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Journal of wuhan university of technology(Materials science) 2007年第1期22卷 112-116页

作者：刘卫杨祥良 College of Life science and technology Huazhong University of Science and Technology

To assess the merits of PEGylated poly （lactic-co-glycolic acid）（PEG-PLGA） nanoparticles as drug carriers for tumor necrosis factor-α receptor blocking peptide （TNFR-BP）, PEG-PLGA copolymer, which could be used to prepare the stealth nanoparticles, was synthesized with methoxypolyethyleneglycol, DL-lactide and glycolide. The structure of PEG-PLGA was confirmed with ^1H-NMR and FT-IR spectroscopy, and the molecular weight （MW） was determined by gel permeation chromatography. Fluorescent FITC-TNFR- BP was chosen as model protein and encapsulated within PEG-PLGA nanoparticles using the double emulsion method. Atomic force microscopy and photon correlation spectroscopy were employed to characterize the stealth nanoparticles fabricated for morphology, size with polydispersity index and zeta potential. Encapsulation efficiency （EE） and the release of FITC-TNFR-BP in nanopartieles in vitro were measured by the fluorescence measurement. The stealth nanoparticles were found to have the mean diameter less than 270 nm and zeta potential less than -20 mV. In all nanoparticle formulations, more than 45% of EE were obtained. FITC-TNFR-BP release from the PEG-PLGA nanoparticles exhibited a biphasic pattern, initial burst release and consequently sustained release. The experimental results show that PEG-PLGA nanoparticles possess the potential to develop as drug carriers for controlled release applications of TNFR-BP.

关键词： tumor necrosis factor-α receptor blocking peptide PEG-PLGA stealth nanoparticles ring-opening polymerization controlled and sustained drug release

Sea level variations in the South china Sea inferred from satellite gravity,altimetry,and oceanographic data

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science china Earth sciences 2012年第10期55卷 1696-1701页

作者： FENG Wei 1,2,ZHONG Min 1,3 & XU HouZe 1,3 1 State Key Laboratory of Geodesy and Earth’s Dynamics,Institute of Geodesy and Geophysics,Chinese Academy of sciences,wuhan 430077,china 2 Graduate university of Chinese Academy of sciences,Beijing 100049,china 3 Institute of Geophysics,huazhong university of science and technology,wuhan 430074,china State Key Laboratory of Geodesy and Earth’s Dynamics Institute of Geodesy and Geophysics Chinese Academy of Sciences Wuhan China Graduate university of Chinese Academy of sciences Beijing China Institute of Geophysics Huazhong University of Science and Technology Wuhan China

Sea level variations(SLVs) can be divided into two major components:the steric SLV and the mass-induced *** two components of SLV in the South china Sea(SCS) are studied by using satellite altimetry,GRACE(Gravity Recovery and Climate Experiment) satellite gravity,and oceanographic data on annual and inter-annual *** the annual timescale,the geographic distribution of mass-induced SLV's amplitude jointly estimated from altimetry and the ECCO(Estimation of the Circulation and Climate of the Ocean) model agrees very well with that from *** observes obvious seasonal mass-induced SLV in the SCS with annual amplitude of 2.7±0.4 cm,which is consistent with the annual amplitude of 2.7±0.3 cm estimated from the steric-corrected *** the inter-annual timescales,the mean SLV in the SCS shows a large oscillation,which is mainly caused by the steric *** trend of mean SLV inferred from altimetry in the SCS is 5.5±0.7 mm/yr for the period of 1993-2009,which is significantly higher than the global sea level rise rate of 3.3±0.4 mm/yr in the same *** is no obvious trend signal in the mass-induced SLV detected from GRACE that indicates the water exchange between the SCS and its adjacent seas and land is in balance within the study period.

关键词： altimetry GRACE ECCO the South china Sea sea level variation

A novel method to analyze damping effect of VSC based FACTS

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science china(Technological sciences) 2008年第12期51卷 2112-2119页

作者： DU WenJuan1,WANG HaiFeng2 & CHENG ShiJie3 1 Southeast university,Nanjing 210096,china 2 Queen’s university of Belfast,Belfast,BT9 5AH,UK 3 huazhong university of science and technology,wuhan 430074,china Southeast university Nanjing China Queen’s university of Belfast Belfast UK huazhong university of science and technology Wuhan China

A novel method to analyze the damping effect of the VSC based FACTS(VBF) device is proposed,which is developed on the basis of the well-known equalarea criterion and small-disturbance analysis of power system *** use of the proposed method,two conclusions are obtained for study of the damping effect of the *** research results clearly show the contribution of the VBF control to the damping of power system *** results of an example power system are used to verify the effectiveness of the proposed method.

