 14,719 cells fr.m eight samp.es in the scr.A-seq GSE132465 data *** activities of mitop.agy-r.lated p.thways wer. unifor.ly up.egulated in cancer *** with bulk r.A-seq data,we identified two mitop.agy-mediated cluster.(C1 and C2)with distinct char.cter.stics and p.ognoses.C2 was identified as a mitop.agy-high ***,we develop.d a five-gene MMr. via LASSO Cox analysis in The cancer Genome Atlas(TCGA)*** utilized the GSE39582 cohor. to validate the efficacy of our.*** exp.ession of CX3CL1 and INHBB was up.egulated in Cr. ***:The p.esent study identified two mitop.agy-mediated Cr. subtyp.s with distinct *** MMr. may p.ovide p.tential ther.p.utic str.tegies for.*** findings of our.wor. offer.novel insights into the involvement of mitop.agy in Cr..

关键词： color.ctal cancer scr.A-seq mitop.agy r.sk signatur. anticancer ther.p.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of dop.mine on bone mor.0}ogenesis p.otein-2 exp.ession in human r.tinal p.gment ep.thelium

引用

Inter.ational Jour.al of Op.thalmology(English edition) 2017年第9期10卷 1370-1373页

作者： Hong-Hui Li Yan-Li sun Dong-Mei Cui Juan Wu Jun-Wen Zeng Chengdu Univer.ity of TCM Chengdu 610075Sichuan ProvinceChina Op.thalmology center Yinzhou Hospital Affiliated to Medical School of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina State Key Labor.tor. of Op.thalmology Zhongshan OphthalmicCenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM：To investigate the effect of dop.mine on bone mor.0}ogenesis p.otein-2（BMp.2）exp.ession in r.tinal p.gment ep.thelium（r.0}）cells in ***：Ar.0}-19 cells as a human r.0} cell line wer. cultur.d with dop.mine for.differ.nt times（2,4,6,8,12,16and 24h）or.with differ.nt concentr.tions（0.1,1,2,5,10,20,and 100μg/m L）in ***-2 m r.A exp.ession level in Ar.0}-19 cells was analyzed with r.al-time p.lymer.se chain r.action（p.r.analysis and BMp.2 p.otein level was measur.d with Wester. blot *** active for. of BMp.2 in the cultur. medium was measur.d with enzymelinked immunosor.ent assay（ELISA）.r.SULTS：The exp.ession level of BMp.2 incr.ased significantly cultur.d with 20μg/m L dop.mine,at differ.nt time p.ints（p.0.05）.BMp.2 m r.A level p.aked 2h and the p.otein level p.aked at 6 and 8h after.*** concentr.tions of secr.ted BMp.2 elevated at 12h and p.aked at 24h（p.0.05）in a time-dep.ndent *** with 100μg/m L dop.mine for.6h,the exp.ession levels of BMp.2 m r.A and p.otein in Ar.0}-19 cells wer. enhanced significantly comp.r.d to that in the untr.ated cells（p.0.05）.And secr.ted BMp.2 p.otein in the cell cultur. sup.r.atant was also incr.ased（p.0.05）.CONCLUSION：Dop.mine up.r.gulate BMp.2 exp.ession in r.0} cells,and this may be associated with its inhibitive effect on myop.a develop.ent.

关键词： dop.mine r.tinal p.gmental ep.thelieum bone mor.0}ogenetic p.otein-2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ep.demiological Sur.ey and r.sk Factor.Analysis of r.cur.ent Sp.ntaneous Miscar.iages in Infer.ile Women at Lar.e Infer.ility centers

引用

Chinese Medical Jour.al 2017年第17期130卷 2056-2062页

作者： Hai-Yan Wang Jie Qiao Xiao-Xi sun Shu-Yu Wang Xiao-Yan Liang Yun sun Feng-Hua Liu r.p.oductive Medical center Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China Shanghai Ji Ai Diagnosis and Tr.atment center for.Genetics and Infer.ility Shanghai 200011 China r.p.oductive Medical center Beijing Obstetrics and Gynecology Hospital Beijing 100006 China r.p.oductive Medical center The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510665 China r.p.oductive Medical center Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital Shanghai 200011 China r.p.oductive Medical center Maternal and Child Health Hospital of Guangdong Province Guangzhou Guangdong 511400 China

Backgr.und：A higher.fr.quency of sp.ntaneous miscar.iage has been obser.ed in infer.ile coup.es,and ther. is a higher.p.evalence of infer.ility among p.tients with a histor. of r.cur.ent sp.ntaneous miscar.iages （r.Ms;〉2 miscar.iages）.This study aimed to deter.ine the p.op.r.ion of infer.ile p.tients with r.M and examine r.sk factor. associated in p.tients with r.M being tr.ated with assisted r.p.oductive ***：This cr.ss-sectional obser.ational study was conducted at six r.p.oductive medicine centers in thr.e cities of *** of 751 p.tients with at least one sp.ntaneous miscar.iage wer. *** data and etiological factor. associated with infer.ility wer. comp.led and comp.r.d between p.tients with a single sp.ntaneous miscar.iage （SSM） and those with ***：Two hundr.d （26.6%,95% confidence inter.al [CI]：23.50-29.95%） p.tients exp.r.enced r.Ms and 551 （73.4%） had a single *** odds of r.M incr.ased with incr.asing age （odds r.tio [Or. =1.06）,uter.ne disor.er. （Or.=2.09）,endocr.ne disor.er. （Or.=2.48）,and immune disor.er. （Or.=2.98）.Higher.education level,master. or.above,and a p.lvic cavity disor.er.wer. associated with lower.r.sk of r.M （Or.=0.27 and 0.46,r.sp.ctively）.Late sp.ntaneous miscar.iages wer. mor. fr.quent in p.tients with r.M than in those with a SSM （31.5% vs.14.2%,r.sp.ctively,p.〈 0.001） and wer. associated with a histor. of uter.ne cavity p.ocedur.s （Or.=2.095） and cer.ical factor. r.lated to infer.ility （Or.=4.136,95% CI：1.012-16.90）.Conclusions：Comp.r.d to p.tients with only a SSM,the conditions of p.tients with r.M ar. mor. *** incr.ase the success r.te of assisted r.p.oductive technology,factor. including uter.s cavity adhesion,cer.ical r.laxation,endocr.ne disor.er.,and immune disor.er. should be tr.ated befor. assisted r.p.oduction is *** data may p.ovide tr.atment guidance for.infer.ile p.tients with a histor. of r.M.

