Study on the Total Synthesis of Et 743 and its Analogues: Synthesis of a Tricyclic Intermediate and its 11-Epimer

作     者：Ye Feng TANG, Zhan Zhu LIU, Shi Zhi CHENInstitute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union MedicalCollege, Beijing 100050 

作者机构：Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2003年第14卷第10期

页      面：996-998页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Et 743 tricyclic compound synthesis stereochemistry. 

摘      要：The tricyclic compound 1, a key intermediate of the pentacyclic core of Et 743 and its analogues, was synthesized. Its 11-epimer was found as the product of racemization when BOP was used as the coupling agent, but not when BOP-C1 used in the same reaction. The stereochemistry of both isomers was confirmed on basis of the 1H NMR and NOE-difference spectra.