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Anti-inflammatory effect of amurensin H on asthma-like reaction induced by allergen in sensitized mice

Acta Pharmacologica Sinica 2006年第6期27卷 735-740页

作者： Yi-tang LI~2 Chun-suo YAO~3 Jin-ye BAI~2 Man LIN~3 Gui-fang CHENG~(2,4)2 Department of Pharmacology,Institute of Materia Medica,Peking Union Medical College and chinese academy of Medical sciences,beijing 100050,china 3 Department of Photochemistry,Institute of Materia Medica,chinese academy of Medical sciences and Peking Union Medical College,beijing 100050,china Department of Pharmacology Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Department of Photochemistry Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Aim:To explore the anti-inflammatory effects of amurensin H on asthma-like reac-tion induced by allergen in sensitized ***:BALB/c mice were sensi-tized by ovalbumin(OVA,ip)on d 0 and d 14 and challenged with 1% OVA on d 18to *** developed airway eosinophilia,mucus hypersecretion,and elevationin cytokine *** were administered amurensin H orally at the doses of 49,70,or 100 mg/kg once every day from d 15 to the last *** lavagefluid(BALF)were collected at 24 h and 48 h after the last OVA *** tumor necrosis factor-α(TNF-α),interleukin 4(IL-4),interleukin 5(IL-5),andinterleukin 13(IL-13)in BALF were measured using ELISA *** counts of macrophages,lymphocytes,neutrophils and eosinophils were per-formed in 200 cells per slide(one slide per animal).Lung tissue sections of 6-μmthickness were stained with Mayer’s hematoxylin and eosin for assessment of cellinfiltration,mucus production,and tissue ***:Oral administrationof amurensin H significantly inhibited OVA-induced increases in total cell counts,eosinophil counts,and TNF-α,IL-4,IL-5 and IL-13 levels in *** addition,amuresin H dramatically decreased OVA-induced lung tissue damage and ***:Amurensin H may have therapeutic potential for thetreatment of allergic airway inflammation.

关键词： amurensin H asthma ovalbumin tumor necrosis factor-α Th2 cells cytokines

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A Two-Moment Bulk Microphysics Coupled with a Mesoscale Model WRF:Model Description and First Results

A Two-Moment Bulk Microphysics Coupled with a Mesoscale Mode...

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强化科技基础推进气象现代化——第29届中国气象学会年会

作者： Gao Wenhua 1,Zhao Fengsheng 1,Hu Zhijin 2,and Feng Xuan 1 1 National Satellite meteorological Center,china meteorological administration,beijing 100081 2 chinese academy of meteorological sciences,china meteorological administration,beijing 100081

The chinese academy of meteorological sciences(CAMS) two-moment bulk microphysics scheme was adopted in this study to investigate the representation of cloud and precipitation processes under different environmental *** scheme predicts the mixing ratio of water vapor as well as the mixing ratios and number concentrations of cloud droplets,rain,ice,snow,and graupel.A new parameterization approach to simulate heterogeneous droplet activation was developed in this ***,the improved CAMS scheme was coupled with the Weather Research and Forecasting model(WRF v3.1),which made it possible to simulate the microphysics of clouds and precipitation as well as the cloud-aerosol interactions in selected atmospheric *** rain event occurring on 27-28 December 2008 in eastern china was simulated using the CAMS scheme and three sophisticated microphysics schemes in the WRF *** showed that the simulated 36-h accumulated precipitations were generally agreed with observations,and the CAMS scheme performed well in the southern area of the nested *** radar reflectivity,the averaged precipitation intensity,and the hydrometeor mixing ratios simulated by the CAMS scheme were generally consistent with those from other microphysics *** hydrometeor number concentrations simulated by the CAMS scheme were also close to the experiential values in stratus *** model results suggest that the CAMS scheme performs reasonably well in describing the microphysics of clouds and precipitation in the mesoscale WRF model.

