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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.kong Maria V.Babak Yudai Matsuda department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Surface and Interface Properties in Organic Light-Emitting Diodes

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Surface and Interface Properties in Organic Light-Emitting D...

第九届全国发光学术会议

作者： R. Fung, C. S. Lee and S.T. Lee Center Of Super Diamond and Advanced Films (COSDAF) & department of Physics and Materials Science city university of hong kong hong kong, china

Device surfaces and interfaces in organic light-emitting diodes have been studied by X-rayphotoelectron spectroscopy (XPS), ultra-violet photoemission spectroscopy (UPS), and high-resolutionenergy loss spectroscopy (H...

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Volatile Solid and Bury Period Influence on Odorous Material Production in Simulating Landfill Treatment

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Journal of Geoscience and Environment Protection 2024年第1期12卷 120-129页

作者： Peng Lu Yuanyuan Zhang Linan Xing Ying Wang hong Lu Dongbei Yue Wei Cheng Jin Liu department of Environmental Engineering Technology Beijing Polytechnic Beijing China Beijing Municipal Institute of city Management Beijing China department of Environmental Science and Engineering Tsinghua University Beijing China Chinese Academy of Meteorological Sciences Beijing China china Meteorological Administration Beijing China

Odor pollution in landfill area has attracted more social attention in china. It is very important to control the generation of odor pollutants in situ. Analyzing odorous materials production form buried waste, simulated columns of different volatile solid (VS) content and different buried period waste were designed. Gas compounds produced from the columns were collected and analyzed by comprehensive two-dimensional gas chromatography (GC × GC) method. It has remarkable relationship between VS content and concentrations of odorous material. When VS content more than 40%, the total amount of odorous compounds increases remarkably. It can be inferred that reduced VS content of original waste may effective decreasing odorous materials production in landfill area. The old rubbish produced more odorous compounds than that of fresh one in simulated columns.

关键词： Volatile Solid Odorous Material Bury Period

Second-Order Consensus for Nonlinear Multi-Agent Systems with Intermittent Measurements

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Second-Order Consensus for Nonlinear Multi-Agent Systems wit...

2011 Chinese Control and Decision Conference（CCDC）

作者： Guanghui Wen,Zhisheng Duan are with the State Key Lab for Turbulence and Complex Systems and the department of Mechanics and Aerospace Engineering,College of Engineering,Peking university,Beijing 100871,china Guanrong Chen is with the department of Electronic Engineering,city university of hong kong,hong kong SAR,china Wenwu Yu is with the department of Mathematics,Southeast university,Nanjing 210096,china

In this paper,the consensus problem is investigated for a class of second-order nonlinear multi-agent systems with intermittent measurements and directed topology.A novel protocol designed based only on the intermittent local feedback is introduced to guarantee the states of multiple agents to *** virtue of the Lyapunov control approach,it is theoretically proved that second-order consensus can be achieved exponentially if the general algebraic connectivity and the communication time duration are larger than their corresponding threshold values ***,a simulation example is given to verify the theoretical analysis.

关键词： Multi-agent system Second-order consensus Intermittent measurement Directed topology

Surface and interface properties in OLED

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Surface and interface properties in OLED

第九届全国发光学术会议

作者： S.T.Lee Center of Super-Diamond and Advanced Films(COSDAF) & department of Physics and Materials Science, city university of hong kong SAR, china

Device surfaces and interfaces in organic light-emitting diodes have been studied by X-Rayphotoelectron spectroscopy (XPS), ultra-violet photoemission spectroscopy (UPS), and high-resolutionenergy loss spectroscopy (H...

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Exploring a New Change of Urban Residential Differentiation in china's Transition to a Housing Market: Case Study on Panyu, Guangzhou

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Exploring a New Change of Urban Residential Differentiation ...

中国地理学会2004年学术年会暨海峡两岸地理学术研讨会

作者： Limei Li, PhD Candidate department of Geography, hong kong Baptist university, Kowloon Tong, hong kong SAR

Institutional reform and marketization of housing have achieved tremendous success in some cities of china. With ongoing housing reform and massive increase in commodity housing construction, the traditional residential structure organized around the work units are being decomposed gradually while new neighborhoods are under construction. The real estate market begins to act as a sorting mechanism in residential relocation. The research intends to explore the new change of urban residential differentiation in transitional china making use of a case study on Panyu, Guangzhou. Data are analyzed from a survey conducted among the households of two real estate communities in Panyu in August 2004 and 2000 Population *** finding suggests that large residential population has voluntarily shifted from the inner city to the outer suburbs. People relocated to outer city are typically young with high education attainment level. The population shift is accompanied by a shift from rent to own tenure. The housing reform forces them independent of work-unit housing provision. Better education, absence of work-unit affiliation, greater earning capacity, higher expectation of housing consumption contribute to their active relocation behavior through commodity housing *** outer suburban presents a complex set of opportunities and constraints as a region in which to live. Most of movers have become owner-occupiers and gained increase of living area but suffered from the increase in commuting time and cost and decreased accessibility of the city center after relocation. They attach priority to living environment rather than other characteristics of the accommodation. Thus many young and well-educated persons at the family-forming stage of the life-cycle have to move some distance to the outer suburbs, if they are to acquire affordable housing and get better living environment. Housing decision represents a tradeoff between access to the workplace and publicly provided

