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中国医院用药评价与分析 2024年第4期24卷 385-389,395页

作者：广东省药学会药物警戒专业委员会陈娟郑萍不详南方医科大学南方医院药学部南方医科大学南方医院临床药学中心

重组人凝血因子Ⅷ为众多权威指南推荐的血友病A首选替代治疗药物。重组人凝血因子Ⅷ各品种能够暂时替代患者体内缺失的凝血因子Ⅷ,具有相同的药物作用机制,但在经济性、药学特性及其他属性等方面存在差异。为此,广东省药学会药物警戒专... 详细信息

重组人凝血因子Ⅷ为众多权威指南推荐的血友病A首选替代治疗药物。重组人凝血因子Ⅷ各品种能够暂时替代患者体内缺失的凝血因子Ⅷ,具有相同的药物作用机制,但在经济性、药学特性及其他属性等方面存在差异。为此,广东省药学会药物警戒专业委员会组织药学与临床专家共同制定了《广东省重组人凝血因子Ⅷ药物评价与遴选专家共识》,对我国已上市的6种重组人凝血因子Ⅷ从药学特性、有效性、安全性、经济性及其他属性等五大方面进行多维度评价,为医疗机构药品遴选及临床合理用药提供参考依据。

关键词：血友病A 重组人凝血因子Ⅷ 药物评价遴选专家共识

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Neuroprotective effect of epigallocatechin-3.gallate on spinal cord injury induced by hemisection in rats

Neuroprotective effect of epigallocatechin-3-gallate on spin...

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共铸医药学术新文明——2012年广东省药师周大会

作者： Fengjun Deng~1,Rubing Li~2,Yingbao Yang~3.Dan Zhou~4,Qian Wang~3.Jiangping Xu~3.~1Department of pharmaceutical Sciences,Hunan Yiyang Medical college,Yiyang 413.00,Hunan Province, china ~2pharmaceutical Preparation Section,General Hospital of guangzhou Military Command of PLA, guangzhou 510010,guangdong Province,china ~3.epartment of Pharmacology,School of pharmaceutical Sciences,Southern Medical University, guangzhou 510515,guangdong Province,china ~4Pingxiang Healthy School,Pingxiang 3.7000,Jiangxi Province,china

Epigallocatechin-3.gallate(EGCG),a naturally occurring compound in green tea,has been widely used as an antioxidant *** the present study,model rats with acute spinal cord injury were intraperitoneally injected with 25,50,and 100 mg/kg EGCG,and spinal cord ultrastructure,oxidative stress reaction,inflammatory factors,and apoptosis-associated gene expression were *** showed that EGCG attenuated neuronal and axonal injury 24 hours post *** also decreased serum interleukin-lβ,tumor necrosis factor-a,and intercellular adhesion molecule-1 release,and decreased apoptosis-associated gene expression. Furthermore,it increased the level of the superoxide anion(O2?),superoxide dismutase,and B-cell lymphoma/leukemia-2,and reduced malondialdehyde ***,it reduced the expression of the pro-apoptotic protein ***,EGCG at the 100 mg/kg dosage exhibited similar effects as methylprednisolone sodium succinate,which has been frequently used for clinical acute spinal *** results demonstrated that EGCG can significantly inhibit inflammation,suppress oxidation,and reduce apoptosis in acute spinal ,superoxide dismutase,and B-cell lymphoma/leukemia-2,and reduced malondialdehyde ***,it reduced the expression of the pro-apoptotic protein ***,EGCG at the 100 mg/kg dosage exhibited similar effects as methylprednisolone sodium succinate,which has been frequently used for clinical acute spinal *** results demonstrated that EGCG can significantly inhibit inflammation,suppress oxidation,and reduce apoptosis in acute spinal cord injury. Sciences,Southern Medical University from March 2008 to May 2009.

