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第4届国际脑血管病高峰论坛

作者： L Zhou.L Wang,Q Dong,X Yu,S Xu department of neurology,Huashan hospital affliated to Fudan University,Faculty of Neurolgy,Shanghai medical college,Fudan University,Shanghai 200040,china

Background:High-resolution magnetic resonance has been gradually used to evaluate carotid atherosclerosis plaque with the merit of noninvasive,safe,good repeatable,good sensitivity and specificity. It can display the size and the internal component of carotid atherosclerosis plaque and reveal the relation between this character of

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神经节苷脂治疗急性脑梗死

中国新药与临床杂志 2003年第1期22卷 19-21页

作者：孟庆莲耿家贵泰山医学院第一教学医院神经内科山东泰安271000

目的 :观察神经节苷脂治疗急性脑梗死的疗效。方法 :急性脑梗死 6 0例 ,分为神经节苷脂组及对照组。神经节苷脂组 30例 ,给予 6 0～ 10 0mg加入氯化钠注射液 2 5 0mL ,iv ,gtt× 2wk ;对照组30例 ,给予胞磷胆碱 0 .5～ 0 .75 g或吡拉西... 详细信息

目的 :观察神经节苷脂治疗急性脑梗死的疗效。方法 :急性脑梗死 6 0例 ,分为神经节苷脂组及对照组。神经节苷脂组 30例 ,给予 6 0～ 10 0mg加入氯化钠注射液 2 5 0mL ,iv ,gtt× 2wk ;对照组30例 ,给予胞磷胆碱 0 .5～ 0 .75 g或吡拉西坦 4 g ,治疗 2wk ,于治疗前、治疗后 1wk和 2wk对 2组病人进行神经功能缺损程度 (NDS)及日常生活活动量 (ADL)评分 ,并进行比较。结果 :神经节苷脂组与对照组疗效比较经Ridit分析 ,差异有显著意义 (P2NDS和ADL评分与治疗前相比 ,差值分别为 (- 12 .0±s 0 .5 )分 ,(- 3.3±0 .3)分 ;(- 17.4± 0 .7)分 ,(- 4.5 4± 0 .2 5 )分 ;(31.8± 2 .4 )分 ,(2 .1± 0 .6 )分 ;(5 2± 10 )分 ,(6± 6 )分 (P <0 .0 1)。结论 :神经节苷脂治疗急性脑梗死有显著的疗效 ,能促进神经功能的早期恢复。

关键词：神经节苷脂类神经节苷脂脑梗死药物疗法

云南少数民族和汉族特发性癫痫CLCN2基因多态性研究

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中风与神经疾病杂志 2012年第2期29卷 151-154页

作者：唐于荔王文敏俞志鹏昆明医学院第一附属医院神经内科昆明95429部队医院北京大学第三医院神经内科

目的检测云南省5种独有少数民族(基诺族、阿昌族、布朗族、佤族、拉祜族)与汉族人群特发性癫痫与电压门控氯通道-2基因CLCN2基因多态性是否相关。方法采用PCR、单碱基延伸(SNap shot)等技术,应用病例-对照法检测云南少数民族特发性癫痫... 详细信息

目的检测云南省5种独有少数民族(基诺族、阿昌族、布朗族、佤族、拉祜族)与汉族人群特发性癫痫与电压门控氯通道-2基因CLCN2基因多态性是否相关。方法采用PCR、单碱基延伸(SNap shot)等技术,应用病例-对照法检测云南少数民族特发性癫痫患者92例及其未发病亲属170例、云南汉族特发性癫痫患者107例及63例健康人群外周血CLCN2基因多态性。统计少数民族与汉族人群中rs13099401、rs4912540两个位点的基因型、等位基因频率,分别用χ2等检验进行统计分析。结果 CLCN2基因rs13099401位点基因型频率分布在少数民族病例组与汉族病例、对照组之间有统计学差异(χ2=6.828,P=0.033;χ2=9.246,P=0.010,均P2=9.245,OR=3.26,P=0.002,P2540位点基因型频率在各组间无统计学差异(P>0.05)。结论 CLCN2基因位点rs13099401可能是云南少数民族特发性癫痫患者的相关性位点,基因型CC为汉族特发性癫痫发作的一个保护性因素;rs4912540与云南人群特发性癫痫无显著相关性。

关键词：特发性癫痫遗传学 CLCN2 云南少数民族单核苷酸多态性

The role of cell cycle control correlative gene protein in arsenism caused by burning coal contain arsenic

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The role of cell cycle control correlative gene protein in a...

贵州省环境诱变剂学会第二届学术交流会

作者： Hong Feng~#,Aihua Zhang~#,Xiaoxin Huang~+,Xuexin Dong~+ # department of Prevention Medicine,Guiyang medical college,Guiyang,550004,china. + The 44~(th) hospital of PLA,Guiyang,550009,china.

Arsenism has been all over the world and also become one of the urgent public health *** an animal model for the carcinogenicity of arsenic has never been developed,its mechanism related to chronic poisoning and especially to carcinoma is not *** purpose of this study was to study the mechanisms of arsenism especially resulting in skin carcinoma caused by burning coal contain arsenic.70 skin samples from arsenism patients caused by burning coal contain arsenic were included and according to the pathological diagnosis,they were divided into carcinoma grou(A group),Precancerous lesions group(B group),hyperkeratosis group(C group) and general pathological changes group(D group).The expressions of cell cycle control correlative gene P16、P21 and cyclinDl proteins in skins from arsenism patient were detected by immunohistochemistry *** the increasing pathologic change in skin,the positive cell density and percentage of P16 were gradually decreased,but these of P21 and cyclinD1 were gradually *** of P16 protein in A,B and C groups were lower than D and the control groups(P21 protein in all pathological groups were higher than the control(P21,cyclinD1 and urinary arsenic are positive *** has been demonstrated that P16、P21 and cyclinD1 may related to cause skin carcinoma and may play a significant role in the development of arsenism and skin hyperkeratosis may be earlier stage of *** monitoring of expressions of P16、P21 and cyclinD1 proteins may be useful for early detecting and treatment and prognostic judgment of skin carcinoma caused by arsenic.

关键词： Arsenism P16 P21 CyclinD1 Skin with pathological signs

肌电图检查在定位周围神经疾病时的应用价值(附340例临床分析)

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新疆医学院学报 1985年第3期 209-214页

作者：王禄培新疆医学院第一附属医院神经科

报告340例肌电图的临床分析。对前角、脊神经根、神经丛、神经干、神经肌肉接头和肌肉六个不同部位损害的肌电图特点进行总结。强调背深层肌肌电图对脊神经根损害定位诊断的优点为手续简单,可靠性大。首次在国内报告9例肉毒中毒肌电图,... 详细信息

报告340例肌电图的临床分析。对前角、脊神经根、神经丛、神经干、神经肌肉接头和肌肉六个不同部位损害的肌电图特点进行总结。强调背深层肌肌电图对脊神经根损害定位诊断的优点为手续简单,可靠性大。首次在国内报告9例肉毒中毒肌电图,其特征性改变是用每秒5～50次连续电刺激神经,诱发动作电位波幅渐增,有协助确诊肉毒中毒的价值,但需和Lambert-Eaton综合征鉴别。

关键词：肌电描记法周围神经疾病

肺癌患者血清sCD23水平与EB病毒感染相关性探讨

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实用肿瘤杂志 2008年第2期23卷 136-138页

作者：邹吉敏袁宝军王菊惠康向辉马立人华北煤炭医学院附属开滦医院检验科河北唐山063000 华北煤炭医学院附属开滦医院口腔科河北唐山063000 华北煤炭医学院病原生物系河北唐山063000

目的观察肺癌患者血清sCD23水平的变化,及其与EB病毒感染的关系。方法采用ELISA法检测102例未经治疗的肺癌患者及32例健康对照血清sCD23水平,结合肺癌的临床病理特征及血清EB病毒抗体进行分组分析。结果肺癌患者血清sCD23水平为(60.69±... 详细信息

目的观察肺癌患者血清sCD23水平的变化,及其与EB病毒感染的关系。方法采用ELISA法检测102例未经治疗的肺癌患者及32例健康对照血清sCD23水平,结合肺癌的临床病理特征及血清EB病毒抗体进行分组分析。结果肺癌患者血清sCD23水平为(60.69±27.20)U/ml,高于对照组(42.56±14.68)U/ml(P23水平与肺癌的组织学类型、肿瘤部位、临床类型、TNM分期无关;EB病毒感染组血清sCD23水平(58.67±26.3)U/ml略低于未感染组(73.34±30.19)U/ml,但差异无统计学意义(P>0.05)。结论肺癌患者血清sCD23水平升高,sCD23可能参与肺癌的免疫病理机制。

关键词：肺肿瘤/病理学酶联免疫吸附测定疱疹病毒4型,人

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学龄期局灶性发作癫患儿睡眠结构的变化

实用儿科临床杂志 2010年第6期25卷 433-436页

作者：许杰刘智胜孙丹张苏明江军吴革菲胡家胜王芳琳华中科技大学同济医学院附属同济医院神经内科武汉430030 武汉市儿童医院神经内科武汉430016

目的研究学龄期局灶性癫患儿发作间期睡眠结构的变化。方法应用Solar2000N神经中央监护系统对23例6～12岁局灶性癫患儿(男15例,女8例)及15例年龄、性别与之相匹配的健康儿童(健康对照组,男11例,女4例)进行全夜自然睡眠多导监测,并... 详细信息

目的研究学龄期局灶性癫患儿发作间期睡眠结构的变化。方法应用Solar2000N神经中央监护系统对23例6～12岁局灶性癫患儿(男15例,女8例)及15例年龄、性别与之相匹配的健康儿童(健康对照组,男11例,女4例)进行全夜自然睡眠多导监测,并将23例局灶性癫患儿按照样放电出现部位(额叶癫组、颞叶癫组、枕叶癫组),发作好发时间(睡眠发作组、清醒发作组、睡眠+清醒发作组)及服用抗癫药物类型(卡马西平治疗组,卡马西平+托吡酯治疗组)进行分组,应用SPSS13.0软件分析各组患儿与健康儿童之间各项睡眠参数的差异。结果与健康对照组比较,学龄期局灶性癫患儿非快速眼动(NREM)睡眠1期比例延长(P<0.05),慢波睡眠(SWS)比例显著减少(P<0.01);额叶癫组各项睡眠参数与健康对照组比较差异无统计学意义,颞叶癫组患儿NREM睡眠1期比例及觉醒时间延长(Pa<0.05),枕叶癫组SWS比例与健康对照组比较差异有统计学意义(P<0.05);睡眠发作组觉醒次数增加(P<0.05),NREM睡眠1期比例增加(P<0.05),清醒发作组SWS比例减少(P<0.05);卡马西平+托吡酯组与未服药组比较,快速眼动(REM)睡眠时间增加(P<0.05)。结论学龄期局灶性癫患儿浅睡眠增多,深睡眠减少,以NREM1期睡眠增多为主;颞叶癫显示了更多的觉醒时间;易在睡眠中发作的癫患儿觉醒次数增加;卡马西平+托吡酯治疗可增加局灶性癫患儿的REM睡眠时间。

关键词：局灶性癫 睡眠结构儿童

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国产去纤酶治疗脑血栓形成

湖南医学院学报 1982年第2期 163-167页

作者： Cerebrovascular Research Group,department of neurology The First affiliated hospital Hunan Medicel college 湖南医学院第一附属医院神经科脑血管研究小组

本文报告去纤酶——一种新型抗凝剂治疗26例脑血栓形成的临床结果,有效率达84.7%。与经现有的综合疗法治疗的23例对照,疗效相当。去纤酶治疗具有副作用小,易于控制,毋需特殊监测,方法简便等优点。本品药效机制尚不清楚,本文提供了低纤... 详细信息

本文报告去纤酶——一种新型抗凝剂治疗26例脑血栓形成的临床结果,有效率达84.7%。与经现有的综合疗法治疗的23例对照,疗效相当。去纤酶治疗具有副作用小,易于控制,毋需特殊监测,方法简便等优点。本品药效机制尚不清楚,本文提供了低纤维蛋白元血症及血粘度降低等资料,作为机制探索的参考。

关键词：去纤酶纤维素治疗后脑血栓

Successful short-term pulse cyclophosphamide in severe pediatric neuropsychiatric lupus with ITP as the initial manifestation and complicating parkinsonism:A case report

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Successful short-term pulse cyclophosphamide in severe pedia...

中华医学会第十八次全国皮肤性病学术年会

作者： Ya Li~(1,2),Yujue Wang~1,Liu Yang~1,Xilin Zhang~(1,3),Gang Li~1,Shan Gao~1,Jing Wang~1,Yating Tu~1,Juan Tao~1 1 department of Dermatology and Venereology,and department of neurology,Union hospital,Tongji medical college,Huazhong University of Science and Technology,Wuhan,430022,the People’s Republic of china 2 department of Dermatology,Huaxin hospital,Tsinghua University,Beijing,100016,the People’s Republic of china 3 department of Dermatology,Changhai hospital,the Second Military medical University,Shanghai, 200433,the People’s Republic of china

Idiopathic thrombocytopenic purpura(ITP) as the initial manifestation and parkinsonism in association with juvenile systemic lupus erythematosus(SLE)has not been reported *** report a 11-year-old Chinese girl with severe neuropsychiatric SLE(NPSLE),who was diagnosed with ITP eight months previously and complicating parkinson-like symptoms during the course of *** cerebral lupus was unresponsive to

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Protective effects of cystine C60 derivative on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells

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Protective effects of cystine C60 derivative on hydrogen per...

湖北省化学化工学会2006年年会暨循环经济专家论坛

作者： Zhen Hu Lizhen Huang Haiping Xing Zhou Zhu Wei Wang Wenchao Guan Departmen of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, PR china department of neurology,Tongji hospital, Tongji medical college, Huazhong University of Science and Technology, 430030, PR china

Oxidative stress has been considered as a major cause of cellular injuries in a variety of clinical abnormalities, especially prominent in neural diseases. One of the usable ways to prevent the reactive oxygen species (ROS)-mediated cellular injury is dietary or pharmaceutical augmentation of some free radical scavenger. Water-soluble amino-fullerene is a novel compound that behaves as a free radical scavenger with excellent biology consistent. In the present study, we have synthesized a novel amino- fullerene derivative for the first time, and investigated the effects on hydrogen peroxide-induced oxidative stress and apoptotic death in cultured rat pheochromocytoma (PC12) cells. The product was characterized by UV, 1HNMR, 13CNMR, MS, and elemental analysis. The scavenging ability to ROS in vitro was studied by chemiluminescence. Furthermore, the results of MTT and flow cytometry (FCM) analysis has indicated that cystine C60 derivative had excellent protective effects on hydrogen peroxide-induced apoptosis in PC12 cells.

关键词： Cystine C60 derivatives TBAH Chemiluminescence MTT Flow cytometry analysis Apoptosis PC12 cells