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Modeling of Amperometric Immunosensor for CMOS Integration

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稀有金属材料与工程 2006年第S3期 439-442页

作者： Ce Li~(1,2) Haigang Yang~1 Shanhong Xia~1 Chao Bian~(1,2) (1.The State Key Lab of Transducer Technology,Institute of Electronics,CAS,beijing 100080,china) (2.graduate university of chinese academy of sciences,beijing 100039,china)

A circuit model of the Amperometric immunosensor for use in the biosensor system-on-chip simulation is proposed in this *** model parameters are extracted with several methods and verified by MATLAB and SPICE simulation.A CMOS potentiostat circuit required for conditioning the Amperometric immunosensor is also included in the circuit *** mean square error norm of the simulated curve against the measured one is 8.65×10-17The whole circuit has been fabricated in a 0.35μm CMOS process.

关键词： amperometric microelectrode circuit model potentiostat folded-cascode

A Full CMOS Integration Including ISFET Microsensors and Interface Circuit for Biochemical Applications

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稀有金属材料与工程 2006年第S3期 443-446页

作者： Jinbao Wei~(1,2) Haigang Yang~(1*) Hongguang Sun~(1,2) Zengjin Lin~(1,2) Shanhong Xia~1 (1.The State Key Lab of Transducer Technology,Institute of Electronics,CAS,P.O.Box 2652,beijing 100080,china) (2.graduate university of the chinese academy of sciences,beijing 100039,china)

One of today's challenges is the integration of ISFETs in chemical and biochemical *** article presents a full integration of ISFET chip containing the ISFET/REFET(reference FET) pair,ISFET/REFET amplifiers,bias current generator,as well as a reference electrode structure,all integrated on the same chip based on CMOS *** sensor chip was fabricated in a standard 0.35μm CMOS process(Chartered Semiconductor,Singapore).The extra post processing steps have been developed and added for depositing ***,the pH response of the integrated sensor was measured with the interface circuit.

关键词： ISFET interface circuit integration and post processing

基于CARTWHEEL构型的小卫星星座有效基线分析

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系统仿真学报 2009年第16期21卷 4938-4941页

作者：夏玉立雷宏黄瑶中国科学院电子学研究所北京100080 中国科学院研究生院北京100039

编队小卫星有效基线分析是编队小卫星SAR系统性能分析的关键,提出了针对Cartwheel编队构型的精确基线分析方法。将小卫星星座绕飞轨迹Hill方程与地球自转相结合,综合考虑两者的影响,精确的对Cartwheel构型星座有效基线进行仿真计算,并... 详细信息

编队小卫星有效基线分析是编队小卫星SAR系统性能分析的关键,提出了针对Cartwheel编队构型的精确基线分析方法。将小卫星星座绕飞轨迹Hill方程与地球自转相结合,综合考虑两者的影响,精确的对Cartwheel构型星座有效基线进行仿真计算,并且对星座在不同轨道位置的基线偏差进行了分析。

关键词：小卫星星座有效基线 Cartwheel编队构型 Hill方程地球自转

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Experimental Study On The Distribution Of Particles Concentration Of Gas-Solid Fluidized Bed With Disparately Sized Binary Particles

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中国颗粒学会第六届学术年会暨海峡两岸颗粒技术研讨会

作者： Jiantao Cao~(1,2),Zhonghu Cheng~1,Yitian Fang~1,Yang Wang~1 (1.Institute of Coal Chemistry,chinese academy of sciences,Taiyuan,Shanxi 030001,china 2.graduate university of the chinese academy of sciences,beijing 100039,china)

＜正＞Experiments were carried out to study the concentration distribution of disparately sized binary particle in the jet region of a 1-m dia ＆ 8-m high semicircular jetting fluidized bed with a conical *** particles concentration was measured by the optical fiber probe system and *** fine particles were injected coaxially to simulate fines recycled into the jet high temperature region in an actual operating unit with different fine particles feed-in *** was found that the coarse particles concentration increases when the jet gas-velocity reaches to the certain *** distributor gas-velocity increasing results in the increasing of the time-averaged particles volume concentration in the jet *** annular gas-velocity increase causes the particles concentration to *** there is high fine concentration existing in the jet region of large jetting fluidized *** fine particles concentration in the jet region increases with the increasing of fine particles feed-in quantity,and the fine concentration increased toward the bed surface. When reaching to a certain bed height,the fine concentration begins to decrease.