关键词： Epigallocatechin-3.gallate(EGCG) Spinal cord injury(SCI) Neuroprotctive effect Oxidative stress

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我国“211工程”院校图书馆开放存取资源开发利用调查

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图书馆杂志 2011年第3期30卷 53-58页

作者：麦淑平广东药学院图书馆广州510006

对我国112所"211工程"院校图书馆揭示和利用开放存取资源的情况进行了调查研究。主要从对OA资源的组织方式及揭示不同类型的OA资源数量两方面进行考察,来反映211院校图书馆利用开放存取资源的情况,希以此为图书馆开发利用OA资源提供参考。

关键词：开放存取高校图书馆 211工程院校信息组织调查

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A Web Page Classifier Based on Immune Algorithm

A Web Page Classifier Based on Immune Algorithm

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第四届全国信息检索与内容安全学术会议

作者： Qirui ZHANG~1 Jinghua TAN~2 Weiye TAO~1 Hexian WANG~(1,+) ~1 college of Medical Information Engineering,guangdong pharmaceutical University,{3. 510006,china ~2 {3. Research and Development Center,china Telecom,{3. 51063.,china

The nature of immune algorithm is to distinguish between self and *** the basis of immune algorithm,we propose a new method of text categorization called the Clonal Selection Algorithm Based on Antibody *** to the clonal selection principle and density control mechanism,only those cells that have higher affinity and lower density are selected to *** ultimate classifier is composed with many memory *** the whole,it considers the accuracy of individuals as well as variety and is successfully implemented in text *** realize a Web page classifier based on immune algorithm,and tests the system on Sina set and CCT2002-v1.1 data *** experiment results show that it can obtain the better classification performance.

关键词： Web Page Categorization Immune Algorithm Antibody Density Text Categorization

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Two new ent-Kaurane Glycosides from Ranunculus muricatus Linn.

Two new ent-Kaurane Glycosides from Ranunculus muricatus Lin...

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中国化学会第9届天然有机化学学术会议

作者： WU Bi-ling~(a,b),ZHANG Ying~(a,b),TANG Yu-zhi~c,ZHOU Guang-xiong~(a,b,*) a Institute of Traditional Chinese Medicine and Natural Products,Jinan University guangzhou 51063., china b guangdong Province Key Laboratory of Pharmacodynamic Constitu guangzhou 51063.,china c college of Pharmacy,guangdong pharmaceutical University,guangzhou 510224,china

＜正＞Ranunculus muricatus L.,one of the herbal plants belonging to the genus Ranunculus,is widely distributed in Asian,South American,Australasia and *** plant especially grows in Eastern ***,it used as folklore medicines in Kurukshetra District （Haryana） of India for the therapy of Tonsilitis diseases" for a long history. Previous extensive phytochemical studies on plants in genera Ranunculus led to isolating the majority of structurally diverse flavonoids and their glycosides,andγ-*** our phytochemical investigation,we have isolated twelve flavonoid glycosides from R.

关键词： Ranunculus muricatus L. flavonoid ent-kaurane glycosides

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The response of P50 sensory gating in substantia Nigra on estrogen against dopaminergic neurons depleted by oxidative stress

The response of P50 sensory gating in substantia Nigra on es...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Jinlan MENG~(1,2),Yuanyi MA~(1,3.,Haiyun LUO~1,Min HE~(1*) 1 Department of Physiology,Kunming Medical college,Kunming,Yunnan 65003.,china 2 Department of Physiology,guangdong {3. University,guangzhou,guangdong 510006,china 3.Fourth Military Medical University Press,Xian,Shanxi 71003.,china