关键词： droplet activation two-moment bulk microphysics WRF coupling

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Variations of Snow Temperature and their Influence on Snow Cover Physical Parameters in the Western Tianshan Mountains,china

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Journal of Mountain Science 2011年第6期8卷 827-837页

作者： CHEN Xia WEI WenShou LIU MingZhe GU GuangQin Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China Hebei Key Laboratory for Meteorology and Eco-environmen Shijiazhuang 050021 China HeBei Climate Center Shijiazhuang 050021 China Institute of Desert Meteorology China Meteorological Administration Urumqi 830011 China Tianshan Station for Snow-cover and Avalanche Research Chinese Academy of Sciences Urumqi 830011 China

This article discussed about snow temperature variations and their impact on snow cover parameters. Automatic temperature recorders were used to sample at lo-minute intervals at the Tianshan Station for Snow-cover and Avalanche Research, chinese snow temperature academy of sciences. lo-layer and the snow cover parameters were measured by the snow property analyzer （Snow Fork） in its Stable period, Interim period and Snow melting period. Results indicate that the amplitude of the diurnal fluctuation in the temperature during Snow melting period is 1.62 times greater than that during Stable period. Time up to the peak temperature at the snow surface lags behind the peak solar radiation by more than 2.5 hours, and lags behind the peak atmospheric temperature by more than 0.2 hours during all three periods. The optimal fitted function of snow temperature profile becomes more complicated from Stable period to Snow melting period. 22 h temperature profiles in Stable period are the optimal fitted by cubic polynomial equation. In Interim period and Snow melting period, temperature profiles are optimal fitted by exponential equation between sunset and sunrise, and by Fourier function when solar radiation is strong. The vertical gradient in the snow temperature reaches its maximum value at the snow surface for three periods. The peak of this maximum value occurs during Stableperiod, and is 4.46 times greater than during Interim period. The absolute value of temperature gradient is lower than 0.1℃ cm-1 for 30 cm beneath snow surface. Snow temperature and temperature gradient in Stable period-Interim period indirectly cause increase （decrease） of snow density mainly by increasing （decreasing） permittivity. While it dramatically increases its water content to change its permittivity and snow density in Snow melting period.

关键词： Snow temperature Vertical temperaturegradient Optimal fitting function Snow density Western Tianshan Mountains china

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Sporopollen analysis of Core B10 in the southern Yellow Sea and the reflected characteristics of climate changes

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chinese Science Bulletin 2003年第B6期48卷 42-48页

作者： FU Mingzuo~(1,2,3), LI Zhen~1, XU Xiaowei~1 & SHl Xuefa~1 1. Key Laboratory of Marine Sedimentology and Environmental Geology, First institute of Oceanography. State Oceanic administration, Qingdao 266061. china 2. Institute of Oceanology, chinese academy of sciences, Qingdao 266071. china 3. Graduate School, chinese academy of sciences, beijing 100039. china Key Laboratory of Marine Sedimentology and Environmental Geology First institute of Oceanography State Oceanic Administration Qingdao China Institute of Oceanology Chinese Academy of Sciences Qingdao China Graduate School Chinese Academy of Sciences Beijing China

Eight sporopollen zones have been divided based on the results of high-resolution sporopollen analysis of Core B10 in the southern Yellow Sea. Based on the results along with ^14C datings and the subbottom profiling data,climatic and environmental changes since the last stage of late Pleistocene are discussed. The main conclusions are drawn as follows: (1) the vegetation evolved in the process of coniferous forest-grassland containing broad-leaved trees→coniferous and broad-leaved mixed forest→coniferons and broad-leaved mixed forest-grassland prevailed by coniferous trees→coniferous and broad-leaved mixed forest-grassland containing evergreen broad-leaved trees→coniferons and broad-leaved mixed forest-grassland prevailed by broadleaved trees→deciduous broad-leaved forest-meadow containing evergreen broad-leaved trees→coniferous and broadleaved mixed forest-grassland prevailed by broad-leaved trees→coniferous and broad-leaved mixed forest containing evergreen broad-leaved trees; (2) eight stages of climate changes are identified as the cold and dry stage, the temperate and wet stage, the cold and dry stage, the warm and dry stage, the temperate and wet stage, the hot and dry stage, the temperate and dry stage, then the warm and dry stage in turn; (3) the sedimentary environment developed from land,to littoral zone, to land again, then to shore-neritic zone; and (4) the Yellow Sea Warm Current formed during early-Holocene rather than Atlantic stage.

关键词：中国黄海气候变化碳14年代测定底基压型数据更新世沉积环境大西洋

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Simulating leaf net CO2 assimilation rate of C3 and C4 plants and its response to environmental factors

Simulating leaf net CO2 assimilation rate of C3 and C4 plant...

