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子宫颈癌前哨淋巴结活检临床应用中国专家共识

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中华肿瘤杂志 2021年第10期43卷 981-988页

作者：中国研究型医院学会妇产科学专业委员会李斌王建六胡元晶陈晓军宋艳沈丹华不详国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院妇科100021 北京大学人民医院妇产科 100044 天津市中心妇产科医院妇瘤科复旦大学附属妇产科医院妇科国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院病理科北京大学人民医院病理科

子宫颈癌是妇科常见的恶性肿瘤。大多数早期子宫颈癌患者接受了不必要的系统盆腔淋巴结切除,增加了手术并发症的风险。目前,前哨淋巴结活检在国外已经应用于子宫颈癌的临床实践,但在中国尚处于起步阶段,亟需应用和推广。中国研究型医院... 详细信息

子宫颈癌是妇科常见的恶性肿瘤。大多数早期子宫颈癌患者接受了不必要的系统盆腔淋巴结切除,增加了手术并发症的风险。目前,前哨淋巴结活检在国外已经应用于子宫颈癌的临床实践,但在中国尚处于起步阶段,亟需应用和推广。中国研究型医院学会妇产科学专业委员会邀请中国妇科肿瘤领域专家,基于当前研究现状,对子宫颈癌前哨淋巴结活检的应用价值、患者评估、技术方法、操作要点、病理检测等诸多关键性问题进行探讨,达成子宫颈癌前哨淋巴结活检临床应用中国专家共识,以指导子宫颈癌前哨淋巴结活检在中国的规范化开展。

关键词：子宫颈肿瘤前哨淋巴结活检前哨淋巴结诊断准确性临床应用专家共识

Ability of Mn2. to Permeate the Eye and Availability of Manganese-enhanced Magnetic Resonance Imaging for Visual Pathway Imaging via Topical Administration

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Chinese Medical Journal 2016年第15期129卷 1822-1829页

作者： Yao Chen Chun-Yan shi Ying Li Yun-Tao Hu Hong-Bin Han Xiao-Dong sun salyajeel s salvi Zhi-Zhong Ma department of ophthalmology Key Laboratory of Vision Loss and Restoration Ministry of Education Peking University Third Hospital Beijing 100191 China department of Radiology Key Laboratory of Magnetic Resonance Imaging Equipment and Technology Peking University Third Hospital Beijing 100083 China department of ophthalmology Beijing Tsinghua Chang Gung Hospital Beijing 102218 China department of ophthalmology Affiliated First People's Hospital of Shanghai Jiao Tong University Shanghai 200080 China

Background： Manganese-enhanced magnetic resonance imaging （MEMR1） for visual pathway imaging via topical administration requires further research. This study investigated the permeability of the corneal epithelium and corneal toxicity after topical administration of Mn2. to understand the applicability of MEMR1. Methods： Forty New Zealand rabbits were divided into 0.05 mool/L, 0.10 mol/L, and 0.2. mol/L groups as well as a control group （n ： 10 in each group）. Each group was i-hrther subdivided into epithelium-removed and epithelium-intact subgroups （n = 5 in each subgroup）. Rabbits were given 8 drops of MnCl2.in 5 min intervals. The Mn2. concentrations in the aqueous and vitreous humors were analyzed using inductively coupled plasma-mass spectrometry at different time points. MEMRI scanning was carried out to image the visual pathway after 2. h. The corneal toxicity of Mn2. was evaluated with corneal imaging and pathology slices. Results： Between the aqueous and vitreous humors, there was a 10 h lag for the peak Mn2. concentration times. The intraocular Mn2. concentration increased with the concentration gradients ofMn2. and was higher in the epithelium-removed subgroup than that in the epithelium-intact subgroup. The enhancement of the visual pathway was achieved ill the 0.10 mol/L and 0.2. mol/L epithelium-removed subgroups. The corresponding peak concentrations of Mn2. were 5087 ~ 666 ng/ml, 2.92. ± 1188 ng/ml ill the aqueous humor and 884 ± 78 ng/ml, 2.56 ± 492.ng/ml in the vitreous body, respectively. Corneal injury was evident in the epithelium-removed and 0.2. mol/L epithelium-intact subgroups. Conclusions： The corneal epithelium is a barrier to Mn2., and the iris and lens septum might be another intraocular banier to the permeation of Mn2.. An elevated Mn2. concentration contributes to the increased permeation of Mn2., higher MEMRI signal, and corneal toxicity. The enhancement of the visual pathway requires an effective Mn2. concentration in the vitreous bo