关键词： power system low frequency oscillations FACTS equal-area criterion

Kinetics of the Thermal Decomposition of Wangjiatan Siderite

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Journal of wuhan university of technology(Materials science) 2011年第3期26卷 523-526页

作者：冯志力 huazhong university of science and technology

The thermal decomposition processes of Wangjiatan siderite samples were studied in nitrogen by thermogravimetric（TG）*** mechanism of thermal decomposition of the siderite obeyed an F n kinetic law and the n-order was between 1.16 and *** results from non-isothermal experiments show that the size of particles has an obvious effect on the logarithm of pre-exponential factor in kinetics parameter of the thermal decomposition of Wangjiatan siderite.A linear relationship is shown between the size of particles and the logarithm of pre-exponential *** F 1 kinetic model containing size factor describes the thermal decomposition of Wangjiatan siderite well.

关键词： thermal decomposition mechanism kinetics siderite

New selenoproteins identified in silico from the genome of Anopheles gambiae

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science china(Life sciences) 2007年第2期50卷 251-257页

作者： JIANG Liang1,2,LIU Qiong1,CHEN Ping3,GAO ZhongHong3 & XU HuiBi3 1 College of Life science,Shenzhen university,Shenzhen 518060,china 2 Changchun Institute of Applied Chemistry,Chinese Academy of sciences,Changchun 130022,china 3 Department of Chemistry,huazhong university of science and technology,wuhan 430074,china College of Life science Shenzhen University Shenzhen China Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun China Department of Chemistry Huazhong University of Science and Technology Wuhan China

Selenoprotein is biosynthesized by the incorporation of selenocysteine into proteins,where the TGA codon in the open reading frame does not act as a stop signal but is translated into *** dual functions of TGA result in mis-annotation or lack of selenoproteins in the sequenced genomes of many *** computational tools fail to correctly predict ***,we devel-oped a new method to identify selenoproteins from the genome of Anopheles gambiae *** on released genomic information,several programs were edited with PERL language to identify selenocysteine insertion sequence(SECIS)element,the coding potential of TGA codons,and cys-teine-containing homologs of selenoprotein *** results showed that 11365 genes were termi-nated with TGA codons,918 of which contained SECIS *** search revealed that 58 genes contained Sec/Cys pairs and similar flanking regions around in-frame TGA ***,7 genes were found to fully meet requirements for selenoproteins,although they have not been anno-tated as selenoproteins in NCBI *** from their basic properties,the newly found se-lenoproteins in the genome of Anopheles gambiae are possibly related to in vivo oxidation tolerance and protein regulation in order to interfere with anopheles' vectorial capacity of *** study may also provide theoretical bases for the prevention of malaria from anopheles transmission.

关键词： selenoprotein selenocysteine Anopheles gambiae genome bioinformatics

具有色关联的色噪声驱动下单模激光线性模型的随机共振

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物理学报 2003年第5期52卷 1174-1178页

作者：张良英曹力吴大进华中科技大学激光技术国家重点实验室华中科技大学物理系武汉430074

研究了具有指数形式关联的两色噪声驱动下单模激光线性模型受信号调制后其输出信噪比 ,发现了随机共振现象 .根据计算结果讨论了噪声 (即噪声强度、噪声间互关联程度和关联时间 )和信号 (信号频率和信号振幅 )

关键词：色关联色噪声驱动单模激光线性模型随机共振信噪比激光器噪声强度噪声关联时间噪声关联程度

Morphological Evolution of Nb_2O_5 in a Solvothermal Reaction: From Nb_2O_5 Grains to Nb_2O_5 Nanorods and Hexagonal Nb_2O_5 Nanoplatelets

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Journal of wuhan university of technology(Materials science) 2009年第2期24卷 245-248页

作者：胡卫兵 School of Chemical and Environmental Engineering Hubei Institute for Nationalities Department of Physics Huazhong University of Science and Technology

Novel Nb2O5 nanorods and polygonal Nb2O5 platelets were generated by a simple solvothermal technique. The geometry evolution of the resultant Nb2O5 from amorphous nanoparticles to crystallized particles, from polygonal platelets to well-elongated nanorods was been studied in detail. The processing parameters, including the reaction temperature, reaction time, concentration of the precursors, and pH value of the solution, which affect the shape and size of the nanorods, were investigated. The Nb2O5 nanorods with different aspect ratios were examined by XRD, SEM and TEM. The experimental results show that Nb2O5 nanorod is the orthorhombic structure and well-crystallized. The growth of the nanorods follows their [001] direction. The successful generation of high quality Nb2O5 nanorods is not only important for transition metal oxide research, but also potentially important for further formation of new Nb-based 1-D nanostructures, such as NbS2 and NbN.

