Selective Cyclooxygenase-2 Inhibitors: Design and Synthesis
Selective Cyclooxygenase-2 Inhibitors: Design and Synthesis作者机构:Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:1999年第10卷第6期
页 面:469-472页
核心收录:
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题:cyclooxygenase cyclooxygenase-2 inhibitor selective
摘 要:The discovery of COX-2 provides a novel target developing more effective NSAIDs with fewer side effects. On the basis of results from the structure-activity relationships (SAR) of selective COX-2 inhibitors, we have designed and synthesized some promising compounds.