关键词： Corneal Permeability Manganese Manganese-enhanced Magnetic Resonance Imaging Optic Nerve superior Colliculus Topical Toxicity Visual Pathway

Assessing the association of appropriateness of coronary revascularization and 1-year clinical outcomes for patients with stable coronary artery disease in China

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Chinese Medical Journal 2020年第1期133卷 1-8页

作者： shen Lin Heng Zhang Chen-Fei Rao si-Peng Chen shu-Bin Qiao Hong-Bing Yan Ke-Fei Dou Yong-Jian Wu Yi-Da Tang Xin-Chun Yang Zhu-Jun shen Jian Liu Zhe Zheng National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Cardiovascular surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Information Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Cardiology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Cardiology Peking University People's HospitalBeijing 100044China.

Background:The Chinese appropriate use criteria(AUC)for coronary revascularization was released in 2.16 to improve the use of coronary *** study aimed to evaluate the association between the appropriateness of coronary revascularization based on the Chinese AUC and 1-year outcomes in stable coronary artery disease(CAD)***:We conducted a prospective,multi-center cohort study of stable CAD patients with coronary lesion stenosis≥50%.After the classification of appropriateness based on Chinese AUC,patients were categorized into the coronary revascularization group or the medical therapy group based on treatment *** primary outcome was a composite of death,myocardial infarction,stroke,repeated revascularization,and ischemic symptoms with hospital ***:From August 2.16 to August 2.17,6085 patients were consecutively *** revascularization was associated with a lower adjusted hazard of 1-year major adverse cardiovascular and cerebrovascular events(MACCEs;hazard ratio[HR]:0.62.95%confidence interval[CI]:0.45-0.86;P=0.004)than medical therapy in patients with appropriate indications(n=1617).No significant benefit in 1-year MACCEs was found after revascularization compared to after medical therapy in patients with uncertain indications(n=2.58,HR:0.81;95%CI:0.52.1.2.;P=0.338)and inappropriate indications(n=1810,HR:0.80;95%CI:0.51-1.2.;P=0.308).Conclusions:In patients with appropriate indications according to Chinese AUC,coronary revascularization was associated with significantly lower risk of MACCEs at 1 *** benefit was found in coronary revascularization in patients with inappropriate *** findings provide evidence for using Chinese AUC to guide clinical decision-making.

关键词： stable coronary artery disease Appropriate use criteria Coronary revascularization

老年髋部骨折患者围术期下肢深静脉血栓基础预防专家共识(2.2.版)

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中华创伤杂志 2024年第9期40卷 769-780页

作者：韩云贾飞飞鹿青肖杏玲林华应瑛丁俊琴桂敏苏晓静陈亚萍张萍许芸黄天雯陈佳丽王谊樊落董芳辉周文娟罗婉霞徐晓燕邓春花陈小华郑玉柳易德坤张林潘韩丽陈洁庄凯鹏周阳眭文洁宁宁吴松梅郭锦丽胡三莲李伦兰孔祥燕余慧朱一飞余锡芬陈晨李水霞高远李秀婷冯乐玲中华护理学会骨科护理专业委员会中国医疗保健国际交流促进会骨科分会护理学部深圳市第二人民医院深圳518035 宁波市第六医院宁波315040 河北医科大学第三医院石家庄050051 南方医科大学第三附属医院广州510630 西安交通大学附属红会医院西安710054 中国人民解放军总医院第一医学中心北京100853 北京协和医院北京100730 南方医科大学南方医院广州510515 中山大学附属第一医院广州510080 四川大学华西医院成都610041 温州医科大学附属第二医院温州325000 兰州大学第一医院兰州730000 上海交通大学医学院附属第六人民医院上海200233 华中科技大学同济医学院附属协和医院武汉430022 佛山市三水区人民医院佛山528100 中国人民解放军联勤保障部队第九二〇医院昆明650032 东南大学附属中大医院南京210009 重庆市人民医院重庆400010 福建医科大学附属第一医院福州350004 陆军军医大学第二附属医院重庆400037 西安交通大学第二附属医院西安710004 重庆医科大学附属第一医院重庆400016 中国人民解放军联勤保障部队第九四〇医院兰州730050 中南大学湘雅医院长沙410008 苏州大学附属第一医院苏州215006 河南省洛阳正骨医院(河南省骨科医院) 郑州450018 山西医科大学第二医院太原030001 安徽医科大学第一附属医院合肥230022 北京大学人民医院北京100044 不详

老年髋部骨折具有高发生率、高致残率、高病死率的特点,已成为威胁老年人健康的公共卫生问题。手术是老年髋部骨折的首选治疗手段,但围术期下肢深静脉血栓(DVT)的发生率极高,一旦进展为肺栓塞将显著增加患者死亡风险。针对这一问题,临... 详细信息

老年髋部骨折具有高发生率、高致残率、高病死率的特点,已成为威胁老年人健康的公共卫生问题。手术是老年髋部骨折的首选治疗手段,但围术期下肢深静脉血栓(DVT)的发生率极高,一旦进展为肺栓塞将显著增加患者死亡风险。针对这一问题,临床指南和专家共识均强调对此类患者应积极采取基础预防、物理预防、药物预防的全面预防措施。在此预防体系中,基础预防是物理和药物预防的基石。目前,临床上对于基础预防措施缺乏统一明确的标准。为此,中华护理学会骨科专业委员会与中国医疗保健国际交流促进会骨科分会护理学部组织相关护理专家,结合循证医学证据和专家临床经验,制订《老年髋部骨折患者围术期下肢深静脉血栓基础预防专家共识(2.2.版)》,共提出10条推荐意见,以规范老年髋部骨折患者围术期下肢DVT的基础预防措施,促进患者康复。

关键词：髋骨折老年人静脉血栓形成专家共识

急性缺血性卒中合并心脏病患者血压管理专家共识

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中华内科杂志 2021年第4期60卷 306-313页

作者：中国医疗保健国际交流促进会高血压分会北京脑血管病防治协会孙宁玲赵性泉许杰陈源源陈鲁原李建平张新军刘靖马志毅不详北京大学人民医院高血压研究室 100044 首都医科大学附属北京天坛医院神经内科 100070 首都医科大学附属北京天坛医院神经病学中心广东省人民医院心内科高血压研究室北京大学第一医院心血管内科四川大学华西医院老年医学中心北京大学人民医院心血管内科

急性缺血性卒中的血压管理不同于陈旧缺血性卒中的血压管理。当急性缺血性卒中合并心脏病(如急性心肌梗死或心力衰竭等)时,对于血压管理的要求就变得更加复杂。本共识围绕急性缺血性卒中合并急慢性冠状动脉综合征、合并心力衰竭等临床... 详细信息

急性缺血性卒中的血压管理不同于陈旧缺血性卒中的血压管理。当急性缺血性卒中合并心脏病(如急性心肌梗死或心力衰竭等)时,对于血压管理的要求就变得更加复杂。本共识围绕急性缺血性卒中合并急慢性冠状动脉综合征、合并心力衰竭等临床复杂情况,对降压时机、降压目标、降压用药及处置流程等进行专家意见的总结。

关键词：血压疾病管理急性缺血性卒中心脏病

Evaluation of Circulating Endometrial Cells as a Biomarker for Endometriosis

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Chinese Medical Journal 2017年第19期130卷 2339-2345页

作者： Ying Chen Hong-Lan Zhu Zhe-Wen Tang Kuang Hong Neoh Dong-Fang Ouyang Heng Cui Hong-Yan Cheng Rui-Qiong Ma Xue Ye Ray P. s. Han Xiao-Hong Chang Gynecological Oncology Center Peking University People's Hospital Beijing 100044 China department of Materials science and Engineering Peking University Beijing 100871 China department of Mechanical and Industrial Engineering University of Toronto Toronto Ontario M5S 3G8 Canada