＜正＞Estrogen as a natural antioxidant of membrane phospholipids peroxidation can block the damage of dopaminergic neurons in substantia nigra（SN） lesioned by exotic toxicant like 6-hydroxydopamine（6-OHDA） to protect dopaminergic neurons in *** now researching the relationship between estrogen and the system of dopaminergic neurons in SN generally adopt ex vivo and acute animal microdialysis experiments which can not reflect estrogen’s internal proptection of antioxidative stress to dopaminergic neurons.A lot of substantial evidences strongly implied that P50 sensory gating （P50） and dopaminergic neurotransmitter have affinities,P50 can be recorded in a quite and awake *** the present P50 sensory gating in SN was studied in normal group（F-INT）,Parkinson’s disease model group with 6-OHDA lesioned SN（FPD）, ovariectomy + 6-OHDA Parkinson’s disease model group（F-OVX-PD） and ovariectomy + estrogen replacement + 6- OHDA Parkinson’s disease model group（F-OVX-E2-PD） to determine the change of P50 sensory gating in SN on estrogen against dopaminergic neurons depleted by oxidative stress.P50 auditory evoked potentials by two brief acoustic stimuli were recorded in the SN and the number of TH immunohistochemistry stained dopaminergic neurons in the SN was investigated after the determination of *** results demonstrated that:（1） The testing/conditioning（T/C） ratio of P50 is decreased significantly in F-PD group（0.3.9±0.074,n=15） as compared to F-INT group（0.667±0.03.,n=21）（P＜0.01）;（2） The T/C ratio of P50 is decreased significantly in F-OVX-PD group（0.219±0.059,n=12） as compared to F-PD group and FOVX -E2-PD group（0.498±0.166,n=15）（P＜0.01）;（3. The T/C ratio of P50 is no difference between F-OVX-E2-PD group and F-PD group（P＞0.05）.（4） The number of TH+ cells in right SN（lesioned by 6-OHDA） of F-OVX-PD group decreased about 57.14%and 60.86%as compared to F-PD group and F-OVX-E2-PD group（P＜0.05）.The number of TH+ cells in right SN is decreased significantly as compared

关键词： P50 sensory gating estrogen dopaminergic neurons oxidative stress

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Suzuki Coupling of Aryl Halides with PhB(OH)2 Catalyzed by Novel Palladium Catalysts

Suzuki Coupling of Aryl Halides with PhB(OH)2 Catalyzed by N...

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有机合成创新—产业化的新动力——中国化学会全国第三届有机合成化学与过程学术讨论会

作者： Tan,Cheng Liu,Fengshou Shen,Dongsheng~* Zhou,Zongzhou (School of Chemistry and Chemical Engineering,guangdong pharmaceutical University, guangzhou 510006{3.)

Very recently,Akira Suzuki,who had devoted all his life into the Suzuki reaction named after him,along with R. *** and Ei-ichi Negishi were awarded the 2010 Nobel Prize for Chemistry because of their excellent work in the cross-coupling reactions catalyzed by palladium *** is known to us all,Suzuki reaction plays a very important role in the carbon-carbon single bond formation,which is widely used in organic synthesis,pharmaceutical industry,agrochemical manufacturing et al..Meanwhile,as the rapid development of different palladium catalysts used in the Suzuki reaction, numbers of researchers did explorations and deep investigations in this *** example,there are mainly phosphine ligands,carbenes,palladacycles et al to be used as ligands complexed with different palladium salts to catalyze the Suzuki coupling reaction,and these ligands showed excellent catalyzing ***,these ligands,in some degree, had instabilities in moisture and *** instance,phosphine containing ligands sometimes are thermally instable while carbenes are too ***,some of these ligands are hard to be prepared or hardly commercially available..Thus, phosphine-free ligands are going to be developed by many *** phosphine-free ligands are easily to be synthesized with materials commercially available,and are not so sensitive in air and moisture,which provides much milder conditions for the Suzuki coupling ***,our group had developed series of novel[N,N]bidentate ligands(Figure 1) complexed with palladium dichloride in situ to catalyze the Suzuki coupling of different aryl halides and phenyl boronic *** these catalysts gave good to excellent yields in catalyzing the hindered arylbromide substrates with phenyl boronic acid,while compared with arylchlorides,which are notorious for its low activation of the C-Cl bond.

关键词： Suzuki coupling catalyst palladium salts

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Analysis of dynamic state of rheo-encephalogram during the procedure of hyperbaric oxygen therapy

Analysis of dynamic state of rheo-encephalogram during the p...

