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Development of survivin and tumor research

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Development of survivin and tumor research

两岸三地药理学与临床药理学术会议

作者： JI Yu-bin~(1,2,3. LIU Guang-da~1 YU Lei~(1,2,3. LI Hai-jiao~1 YANG Hai-fan~1 PANG Lin-lin~1 (1. Center of Research and Development on Life sciences and environmental sciences, Harbin {3. of Commerce, Harbin 150076, china 2. Institute of Materia Medica and Postdoctoral Programme of Harbin {3. of Commerce, Harbin 150076 3.Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin 150076, china)

Survivin was firstly separated in hybridization of Effector Cell Protease Receptor-1(EPR-1)cD- NA in human genome by Yale university’s Ambrosini in 1997,which is member of the inhibitor of apopto- sis proteins(IAPS).Unlike other IAP protein,found during embryonic and fetal development,survivin was- completely down-regulated and undetectable in normal adult tissues,and became prominentlyre expressed in all of the most common *** through includes the eysteine/histidine rod-shaped viral IAP repetition sequence baculoviral IAP repeats(BIRs)the structure territory directly or intervenes Caspases the function to display indirectly its anti-perishes weakly the function,simultaneously it also is in the cell division process the chromosome traveler protein(chromosome passenger protein).There are three approaches by which sur- vivin inhibits the processing of apoptosis:(1)inhibits processing of down stream effector caspase-3.caspase- 7and caspase-9 in cell receiving apoptotic stimuls;(2)with the Smac/DIABLO function,sends the XIAP ac- tiveness to increase,XIAP through directly affects and restrains its function with caspases,achieved restrains function which perishes weakly;(3.through restrains p53.the function to block perishes weakly the pro- *** expressed specificity and its function *** only expresses in tumor tissues and cannot be found in normal terminally differentiated *** kind of expression is been extremely low the cell cycle strict regulation in the G1 time expression,the S time is G1 time 6 times,the G2/M time ad- vances to 40 times,demonstrated its expression has the G2/M time dependence *** has bi-function of inhibiting apoptosis and involving in cell cycle *** has found in most of tumor cells in recent- ly *** expresses generally in all tumor cell line in the American State-run Cancer Research institute anti-tumor medicine screening procedure 60 different tumor cells,in which ex

关键词： survivin cancer research advance

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高校毕业生农村支教政策的问题及对策

教育发展研究 2009年第15期29卷 20-22页

作者：付卫东华中师范大学教育学院武汉430079

国家鼓励高校毕业生到农村支教的目的是弥补农村教师资源短缺,改善农村教师结构和素质,促进农村教育发展。本文指出该政策在执行过程中存在着紧缺学科师资依然严重短缺、利益相关者间存在博弈、相关配套政策不到位导致与支教生服务期满... 详细信息

国家鼓励高校毕业生到农村支教的目的是弥补农村教师资源短缺,改善农村教师结构和素质,促进农村教育发展。本文指出该政策在执行过程中存在着紧缺学科师资依然严重短缺、利益相关者间存在博弈、相关配套政策不到位导致与支教生服务期满后的去向问题难以确定等问题,并建议要改进遴选办法、创建"选择性激励制度"和重视完善支教生就业工作等相关配套政策。

关键词：高校毕业生农村支教

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广西少数民族传统体育现状及发展对策研究

天津体育学院学报 2005年第1期20卷 28-30页

作者：余万予郑国华朱小丽江西师范大学体育学院南昌330027 桂林旅游专科学校桂林541004

运用查阅文献资料、问卷调查和数理统计等方法,对广西11个少数民族的传统体育项目进行了统计分析。结果表明,广西少数民族的传统体育项目种类齐全,数量丰富,文化内涵丰韵,具有竞技性、娱乐性、健身性、传播性、观赏性、群众性等特点,是... 详细信息

运用查阅文献资料、问卷调查和数理统计等方法,对广西11个少数民族的传统体育项目进行了统计分析。结果表明,广西少数民族的传统体育项目种类齐全,数量丰富,文化内涵丰韵,具有竞技性、娱乐性、健身性、传播性、观赏性、群众性等特点,是少数民族地区人们健身、娱乐和促进生产的有效手段。提出广西少数民族传统体育项目的发展对策,为整个中华民族传统体育研究和发展提供参考。

关键词：少数民族民族传统体育

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罗隆基:社会民主主义宪政的追寻者

唐山学院学报 2011年第6期24卷 86-89,98页

作者：张扩振黄振江西师范大学政法学院南昌330022

罗隆基的人权理念,是以生存权为基础的功利主义的人权观;罗隆基的政治理想,是实现以专家政治为基础的民主宪政;罗隆基的经济理想,是以国营和计划的方式促进民生的均足。以此观之,罗隆基是一位对社会民主主义宪政情有独钟的爱国人士。

