检索结果-南通市图书馆

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

社会信任与群众文化互动的伦理辨析

湘潭大学学报(哲学社会科学版) 2006年第2期 17-21页

作者：李萍中国人民大学哲学学院北京100872

群众文化常常因其为“下里巴人”的艺术而受不到关注,虽然在一些主流话语中群众文化也可能得到重视,但那种重视并非从群众文化内部生长出来的,更非从构建社会整体文化认同和社会信任的高度立意的。群众文化不仅是传统文化的载体,同时也... 详细信息

群众文化常常因其为“下里巴人”的艺术而受不到关注,虽然在一些主流话语中群众文化也可能得到重视,但那种重视并非从群众文化内部生长出来的,更非从构建社会整体文化认同和社会信任的高度立意的。群众文化不仅是传统文化的载体,同时也是公民接受社会化和信任他人的“精神储备”。只有从维护和推广社会信任的层面入手,才能真正深刻领会扶持群众文化和辨明群众文化现代意义的重要性。

关键词：群众文化社会信任公民文化认同

Comparison of the Sesquiterpene Ester Profiles of Different Specialized Armillariella mellea Mycelia Using HPLC-DAD Chromatography

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

食用菌学报 2006年第4期 44-48页

作者： CHENG Xian-hao 1,2, WANG Chun-lan 1, GUO Shun-xing 1* 1Institute of Medicinal Plant Development, Chinese Academy of Medical sciences & Peking union Medical college, {3. 100094, china 2college of Life Science, Ludong university, Yantai, Shandong 264025, china

Sesquiterpene profiles in methanolic extracts of crustose aerial hyphae, rhizomorphs and fruit bodies of Armillariella mellea grown on semi-solid wort medium, and of fungal mycelium grown in submerged culture on liquid wort medium, were compared using High Performance Liquid Chromatography-Diode Array Detector (HPLC-DAD). The sesquiterpene ester components of mycelium grown in submerged culture were distinct from the sesquiterpene esters detected in rhizomorphs, crustose aerial hyphae and fruit bodies. The sesquiterpene ester profile of rhizomorphs was similar to that of crustose aerial hyphae, but was considerably different to the profiles of fungal mycelium grown in submerged culture and fruit bodies.

关键词： Aerial hyphae Armillariella mellea Fruit body HPLC-DAD Rhizomorph Wort medium

Selenite Induces Oxidative Stress and Apoptosis in Colon Cancer Cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Selenite Induces Oxidative Stress and Apoptosis in Colon Can...

2008年全国生物化学与分子生物学学术大会

作者： Fang Huang~1 Quan Chen~2 Cai-min Xu~1 1 National Laboratory of Medical Molecular Biology,Institute of Basic Medical sciences,Chinese Academy of Medical sciences and Peking union Medical {3.,beijing,china 2 Joint Laboratory of Apoptosis and Cancer Biology,{3. of Life sciences,Nankai university,Tianjin 3.0071,china and The State Key Laboratory of Biomembrane and Membrane Biotechnology,Institute of Zoology,Chinese Academy of sciences,beijing 100101,china.

As a chemotherapeutic principle,tumor cells are often sensitive to oxidative stress,there are emerging evidences showing the difference in sensitivity between tumor and normal cells in response to selenite,including p...

关键词：

Ginsenoside enhances synapsin Ⅰ phosphorylation and glutamate release through PKA and MAPK cascades

在线全文

cnki会议

学校读者我要写书评

暂无评论

Ginsenoside enhances synapsin Ⅰ phosphorylation and glutama...

全国生化与分子药理学药物靶点研讨会

作者： Ming ZHAO Zhi-jun LIU Yi-yue ZHANG Jian-fei XUE Yun ZHANG Nai-hong CHEN (Institute of Material Medica,Chinese Academy of Medical sciences and Peking union Medical college,{3. 100050,china {3. Hospital of the Ministry of Health,{3. 100050,china)

To investigate whether cAMP-dependent protein kinase(PKA)and/or Ca-calmodulin-dependent protein kinase(CaMKII)is/are involved in Rb and Rg-enhanced synapsinⅠphosphorylation and glutamate release in PC12 cells,differentiated or undifferentiated PC12 cells were incubated with Rb and Rg,following a 3.-min pretreatment with or without H89,an inhibitor of PKA or W7,of calmodulin.