关键词： Fluidized bed Particle concentration Binary particles Distinct size difference Jet

2-D Frequency Spectrum Features and Error Analysis for Interferometric Passive Microwave Imager

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2-D Frequency Spectrum Features and Error Analysis for Inter...

IEEE 2007 International Symposium on Microwave,Antenna,Propagation and EMC Technologies for Wireless Communications(ISMAPE-2007)

作者： Pan Bei~(1,2)Wu Ji~1 (1.Center for Space Science and Applied Research,chinese academy of Science,P.O.Box 8701,beijing 100080, china 2.graduate university of chinese academy of sciences,beijing 100039,china

This paper introduces the basic concepts of Interferometric Passive Microwave Imager(Aperture Synthesis Interferometric Radiometers),and presents several features of 2-D frequency *** basis of those features,the directions and positions of baselines with errors can be identified approximately. And the effects caused by several systematic errors (antenna position error,baseline absence,amplitude error and phase error in channels,and antenna pattern error)on the reconstructed images,are analyzed particularly. The analyses in the paper can provide the evidences to identify the error types and sources in Interferometric Passive Microwave Imager,and can supply important references to design enhancement algorithms.

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Mining and characterization of ubiquitin E3 ligases from the mouse genome

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Mining and characterization of ubiquitin E3 ligases from the...

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Xiaojun Hou~1,Wei Zhang~(1,2),Chunsheng Han~1 1.State Key Laboratory of Reproductive Biology,Institute of Zoology,chinese academy of sciences,beijing 100101,china 2.graduate university of chinese academy of sciences,beijing 100039,china

Ubiquitin-mediated protein modification and degradation are believed to play important roles in mammalian *** our previous studies,we have identified several ubiquitin E3 Iigases that belong to the RING finger protein *** the present study,we first did a genome-wide mining of all potential mouse E3 Iigases,and identified those that are highly or specifically expressed in the *** a result,92 putative E3s belonging to the RING,U-box,and F-box subfamilies were discovered and 21 of them are abundantly expressed in the testis based on microarray expression *** selected 15 such genes for further characterization by examining their expression,cellular localization and E3 ligase activity. RT-PCR results showed that all the selected genes are predominately expressed in *** nuclear localization was observed in CHO and Hela cell *** addition,some novel proteins possess E3 ubiquitin ligase activity indicated by both in vivo and in vitro *** results indicated that large number of E3 Iigases are probably involved in *** will be important to identify their substrate in order to elucidate their molecular functions in spermatogenesis.

关键词： spermatogenesis Ubiquitination E3 ligase

Ribophorin II is a substrate of spermatid-specific E3 ligase RNF148

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Ribophorin II is a substrate of spermatid-specific E3 ligase...

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Wei Zhang~(1,2),Zhenyu Xiao~(1,2),Chunsheng Han~1 1.State Key Laboratory of Reproductive Biology,Institute of Zoology,chinese academy of sciences,beijing 100101,china 2.graduate university of chinese academy of sciences,beijing 100039,china

