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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cellular & Molecular Immunology 2024年第2期21卷 103-118页

作者： S.Cankat M.u.Demael L.Swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2,MERS-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,HKu1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection universal

Changes in Calcareous Nannofossil Assemblages and Paleoenvironmental Interpretation of the Early Miocene Lice Formation, Kahramanmara? Basin, Turkey, East Mediterranean

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 1021-1034页

作者： Caner KAYAÖZER Muazez Esra ORHAN uğur TEMİZ Yozgat Bozok university DivanlıRoadYozgat 66900Turkey

This study investigated the calcareous nannofossil assemblages in detail from the early Miocene aged Lice Formation outcropping in the Kahramanmara? basin. The biostratigraphy of calcareous nannofossils was outlined and paleoenvironmental features determined. In 81 samples taken from three measured sections in the region, 17 calcareous nannofossil genus and 48 nannofossil species were identified. These calcareous nannofossil genus and species identified the Lice Formation as being in the CNM4 nannofossil biozone. The abundance and diversity of early Miocene calcareous nannofossil species varied in the measured sections, with the samples generally moderate-poor, apart from a few samples. The relative abundance of individuals of Cyclicargolithus floridanus, Coccolithus pelagicus, Reticulofenestra hagii and Sphenolithus moriformis species, with paleoecological importance identified in the study region, indicate that in early Miocene times, the basin in which the Lice Formation deposited was meso-eutrophic with excess nutrient input, temperate and generally stable shallow marine conditions.

关键词： paleoecology nannofossil Burdigalian East Mediterranean

Combinations of electron and proton donors in transition-metal complex mediated nitrogen reduction reactions

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Science China Chemistry 2024年第7期67卷 2136-2154页

作者： Delong Han Li Yang Hao Huang Priyanka Chakraborty Shashikant u.Dighe Kuo-Wei Huang KAuST Catalysis Center and Division of Physical Science and Engineering King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia Agency for Science Technologyand ResearchInstitute of Materials Research and Engineering and Institute of Sustainability for ChemicalsEnergy and EnvironmentSingapore 138634Singapore

Nitrogen fixation is a complex process involving the transfer of six electrons and *** from the conventional Haber-Bosch process,which relies on hydrogen(H_(2))to provide both electrons and protons to reduce nitrogen(N_(2)),homogeneous transition metal complex-catalyzed N_(2)reduction reactions(NRR)employ an array of electron and proton donors or even electron donors combined with *** the synthesis of diverse catalytic progress,the categories of donors have seen rapid ***,existing literature only provides summaries regarding the metal,ligands,and *** the significance of electron and proton donor combinations in nitrogen reduction reactions,no literature has thoroughly reviewed this ***,we hereby compiled a comprehensive list of commonly used reagents in N_(2)reduction and classified them according to their specific donor *** review presents clear and organized information about these combinations,along with a summary of their general performance trend in NRR with related ***,we conclude the discussion by highlighting key points for researchers to consider when selecting catalysts and donor combinations,with the ultimate goal of advancing the field of nitrogen fixation.

关键词： dinitrogen reduction reaction reducing donor combination transition metal complexes homogeneous catalysis

Development of immature ovarian teratoma after mature teratoma in a girl with familial ovarian teratoma:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1442-1447页

作者： u Chul Ju Woo Dae Kang Seok Mo Kim Department of Obstetrics and Gynecology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROuND Immature ovarian teratoma is a rare and aggressive neoplasm that affects young *** report is the first to describe the development of immature teratoma after ovarian cystectomy for mature teratoma of the ovary in an adolescent female with a family history of ovarian *** SuMMARY A 16-year-old girl who had undergone bilateral ovarian cystectomy for mature teratomas 3 years ago showed bilateral adnexal tumors during her regular ultrasonography follow-up every 6 *** received laparoscopic bilateral ovarian cystectomy,and final histopathology showed grade-1 immature teratoma of the left ovary and mature teratoma of the right *** left salpingo-oophorectomy and staging procedures were performed *** mother,maternal aunt,and maternal grandmother had also received surgeries for mature ovarian *** It is important to have guidance on management of patient and family members with familial ovarian teratomas.

