检索结果-南通市图书馆

维普期刊数据库

FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第33期18卷 4533-4541页

作者： Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel Service de Gastroentérologie-Pancréatologie Hpital Beaujon 100 Boul-evard du Général Leclerc 92110 Clichy La Garenne AP-HP France Service d'Oncologie Médicale Hpital Saint Antoine 184 Rue du Faubourg Saint-Antoine 75012 Paris AP-HP France Unité de Biostatistique et d'Epidémiologie EA 4184 Centre Georges Franois Leclerc 1 Rue du Pr Marion 21079 Dijon France Service d'Oncologie Médicale Hpital Beau-jon 100 Boulevard du Général Leclerc 92110 Clichy La Garenne AP-HP France Département d'Oncologie Médicale Institut Mutualiste Montsouris 42 Boulevard Jourdan 75014 Paris France

AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3.(irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3. biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3.4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 3..1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 3.) or 3.lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3.mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3.). Tumor control was achieved in 25 patients (3..7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3.8.1 mo). Dose adaptation was required in 3. patients (57.1%). Fifteen patients (23.8%) had grade 3.4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3.patients. There was no toxic death. PS 2 was significantly associated w

关键词： Pancreatic cancer Pancreatic adenocarcinoma Metastases Chemotherapy 5-fluorouracil Irinotecan Camptothecin FOLFIRI regimen

Functional Accumulation of Antenna Proteins in Chlorophyll b-Less Mutants of Chlamydomonas reinhardtii

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2017年第1期10卷 115-130页

作者： Sandrine Bujaldon Natsumi Kodama Fabrice Rappaport Rajagopal Subramanyam Catherine de Vitry Yuichiro Takahashi FrancisAndre Wollman institut de Biologie Physico-Chimique UMR7141 CNRS-UPMC Paris 75005 France Research institute for Interdisciplinary Science Okayama University Okayama 700-8530 Japan JST-CREST Okayama University Okayama 700-8530 Japan department of Plant Sciences School of Life Sciences University of Hyderabad Hyderabad 500046 India These authors contributed equally to this article deceased while manuscript was in progress

The green alga Chlamydomonas reinhardtii contains several light-harvesting chlorophyll a/b complexes （LHC）- four major LHCIIs, two minor LHClIs, and nine LHCIs. We characterized three chlorophyll b-less mutants to assess the effect of chlorophyll b deficiency on the function, assembly, and stability of these chlorophyll a/b binding proteins. We identified point mutations in two mutants that inactivate the CAO gene responsible for chlorophyll a to chlorophyll b conversion. All LHClIs accumulated to wild-type levels in a CAO mutant but their light-harvesting function for photosystem II was impaired. In contrast, most LHCIs accumulated to wild-type levels in the mutant and their light-harvesting capability for photosystem I remained unaltered. Unexpectedly, LHCl accumulation and the photosystem I functional antenna size increased in the mutant compared with in the wild type when grown in dim light. When the CAO mutation was placed in a yellow-in-the-dark background （yid-BF3., in which chlorophyll a synthesis remains limited in dim light, accumulation of the major LHClIs and of most LHCls was markedly reduced, indicating that sustained synthesis of chlorophyll a is required to preserve the proteolytic resistance of antenna pro- teins. Indeed, after crossing yid-BF3.with a mutant defective for the thylakoid FtsH protease activity, yid- BF3.ftshl restored wild-type levels of LHCI, which defines LHCI as a new substrate for the FtsH protease.

关键词： Chlamydomonas reinhardtii chlorophyll b-less mutant antenna protein CAO gene

SARS-CoV-2 Antibody Seroprevalence in Children and Workers from Belgian French-Speaking Primary Schools

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2023年第9期15卷 917-937页

作者： Kelly Cremer Julie Frère Olga Chatzis Ricardo de Mendonca Benoît Kabamba Florence Renard Mathilde de Keukeleire Dimitri Van der Linden Annie Robert institut de recherche Expérimentale et Clinique Department of Epidemiology and Biostatistics Faculty of Public Health Université Catholique de Louvain Brussels Belgium Pediatric Infectious Diseases Pediatric Department CHU Liège Liège Belgium Pediatric Infectious Diseases Specialized Pediatric Service Pediatric Department Cliniques Universitaires Saint-Luc Brussels Belgium department of Pathology Erasme University Hospital Université Libre de Bruxelles (ULB) H&#244pital Universitaire de Bruxelles (HUB) CUB H&#244pital Erasme Brussels Belgium institut de recherche Expérimentale et Clinique Université Catholique de Louvain Brussels Belgium department of Microbiology Cliniques Universitaires Saint-Luc Brussels Belgium Office de la Naissance et de L’enfance Brussels Belgium