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第十六届国际高气压医学学术会议暨第十七届全国高压氧医学学术会议

作者： Hongjun Wang~1 Qibiao Weng~1 Lingling Chen~1 Xuelin Chen~1 quyun Yang~2 Jin Liu~1 Guimei Zhou~1 1.Zhujiang Hospital attached to Southern Medical University,Department of Hyperbaric oxygen,guangzhou,china 2.The First Hospital attached to guangdong {3. college,guangzhou,china 3.Shilong People’s Hospital of Dongguan City,guangdong Province,guangzhou,china

*** Second People’s Hospital of Nanhai District,Foshan City,guangdong Province,guangzhou,china Objective:Three dynamic states of rheo-encephalogram(before HBOT,during HBOT and after HBOT)of patients who received the HBOT(hyperbaric oxygen therapy)were analyzed,so as to observe and analyze the effect of the whole procedure of HBOT on function of cerebral vessels,to know about the diversity and

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Tannin inhibits HIV-1 entry by targeting gp41

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Acta Pharmacologica Sinica 2004年第2期 87-92页

作者： Lin Lü2, Shu-wen LIU2,3. Shi-bo JIANG3. Shu-guang WU2,4 2Institute of pharmaceutical Sciences of the First Medical University of PLA, Key Lab of GD for Screening of New Drug, guangzhou, guangdong 510515,{3. Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA

AIM: To investigate the mechanism by which tannin inhibits HIV-1 entry into target cells. METHODS: The inhibitory activity of tannin on HIV-1 replication and entry was detected by p24 production and HIV-1-mediated cell fusion, respectively. The inhibitory activity on the gp41 six-helix bundle formation was determined by an improved sandwich ELISA. RESULTS: Tannins from different sources showed potent inhibitory activity on HIV-1 replication, HIV-1-mediated cell fusion, and the gp41 six-helix bundle formation. CONCLUSION: Tannin inhibits HIV-1 entry into target cells by interfering with the gp41 six-helix bundle formation, thus blocking HIV-1 fusion with the target cell.

关键词： tannin drug dose-response relationship enzyme-linked immunosorbent assay HIV envelope pro- tein gp41 phenols plant extracts medical plants

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Study on bioactive metabolites from marine bacteria Pseudomonas *** different temperature controlling quorum sensing signal molecules

Study on bioactive metabolites from marine bacteria Pseudomo...

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中国化学会第9届天然有机化学学术会议

作者： Wen Lu~*,Wei Qi-Qiu,Chen Gang,Zhang Shi-Chang Department of Pharmacy,guangdong pharmaceutical University,guangzhou,510006,P R{3..

＜正＞Bacteria use small molecule signals to access their local population densities in a process called quorum sensing（QS）.Once a threshold signal concentration is reached,and therefore a certain number of bacteria have assembled,bacteria use QS to change gene expression levels and initiate behaviors that benefit the *** homoserine lactones （AHLs） are a major class of quorum sensing signaling *** systems are often affected by environmental factors,such as temperature,pH,and nutrient levels,it is hence proposed that the evolution of bacterial cooperation,such as the QS,is rather a dynamic and ever-changing process which is radically affected by environmental conditions,genetic exchanges,as well as by changes in microbial community. In our experiment,the influence of temperature on the AHLs profile produced by marine bacteria Pseudomonas *** *** and characterized AHLs signal molecule by thin layer chromatography with different temperatures controlled in the bacterial trace *** results showed that the strains produced two types of AHLs at 27℃.The long chain AHLs were produced mainly,and the short chain AHLs disappeared when the strains were grown at 20℃.The strains produced the different types of AHLs when grown in the different *** bacteria（10 L） were fermented in the two temperatures, respectively,two main ingredients prodigiosin and violacein were *** two compounds showed strong antimicrobial *** conclusion,it could produce various bioactive metabolites from the strains,with different temperature controlling QS signal *** all,the dependence of QS on small molecule signals has inspired organic chemists,novel strategies are provided for developing novel antimicrobials by interfering with communication in bacteria.

关键词： marine bacteria quorum sensing quorum sensing signal molecule antimicrobial activity

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