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中国气象学会2003年年会

作者： Zhang Jiahua (chinese academy of meteorological sciences, beijing, 100081, P. R. china)

＜正＞ It is well recognized that the global climate is becoming warmer and warmer owing to increased emission of greenhouse gases affected by human activities. The better method of predicting future climate trend is to use regional and global climate model. In recent years, a series of numerical models have been developed to describe the interaction and gas exchanges between the biosphere to atmosphere, and several of land surface interaction complex process schemes have been incorporated into regional or global climate models （Dickinson et al., 1986;Sellers et al., 1986, 1992, 1996;Xue et al. 1991;Foley et al, 1996;Zhang et al., 1999, 2000, 2002a）. As we know, the land sur-

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Sensitivity of sea ice and ocean simulations to sea ice salinity in a coupled global climate model

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Science china Earth sciences 2010年第6期53卷 911-918页

作者： LIU JiPing State Key Laboratory of Numerical Modeling for Atmospheric sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, chinese academy of sciences, beijing, 100029, china State Key Laboratory of Numerical Modeling for Atmospheric sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China

The impacts of the spatiotemporal variations of sea ice salinity on sea ice and ocean characteristics have not been studied in detail, as the existing climate models neglect or misrepresent this process. To address this issue, this paper formulated a parameterization with more realistic sea ice salinity budget, and examined the sensitivity of sea ice and ocean simulations to the ice salinity variations and associated salt flux into the ocean using a coupled global climate model. Results show that the inclusion of such a parameterization leads to an increase and thickening of sea ice in the Eurasian Arctic and within the ice pack in the Antarctic circumpolar region, and a weakening of the North Atlantic Deep Water and a strengthening of the Antarctic Bottom Water. The atmospheric responses associated with the ice changes were also discussed.

关键词： sea ice salinity coupled global climate model Arctic and Antarctic

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A novel approach in predicting non-stationary time series by combining external forces

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Science Bulletin 2011年第Z2期 3053-3056页

作者： WANG GeLi 1* , YANG PeiCai 1 , BIAN JianChun 1 & ZHOU XiuJi 2,3 1 Laboratory for Middle Atmosphere and Glotal Environment Observation, Institute of Atmospheric Physics, chinese academy of sciences, beijing 100029, china 2 chinese academy of meteorological sciences, beijing 100081, china 3 State Key Laboratory of Severe Weather, beijing 100081, china

In this paper, we investigate a novel technique that reconstructs the observed time series and incorporates driving forces. Furthermore, to illustrate and test the technique, we consider a couple of predictive experiments using ideal time series provided by the logistic and Lorenz systems with specific driving forces. The preliminary results show this approach can improve prediction proficiency to some extent, and the external forces play a similar role to that of state variables.

关键词： driving force non-stationary system climate prediction time series prediction

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Cenozoic terrestrial palynological assemblages in the glacial erratics from the Grove Mountains, east Antarctica

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Progress in Natural Science:Materials International 2009年第7期19卷 851-859页

作者： Aimin Fang a, Xiaohan Liu b, Weiming Wang c, Feixin Huang b, Lianjun Yu a a Institute of Geology and Geophysics, chinese academy of sciences, beijing 100029, china b Institute of Tibet Plateau Research, chinese academy of sciences, beijing 100029, china c Nanjing Institute of Geology and Palaeontology, chinese academy of Science, Nanjing 210008, china Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Tibet Plateau Research Chinese Academy of Sciences Beijing 100029 China Nanjing Institute of Geology and Palaeontology Chinese Academy of Science Nanjing 210008 China

