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chinese Chemical Letters 2000年第7期11卷 571-572页

作者： Xin CHEN Lin WANG Zhi Zhong ZHAO Xing Quan ZHANG Xiang Hong CHEN Hong Shan CHEN(institute of materia medica, chinese academy of medical sciences & peking union medical college, beijing 100050 institute of Medicinal Biotechnology, chinese academy of M institute of materia medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China institute of Medicinal Biotechnology Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, ii) can inhibit HIV-I RT with IC50 20.0, 43.8, and 63.7 mu M, respectively.

关键词： piperazine phthalimide HIV1-RT inhibitor

Studies on the Total Synthesis of Hainanolide (VI)-The First Access to the Lactone Functionality

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chinese Chemical Letters 2000年第4期11卷 295-296页

作者： Xiao Ming YU Shi Zhi CHEN Liang HUANG (institute of materia medica. chinese academy of medical sciences & peking union medical college. No. 1 Xian Nong Tan Street. beijing 100050) institute of materia medica Chinese Academy of Medical Sciences Peking Union Medical College No. 1 Xian Nong Tan Street Beijing 100050 China

C-2a- beta-H ketone 6 was synthesized from the exo-IMDA-additive 4 with the aid of singlet oxygen, and ring E of hainanolide was assembled via kinetic enol ether of 6.

关键词： hainanolide exo-IMDA-additive 1,4-lactone

Selective Cyclooxygenase-2 Inhibitors: Design and Synthesis

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chinese Chemical Letters 1999年第6期10卷 469-472页

作者： Xin Sheng LEI Zong Ru GUO Ling Bo QU Qi Qing ZHU(institute of materia medica. chinese academy of medical sciencesAnd peking union medical college. beijing 100050) institute of materia medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

The discovery of COX-2 provides a novel target developing more effective NSAIDs with fewer side effects. On the basis of results from the structure-activity relationships (SAR) of selective COX-2 inhibitors, we have d... 详细信息

关键词： cyclooxygenase cyclooxygenase-2 inhibitor selective

The Synthesis of Hexamethyl Ether of Salvianolic Acid A Benzyl Ester

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chinese Chemical Letters 1996年第10期7卷 888-891页

作者： Yan ZHUANG Zong Ru GUO Guang Zhong YANG Xiao Tian LIANG(institute of materia medica.chinese academy of medical sciences peking union medical college, 1 Xian Nong Tan Street, beijing 100050) institute of materia Medico Chinese Acad. Med. Sci. Peking U. 1 Xian Nong Tan Street Beijing 100050

A salvianolic acid A derivative, hexamethyl ether of salvianolic acid A benzyl ester, was synthesized in fourteen steps. The overall yield was 3.4 parts per thousand. The compound was identified by (1)HNMR and MS. Thi... 详细信息

关键词： The Synthesis of Hexamethyl Ether of Salvianolic Acid A Benzyl Ester

Liu Shih-Hao:Pioneer of translational medicine in china

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Science china(Life sciences) 2011年第12期54卷 1089-1095页

作者： LI NaiShi department of Endocrinology,peking union medical college Hospital,peking union medical college,chinese academy of medical sciences Key Laboratory of Endocrinology,Ministry of Health of china,beijing 100730,china department of Endocrinology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China

Editorial comment Translational medicine is a new discipline which aims to eliminate the barrier between preclinical and clinical medicine. Here, Dr. Li discusses the application of translational medicine in the research, teaching and clinical work of Prof. Liu Shih-Hao, the founder of endocrinology in china, who was particularly renowned for his early work in calcium and phosphorus metabolism. This well-known success story can be traced back to an early appreciation of translational medicine by Prof. Liu Shih-Hao, and serves as an important and revelatory lesson for us all.