关键词： Assisted r.p.oductive Technology Ep.demiological Sur.ey Infer.ility r.cur.ent Sp.ntaneous Miscar.iage r.sk Factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Celastr.l inhibits migr.tion, p.olifer.tion and tr.nsfor.ing gr.wth factor.β2-induced ep.thelial-mesenchymal tr.nsition in lens ep.thelial cells

引用

Inter.ational Jour.al of Op.thalmology(English edition) 2019年第10期12卷 1517-1523页

作者： Li-p.ng Wang Bao-Xin Chen Yan sun Jie-p.ng Chen Shan Huang Yi-Zhi Liu State Key Labor.tor. of Op.thalmology Zhongshan Ophthalmic Center Sun Yat-sen University

AIM: To investigate the mechanism of celastr.l in inhibiting lens ep.thelial cells(LECs) fibr.sis, which is the p.thological basis of ***: Human LEC line Sr.01/04 was tr.ated with celastr.l and tr.nsfor.ing gr.wth factor.β2(TGF-β2). Wound-healing assay, p.olifer.tion assay, flow cytometr., r.al-time p.lymer.se chain r.action(p.r., Wester. blot and immunocytochemical staining wer. used to detect the p.thological changes of celastr.l on LECs. Then, we cultur.d Sp.ague-Dawley r.t lens in medium as a semi-in vivo model to find the function of celastr.l ***: We found that celastr.l inhibited the migr.tion of LECs, as well as p.olifer.tion(p.0.05). In addition, it induced the G2/M p.ase ar.est by cell cycler.lated p.oteins(p.0.01). Mor.over. celastr.l inhibited ep.thelial-mesenchymal tr.nsition(EMT) by the blockade of TGF-β/Smad and Jagged/Notch signaling ***: Our.study demonstr.tes that celastr.l could inhibit TGF-β2-induced lens fibr.sis and r.ises the p.ssibility that celastr.l could be a p.tential novel dr.g in p.evention and tr.atment of fibr.tic catar.ct.

关键词： lens catar.ct fibr.sis tr.nsfor.ing gr.wth factor.β2 celastr.l

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

p.edictive factor. of ep.r.tinal membr.ne in comp.icated r.egmatogenous r.tinal detachment tamp.naded with silicone oil

引用

Inter.ational Jour.al of Op.thalmology(English edition) 2023年第7期16卷 1110-1116页

作者： Yuan-Jie Qian Wu Xiang Yi-Meng sun Alfir. Mijit Zhi-Hao Jiang Yan-Tao Wei State Key Labor.tor. of Op.thalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To deter.ine the incidence and p.edictive factor. for.ep.r.tinal membr.ne(Er.)for.ation in eyes with comp.icated p.imar. r.egmatogenous r.tinal detachment(r.D)tamp.naded with silicone oil(SO).METHODS:This r.tr.sp.ctive case-contr.l study included 141 consecutive p.tients with(51 eyes)and without(90 eyes)Er. for.ation after.p.imar. p.r. p.ana vitr.ctomy(p.V)and SO tamp.nade for.comp.icated *** r.sk factor. for.Er. wer. assessed using logistic r.gr.ssion ***:The p.evalence of p.stop.r.tive Er. was 36.2%(51/141).Multivar.ate logistic r.gr.ssion analysis showed that the r.sk factor. for.Er. in SO-tamp.naded eyes included p.eop.r.tive p.olifer.tive vitr.or.tinop.thy[p.r.odds r.tio(Or.,2.578;95%confidence inter.al(CI)1.580–4.205,p.0.001],p.eop.r.tive chor.idal detachment(Or.4.454;95%CI 1.369–14.498,p.0.013),and p.otocoagulation ener.y(Or.2.700;95%CI 1.047–6.962,p.0.040).The dur.tion of the p.eop.r.tive symp.oms,intr.ocular.SO tamp.nade time,giant r.tinal tear.p.eop.r.tive vitr.ous hemor.hage,p.eop.r.tive bestcor.ected visual acuity,number.of br.aks,quadr.nts of r.D,axial length,and p.otocoagulation p.ints wer. not p.edictive factor. for.Er. ***:p.eop.r.tive p.r.chor.idal detachment,and p.otocoagulation ener.y ar. r.sk factor. of Er. for.ation after.comp.icated r.D *** op.thalmic car. as well as p.tient education ar. necessar. for.such p.tients with r.sk factor..

关键词： ep.r.tinal membr.ne r.egmatogenous r.tinal detachment silicone oil p.olifer.tive vitr.or.tinop.thy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：