Purpose: During the COVID-19 pandemic, closing schools was discussed to limit the virus transmission, despite a lack of evidence on the role of young children in the virus spread. We undertook a study among Belgian primary schools to assess the SARS-CoV-2 antibody seroprevalence and its relationship with local incidence, school size, and socioeconomic status (SES). Methods: Schools were purposively selected using three criteria: an area with either a low or a high COVID-19 incidence, either a small or a large size, and either a low or a high SES. 93. (/2488, 3.%) children and 242 (/444, 55%) staff signed informed consent. COVID-19 antibodies were tested using rapid finger prick tests. Results: Children participation was positively correlated with staff (r = +0.3.;95% CI [−0.3.;0.78]), and strongly with SES (r = +0.81;95% CI [0.40;0.95]). Seroprevalence was 21% in children (191/922) and 25% in staff (61/240). Seroprevalence did not correlate with local cumulative incidence (children: r = +0.06;95% CI [−0.59;0.67];staff: r = +0.26;95% CI [−0.40;0.74]). In staff, seroprevalence was higher in schools with higher SES (r = +0.3.;95% CI [−0.29;0.79]), but not in children (r = −0.10;95% CI [−0.66;0.53.). Conclusion:The lower seroprevalence in children suggests they are lower transmitters than adults, but poor socioeconomic levels were less representative.

关键词： SARS-CoV-2 Children Schools Seroprevalence Socioeconomic Status Belgium

Children and Workers Well-Being in Belgian French-Speaking Primary Schools during the COVID-19 Pandemic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2023年第6期15卷 676-694页

作者： Kelly Cremer Julie Frère Olga Chatzis Benoît Kabamba Florence Renard Mathilde de Keukeleire Ricardo de Mendonca Dimitri Van der Linden Annie Robert department of Epidemiology and Biostatistics Institut de Recherche Expérimentale et Clinique Faculty of Public Health UCLouvain Brussels Belgium department of Pediatric Pediatric Infectious Diseases CHU Liège Liège Belgium department of Pediatric Pediatric Infectious Diseases Specialized Pediatric Service Cliniques Universitaires Saint-Luc Brussels Belgium institut de recherche Expérimentale et Clinique UCLouvain Brussels Belgium department of Microbiology Cliniques Universitaires Saint-Luc Brussels Belgium Office de la Naissance et de l’Enfance Brussels Belgium department of Pathology Erasme University Hospital Université Libre de Bruxelles (ULB) H&#244pital Universitaire de Bruxelles (HUB) CUB H&#244pital Erasme Brussels Belgium

Purpose: During the COVID-19 pandemic, a significant number of measures were taken worldwide to limit the transmission of SARS-CoV-2, and in many ways, changed human life. All these measures had harmful consequences and impacted the well-being of many people. Children were one of the most vulnerable groups. We conducted the present study to assess children’s and staff’s well-being in French-speaking primary schools in Belgium during the COVID-19 pandemic. Methods: A 3.-question questionnaire for each child based on the Revised Children’s Manifest Anxiety Scale (RCMAS), and a 14-question questionnaire for each staff based on the Hospital Anxiety and depression (HAD) scale was undertaken in order to assess the well-being. Multiple logistic regressions were performed to assess the relationship between RCMAS or HAD and other explanatory variables. Staff reported their perception of their current life and their future life in 5 years on a Visual Analogue Scale (VAS). Results: A total of 23. children and 221 staff in 11 primary schools answered the well-being questionnaire between January and May 2021. 53. (122/23.) of children had symptoms of anxiety. Girls reported more anxiety symptoms than boys (≥10: 59%;Adj OR = 2.25;95% CI [1.28;4.03.). 52% (120/23.) of children had a definite state of social desirability. According to age, the youngest (6 - 7 years) children were more likely to have social desirability (≥5: 71%;Adj OR = 3.44;95% CI [1.53.8.09]) compared to the oldest (10 - 12 years). Children who did not practice outdoor/street activities were more likely to have social desirability (≥5: 60%;Adj OR = 2.59;95% CI [1.3.;4.99]). In schools with a higher local incidence of SARS-CoV-2, children were more likely to have social desirability (≥5: 64%;Adj OR = 2.15;95% CI [1.13.4.17]). In schools with a lower socioeconomic status, children were more likely to have social desirability (≥5: 72%;Adj OR = 2.74;95% CI [1.23.6.3.]). Higher RCMAS anxiety (r = −0.18;p −0.23.p −0.20