Fossiliferous glacial erratics have been found in moraines of the Grove Mountains, east Antarctica since 1998 by chinese National Antarctic Research Expedition (CHNARE) teams. These erratics were derived from a suite of glaciogene strata hidden beneath the Antarctic Ice Sheet in the Lambert glacier drainage system, and thus provide a record of Cenozoic paleoenvironmental conditions and fossil biotas that are so far unknown from outcrops and drill cores in this region. By microfossil analysis, sparse Neogene spores and pollen grains are revealed, including: Toroisporis (Lygodiaceae), Granulatisporites (Pteridaceae?), Osmunda (Osmundaceae), Polypodiaceae, Magnastriatites (Parkeriaceae), Deltoidospora, Araucariaceae, Taxodiaceae, Podocarpus (Podocarpaceae), Dacrydium (Podocarpaceae), Pinus (Pinaceae), Keteleeria (Pinaceae), Picea (Pinaceae), Tsuga (Pinaceae), Chenopodiaceae, Artemisia (Asteraceae), Asteraceae, Gramineae, Fraxinoipollenites (Oleaceae), Oleoidearumpollenites (Oleaceae), Oleaceae, Operculumpollis, Nothofagidites (Nothofagus), Rhus, Quercus (Fagaceae), Juglans (Juglandaceae), Pterocarya (Juglandaceae), Liquidambar (Hamamelidaceae), Ulmus (Ulmaceae), Ulmoidepites (Ulmaceae), Tilia, Proteacidites (Proteaceae) and Tricolpopollenites; but without any marine diatoms. Most of the spores and pollen grains in the erratics are considered to originate from local sources except for some older exotic components that might be recycled from the basement sedimentary rocks by the ice sheet, so they are in situ sporo-palynological assemblages. Furthermore, since the source areas of the glaciogenic sedimentary rocks are assumed to be local or in the up glacier areas, the palynological assemblages in these erratics represent an inland terrestrial flora during a warmer period of the ice-sheet evolutionary history. The ages of these erratics are also discussed based on the occurrence of some diagnostic pollens such as the Artemisia, Chenopodiaceae and Nothofagus, which implies

关键词： East Antarctica Grove Mountains Glacial erratics Spores and pollen Neogene

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Uncertainties in assessing the effect of climate change on agriculture using model simulation and uncertainty processing methods

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chinese Science Bulletin 2011年第8期56卷 729-737页

作者： YAO FengMei QIN PengCheng ZHANG JiaHua LIN ErDa BOKEN Vijendra College of Earth Science Graduate University of Chinese Academy of Sciences Beijing 100049 China Center for Earth Observation and Digital Earth Chinese Academy of Sciences Beijing 100094 China chinese academy of meteorological sciences Beijing 100081 China School of Geoscience Yangtze University Jingzhou 434025 China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences Beijing 100081 China Department of Geography and Earth Science University of Nebraska at Kearney Kearney NE 68849 USA

Model simulation is an important way to study the effects of climate change on *** assessment is subject to a range of uncertainties because of either incomplete knowledge or model technical uncertainties,impeding effective decision-making to climate *** the basis of uncertainties in the impact assessment at different levels,this article systematically summarizes the sources and propagation of uncertainty in the assessment of the effect of climate change on agriculture in terms of the climate projection,the assessment process,and the crop models linking to climate ***,techniques and methods focusing on different levels and sources of uncertainty and uncertainty propagation are introduced,and shortcomings and insufficiencies in uncertainty processing are pointed ***,in terms of how to accurately assess the effect of climate change on agriculture,improvements to further decrease potential uncertainty are suggested.

关键词：不确定性模型影响评估气候变化农业影响模型模拟不确定性传播气候预测气候模型

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Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry

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Acta Pharmacologica Sinica 2007年第6期28卷 789-795页

作者： Xiao-fen LI~(2,3),Yi-ping WANG~(2,4)~2 State Key Laboratory.of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological sciences,chinese academyof sciences,Shanghai 201203,china,~3 Graduate School of chinese academy of sciences,beijing 100049,china State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Graduate School of chinese academy of sciences Beijing China

Aim:To investigate the effects of depside salts from Salvia miltiorrhiza on myo-cardial microperfusion and systemic hemodynamics in open-chest anaesthetizedSprague-Dawley ***:Myocardial microperfusion was measured bylaser Doppler flowmetry with a needle probe;cardiac output (CO) was determinedusing ultrasonic Doppler *** hemodynamic parameters,includingfemoral artery blood pressure,cardiac inotropy,and systemic vascular resistance(SVR) were simultaneously recorded by the PowerLab ***:Intrave-nous administration of S miltiorrhiza depside salts resulted in a significant imme-diate increase in CO and cardiac inotropy,but a fall in SVR.S miltiorrhiza depsidesalts (30 mg/kg and 60 mg/kg) promoted cardiac index (CI) by 12.2%±6.3% (P3.5% (P3%±2.9% (P30 mg/kgand 60 mg/kg S miltiorrhiza depside salts,***:Theseresults indicated that S miltiorrhiza depside salts improved myocardial micro-perfusion,as well as CO.

关键词： lithospermate B myocardial microperfusion laser Doppler flowmetry cardiac output ultrasonic Doppler flowmetry

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