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Intrathecal administration of Cav3.2 and Cav3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion

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Acta Pharmacologica Sinica 2006年第12期27卷 1547-1552页

作者： Xian-jie WEN~(1,2)Zhang-jun LI~2 Zhi-xin CHEN~2 Zhi-yuan FANG~3 Chen-xiang YANG~1 Heng LI~1 Yin-ming ZENG~(2,4)1 department of anesthesiology,the First People's hospital of FoShan & Affiliated FoShan hospital of Sun-Yat Sen University,Foshan 528000,china 2 Jiangsu Province Institute of anesthesiology,Xuzhou Medical College,Xuzhou 221002,china 3 department of anesthesiology,the municipal hospital of suzhou,suzhou 215002,china department of anesthesiology the First People's Hospital of FoShan & Affiliated FoShan Hospital of Sun-Yat Sen University Foshan China Jiangsu Province Institute of anesthesiology Xuzhou Medical College Xuzhou China department of anesthesiology the Municipal Hospital of Suzhou Suzhou China

Aim:The present study aimed to elucidate the role of T-subtype calcium channels（Cav3.1,Cav3.2,and Cav3.3）in the pathogenesis of neuropathic pain at spinal ***:The chronic compression of the dorsal root ganglion（CCD）rat modelwas *** antisense oligonucleotide of Cav3.1,Cav3.2,and Cav3.3 or nor-mal saline（NS）were intrathecally administered twice per day from the first day tothe fourth day after *** mechanical withdrawal threshold and pawthermal withdrawal latency were measured to evaluate the tactile allodynia andthermal hyperalgesia,***:CCD rats developed reliable tactileallodynia and thermal hyperalgesia after *** administration ofantisense oligonucleotide of Cav3.2 and Cav3.3 significantly relieved tactileallodynia and thermal hyperalgesia in CCD rats,but not ***:Cav3.2and Cav3.3 subtype calcium channels in the spinal cord may play an important rolein the pathogenesis of neuropathic pain,which may contribute to the manage-ment of the neuropathic pain.

关键词： T-type calcium channels neuropathic pain spinal cord antisense oligonucleotide

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A polymorphism within ErbB4 is associated with risk for hepatocellular carcinoma in Chinese population

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World Journal of Gastroenterology 2012年第4期18卷 383-387页

作者： Qiang Yu,Chun-Xiao Zhou,Nan-Sheng Chen,Shu-Dan Zheng,Li-Ming Shen,Jin-Kun Zhang,department of Gastroenterology,suzhou municipal hospital,Affiliated suzhou hospital of Nanjing Medical University,suzhou 215002,Jiangsu Province,china department of Gastroenterology Suzhou Municipal Hospital Affiliated Suzhou Hospital of Nanjing Medical University Suzhou 215002 Jiangsu Province China.

AIM:To investigate the association between hepatocel-lular carcinoma (HCC) susceptibility and a 12-bp inser-tion/deletion polymorphism (rs6147150) in the 3'UTR of ***:Using a case-control design,the rs6147150 genotypes in 270 patients with HCC and 270 healthy controls were determined by direct polymerase chain reaction and polyacrylamide gel *** regression was used to analyze the association between the polymorphism and cancer ***:Computational modeling suggested that rs6147150 was located in the seed region of hsa-let-7c,a potential target sequence in ErbB4 3'*** re-gression analysis showed that,compared with individu-als homozygous for wild-type,heterozygotes [adjusted odds ratio (OR)=1.48,95% confidence interval (CI)= 1.03-2.17,P=0.034] and individuals homozygous for 12-bp del/del (OR=2.50,95% CI=1.37-4.56,P=0.001) were at significantly higher risk of ***-riers of the "del" allele of rs6147150 had a 1.59-fold increased risk for HCC (95% CI=1.22-2.07,P=0.003).CONCLUSION:rs6147150 may be associated with HCC risk,in part through let-7c-mediated regulation,and may be involved in the pathogenesis of HCC in Chi-nese populations.