关键词： COVID-19 Well-Being Children Schools

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

近江牡蛎的摄食习性

海洋与湖沼 1959年第3期 163-179页

作者：张玺齐钟彦谢玉坎中国科学院海洋研究所

牡蛎(Ostrea)是重要的经济贝类之一,我国广东、福建沿海个别地区养殖的近江牡蛎(O. rivularis Gould)为其中经济价值巨大的一种。世界学者们在牡蛎的研究方面已经做了许多工作,对壮蛎的养殖生产曾起了很大的推动作用;但目前在基础理论... 详细信息

牡蛎(Ostrea)是重要的经济贝类之一,我国广东、福建沿海个别地区养殖的近江牡蛎(O. rivularis Gould)为其中经济价值巨大的一种。世界学者们在牡蛎的研究方面已经做了许多工作,对壮蛎的养殖生产曾起了很大的推动作用;但目前在基础理论和实际应用方面,都还存在着很多需要研究和争论未决的问题,牡蛎的摄食习性就是其中之一。

关键词：摄食习性平均黎明内容物悬浮物海水悬浮体软体部

Recycling process and proto-kimberlite melt metasomatism in the lithosphere-asthenosphere boundary beneath the Amazonian Craton recorded by garnet xenocrysts and mantle xenoliths from the Carolina kimberlite

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2022年第5期13卷 89-105页

作者： Fernanda Gervasoni Tiago Jalowitzki Marcelo Peres Rocha Ricardo Kalikowski Weska Eduardo Novais-Rodrigues Rodrigo Antonio de Freitas Rodrigues Yannick Bussweiler Elisa Soares Rocha Barbosa Jasper Berndt Elton Luiz Dantas Valmir da Silva Souza Stephan Klemme Centro de Engenharias Universidade Federal de Pelotas(UFPel)PelotasBrazil Programa de Pós-graduação em Geociências Universidade Federal do Rio Grande do SulPorto AlegreBrazil Programa de Pós-graduação em Geologia Instituto de GeociênciasUniversidade de Brasília(UnB)BrasíliaBrazil Faculdade de Geociências Universidade Federal do Mato Grosso(UFMT)CuiabáBrazil institut für Geologie und Mineralogie Universität zu KölnGermany Faculdade de Ciências e Tecnologia Universidade Federal de Goiás(UFG)Aparecida de GoiâniaBrazil institut für Mineralogie Universität MünsterMünsterGermany

Here we present new data on the major and trace element compositions of silicate and oxide minerals from mantle xenoliths brought to the surface by the Carolina kimberlite,Pimenta Bueno Kimberlitic Field,which is located on the southwestern border of the Amazonian *** also present Sr-Nd isotopic data of garnet xenocrysts and whole-rocks from the Carolina *** xenoliths are mainly clinopyroxenites and *** of the clinopyroxenites were classified as GPP–PP–PKP(garnet-phlogopite peridotite,phlogopite-peridotite,phlogopite-K-richterite peridotite)suites,and two clinopyroxenites(eclogites)and two garnetites are relicts of an ancient subducted *** and pressure estimates yield 855–1102℃ and 3.6–7.0 GPa,*** are enriched in light rare earth elements(LREE)(la_(N)/Yb_(N)=5–62;Ce_(N)/Sm_(N)=1–3.where N=primitive mantle normalized values),they have high Ca/Al ratios(10–410),low to medium Ti/Eu ratios(742–2840),and low Zr/Hf ratios(13.26),which suggest they were formed by metasomatic reactions with CO_(2)-rich silicate *** with high TiO_(2)(>2.0 wt.%),Al_(2)O_(3.(>12.0 wt.%),and FeOt(5.0–13.0 wt.%)resemble those found in the groundmass of kimberlites,lamproites and ***,phlogopite with low TiO_(2)(3.(lar to those present in GPP-PP-PKP,and in MARID(mica-amphibole-rutile-ilmenite-diopside)and PIC(phlogopite-ilmenite-clinopyorxene)*** GPP-PP-PKP suite of xenoliths,together with the clinopyroxene and phlogopite major and trace element signatures suggests that an intense proto-kimberlite melt metasomatism occurred in the deep cratonic lithosphere beneath the Amazonian *** Sr-Nd isotopic ratios of pyrope xenocrysts(G3.G9 and G11)from the Carolina kimberlite are characterized by high ^(143.Nd/^(144)Nd(0.51287–0.513.1)and eNd(+4.55 to+20.85)accompanied with enriched ^(87)Sr/^(86)Sr(0.70405–0.71098).These results suggest intera

