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Identifying Qingkailing(清开灵)ingredients-dependent mesenchymal-epithelial transition factor-axiation“π”structuring module with angiogenesis and neurogenesis effects

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Journal of Traditional Chinese Medicine 2024年第1期44卷 35-43页

作者： CHENG kunming YUAN Jianan LIU Jun ZHANG Shengpeng XU Qixiang XIE Yong ZHAO Jingfeng ZHANG Xiaoxu TANG Xudong ZHENG Yongqiu WANG Zhong Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui Teaching and Research Section of Traditional Chinese MedicineSchool of PharmacyWannan Medical CollegeWuhu 241000China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationDepartment of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Department of Gastroenterology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

OBJECTIVE:To explore the functional role of the drugdependent mesenchymal-epithelial transition(Met)-axiation"π"structural module of neurogenesis after processing by three components of Qingkailing injection in neurogenesis and angiogenesis in cerebral ***:We used a Glutathione S-transferase(GST)-pull down assay,isothermal titration calorimetry assay,and other related methods to identify the relationships among Met,inositol polyphosphate phosphatase like 1(Inppl1),and death associated protein kinase 3(Dapk3)in this allosteric *** biological effects of the modules of neurons generation composed of Met,Inppl1,and Dapk3 were measured through Western blot,apoptosis analysis,and double immunofluorescence ***:The GST-pull down assay revealed that proline-serine-threonine rich domain of Met binds to the Src homology domain of Inppl1 to form a protein-protein complex;Dapk3 with a C-terminal domain interacts weakly with the protein kinase C domain of Met in the intracellular ***,we obtained a“π”structuring module considered a neural regeneration *** biological effects of angiogenesis and neurogenesis modules composed of Met,Inppl1,and Dapk3 were also ***:The study suggested that understanding the functional modules that contribute to pharmaceutics might provide novel signatures that can be used as endpoints to define disease processes under stroke or cerebral ischemia conditions.

关键词： brain ischemia stroke neurogenesis angiogenesis modular pharmacology Met-axiation allosteric module

Bifurcations of travelling wave solutions for two generalized Boussinesq systems

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science china Mathematics 2008年第9期51卷 1577-1592页

作者： LI JiBin1,2 1 Department of Mathematics, Zhejiang Normal university, Jinhua 321004, china 2 Department of Mathematics, kunming university of science and technology, kunming 650093, china Department of Mathematics Zhejiang Normal University Jinhua China Department of Mathematics Kunming University of Science and Technology Kunming China

Using the methods of dynamical systems for two generalized Boussinesq systems, the existence of all possible solitary wave solutions and many uncountably infinite periodic wave solutions is obtained. Exact explicit parametric representations of the travelling solutions are given. To guarantee the existence of the above solutions, all parameter conditions are determined.

关键词： nonlinear wave bifurcation solitary wave exact explicit solution generalized Boussinesq system 34C37 34C23 74J30 58Z05

The Information Integration of CAPP in CIMS

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厦门大学学报（自然科学版） 2002年第S1期41卷 182-183页

作者： ZHANG Yu 1, XIONG Man-chen 2 (CIMS Application and Research center, Faculty of Mechanical and Electr onic Engineering, kunming university of science and technology, kunming 65009 3, china)

This paper analyzes the flow of the process design an d the fountain of the technique data in a manufacturing enterprise, and discusse s the information flows between CAPP and other systems in CIMS, such as CAD syst em and Enterprise Resource Planning (ERP) system. And then, it discusses the pla ns of information integration between CAPP and CAD, as well as between CAPP and ERP. To design the processes of a product requires the manufacture information, such as blank material and machine tool, which is saved in a database in ERP. General ly, a traditional CAPP system considers the information of the manufacturing res ources, such as machine tool, as changeless. However, it is real changing, becau se the resources may be occupied or the machine tool may be under repair. Theref ore, in order to design the processes more reasonably, we must consider the real change of resources in a workshop. Creating a public resource database to suppo rt the real change of resources is put forward in this paper. With the public re source database, the resource integration between CAPP system and ERP is realize d; and by information collections in CAPP system, such as BOM, the material cons umption and man-hour consumption and their output to ERP, the information integ ration between CAPP system and ERP is realized.

