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中国视频头脉冲试验临床实践专家共识(2024)

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中华耳鼻咽喉头颈外科杂志 2024年第4期59卷 315-320页

作者：中华耳鼻咽喉头颈外科杂志编辑委员会中华医学会耳鼻咽喉头颈外科学分会听力学组王利一张青徐先荣陈太生刘玉和庄建华不详北京医院耳鼻咽喉科、国家老年医学中心、中国医学科学院老年医学研究院北京100730 上海交通大学医学院附属新华医院耳鼻咽喉头颈外科、上海交通大学医学院耳科学研究所、上海市耳鼻疾病转化医学重点实验室上海200092 空军特色医学中心天津市第一中心医院耳鼻咽喉头颈外科首都医科大学北京友谊医院耳鼻咽喉头颈外科海军军医大学附属长征医院神经内科

视频头脉冲试验(video head impulse test,vHIT)是采用高帧率摄像头与陀螺仪分别记录受检者的眼球运动和头部运动,通过快速、小幅度的被动甩头动作,分别在三个平面上刺激对应的三对偶联半规管(双侧外半规管,左前和右后半规管,右前和左... 详细信息

视频头脉冲试验(video head impulse test,vHIT)是采用高帧率摄像头与陀螺仪分别记录受检者的眼球运动和头部运动,通过快速、小幅度的被动甩头动作,分别在三个平面上刺激对应的三对偶联半规管(双侧外半规管,左前和右后半规管,右前和左后半规管)。

关键词：头部运动眼球运动临床实践高帧率摄像头三个平面外半规管陀螺仪

hIL-15成熟肽段基因的克隆及其原核表达载体的构建

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上海免疫学杂志 1999年第1期19卷 24-26页

作者：纪宗玲陈苏民余宙耀高磊陈南春路凡粟宽源第四军医大学生物化学与分子生物学教研室中国人民解放军传染病中心

本文采用ＲＴＰＣＲ的方法自成人脾脏中扩增出ｈＩＬ１５成熟肽段基因，定向克隆入ｐＵＣ１９中，筛选带有插段的阳性克隆。经序列测定证实后，插入大肠杆菌融合表达载体ｐＧＥＸ４Ｔ１中，构建重组表达质粒ｐＧＩＬ１５。Ｓ... 详细信息

本文采用ＲＴＰＣＲ的方法自成人脾脏中扩增出ｈＩＬ１５成熟肽段基因，定向克隆入ｐＵＣ１９中，筛选带有插段的阳性克隆。经序列测定证实后，插入大肠杆菌融合表达载体ｐＧＥＸ４Ｔ１中，构建重组表达质粒ｐＧＩＬ１５。ＳＤＳＰＡＧＥ证实ｐＧＩＬ１５大肠杆菌中可表达分子量为３８６ｋＤ的融合蛋白带，表达量约占菌体总蛋白的１８５％。目的蛋白经纯化后具有促进靶细胞ＤＮＡ合成的作用。

关键词： hIL-15 RT-PCR 分子克隆原核表达活性测定

Expert consensus on the evaluation and diagnosis of combat injuries of the Chinese People's Liberation Army

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military medical Research 2018年第3期5卷 189-198页

作者： Zhao-wen Zong Lian-yang Zhang Hao Qin Si-xu Chen Lin Zhang Lei Yang Xiao-xue Li Quan-wei Bao Dao-cheng Liu Si-hao He Yue Shen Rong Zhang Yu-feng Zhao Xiao-zheng Zhong representing the PLA Professional Committee and Youth Committee on Disaster medicine State Key laboratory of Trauma Burn and Combined InjuryDepartment of Trauma SurgeryDaping HospitalArmy Medical UniversityChongqingChina Special Slinic department of Bethune medical Profession Sergeant School ShijiazhuangChina Research Institute of Disaster medicine General Hospital of Chinese People's Armed Police ForcesBeijingChina military medical Training Brigade of Chinese People's Liberation Army HutubiXinjiangUygur Autonomous RegionChina 不详

The accurate assessment and diagnosis of combat injuries are the basis for triage and treatment of combat casualties. A consensus on the assessment and diagnosis of combat injuries was made and discussed at the second annual meeting of the Professional Committee on Disaster medicine of the Chinese People's Liberation Army(PLA). In this consensus agreement, the massive hemorrhage, airway, respiration, circulation and hypothermia(MARCH) algorithm, which is a simple triage and rapid treatment and field triage score, was recommended to assess combat casualties during the first-aid stage, whereas the abbreviated scoring method for combat casualty and the MARCH algorithm were recommended to assess combat casualties in level Ⅱ facilities. In level Ⅲ facilities, combined measures, including a history inquiry, thorough physical examination, laboratory examination, X-ray, and ultrasound examination, were recommended for the diagnosis of combat casualties. In addition, corresponding methods were recommended for the recognition of casualties needing massive transfusions, assessment of firearm wounds, evaluation of mangled extremities, and assessment of injury severity in this consensus.