关键词：

Acute neurovascular unit protective action of pinocembrin against permanent cerebral ischemia in rats

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acute neurovascular unit protective action of pinocembrin ag...

药学发展前沿论坛及药理学博士论坛

作者： Mei Gao~a Rui Liu~a Shen-Yin Zhu~b Guan-Hua Du~(a*) a Institute of Materia Medica,Chinese Academy of Medical sciences and Peking union Medical college,{3. 100050,china b Chongqing university of Medical Science,Chongqing 400016,china

Acute vascular-and neuroprotective effects of pinocembrin were evaluated in a rat model of focal cerebral *** cerebral ischemia was induced by the middle cerebral artery occlusion (MCAO) for 24 *** (3.10,or 3. mg/kg),intravenously injected at 0,8, and 16 h after MCAO,reduced the cerebral infarct volumes by 47,3.,and 3.%,respectively, as visualized by 2,3.5-triphenyltetrazolium chloride staining (P<0.01).Treatment with pinocembrin also reduced brain swelling and improved behavioral deficits significantly (P<

关键词： pinocembrin neurovascular unit cerebral ischemia blood-brain barrier

Formation of 4'-carboxyl acid metabolite of imrecoxib by rat liver microsomes

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第4期27卷 506-512页

作者： Hai-yan XU~2 Peng ZHANG~2 Ai-shen GONG~3.Yu-ming SUN~2 Feng-ming CHU~4 Zong-ru GUO~4 Da-fang ZHONG~(2,5,6)2 Laboratory of Drug Metabolism and Pharmacokinetics,Shenyang Pharmaceutical university,Shenyang 110016,china 3.Research and Development Center,Shanghai Hengrui Pharmaceutical Co,Shanghai 200245,china:4 Institute of Materia Medica,Chinese Academy of Medical {3. and Peking union Medical college,beijing 100050,china 5 Shanghai Institute of Materia Medica,Chinese Academy of {3.,Shanghai 201203.china LaboratoryofDrugMetabolismandPharmacokinetics ShenyangPharmaceuticalUniversityShenyang110016China

Aim:Imrecoxib is a novel and moderately selective COX-2 *** aim ofthe present in vitro investigation was to study the formation of the major metabo-lite 4′-carboxylic acid imrecoxib（M2）and identify the enzyme（s）involved in ***:The formation of M2 was studied in rat liver cytosol in theabsence or presence of liver *** formed metabolite was identifiedand quantified by LC/MS~*** addition,to characterize the cytochrome P450（CYP）isozymes involved in M2 formation,the effects of typical CYP inhibitors（such asketoconazle,quinine,α-naphthoflavone,methylpyrazole,and cimetidine）on theformation rate of M2 were ***:The formation of M2 from 4’-hydroxymethyl imrecoxib（M4）was completely dependent on rat liver microsomesand *** kinetic studies demonstrated that the formation rate of M2conformed to monophasic Michaelis-Menten *** experimentsshowed that the formation of M2 was induced significantly by dexamethasoneand lowered by ketoconazole strongly and ***,other CYP inhibitors,such as α-naphthoflavone,cimetidine,quinine,and methylpyrazole had no inhibitory effects on this metabolic ***:These biotransformation studies of M4 and imrecoxib in rat liver atthe subcellular level showed that the formation of M2 occurs in rat liver microsomesand is *** reaction was mainly catalyzed by CYP 3. inuntreated rats and in dexamethasone-induced *** CYP,such as CYP 1A,2C,2D,and 2E,seem unlikely to participate in this metabolic pathway.