关键词： CIMS CAPP ERP information integration techniq ue data

TOPSISEvaluation Method on″Have Both Hardand Soft″Systems

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Journal of Systems science and Systems Engineering 2001年第1期13卷 121-124页

作者： CHEN Shi\|lian kunming university of science and technology, kunming 650093, china Kunrning university of science and technology Kunming 650093 China

：In "Have Both Hard and Soft" systems, the soft targets and hard targets are divided into twodistinct target system. The measured results of soft target system are regarded as a matrix with intervalnumbers. On the basis of Topsis method, we discuss a new Topsis evaluation method on "Have Both Hardand Soft" systems, which combined soft targets with hard targets.

关键词： soft target hard target Close degree

Concentration Boundary Layer Model of Mortar Corrosion by Sulfuric Acid

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Journal of Wuhan university of technology(Materials science) 2011年第3期26卷 527-532页

作者：宋志刚 College of Architectural Engineering Kunming University of Science and Technology

A long time immersion experiment of mortar specimens is carried out to investigate their degradation mechanism by sulfuric ***-cement ratios of mortar are ranging from 0.5 to 0.7 and the pH value of sulfuric acid is 3.5 and 4.0 *** pH meter is used to monitor the soak solution and the titration sulfuric acid with given concentration is added to maintain original pH value,through which the acid consumption of mortar is recorded.A theoretical reaction rate model is also proposed based on concentration boundary layer *** results show that theoretical model fits the experimental results well and the corrosion mechanism can be modeled by a diffusion process accompanied with an irreversible chemical reaction when pH value of soak solution is no less than 3.5.

关键词： mortar sulfuric acid corrosion durability

3D visualization model and key techniques for digital mine

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中国有色金属学会会刊：英文版 2011年第S3期21卷 748-752页

作者： JIN Bao-xuan1,FANG Yuan-min2,SONG Wei-wei2 1. Yunnan Provincial Geomatics Centre, kunming 650034, china 2. Faculty of Land Resource Engineering, kunming university of science and technology, kunming 650093, china Yunnan Provincial Geomatics Centre Kunming 650034 China Faculty of Land Resource Engineering Kunming University of Science and Technology Kunming 650093 China

Digital mine is the inevitable outcome of the information processing, and is also a complicated system engineering. Firstly, for the 3D visualization application of the digital mine, the ground and underground integrative visualization framework model was proposed based on the mine entity database. So, the visualization problem was availably resolved, as well as the professional analytical ability was improved. Secondly, aiming at the irregularities, non-uniformity, dynamics of mine entities, mix modeling method based on the entity character was put forward, in which 3D expression of mine entities was realized. Lastly, the 3D visualization project for a copper mine was experimentally studied. Satisfactory results were acquired, and the rationality of visualization model and feasibility of 3D modeling were validated.

关键词： digital mine three dimension visualization framework model spatial data modeling

RESIDENTIAL SPACE DIFFERENTIATION OF NANJING METROPOLIS AND ITS DYNAMIC MECHANISM IN 1912-1998

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Chinese Geographical science 2000年第2期10卷 125-130页

作者： ZHU Xi-gang WU Qi-yan CUI Gong-hao(Department of Urban and Resource science, Nanjing university Nanjng 210093, P.R.china)(Architecture Deportment, kunming university of technology kunming 650051, P.R.china) Department of Urban and Resources science Nanjing University Nanjing P. R. China Architecture Deportment Kunming University of Technology Kunming P. R. China

Since 1978, within social geographic pattern of Chinese metropolis, differentiation not only has come to be in social entity,. but also by some degree embodied within residential space. Through the 8tudy on spatial segregation, the authors implicate these above spatial differentiation from social polarization to residential segregation cause by change in the political economy, in the organization of urban and real estate development (from project-specific to comprehensive development and real estate development) and in the functions and value of urban planning (from a sectional-subordinated to a municipally based control). The imprints of transition on social space are illustrated eight references to the example of Nanjing metropolis. Among the new phenomenal identified here are the six types of residential area according to soci-economic status.