关键词： Combat injuries Assessment Diagnosis Expert consensus

Guidelines for the diagnosis and treatment of chronic pancreatitis in china(2018 edition)

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 103-109页

作者： Wen-Bin Zou Nan Ru Hao Wu Liang-Hao Hu Xu Ren Gang Jin Zheng Wang Yi-Qi Du Ya-Nan Cao Lei Zhang Xiao-Yan Chang Rong-Chun Zhang Xiao-Bin Li Yan Shen Peng Li Zhao-Shen Li Zhuan Liao Pancreatitis Group of Chinese medical Doctor Association department of Gastroenterology Digestive Endoscopy CenterChanghai HospitalNaval Medical UniversityShanghai 200433China department of General Surgery Peking Union Medical College HospitalBeijing 100730China department of Hepatobiliary Pancreatic Surgery First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003China department of Digestive Endoscopy Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China 不详 shanghai Institute of Pancreatic Diseases Shanghai 200433China department of Gastroenterology Heilongjiang Provincial HospitalHarbin 150030China department of Hepatobiliary Pancreatic Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China shanghai Clinical Center for Endocrine and Metabolic Diseases Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200025China department of Radiology Shanghai First People’s HospitalShanghai 200080China department of Pathology Peking Union Medical College HospitalBeijing 100730China department of Gastroenterology Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Chronic pancreatitis(CP)is a progressive inflammatory disease of pancreas that alters the organ’s normal structure and *** seriously affects the quality of life of patients and greatly increases the public medical burden of *** recent years,the incidence of CP has increased *** concepts of etiology and therapies have been continuously updated.

关键词： Guidelines diagnosis and treatment pancreatitis

Physiological significance of probability plasticity

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Physiological significance of probability plasticity

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Jian-Dong YU,Jin-Hui WANG The State Key laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences

Short-term plasticity in synaptic transmission is believed to control the efficiency of signal communication among the neurons,one of key processes in neural *** better understand the mechanisms underlying synaptic transmission,we conduct paired-recordings between neocortical regular-spiking pyramidal neurons(RS) and a specific subtype of inhibitory interneuron("GIN cells":low threshold-spiking,somatostatin-expressing,EGFP-labeled interneurons in the GIN line of transgenic mice) in brain *** from glutamatergic unitary synapses on pyramidal neurons and GABAergic interneurons are mainly *** both the net amplitude of synchronous release and the amplitude of asynchronous release of each EPSC are *** suggests the quantum size underlying short-term facilitation is not *** contrast,the probabilities of synchronous and asynchronous release of each EPSC are both increased ***,the release probabilities are relative increased when we augment the facilitation by changing the firing frequency of presynaptic *** results indicate the short-term facilitation can be explained by the increasing of release *** examine the role of presynaptic Cal in synaptic release probability and facilitation, we reduced Ca levels by infusing BAPTA(a Ca chelator) into presynaptic *** reduction of presynaptic Ca level significantly blocks synaptic vesicle release,and makes synaptic facilitation *** elevation of presynaptic Ca by adenophostin increases synaptic release probability,but attenuates synaptic *** integrated current pulses mathematically based on different release probability and found that high probability can improve both spike capacity and timing *** conclusion,the elevation of release probability is the main mechanism of short-term facilitation,and it can improve the spike programming.

关键词： short-term plasticity probability plasticity calcium quantum size

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cnki会议

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儿童急性白血病深部真菌感染的研究

铁道医学 1998年第4期26卷 230-232页

作者：刘兴元谢晓恬杨剑倩上海铁道大学附属甘泉医院儿科

目的研究儿童白血病深部真菌感染的临床特征及治疗效果。方法对５０例急性白血病实施强烈化疗，可疑病人作真菌培养等检查，并提出深部真菌感染的诊断方法及疗效标准，对确诊深部真菌感染的病例以氟康唑治疗，并采取积极的支持治疗及抗... 详细信息

目的研究儿童白血病深部真菌感染的临床特征及治疗效果。方法对５０例急性白血病实施强烈化疗，可疑病人作真菌培养等检查，并提出深部真菌感染的诊断方法及疗效标准，对确诊深部真菌感染的病例以氟康唑治疗，并采取积极的支持治疗及抗生素预防治疗。结果５０例患者中２１例２２例次发生深部真菌感染，全部病例均有严重的骨髓抑制及高热，予氟康唑治疗，治愈率８６．４％，无明显毒副作用；深部真菌感染的发生与粒细胞减少程度以及持续时间有关，与疾病的种类无关，Ｐ＞０．０５；缓解前的诱导治疗较缓解后的巩固强化治疗易发生深部真菌感染，Ｐ＜０．０１。结论中性粒细胞严重减少的病人易发生深部真菌感染，诱导治疗阶段尤为多见。