关键词：罗隆基人权社会民主主义

A multi-layer model for early diagenesis

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Chinese Science Bulletin 1997年第16期42卷 1385-1387页

作者： MEI HongmingDepartment of Marine Geology, Tongji university, Shanghai 200092, china Department of Marine Geology Tongji University Shanghai China

EARLY diagenesis is defined here as a series of physical, chemical and biological reactions operating between depositional particles, porewaters and environmental water medium in the processes of deposition and shallow burial. Early diagenesis can produce geochemical succession within deposits, which can be divided from top to bottom into oxidation zone (OX), sulphate reduction zone (SR) and methanogenesis zone (ME). Part of the reaction

关键词： early diagenesis biogeochemical zone multi-layer model.

Study on Mesoscale Circulation Characteristics of Heavy Rainstorm in Wangmo County in Qianxinan on June 6,2011

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Meteorological and environmental Research 2011年第11期2卷 13-16,22页

作者： CUI Ting1,2,WU Gu-hui3.ZHAO Yu-jin2,YANG Ling2,ZHANG Qiang-yi2 1.College of Atmospheric sciences,Lanzhou university,Lanzhou 73.000,china 2.Qianxinan Meteorological Bureau,Xingyi 562400,china 3.Guizhou Meteorological Observatory,Guiyang 550002,china

[Objective] The aim was to analyze the causes of '6.06' heavy rainstorm in Wangmo County in Qianxinan.[Method] By dint of NCEP/NCAR 1°×1° reanalysis data,FY-2E TBB data,seven ground elements and two elements from automatic station data,the main influential system and all kinds of physical quantity field features of heavy rainstorm in upper reaches of Wangmo County in Qianxinan from the evening on 5 June to 08:00 on 6 June in 2011 were studied.[Result] The rainstorm was the result of cold air,which was provided by 850 hPa cold shear line and ground radiation line,and warm and wet airstream on the northwest edge of subtropical *** was the main reason for such heavy *** warm and wet airstream in middle lower part provided sufficient water vapor for the *** 850 hPa water vapor flux divergence center moved from north to south along ground convergence line to *** location and water vapor flux as well as convergence center were *** rainfall intensity also was consistent with the amount of water vapor flux and water vapor convergence.[Conclusion] The study provided reference for the report of heavy rainstorm.

关键词： Wangmo County Heavy rainstorm Shear line Subtropical high pressure Ground convergence line china

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美国学区新教师的入门培训及启示

外国教育研究 2003年第6期30卷 51-53页

作者：项亚光上海师范大学教育科学学院上海200234

新教师的入门培训是教师专业发展的重要方面。本文以三个学区为例,介绍美国当前新教师入门计划的主要内容和特点,并提出我国新教师入门培训改革的启示。

关键词：美国学区教师培训入门培训培训计划师徒制

Cloning and Expression Analysis of p26 Gene in Artemia sinica

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Acta Biochimica et Biophysica Sinica 2007年第5期39卷 351-358页

作者： Lijuan JIANG~1, Lin HOU~(1*), Xiangyang ZOU2, Ruifeng ZHANG~1, Jiaqing WANG~1, We njing SUN~1, Xintao ZHAO~1, and Jialu AN~1 1 College of Life sciences, Liaoning normal university, Dalian 116029,{3. 2 Department of Biology, Dalian Medical university, Dalian 116027,{3. CollegeofLifesciences LiaoningNormalUniversityDalian116029China DepartmentofBiology DalianMedicalUniversityDalian116027China

The protein p26 is a small heat shock protein that functions as a molecular chaperone to protect embryos by preventing irreversible protein damage during embryonic development. A 542 bp fragment of the p26 gene was cloned and sequenced. The fragment encoded 174 amino acid residues and the amino acid sequence contained the α-crystallin domain. Phylogenetic analysis showed that eight Artemia populations were divided into four major groups. Artemia sinica (YC) belonged to the East Asia bisexual group. Expression of the p26 gene at different developmental stages ofA. sinica was quantified using real-time quantitative polymerase chain reaction followed by cloning and sequencing. The relationship between the quantity of p26 gene expression and embryonic development was analyzed. The results indicated that massive amounts of p26 were expressed during the development of A. sinica. At the developmental stage of 0 h, A. sinica expressed the highest level of p26. As development proceeded, expression levels of the p26 gene reduced significantly. There was a small quantity of p26 gene expression at the developmental stages of 16 h and 24 h. We concluded that p26 might be involved in protecting the embryo from physiological stress during embryonic development.

关键词： Artemia sinica cloning expression p26 gene real-time quantitative PCR

Polysaccharide release by Aphanothece halophytica inhibits cyanobacteria/clay flocculation

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Polysaccharide release by Aphanothece halophytica inhibits c...