关键词： Carolina kimberlite K-rich mantle xenoliths Ancient subducted slab Proto-kimberlite melt metasomatism

维普期刊数据库

Unraveling one billion years of geological evolution of the southeastern Amazonia Craton from detrital zircon analyses

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2022年第5期13卷 129-152页

作者： Camille Rossignol Paul Yves Jean Antonio francesco Narduzzi Eric Siciliano Rego Lívia Teixeira Romário Almeida de Souza Janaína N.Ávila Marco A.L.Silva Cristiano lana Ricardo I.F.Trindade Pascal Philippot departamento de Geofísica Instituto de AstronomiaGeofísica e Ciências Atmosféricas da Universidade de São PauloRua do Matão1226-Cidade UniversitáriaSão Paulo 05508-090Brazil institut de Physique du Globe de Paris Universitéde ParisCNRSParisFrance Géosciences Montpellier Universitéde MontpellierCNRSUniversitédes AntillesMontpellierFrance instituto de Geociências Universidade de São PauloRua do Lago562-Cidade UniversitáriaSão Paulo 05508-080Brazil instituto de Geociências e Engenharias Universidade Federal do Sul e Sudeste do Pará–UNIFESSPAFolha 17Quadra 04Lote especialNova MarabáMarabáPará68505-080Brazil Research School of Earth Sciences The Australian National University142 Mills RoadCanberraACT 2601Australia Applied Isotope Research Group Departamento de GeologiaEscola de MinasUniversidade Federal de Ouro PretoRua Diogo de Vasconcelos12235400-000 Ouro PretoMGBrazil

despite representing one of the largest cratons on Earth,the early geological evolution of the Amazonia Craton remains poorly known due to relatively poor exposure and because younger metamorphic and tectonic events have obscured initial *** this study,we investigated the sedimentary archives of the Carajás Basin to unravel the early geological evolution of the southeastern Amazonia *** Carajás Basin contains sedimentary rocks that were deposited throughout a long period spanning more than one billion years from the Mesoarchean to the *** oldest archives preserved in this basin consist of a few ca.3.6 Ga detrital zircon grains showing that the geological roots of the Amazonia Craton were already formed by the *** the Paleoarchean or the early Mesoarchean(3.1 Ga),the Carajás Basin was large and rigid enough to sustain the formation and preservation of the Rio Novo Group greenstone ***,during the Neoarchean,at ca.2.7 Ga,the southeastern Amazonia Craton witnessed the emplacement of the Parauapebas large Igneous Province(LIP)that probably covered a large part of the craton and was associated with the deposition of some of the world largest iron *** emplacement of this LIP immediately preceded a period of continental extension that formed a rift infilled first by iron formations followed by terrigenous *** major change of sedimentary regime might have been controlled by the regional tectonic evolution of the Amazonia Craton and its emergence above *** the Paleoproterozoic,at ca.2.1 Ga,the Rio Fresco Group,consisting of terrigenous sediments from the interior of the Amazonia Craton,was deposited in the Carajás *** that time,the Amazonian lithosphere could have either underwent thermal subsidence forming a large intracratonic basin or could have been deformed by long wavelength flexures that induced the formation of basins and swells throughout the craton under the influence of

关键词： Carajás Basin Chemical Abrasion–la-ICP-MS analyses Age distribution comparison Parauapebas large Igneous Province Transamazonian orogeny

维普期刊数据库