关键词： translational medicine Liu Shih-Hao

Reference ranges and age-related changes of peripheral blood lymphocyte subsets in chinese healthy adults

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Science china(Life sciences) 2009年第7期52卷 643-650页

作者： JIAO Yang1,QIU ZhiFeng1,XIE Jing1,LI DongJing2 & LI TaiSheng1 1 department of Infectious Disease,peking union medical college Hospital,peking union medical college & chinese academy of medical sciences,beijing,china 2 department of Special Care Unit,peking union medical college Hospital,peking union medical college & chinese academy of medical sciences,beijing,china department of Infectious Disease Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China department of Special Care Unit Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China

This study was performed to build region-specific reference ranges of peripheral blood lymphocyte subsets for chinese healthy adults from the young to the elderly and analyze the trends of changes in lymphocyte subsets for evaluating the impact of age on the values.151 healthy adults aged 19-86 were recruited based on the SENIEUR *** sets of reference ranges were finally built applicable for the healthy young(19-44 years),middle-aged(45-64 years) and elder adults(≥65).Comparisons in parameters among the three cohorts showed that a statistically significant increase in CD16CD56+ NK cell was observed between the middle-aged and elder cohorts,whereas for the majority of the parameters,a significant decline was observed between the young and the middle-aged *** results showed that inverse correlations were observed between the age and CD19+ B,CD3+ T,CD3+CD4+ T,CD4+CD45RA+CD62L+ nave T cell and CD4+CD28+/CD4+,while the positive one was identified between the age and the NK *** significant changes of the most of immune parameters provided evidence for ***,T cell activation markers of CD8+CD38+ and CD8+HLA-DR+ showed reverse trends of association with age,which provides a clue for further researches on the mechanisms underlying the paradoxical clinical presentation of the elder patients.

关键词： lymphocyte subsets age reference range immunosenescence

Intramolecular Induction of Asymmetric Darzen's Condensation of Aldehydes with Chiral α-Chloroacetates

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chinese Chemical Letters 1999年第6期10卷 441-442页

作者： Guo Bin HUANG Gan Feng CAO Ke Met WU Liang HUANG(institute of materia medica. chinese academy of medical sciences & peking union medical college.Xian Nong Tan Street. beijing 100050) institute of materia medica Chinese Academy of Medical Sciences Peking Union Medical College 1 Xian Nong Tan Street Beijing 100050 China

The asymmetric Darzen's condensation of aldehydes with a-chloroacetates of somenaturally occurring or synthetic chiral alcohols was described. The de% of products fell over therange of 4. 78% to 99%.

关键词： Asymmetric Darzen's condensation chiral α-chloroacetates

Taxayuntin I from Thous Yunnanensis

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chinese Chemical Letters 1999年第1期10卷 43-44页

作者： Jin Yun ZHOU Pei Ling ZHANG Wei Ming CHEN and Qi Cheng FANG(institute of materia medica, chinese academy of medical sciences and peking unionmedical college, beijing 100050) institute of materia medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

Taxayuntin I, a new 11I (15→1)abeotaxane. was isolated from the leaves and stems ofTaxes yunnanensis. Its structure was elucidated on the basis of spectroscopic data.

关键词： TaxusyUnnanensis taxoids abeotaxane taxayuntin I

Two Polyoxygenated Pyrrolylpyridine and Bipyrrole Alkaloids from Speranskia tuberculata

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chinese Chemical Letters 2000年第9期11卷 785-788页

作者： Jian Gong SHI Wen Yan HU Guang Xiong ZHOU Yong Chun YANG Han Qing WANG Min WANG institute of materia medica, chinese academy of medical sciences and peking union medical college, beijing 100050 Lanzhou institute of Chemical Physics, chinese academy o institute of materia medica Chinese Academy of Medical Sciences Peking Union Medical College Bejing 100050 China Lanzhou Inst. of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China

Two novel polyoxygenated pyrrolylpyridine and bipyrrole alkaloids, speranskilatine A 1, and speranberculatine A 2, have been isolated from Speranskia tuberculata. Their structures were elucidated by spectroscopic meth... 详细信息

关键词： Speranskia tuberculata Euphorbiaceae pyrrolylpyridine and bipyrrole alkaloids speranskilatine A speranberculatine A

A New Taxoid from the Needles of Taxus × media Hicksii

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chinese Chemical Letters 1997年第12期8卷 0-0页

作者： Yong Li GAO Jin Yun ZHOU Yi Ding and Qi Cheng FANG(institute of Matcria medica, chinese academy of medical sciences and peking union Medital college beijing 100050) institute of materia medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

A new taxoid with 5/716 taxane skeleton, named taxamedin A (1) was isolated from the needles of Taxus x media Hicksii. Its structure was elucidated by spectal analysis

关键词： A New Taxoid from the Needles of Taxus