关键词： Familial ovarian teratomas Adolescent female Immature ovarian teratoma Management Case report

Advancing PCB Quality Control: Harnessing YOLOv8 Deep Learning for Real-Time Fault Detection

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Computers, Materials and Continua 2024年第1期81卷 345-367页

作者： Khan R.u. Shah F. Khan A.A. Tahir H. Faculty of Cognitive Sciences and Human Development Universiti Malaysia Sarawak Kota Samarahan 94300 Malaysia School of Computer Science and Engineering Anhui University of Science and Technology Huainan 232001 China Department Electronic Quaid-i-Azam University Islamabad 45320 Pakistan

Printed Circuit Boards (PCBs) are materials used to connect components to one another to form a working circuit. PCBs play a crucial role in modern electronics by connecting various components. The trend of integrating more components onto PCBs is becoming increasingly common, which presents significant challenges for quality control processes. Given the potential impact that even minute defects can have on signal traces, the surface inspection of PCB remains pivotal in ensuring the overall system integrity. To address the limitations associated with manual inspection, this research endeavors to automate the inspection process using the YOLOv8 deep learning algorithm for real-time fault detection in PCBs. Specifically, we explore the effectiveness of two variants of the YOLOv8 architecture: YOLOv8 Small and YOLOv8 Nano. Through rigorous experimentation and evaluation of our dataset which was acquired from Peking university’s Human-Robot Interaction Lab, we aim to assess the suitability of these models for improving fault detection accuracy within the PCB manufacturing process. Our results reveal the remarkable capabilities of YOLOv8 Small models in accurately identifying and classifying PCB faults. The model achieved a precision of 98.7%, a recall of 99%, an accuracy of 98.6%, and an F1 score of 0.98. These findings highlight the potential of the YOLOv8 Small model to significantly improve the quality control processes in PCB manufacturing by providing a reliable and efficient solution for fault detection. © 2024 The Authors. Published by Tech Science Press.

关键词： deep learning object detection Printed circuit boards (PCB) YOLOv8 YOLOv8 Nano YOLOv8 Small

Predictive factors for percutaneous nephrolithotomy bleeding risks

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Asian Journal of urology 2024年第1期11卷 105-109页

作者： u Phun Loo Chun Hou Yong Guan Chou Teh urology Department Sarawak General HospitalKuchingMalaysia

Objective:This study aimed to identify predictive factors for percutaneous nephrolithotomy(PCNL)bleeding *** better risk stratification,bleeding in high-risk patient can be anticipated and facilitates early ***:A prospective observational study of PCNL performed at our institution was *** adults with radio-opaque renal stones planned for PCNL were included except those with coagulopathy,planned for additional *** including gender,co-morbidities,body mass index,stone burden,puncture site,tract dilatation size,operative position,surgeon's seniority,and operative duration were studied using stepwise multivariate regression analysis to identify the predictive factors associated with higher estimated hemoglobin(Hb)***:Overall,4.86%patients(n=7)received packed cells *** mean estimated Hb deficiency was 1.3(range 0-6.5)g/dL and the median was 1.0 g/*** multivariate regression analysis revealed that absence of hypertension(p=0.024),puncture site(p=0.027),and operative duration(p=0.023)were significantly associated with higher estimated Hb ***,the effect sizes are rather small with partial eta-squared of 0.037,0.066,and 0.038,*** power obtained was 0.621,0.722,and 0.625,*** factors studied did not correlate with Hb ***:Hypertension,puncture site,and operative duration have significant impact on estimated Hb deficiency during ***,the effect size is rather small despite adequate study power ***,operative position(supine or prone),puncture number,or tract dilatation size did not correlate with Hb *** mainstay of reducing bleeding in PCNL is still meticulous operative *** study findings also suggest that PCNL can be safely done by urology trainees under supervision in suitably selected patient,without increasing risk of bleeding.