关键词： Hepatocellular carcinoma ErbB4 rs6147150,Insertion/deletion polymorphism

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Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis

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Acta Pharmacologica Sinica 2006年第8期27卷 1071-1077页

作者： Ming ZHANG~(3,4) Chang-sheng DENG~1 Jia-ju ZHENG~2 Jian XIA~1 ~1department of Gastroenterology,Zhongnan hospital of Wuhan University,Wuhan 430071,china ~2municipal hospital of suzhou,suzhou 215008,china ~3department of Gastroenterology,Drum Tower hospital of Nanjing,Nanjing 210008,china department of Gastroenterology Drum Tower Hospital of Nanjing Nanjing China department of Gastroenterology Zhongnan Hospital of Wuhan University Wuhan China municipal hospital of suzhou Suzhou China

Aim:To investigate the therapeutic effects of curcumin（Cur）on trinitrobenzenesulphonic acid（TNBS）-induced colitis and the effects of Cur on the balance ofTh1/Th2 ***:Colitis was induced by TNBS and treated with Cur(***-1·d-1,ip),dexamethasone(Dex,2 mg·kg-1·d-1),or Cur plus dexamethasone(Cur+Dex,30 ***-1·d-1Cur ip+2 ***-1·d-1Dex,ip).mRNA in colon mucosawere detected by real-time quantitative polymerase chain *** were detected by flow cytometry and concentrations of cytokines insera were detected by enzyme-linked immunosorbent ***:Both Curand Dex improved body weight loss,ameliorated histological images and de-creased macroscopic score and myeloperoxidase *** decreased the ex-pression of Th1 cytokines（IL-12,IFN-γ,TNF-α,IL-1）and increased the expres-sion of Th2 cytokines（IL-4 and IL-10）in colon *** also increased theproportion of IFN-γ/IL-4 in splenocytes and *** and Cur+Dex de-creased the expression of Th1 cytokines but could not increase the expression ofTh2 cytokines and the proportion of IFN-γ/***:Cur exerted thera-peutic effects on colitis by regulating the shift from Th1 to Th2.

关键词： colitis curcumin IL-4 IL-12 Th1 Th2

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Upregulation of VEGF-C in esophageal cancer:gene silencing with shRNA targeting VEGF-C as a therapeutic intervention

Upregulation of VEGF-C in esophageal cancer:gene silencing w...

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2010’全国肿瘤分子标志及应用学术研讨会暨第五届中国中青年肿瘤专家论坛

作者： Jundong Zhou,Pengfei Liu,Jinchang Wu,Shuyu Zhang department of Radiotherapy of suzhou municipal hospital,suzhou 215001,Jiangsu Province, china School of Radiation and Public Health,Soochow University,suzhou 215123,Jiangsu Province, china department of Gastroenterology,the Affiliated Jiangyin hospital of Southeast University, Jiangyin 214400,Jiangsu Province,china

Background:Vascular endothelial growth factor C(VEGF-C) is a key regulator of angiogenesis and ***-C is also implicated in the development of esophageal cancer. Methods:Real-time PCR was used to determine the mRNA levels of VEGF-C, VEGFR2 and VEGFR3 genes in 24 normal esophageal and 60 esophageal squamous cell carcinoma specimens(ESCCs).The influence of VEGF-C on esophageal carcinoma cell proliferation was analyzed in vitro using TE-1 cells that were stably transfected with either a VEGF-C overexpression or a VEGF-C targeted shRNA *** expression of VEGF-C in the above cell lines was examined by reverse transcription-PCR(RT-PCR),real-time PCR,cell immunostaining and enzyme-linked immunosorbent assay(ELISA).Cell proliferation,migration and focus formation were measured for the stable cell *** addition,nude mice bearing TE-1 stable cell xenografts were evaluated to determine the effect of VEGF-C on tumor growth in vivo. Results:Compared with normal esophageal tissues,the mRNA levels of VEGF-C, VEGFR2 and VEGFR3 in human ESCC samples were upregulated by 4.9-,3.2-and 8.6-fold,***-C transcription,translation and secretion were significantly enhanced in TE-1 cells stably transfected with a VEGF-C overexpression vector or attenuated in TE-1 cells stably transfected with a VEGF-C targeted shRNA *** vitro,knockdown of VEGF-C inhibited cell proliferation, migration and focus ***-C expression correlated to CNTN-1 in cell lines and *** vivo,tumor size was significantly increased in nude mice injected with pEGFP-VEGF-C-transfected cells,whereas nude mice injected with VEGF-C shRNA-transfected cells exhibited a decreased tumor size due to VEGF-C induced angiogenesis. Conclusions:VEGF-C upregulation maybe involved in esophageal tumor *** results demonstrate that vector-based RNA interference(RNAi) targeting VEGF-C is a potential therapeutic method for human esophageal carcinoma.