关键词： imrecoxib cytochrome P450 metabolism liver microsomes rats

Preparation of Arsenic Trioxide Albumin Microspheres and its Release Characteristics in Vitro

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Huazhong university of Science and Technology(Medical sciences) 2005年第3期25卷 310-312,319页

作者：周洁曾甫清高翔谢蜀生魏树礼 Department of Urology Union Hospital Tongji Medical College Huazhong University of Science and Technology Laboratory of Immunopharmacology Health Science Center Peking University Faculty of Pharmacy Health Science Center Peking University

Arsenic trioxide albumin microspheres (As_2O_3.BSA-NS) were prepared by using methods of chemical cross-linking. The desirability function (DF), calculated according to the size (0.05). The release experiment in vitro showed that As_2O_3.in As_2O_3.BSA-NS was released more slower than pure As_2O_3. It was concluded that regular As_2O_3.BSA-NS may be prepared by the methods of chemical cross-linking, which was optimized by orthogonal experimental analysis of different factors, and the microspheres can release As_2O_3.slowly.

关键词： Arsenic trioxide Albumin microspheres chemical cross-linking slow release

维普期刊数据库

Influences of theTransportation of Berberine in Coptidis Rhizoma Alcholoids through Rat Primary Culture Cortical Neurons in vitro

在线全文

学校读者我要写书评

暂无评论

Influences of theTransportation of Berberine in Coptidis Rhi...

第五届全国化学生物学学术会议

作者： Yunyun Chen~1 Xueli Wang~1 Hong Xun~2 Dongming Xing~1 Jun Hu~1 Zhuohan Wai~1 Lijun Du~(1*) 1 Laboratory of Pharmaceutical sciences,Department of Biological sciences and Biotechnology,Tsinghua university,{3. 100084,china 2 Institute of Medicinal Plant,Chinese Academy of Medical sciences,Peking union Medical college,Tsinghua university,{3. 100094,china

＜正＞Berberine has multiple cerebral bioactivities and has been used for the treatment of cerebral diseases in *** could pass through the blood-brain barrier and transports into neurons,but its mechanisms of transport are still *** order to study its transport behaviors and characteristics, we investigated factors that the influence of berberine transport and uptake in the neurons,such as incubation temperature,berberine structure analog interation,metabolism inhibitor,p-glycoprotein

关键词： Coptidis Rhizoma alcholoids Berberine Cortical neuron Transportation

Echinacoside attenuates 6-hydroxydopamine-induced neurotoxicity in PC12 cells

在线全文

cnki会议

学校读者我要写书评

暂无评论

Echinacoside attenuates 6-hydroxydopamine-induced neurotoxic...

第二届世界天然药物和传统药物药理学学术会议

作者： Yue-Hua WANG~(1,2),Shuo TIAN~2,Guo-Rong HE~2,Lian-Hua FANG~2,Xiao-Ping PU~(1*),Guan-Hua DU~(2*) (1.Department of Molecular and Cellular Pharmacology,School of Pharmaceutical sciences,Peking university, beijing 100191,{3. 2.beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica,Chinese Academy of Medical sciences & Peking union Medical college, beijing 100050,{3.)

＜正＞AIM To investigate the effects and the underlying mechanism of Echinacoside（ECH） against 6-OHDA-induced injury in *** 6-OHDA was added to cultured PC12 cells after pretreatment for 1 h with different concentration of ECH or saline and co-incubated for another 24 *** evaluate the protective effects of ECH,the morphological change was observed by microscope,the viability of PC12 cells was assayed by MTT *** explore the mechanism of ECH against 6-OHDA neurotoxicity, the mitochondrial oxidation-reduction activity（REDOX）,mitochondrial membrane potential（△ψm）,reactive oxygen species（ROS） production,ATP level,cytochrome c release,the activity of caspase 3.and apoptosis in PC12 cells were *** 6-OHDA induced the decrease of cell viability,ROS generation increase,ATP content decrease,mitochondrial dysfunction,and mitochondria -mediated apoptosis in PC12 *** could attenuate 6-OHDA-induced neurotoxicity,inhibit the collapse of△ψm,reduce the mitochondrial *** also inhibited cyt c release and caspase 3.*** Our results indicate that ECH attenuates 6-OHDA-induced neurotoxicity through anti-oxidative and anti-apoptosis mediated by mitochondria.

关键词： echinacoside Parkinson’s disease 6-hydroxydopamine