关键词： residential space differentiation dynamic mechanism Nanjing Metropolis

The role of MC1R gene in buffalo coat color

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science china(Life sciences) 2010年第2期53卷 267-272页

作者： MIAO YongWang1,2,WU GuiSheng3,WANG Lei2,LI DaLin4,TANG ShouKun5,LIANG JianPing2,MAO HuaMing2,LUO HuaiRong3 & ZHANG YaPing1,6 1 Laboratory for Conservation and Utilization of Bio-resource,Yunnan university,kunming 650091,china 2 Faculty of Animal science and technology,Yunnan Agricultural university,kunming 650201,china 3 kunming Institute of Botany,Chinese Academy of sciences,kunming 650204,china 4 Yunnan Institute of Buffalo science and technology,kunming 650021,china 5 Animal Husbandry and Veterinary Station of Luxi city,Luxi 678400,china 6 State Key Laboratory of Genetic Resources and Evolution,kunming Institute of Zoology,Chinese Academy of sciences,kunming 650223,china Laboratory for Conservation and Utilization of Bio-resource Yunnan University Kunming China Faculty of Animal science and technology Yunnan Agricultural University Kunming China kunming Institute of Botany Chinese Academy of Sciences Kunming China Yunnan Institute of Buffalo science and technology Kunming China Animal Husbandry and Veterinary Station of Luxi city Luxi China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China

Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many *** investigate if the MC1R gene is associated with coat color in water buffalo,the coding region of MC1R gene of 216 buffalo samples was sequenced,which included 49 black river buffalo (Murrah and Nili-Ravi),136 swamp buffalo (Dehong,Diandongnan,Dechang,Guizhou,and Xilin) with white and gray body,and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp *** the three variation sites found,SNP684 was synonymous,while SNP310 and SNP384 were nonsynonymous,leading to p.S104G and p.I128M changes,*** Individuals carrying homozygote EBR/EBR were *** genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele EBR or the allele carrying the amino acid p.104S was important for the full function of *** in silico functional analysis showed that the amino acid substitutions p.G104S and p.M128I had significant impact on the function of *** results indicate that the allele EBR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo.

关键词： Buffalo coat color MC1R

Hemin-mediated Hemolysis in Erythrocytes:Effects of Ascorbic Acid and Glutathione

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Acta Biochimica et Biophysica Sinica 2006年第1期38卷 63-69页

作者： Shu-De LI~(1,2),Yan-Dan SU~3,Ming LI~1,and Cheng-Gang ZOU~(1*) ~1 School of Life sciences,Yunnan university,kunming 650091,china ~2 Department of Biochemistry and~3 Department of Clinical Chemistry,kunming Medical College.kunming 650031,china School of Life sciences Yunnan University Kunming 650091 China Department of Biochemistry Kunming Medical College Kunming 650031 China Department of Clinical Chemistry Kunming Medical College Kunming 650031 China

In the present work,we investigated the effect of ascorbic acid and glutathione on hemolysisinduced by hemin in *** acid not only enhanced hemolysis,but also induced formationof thiobarbituric acid-reactive substances in the presence of *** has been shown that glutathioneinhibits hemin-induced hemolysis by mediating hemin *** depleted of glutathionebecame very sensitive to oxidative stress induced by hemin and ascorbic acid.H2O2was involved in hemin-mediated hemolysis in the presence of ascorbic ***,a combination of glutathione and ascorbicacid was more effective in inhibiting hemolysis induced by hemin than glutathione *** andintracellular ascorbic acid exhibited a similar effect on hemin-induced hemolysis or inhibition of hemin-induced hemolysis by *** current study indicates that ascorbic acid might function as anantioxidant or prooxidant in hemin-mediated hemolysis,depending on whether glutathione is available.

关键词： erythrocyte ascorbic acid hemin glutathione H2O2