关键词： esophageal squamous cell carcinoma(ESCC) vascular endothelial growth factor C(VEGF-C) RNA interference(RNAi) overexpression

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克拉霉素的临床新用途

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中国新药与临床杂志 2002年第6期21卷 366-369页

作者：任少华胡华成丽水市中心医院呼吸科浙江丽水323000 苏州大学附属第二医院江苏苏州215004

克拉霉素为一新型 14元环的大环内酯类抗生素 ,近年来的临床应用日趋广泛。

关键词：克拉霉素肺炎肺肿瘤哮喘临床应用

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Research progresses in the pathogenesis of anaplastic largecell lymphoma

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Chinese Journal of Cancer 2011年第6期30卷 392-399页

作者： Xiao-Lan Shi,Xiao-Wen Tang and De-Pei Wu department of Hematology,the First Affiliated hospitalof Soochow University,Jiangsu Institute of Hematology Key Laboratoryof Thrombosis and Hemostasis of Ministry of Health,suzhou,Jiangsu215006,P.R.china department of Hematology the First Affiliated Hospital of Soochow University Jiangsu 215006 People's Republic of China.

Anaplastic large cell lymphoma(ALCL) is a distinct subset of T-cell non-Hodgkin's *** a consequence of its low incidence,general pathogenic consideration of ALCL is *** this review,we summarize the pathogenesis,epidemiology,clinical manifestations,and treatment of ALCL,so as to better understand key stages of the development of this disease and provide valuable information for future treatment.

关键词：淋巴瘤发病机制细胞变性发病机理流行病学临床表现发病率

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异氟烷预处理对大鼠心肌缺血再灌注损伤的保护作用

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复旦学报（医学版） 2008年第4期35卷 539-542,547页

作者：姜琳王琛覃琴刘霞朱江谢红苏州大学附属第二医院麻醉科

目的研究异氟烷预处理对缺血再灌注损伤大鼠心肌梗死面积的影响,探讨其对心肌缺血再灌注损伤的保护作用。方法建立大鼠心肌缺血再灌注损伤模型,所有大鼠都平衡30min、给予异氟烷30min(除对照外)、异氟烷排除15min、心肌缺血30min和再灌... 详细信息

目的研究异氟烷预处理对缺血再灌注损伤大鼠心肌梗死面积的影响,探讨其对心肌缺血再灌注损伤的保护作用。方法建立大鼠心肌缺血再灌注损伤模型,所有大鼠都平衡30min、给予异氟烷30min(除对照外)、异氟烷排除15min、心肌缺血30min和再灌注2h。实验将48只雄性Sprague Dawley大鼠随机分为6组:CON组、DMSO组、PTN组、ISO组、PTN+ISO组和ISO+PTN组。CON组无任何预处理,单纯心肌缺血再灌注;DMSO组于平衡15min时腹腔注射二甲亚砜(DMSO);PTN组于平衡15min时腹腔注射NF-κB特异性抑制剂小白菊内脂(parthenolide,PTN)500μg/kg;ISO组吸入1.0MAC异氟烷(ISO)30min,15min药物排出;PTN+ISO组和ISO+PTN组分别于异氟烷预处理开始前、后15min腹腔注射PTN500μg/kg。实验中监测血液动力学变化,实验结束用氯化三苯四唑(TPT)染色法测定心肌梗死面积。结果平衡期时,各组间心率(HR),平均动脉压(MAP)和心率-收缩压乘积(RPP)的差别均无统计学意义(P>0.05)。ISO组、PTN+ISO组和ISO+PTN组在吸入异氟烷期间HR、MAP和RPP明显降低(P36.82±4.99)%,而PTN+ISO组(51.56±3.15)%和ISO+PTN组(51.06±1.05)%的心肌梗死面积明显高于ISO组(36.82±4.99)%(P<0.05)。结论异氟烷预处理使大鼠心肌梗死面积减少,对心肌缺血再灌注损伤有一定的保护作用。PTN可阻断此作用,推测NF-κB可能介导了异氟烷预处理的心肌保护作用。

关键词：再灌注损伤心肌缺血异氟烷梗死面积 NF-κB

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高乌甲素与吗啡硬膜外术后镇痛的临床对照研究

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中国新药与临床杂志 2004年第8期23卷 497-499页

作者：卢胜海王赛娇乐清市人民医院麻醉科浙江乐清325600

目的 :探讨高乌甲素硬膜外术后镇痛的效果 ,并与吗啡比较。方法 :手术病人 10 9例 ,采用随机双盲试验方法 ,分为 2组。均采用硬膜外麻醉 ,术毕注入镇痛负荷量 ,然后以 2mL·h- 1匀速注入镇痛液 ,镇痛液中含吗啡或高乌甲素。于术后 6 ,12... 详细信息