关键词：急性白血病深部真菌感染氟康唑儿童

Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019(COVID-19)

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Journal of Intensive medicine 2022年第4期2卷 199-222页

作者： You Shang Jianfeng Wu Jinglun Liu Yun Long Jianfeng Xie Dong Zhang Bo Hu Yuan Zong Xuelian Liao Xiuling Shang Renyu Ding Kai Kang Jiao Liu Aijun Pan Yonghao Xu Changsong Wang Qianghong Xu Xijing Zhang Jicheng Zhang Ling Liu Jiancheng Zhang Yi Yang Kaijiang Yu Xiangdong Guan Dechang Chen Chinese Society of Critical Care medicine,Chinese medical Association department of Critical Care medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China department of Critical Care medicine The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510010China department of Emergency and Critical Care medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China department of Critical Care medicine Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical ScienceBeijing 100730China department of Critical Care medicine Jiangsu Provincial Key Laboratory of Critical Care MedicineZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China department of Critical Care medicine The First Hospital of Jilin UniversityChangchunJilin 130021China department of Critical Care medicine Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China department of Critical Care medicine Shaanxi Provincial HospitalXi’anShannxi 710068China department of Critical Care medicine West China HospitalSichuan UniversityChengduSichuan 610041China department of Critical Care medicine Fujian Provincial HospitalFujian Provincial Center for Critical Care MedicineFuzhouFujian 350001China department of Critical Care medicine The First Hospital of China Medical UniversityShenyangLiaoning 110001China department of Critical Care medicine The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China department of Critical Care medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China department of Critical Care medicine The First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China department of Critical Care medicine The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China department of Critical Care medicine Harbin Medical University Cance

Introduction Coronavirus disease 2019(COVID-19),a disease caused by severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),is highly contagious[1]and has developed into a global *** to July 1,2022,COVID-19 has affected>200 coun-tries and regions across the globe and caused 545,226,550 con-firmed cases and 6334,728 deaths,[2]seriously compromising human life,public properties.

关键词： diagnosis acute respiratory

探究是一种精神(续)——记中国科学院院士、第二军医大学陈宜张教授

维普期刊数据库评论

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维普期刊数据库

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实验室研究与探索 2015年第8期34卷 1-3页

作者：本刊编辑部 <实验室研究与探索>编辑部上海200030

介绍了陈宜张教授如何走上医学科研的道路,他指出科研工作要结合工作实际,要有探究精神。在对人脑的研究过程中,提出了神经生物学的"糖皮质激素作用于神经元的非基因组机制或膜受体"新假说,并通过实验验证,在国际学界引起强烈关注,实验... 详细信息

介绍了陈宜张教授如何走上医学科研的道路,他指出科研工作要结合工作实际,要有探究精神。在对人脑的研究过程中,提出了神经生物学的"糖皮质激素作用于神经元的非基因组机制或膜受体"新假说,并通过实验验证,在国际学界引起强烈关注,实验研究成果被国际上许多权威的专业书籍引用。最后提出了"精确细胞生物学"的新概念。

关键词：大脑神经生理学应激糖皮质激素细胞生物学

无牙颌患者的咬合垂直距离与咀嚼肌肌电关系的实验研究

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上海口腔医学 1995年第3期4卷 128-130页

作者：姚月玲欧阳官安燕汪文骏第四军医大学秦都口腔医学院

作者选择了颌关系正常、能合作的１５名无牙颌受试者。在４ｋｇ咬合力作用下，在不同的咬合垂直距离时，测定了颞肌及嚼肌的肌电幅值。实验结果表明，在控制咬合力状态下，无牙颌患者的咀嚼肌肌电幅值随着垂直距离增加而逐渐下降，两者... 详细信息

作者选择了颌关系正常、能合作的１５名无牙颌受试者。在４ｋｇ咬合力作用下，在不同的咬合垂直距离时，测定了颞肌及嚼肌的肌电幅值。实验结果表明，在控制咬合力状态下，无牙颌患者的咀嚼肌肌电幅值随着垂直距离增加而逐渐下降，两者间呈非常显著性负相关关系；在肌电活动变化过程中，有一相对稳定区域。由此提示，为无牙颌患者重建的咬合垂直距离有一定生理范围，约１．０ｍｍ（后牙区测点）。

关键词：无牙颌咬合垂直距离咀嚼肌肌电图实验研究咬合力全口义齿