关键词： solvothermal morphological evolution Nb2O5 nanomateraials

La_(2/3)Ca_(1/3)MnO_3薄膜的光致电阻率变化特性

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物理学报 2004年第2期53卷 587-591页

作者：汪世林陈长乐王跃龙金克新王永仓任韧宋宙模袁孝西北工业大学应用物理系西安710072 华中科技大学武汉430074

射频磁控溅射法制备了La2 3Ca1 3MnO3纳米薄膜 (LCMO) .该薄膜发生FM PM相变的转变点温度为Tc≈ 30 8K(近似为电阻峰值温度Tp) ;在不同温度下的光电导性质实验表明所制备的LCMO薄膜在连续激光作用时低温段(T 0 ,并在R T曲线拐点附近... 详细信息

射频磁控溅射法制备了La2 3Ca1 3MnO3纳米薄膜 (LCMO) .该薄膜发生FM PM相变的转变点温度为Tc≈ 30 8K(近似为电阻峰值温度Tp) ;在不同温度下的光电导性质实验表明所制备的LCMO薄膜在连续激光作用时低温段(T 0 ,并在R T曲线拐点附近取得极大值 ,(ΔR R) max=4 3 5 % ;当T>Tc 时 ,ΔR R <0 ,即光电导效应 .调制激光脉冲光响应实验发现 ,光致信号强度和温度及偏置电流之间存在非线性关系 :光致电阻率增大信号极大值为偏置电流的二次函数 ,而极大值对应的温度和偏置电流成线性关系 ,同时 ,光响应有一个截止温度 ,并且存在最佳光响应偏置电流和温度条件 .

关键词：钙钛矿薄膜光响应电子自旋小极化子光致电阻率射频磁控溅射法相变转变点温度

Microglial migration mediated by ATP-induced ATP release from lysosomes

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Microglial migration mediated by ATP-induced ATP release fro...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ying DOU~1,Hang-Jun WU~(2,3),Hui-Quan LI~2,Song QIN~1,Hui-Fang LOU~2,Qing-Ming LUO~3,Shu-Min DUAN~(2,*) 1 Institute of Neuroscience and Key Laboratory of Neuroscience,Shanghai Institutes for Biological sciences,Chinese Academy of sciences,Shanghai 200031,china 2 Department of Neurobiology,Key Laboratory of Medical Neurobiology of the Ministry of Health of china,Key Laboratory of Neurobiology of Zhejiang Province,Zhejiang university School of Medicine,Hangzhou 310058,china 3 huazhong university of science and technology,wuhan 430074,china

Microglia are highly motile cells that act as the main form of active immune defense in the central nervous *** by factors released from damaged cells,microglia are recruited towards the damaged or infected site, where they are involved in degenerative and regenerative responses and phagocytotic clearance of cell *** release from damaged neural tissues has been suggested to mediate the rapid extension of microglial process towards the site of ***,the mechanisms of the long-range migration of microglia remain to be ***,we found that lysosomes in microglia contain abundant ATP and exhibit Ca-dependent exocytosis in response to various *** establishing an efficient in vitro chemotaxis assay,we demonstrated that endogenously-released ATP from microglia triggered by local microinjection of ATPyS is critical for the long-range chemotaxis of microglia,a response that was inhibited in microglia treated with an agent inducing lysosome osmodialysis or in cells deficient in Rab 27a,a small GTPase required for the trafficking and exocytosis of secretory *** results suggest that microglia respond to extracellular ATP by releasing ATP themselves through lysosomal exocytosis,thereby providing a positive-feedback mechanism to generate a long-range extracellular signal for attracting distant microglia to migrate towards and accumulate at the site of injury.

关键词： microglia migration ATP lysosome

来源： cnki会议评论

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基于移动代理和工作流技术的电子商务模式

微机发展 2003年第9期13卷 57-59,62页

作者：员亚利姜浩宋丽茹东南大学计算机科学与工程系江苏南京210096 洛阳大学电子工程系河南洛阳471023 华中科技大学交通学院湖北武汉430074

针对现有电子商务的缺点,提出一种新的电子商务模式。用工作流来实现交易过程自动化,引入分布式对象Agent技术实现客户和商家的直接交流和信息的分布式存储,突破存储局限,利于负载平衡,并且实现工作流的柔性。文中给出了系统框架和建模... 详细信息

针对现有电子商务的缺点,提出一种新的电子商务模式。用工作流来实现交易过程自动化,引入分布式对象Agent技术实现客户和商家的直接交流和信息的分布式存储,突破存储局限,利于负载平衡,并且实现工作流的柔性。文中给出了系统框架和建模方法。

关键词：电子商务模式移动代理工作流商务网站 Internet