目的 :探讨高乌甲素硬膜外术后镇痛的效果 ,并与吗啡比较。方法 :手术病人 10 9例 ,采用随机双盲试验方法 ,分为 2组。均采用硬膜外麻醉 ,术毕注入镇痛负荷量 ,然后以 2mL·h- 1匀速注入镇痛液 ,镇痛液中含吗啡或高乌甲素。于术后 6 ,12 ,2 4 ,4 8h观察 2组镇痛效果、不良反应发生率及血浆皮质醇含量变化。结果 :2组各有 5 0例病人完成研究 ,均有满意的镇痛效果 ,恶心、呕吐、皮肤瘙痒发生率均较低 ,且组间无显著差异 (P >0 .0 5 )。高乌甲素组尿潴留发生率 18% (9/ 5 0 ) ,明显低于吗啡组6 8% (39/ 5 0 ) (P 0 .0 5 )。结论 :高乌甲素硬膜外术后镇痛能取得满意镇痛效果 ,对无需留置导尿而又要求术后镇痛的病人更为合适。

关键词：镇痛硬膜外尿潴留氢化可的松高乌甲素

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不同剂量氯胺酮对芬太尼诱发呛咳反应的影响

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泰山医学院学报 2009年第12期30卷 936-937页

作者：张洪兴苏州市立医院北区麻醉科江苏苏州215008

目的对比观察静脉注射氯胺酮对芬太尼诱导的呛咳反应的影响。方法60例患者随机分为3组,A组力月西0.1~0.2 mg/kg,丙泊酚2~3 mg/kg,芬太尼3μg/kg,氯化琥珀胆碱1.5~2 mg/kg;B组力月西0.1~0.2mg/kg,氯胺酮20 mg,丙泊酚2~3 mg/kg,芬太尼3μg... 详细信息

目的对比观察静脉注射氯胺酮对芬太尼诱导的呛咳反应的影响。方法60例患者随机分为3组,A组力月西0.1~0.2 mg/kg,丙泊酚2~3 mg/kg,芬太尼3μg/kg,氯化琥珀胆碱1.5~2 mg/kg;B组力月西0.1~0.2mg/kg,氯胺酮20 mg,丙泊酚2~3 mg/kg,芬太尼3μg/kg,氯化琥珀胆碱1.5~2 mg/kg,C组力月西0.1~0.2 mg/kg,氯胺酮40 mg,丙泊酚2~3 mg/kg,芬太尼3μg/kg,氯化琥珀胆碱1.5~2 mg/kg。观察呛咳反应的发生率。结果呛咳反应发生数A组8例,B组3例,C组2例;B组、C组与A组比较差异有显著意义,B、C两组比较差异无显著性。结论静脉注射20 mg或者40 mg氯胺酮可以有效减轻芬太尼诱导的呛咳反应。

关键词：氯胺酮芬太尼咳嗽

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尼卡地平对脑缺血后海马CA1锥体神经元的影响

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苏州大学学报（医学版） 2002年第5期22卷 521-522页

作者：成浩杨建平苏州大学附属第一医院麻醉科苏州215006

目的　观察尼卡地平对脑缺血后海马CA1锥体神经元的影响。方法　 30只沙土鼠随机分成假手术组 (Ⅰ组 ,n =10 )、缺血组 (Ⅱ组 ,n =10 )和尼卡地平处理组 (Ⅲ组 ,n =10 )。Ⅰ组只进行手术操作 ,不行脑缺血 ;Ⅱ组阻断双侧颈总动脉 15min... 详细信息

目的　观察尼卡地平对脑缺血后海马CA1锥体神经元的影响。方法　 30只沙土鼠随机分成假手术组 (Ⅰ组 ,n =10 )、缺血组 (Ⅱ组 ,n =10 )和尼卡地平处理组 (Ⅲ组 ,n =10 )。Ⅰ组只进行手术操作 ,不行脑缺血 ;Ⅱ组阻断双侧颈总动脉 15min造成前脑缺血模型 ;Ⅲ组在脑缺血前 30min腹腔注射尼卡地平 2mg/kg体重。 3d后取出动物脑组织 ,HE染色计数海马CA1区 1mm长度内正常锥体细胞数。结果　与Ⅰ组相比 ,Ⅱ组和Ⅲ组正常锥体细胞数明显减少 (P <0 .0 1) ;Ⅱ组的正常锥体细胞数少于Ⅲ组 (P <0 .0 1)。结论　尼卡地平能减轻脑缺血后脑细胞损伤。

关键词：海马CA1锥体神经元脑缺血尼卡地平沙土鼠

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