关键词： relocation differentiation residential enclaves Panyu

The conversion factor of K_(eff) to K_(3.7) in thermoluminescence dating

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Nuclear Science and Techniques 1998年第4期9卷 227-230页

作者： Wang Wei-Da Zhou Zhi-Xin Xia Jun-Ding (Research Laborotory for Conservation and Archaeology, Shanghai Museum, Shanghai 200951)Leung P L Stokes M J(department of Physics and Materials Science, city university of hong kong)

In the fine-grain TL dating the full o dose must be converted into the equivalent P dose. The conversion is finished by Keff-value, which is an effective or effectiveness. But the Keff can not be measured directly for each sample and only the external radiative efficiency K3.7 can be measured. In order to obtain the Keff a special study for the conversion factor of Keff to K3.t has been made using the ultrathin TLD. The results show that the conversion factor of tile TLD for archaeological samples is 0.847, which is in agreement with calculated value 0.85.

关键词：考古学热致发光断定年代 Keff-K3.7 变换因子

氧化亚铜改性四针状氧化锌晶须表面及其光催化性能研究

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人工晶体学报 2024年第6期53卷 1042-1050页

作者：刘红刘花蓉范希梅四川建筑职业技术学院材料工程系多组元合金德阳市重点实验室德阳618000 西南交通大学材料先进技术教育部重点实验室成都610031

本文采用简便的液相还原法以乙二醇(EG)为还原剂,聚乙烯吡咯烷酮(PVP)为表面活性剂,制备了Cu_(2)O/T-ZnOw复合半导体催化剂样品,对样品的物相、微观形貌、禁带宽度、光致发光性能、光催化性能,以及可回收利用性能进行了详细研究。结果表... 详细信息

本文采用简便的液相还原法以乙二醇(EG)为还原剂,聚乙烯吡咯烷酮(PVP)为表面活性剂,制备了Cu_(2)O/T-ZnOw复合半导体催化剂样品,对样品的物相、微观形貌、禁带宽度、光致发光性能、光催化性能,以及可回收利用性能进行了详细研究。结果表明:随着PVP添加量的增加,四针状氧化锌晶须(T-ZnOw)表面沉积的Cu_(2)O由立方体形逐渐向球形转变;T-ZnOw表面沉积Cu_(2)O后可使半导体催化剂的禁带宽度(Eg)变窄,且能有效减少光生电子和空穴对的复合,使其光催化活性得到明显改善,紫外光照100 min时复合半导体催化剂对甲基橙(MO)溶液的降解率均提高到90%以上;复合催化剂中Cu_(2)O形貌不同其光催化活性有所差异,同等条件下,立方体形Cu_(2)O/T-ZnOw复合催化剂比球形Cu_(2)O/T-ZnOw表现出更好的光催化活性;同时复合催化剂样品展现出良好的可回收利用性能,经过六个周期的回收循环光催化降解试验后,样品对MO溶液的降解率仍能保持在80%以上。

关键词： Cu_(2)O/T-ZnOw 表面沉积 PVP 甲基橙光催化性能降解率可回收利用性能

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营销渠道中依赖的感知差距对渠道冲突的影响

系统工程理论与实践 2003年第7期23卷 57-62,117页

作者：庄贵军周南周筱莲西安交通大学管理学院陕西西安710049 香港城市大学市场营销系西安财经学院管理学院陕西西安710061

目的是检验营销渠道成员对于相互依赖关系的感知差距 ,以及这一感知差距对渠道冲突的影响 .研究结果表明 :在配对渠道成员的关系中 ,第一 ,存在着对于彼此依赖程度的感知差距 ;第二 ,对彼此依赖程度感知上的差异会导致渠道成员之间更多... 详细信息

目的是检验营销渠道成员对于相互依赖关系的感知差距 ,以及这一感知差距对渠道冲突的影响 .研究结果表明 :在配对渠道成员的关系中 ,第一 ,存在着对于彼此依赖程度的感知差距 ;第二 ,对彼此依赖程度感知上的差异会导致渠道成员之间更多的磨擦或冲突 .最后还讨论了研究结果的应用 .

关键词：营销渠道依赖冲突渠道行为管理