关键词： Percutaneous nephrolithotomy Predictive factor Risk factor Bleeding Blood loss

Assistive techniques and their added value for tremor classification in multiple sclerosis

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Neural Regeneration Research 2024年第5期19卷 977-978页

作者： Nabin Koirala Abdulnasir Hossen Ioannis u.Isaias Jens Volkmann Muthuraman Muthuraman Child Study Center School of MedicineYale UniversityNew HavenCTUSA Department of Electrical&Computer Engineering Sultan Qaboos UniversityAl-KhodMuscatOman Neural Engineering with Signal Analytics and Artificial Intelligence Department of NeurologyUniversity Hospital of WürzburgWürzburgGermany Centro Parkinson e Parkinsonism Azienda Socio Sanitaria Territoriale G.Pini-CTO20126 MilanItaly

Tremor occurs in about half of multiple sclerosis(MS)*** tremor has a broad frequency range of 2.5-7 Hz,with a higher prevalence of postural tremor(44%)compared to intentional tremor(6%)(Alusi et al.,2001).Tremor may affect the upper and lower extremities,head,and trunk,and may even affect the vocal cords in isolated cases of palatal *** tremor is classically attributed to lesions of the brain stem,cerebellum,or cerebellar peduncles,and tremor intensity has been shown to correlate with the number of lesions or their functional ***,recent work has demonstrated that inflammatory damage to the cerebello-thalamic and cortico-thalamic pathways might also play an important role in causing tremor,as it co-occurs with other signs and symptoms of MS such as dysarthria,dysmetria,dysdiadochokinesia,and dystonia(Alusi et al.,2001).

关键词： tremor sclerosis

Stability analysis and soliton solutions of the(1+1)-dimensional nonlinear chiral Schrodinger equation in nuclear physics

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Communications in Theoretical Physics 2024年第9期76卷 1-15页

作者： Fazal Badshah Kalim u Tariq Ahmet Bekir S M Raza Kazmi Emad Az-Zo'bi School of Electrical and Information Engineering Hubei University of Automotive TechnologyShiyan 442002China Department of Mathematics Mirpur University of Science and TechnologyMirpur-10250(AJK)Pakistan Neighbourhood of Akcaglan Imarli StreetNumber:28/426030EskisehirTurkey Department of Mathematics and Statistics Faculty of ScienceMutah UniversityAlKarak 61710Jordan

The nonlinear Schrodinger equation equation is one of the most important physical models used in optical fiber theory to explain the transmission of an optical *** field of chiral soliton propagation in nuclear physics is very interesting because of its numerous applications in communications and ultra-fast signal routing ***(1+1)-dimensional chiral dynamical structure that describes the soliton behaviour in data transmission is dealt with in this work using a variety of in-depth analytical *** work has applications in particle physics,ionised science,nuclear physics,optics,and other applied mathematical *** are able to develop a variety of solutions to demonstrate the behaviour of solitary wave structures,periodic soliton solutions,chiral soliton solutions,and bell-shaped soliton solutions with the use of applied ***,in order to verify the scientific calculations,the stability analysis for the observed solutions of the governing model is taken into *** addition,the3-dimensional,contour,and 2-dimensional visuals are supplied for a better understanding of the behaviour of the *** employed strategies are dependable,uncomplicated,and effective;yet have not been utilised with the governing model in the literature that is now *** resulting outcomes have impressive applications across a large number of study areas and computational physics phenomena representing real-world *** methods applied in this model are not utilized on the given models in previous literature so we can say that these describe the novelty of the work.

关键词： solitons the nonlinear Schrodinger equation stability analysis chiral solitons exact solutions

Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

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Chinese Physics B 2024年第2期33卷 108-114页

作者： u.S.Mahabaleshwar G.P.Vanitha L.M.Pérez Emad H.Aly I.Pop Department of Studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)O_(3)/Cu nanoparticles suspended in H_(2)O past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and Nusselt number were also *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)O_(3)/H_(2)O nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)O ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection