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chinese national clinical practice guideline on diagnosis and treatment of biliary tract cancers

中华医学杂志(英文版) 2024年第19期137卷 2272-2293页

作者： Wang Xu’an Bai Yongrui Chai Ningli Li Yexiong Linghu Enqiang Wang Liwei Liu Yingbin Society of Hepato-pancreatobiliary Surgery of chinese Research Hospital Association Society of Digestive Endoscopy of the chinese medical Association chinese medical Journal Clinical Practice Guideline Collaborative Department of Biliary and Pancreatic Surgery Renji Hospital Shanghai Jiao Tong University School of Medicine State Key Laboratory of Systems Medicine for Cancers Shanghai Cancer Institute Shanghai Key Laboratory for Cancer Systems Regulation and Clinical Translation Shanghai China Department of Radiation Oncology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Department of Gastroenterology and Hepatology the First Medical Center Chinese People’s Liberation Army General Hospital Beijing China State Key Laboratory of Molecular Oncology and Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Beijing China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Department of Oncology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China

Background: Biliary tract carcinoma (BTC) is relatively rare and comprises a spectrum of invasive tumors arising from the biliary tree. The prognosis is extremely poor. The incidence of BTC is relatively high in Asian countries, and a high number of cases are diagnosed annually in china owing to the large population. Therefore, it is necessary to clarify the epidemiology and high-risk factors for BTC in china. The signs associated with BTC are complex, often require collaborative treatment from surgeons, endoscopists, oncologists, and radiation therapists. Thus, it is necessary to develop a comprehensive chinese guideline for ***: This clinical practice guideline (CPG) was developed following the process recommended by the World Health Organization. The Grading of Recommendations Assessment, development, and Evaluation approach was used to assess the certainty of evidence and make recommendations. The full CPG report was reviewed by external guideline methodologists and clinicians with no direct involvement in the development of this CPG. Two guideline reporting checklists have been adhered to: Appraisal of Guidelines for Research and Evaluation (AGREE) and Reporting Items for practice Guidelines in Healthcare (RIGHT).Results: The guideline development group, which comprised 85 multidisciplinary clinical experts across china. After a controversies conference, 17 clinical questions concerning the prevention, diagnosis, and treatment of BTC were proposed. Additionally, detailed descriptions of the surgical principles, perioperative management, chemotherapy, immunotherapy, targeted therapy, radiotherapy, and endoscopic management were ***: The guideline development group created a comprehensive chinese guideline for the diagnosis and treatment of BTC, covering various aspects of epidemiology, diagnosis, and treatment. The 17 clinical questions have important reference value for the management of BTC.

关键词： Biliary tract carcinoma Etiology Diagnosis Treatment Surgery

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Influence of Panax ginseng Continuous Cropping on Metabolic Function of Soil Microbial Communities

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chinese Herbal Medicines 2012年第4期4卷 329-334页

作者： YING Yi-xin1,DING Wan-long1,ZHOU Ying-qun2,LI Yong1 1.Institute of medicinal plant development,chinese academy of medical sciences and peking union medical college,beijing 100193,china 2.china National Corporation of Traditional and Herbal Medicine,beijing 100195,china [a] Institute of medicinal plant development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193 China [b] china National Corporation of Traditional and Herbal Medicine Beijing 100195 China

Objective To investigate the influence of Panax ginseng continuous cropping on the carbon substrate metabolic activity of microbes in soils sampled from Dafang,Huangni,and Wulidi in Jilin Province,*** Soil metabolisms of soil communities were characterized by community level physiological profiles using BIOLOGTM *** Soils sampled from the three sites were analyzed and their metabolic activities were *** component analysis explored the significant variance in metabolic function of microbial communities in soils,though the Shannon index and the evenness index of them were ***,two principal components(PC1 and PC2),which contributed 67.83% and 10.78% of total variance,were extracted *** also,substrates significantly correlated with PC1 and PC2 at the three sampling sites were *** Characteristic of soil is the primary factor influencing microbial communities,and *** continuous cropping has significant influence on microbial *** soil samples show similar microbial metabolic profiles,microbial communities in rhizosphere soil are changed obviously during the cultivation of ***,which would finally result in the unbalance of microbial *** would gradually be the predominants in rhizosphere soil and make *** sick.

关键词： continuous cropping metabolic function microbial community Panax ginseng rhizosphere soil

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A New Taxoid from the Needles of Taxus × media Hicksii

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chinese Chemical Letters 1997年第12期8卷 0-0页

作者： Yong Li GAO Jin Yun ZHOU Yi Ding and Qi Cheng FANG(Institute of Matcria Medica, chinese academy of medical sciences and peking union Medital college beijing 100050) chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China peking union Med Coll Beijing 100050 Peoples R China

A new taxoid with 5/716 taxane skeleton, named taxamedin A (1) was isolated from the needles of Taxus x media Hicksii. Its structure was elucidated by spectal analysis

关键词： A New Taxoid from the Needles of Taxus

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Distribution of tanshinones in the genus Salvia (family Lamiaceae) from china and its systematic significance

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Journal of Systematics and Evolution 2010年第2期48卷 118-122页

作者： 1,2Min-Hui LI 1Yong PENG 1Pei-Gen XIAO 1(Institute of medicinal plant development,chinese academy of medical Science and peking union medical college,beijing 100094,china) 2(Baotou medical college,Baotou 014060,china) (Institute of medicinal plant development Chinese Academy of Medical Science and Peking Union Medical College Beijing 100094 China) (Baotou medical college Baotou 014060 China) *Correspondence: Pei-Gen XIAO *Correspondence: *?Author for correspondence. E-mail: xiaopg@*** Tel.: 86-10-6301-1294 Fax: 86-10-6281-8235.

Salvia L.(family Lamiaceae),a large genus of over 1000 species,is widely distributed throughout tropical and temperate regions of the ***-four species are native to ***,there are many taxonomic uncertainties at the sub-generic *** are a class of secondary metabolites with a large variety of structures that have been used as chemotaxonomic markers at infra-and suprageneric *** the sake of further chemotaxonomic understanding of Salvia,the present study investigated the distribution of tanshinones,a group of biologically active diterpenes known to be present in some chinese members of the *** high-pressure liquid chromatography with a diode array detector,tanshinones in various Salvia species were determined and the distribution supported the circumscription of *** in the original sense of ***,the distribution of tanshinones provides a valuable chemotaxonomic tool for determining infrageneric differences within Salvia.

关键词： chemotaxonomy high-pressure liquid chromatography (HPLC) Salvia tanshinones

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Diels-Alder Reactions of 3-Carboethoxy- and 3-Carbonitrile-2-Cyclohexen-1-one

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chinese Chemical Letters 1998年第3期9卷 233-234页

作者： Wen Qian YANG Shi Zhi CHEN Liang HUANG(Institute of Materia Medica, chinese academy of medical sciences & peking union medicalcollege beijing 100050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

Aluminum chloride induced Diels-Alder reactions of 3-carboethoxy- and 3-carbonitrile-2-cyclohexen-1-one with cyclopentadiene, isoprene and (E)-piperylene were described. Thestereochemistry of the adducts were confirme... 详细信息

关键词： Diels-Alder reaction base-induced isomerization

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Study on the Total Synthesis of Et 743 and its Analogues: Synthesis of a Tricyclic Intermediate and its 11-Epimer

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chinese Chemical Letters 2003年第10期14卷 996-998页

作者： Ye Feng TANG, Zhan Zhu LIU, Shi Zhi CHENInstitute of Materia Medica, chinese academy of medical sciences & peking union medicalcollege, beijing 100050 Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050

The tricyclic compound 1, a key intermediate of the pentacyclic core of Et 743 and its analogues, was synthesized. Its 11-epimer was found as the product of racemization when BOP was used as the coupling agent, but not when BOP-C1 used in the same reaction. The stereochemistry of both isomers was confirmed on basis of the 1H NMR and NOE-difference spectra.

关键词： Et 743 tricyclic compound synthesis stereochemistry.

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TWO NEW ALKALOIDS FROM PIPER PUBERULUM

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chinese Chemical Letters 1994年第3期5卷 203-206页

作者： Qing Li WU Yu Xiu FENG Jun Shan YANG(Instriute of medicinal plant development,chinese academy of medical sciences,beijing 100094)

Two new alkaloids named piperlactam S, piperine S were isolated from Piper puberulum (Benth.)*** structues were elucidated by the spetral data including 1H-1H COSY, 14H-(13)C COSY, long-range 1H-(13)C COSY and NOE.

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Studies on the Reaction of Substituted 6-Nitrocoumarin with Anilines

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chinese Chemical Letters 1999年第10期10卷 811-812页

作者： Long Fei XIE Shi Ping XU Song XU Lan Min LI(Institute of Materia Medica, chinese academy of medical sciencesand peking union medical college, beijing 100050) chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China peking union Med Coll Beijing 100050 Peoples R China

3-Acetyl-7-hydroxy-8-methyl-6-nitrocoumarin reacted with substituted anilines, and fission of the heterocyclic ring occurred.

关键词： 6-nitrocoumarin heterocyclic ring fission Schiff base hydrazone

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Reactivity of C-10 Function in Sinenxan A and Its Derivatives

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chinese Chemical Letters 1997年第12期8卷 0-0,0-0页

作者： Fen Mei YAO Dong Hui WANG Guang Yan HUANG Ji Yu GUO Xiao Tian LIANG(Institute of Materia Medica, chinese academy of medical sciences & peking union Modical college, beijing 100050,china) chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China peking union Med Coll Beijing 100050 Peoples R China

The allylic nature of C-10 in sinenxan A (1) leads to facile SN1 and eliminion reactions

关键词： Reactivity of C-10 Function in Sinenxan A and Its Derivatives

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CIMICIFUGAMIDE AND ISOCIMICIFUGAMIDE,TWO NEW CINNAMAMIDE DERIVATIVES ISOLATED FROM CIMICIFUGA DAHURICA

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chinese Chemical Letters 1993年第10期4卷 891-892页

作者： Cong Jun LI Di Hua CHEN Pei Gen XIAO Institute of medicinal plant development,chinese academy of medical sciences,beijing 100094

Two new cinnamamide derivatives designated as cimicifugamide((?))and isocimicifu- gamide((?)),have been isolated from the rhizomes of Cimicifuga dahurica(Turcz.)Maxim..Their structures were established based on spectral evidence as N-(3'-methoxy-4'-hydroxyphenethyl)- 4-0-β-D-galactopyrano syl-ferulamide(E)and N-(3'-methoxy-4'-hydroxyphenetnyl)-4-0-β-D-ga- lactopyranosyl-isoferulamide(Z)respectively.

关键词： CIMICIFUGAMIDE AND ISOCIMICIFUGAMIDE,TWO NEW CINNAMAMIDE DERIVATIVES ISOLATED FROM CIMICIFUGA DAHURICA Ga

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