Ring finger proteins(RNFs) are a subfamily of zinc finger proteins and many of them function as ubiquitin ligases(E3s).Many RNFs are germ cell-specifically expressed and play important roles in spermatogenesis. Previously,we have shown that RNF133 is a testis-specific endoreticulum-associated *** this study,we show that another spermatid-specific gene Rnf148,located 5k-bp upstream of Rnfl33,also encodes an E3 with similar protein domains including a signal peptide,a protease-association domain,a transmembrane domain and a C3HC4 RING finger *** vitro assays showed that RNF148 worked with ubiquitin-conjugating enzymes(E2s) such as UbcH5b and UbcH7,which is involved in endoreticulum associated degradation(ERAD) ***148 co-localized with the reticulum-associated E2 MmUbc6, and co-immunoprecipitated with CD3-.which is a typical substrate in ERAD *** two-hybrid screening revealed that RNF148 physically interacts with ribophorin II(RPNII),which is a component of ***-immunoprecipitation and cycloheximide treatment experiments confirmed that RPNII is not only a partner but also a substrate of *** was highly expressed in spermatogonia and spermatocytes,in which RNF148 was *** negative correlation of the expression of RNF148 and RPNII in mouse testis implied that RPNII is targeted by RNF148 for degradation in *** RPNII is involved in the biosynthesis process of N-glycans on glycoproteins, which has been reported to play key roles in germ cell-Sertoli cell attachment,we propose that RNF148 may inhibit the synthesis of glycoproteins through the degradation of RPNII resulting in the dissociation of germ cell from Sertoli cells and their release into the seminiferous tubules.

关键词： RNF148 RPNII RING E3 ligase ubiquitination spermatogenesis

Structure and Nonlinear Refractive Index of Bismuth Borate Glass

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Journal of Wuhan university of Technology(Materials Science) 2007年第B12期22卷 868-872页

作者：范慧艳胡丽丽 Shanghai Institute of Optical and Fine Mechanics Chinese Academy of Sciences graduate university of chinese academy of sciences Beijing 100039China

The method of conventional glass melting is used to study the glass formation region of Bi2O3-B2O3-TiO2-La2O3 system. The instrument of Differential Scanning Calorimeter （DSC） is used to research the glass stability. Raman spectra and IR spectra are used to speculate on the structure of glasses. The refractive index of glass is measured by prism coupler. With increase of Bi2O3, the glass stability, the amount of [BiO3] group and boron-oxygen loops decrease, while the content of B-O- bond, refractive index and nonlinear refractive index increase.

关键词： bismuth glass glass structure nonlinear refractive index

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景观“源、汇”的动态特性及其量化方法

水土保持研究 2008年第6期15卷 64-67,71页

作者：许申来周昊中国科学院生态环境中心城市与区域国家重点实验室北京100085 中国科学院研究生院北京100039 国家环保部环境规划院北京100012

正确理解景观格局与生态过程的关系是景观生态学研究的关键,尽管基于"源""汇"过程的景观空间负荷对比指数较好地将景观格局与生态过程联系起来,但是对于如何定量刻画"源""汇"景观及其动态特性没有提出科学的方法。针对上述不足,深入分析... 详细信息

正确理解景观格局与生态过程的关系是景观生态学研究的关键,尽管基于"源""汇"过程的景观空间负荷对比指数较好地将景观格局与生态过程联系起来,但是对于如何定量刻画"源""汇"景观及其动态特性没有提出科学的方法。针对上述不足,深入分析了"源"、"汇"景观的动态特性,并从景观阻力与侵蚀力平衡关系的角度提出了定量判断"源""汇"景观格局的方法。这个方法的特点包括:(1)基于土壤侵蚀过程定量判定景观"源、汇"动态;(2)由于景观"源、汇"动态定量判定中充分考虑到降雨和土壤的异质性,对环境背景值不同的地区也适用。(3)从距离、相对高度和坡度3个方面建立景观格局动态评价模型即景观空间负荷对比动态指数,该指数很好地将景观格局动态与生态过程联系在一起,使定量研究和预测景观格局与过程的关系成为可能。通过分析景观空间负荷对比动态指数与流域出口处泥沙监测值的相关性,可以揭示某一流域景观格局对土壤侵蚀过程的影响。

关键词： “源”“汇”景观理论生态过程景观格局动态距离成本模型

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