Background： Circulating endometrial cells （CECs） have been reported to be present in the peripheral blood of women with endometriosis （EM）, providing clear and specific evidence of the presence of ectopic lesions. In this study, we established a method with a high detection rate of CECs, assessed the diagnostic value of CECs for EM and compared with serum CA12., and proposed a hypothesis for the pathogenesis of EM from the new perspective of CECs. Methods： The participants were enrolled prospectively from October 2.15 to July 2.16. The peripheral blood samples were collected from 59 participants, and the blood cells were isolated for immunofluorescence staining via microfluidic chips. The cells that were positive for vimentin/cytokeratin and estrogen/progesterone receptor and negative for CD45 were identified as CECs. The serum CA12. level was tested with electrochemiluminescence immunoassay. Results： The detection rate of CECs reached 89.5% （17/19） in the EM group, which was significantly higher than that of the control group （15.0% [6/40], P 〈 0.001） and was independent of menstrual cycle phases. Furthermore, a positive CEC assay detected 4/5 cases of stage Ⅰ–Ⅱ EM. In contrast, a positive CA12. test had limited value in detecting EM （13/19, 68.4%） and detected only one case of stage Ⅰ–Ⅱ EM. Conclusion： CECs are promising biomarkers for EM with great potential for a noninvasive diagnostic assay.

关键词： Biomarker Circulating Endometrial Cells Clinical Diagnosis Endometriosis Pathogenesis

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北京社区冠心病患者阿司匹林应用状况分析

中华全科医师杂志 2019年第2期18卷 134-138页

作者：马志毅吴立平杜雪平孙宁玲北京社区阿司匹林规范化行动协作组北京大学人民医院心内科 100044 拜耳医药保健有限公司北京100020 首都医科大学附属复兴医院月坛社区卫生服务中心北京100045 不详

目的了解基层社区冠心病患者在二级预防中的阿司匹林使用情况及其原因。方法采用横断面问卷调查的方式,于2.14年9月至2.15年1月由北京市60家社区卫生服务中心全科医生对就诊的冠心病患者进行阿司匹林使用现状进行调查,分析患者服药... 详细信息

目的了解基层社区冠心病患者在二级预防中的阿司匹林使用情况及其原因。方法采用横断面问卷调查的方式,于2.14年9月至2.15年1月由北京市60家社区卫生服务中心全科医生对就诊的冠心病患者进行阿司匹林使用现状进行调查,分析患者服药持续时间、服用剂量、服药时间、中途停药原因、未使用原因等情况。结果共发放调查问卷61 000份,收回问卷56 969份(有效回收率93.39%)。其中冠心病患者2. 931例。有≥1条诊断依据的冠心病患者中78.2.%(15 105/19 311)服用阿司匹林,自报冠心病而无诊断依据者中81.42.(1 319/1 62.)应用阿司匹林,两者间差异有统计学意义(χ^2.9.06,P<0.01)。有无早发心血管家族史的有诊断依据冠心病患者的阿司匹林使用率差异无统计学意义(P=0.77)。有冠心病诊断依据而未服用阿司匹林的患者中汇报原因按比例由高至低分别为:不明原因的拒绝、担心胃肠道反应、已服用氯吡格雷、不是阿司匹林适用人群、服用其他抗血小板药物。结论北京基层社区卫生机构中就诊的冠心病患者整体阿司匹林服用比例较高,未服用阿司匹林的患者主要原因集中于患者主观拒绝和担心胃肠道不良反应方面,这仍将是未来冠心病二级预防治疗宣教的重点。

关键词：冠状动脉疾病阿司匹林社区卫生中心

建立中国老年骨质疏松症三级防控体系专家共识

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中华内科杂志 2022年第6期61卷 617-630页

作者： “建立中国老年骨质疏松症三级防控体系专家共识”编写组中国老年保健医学研究会老年骨质疏松分会中国老年保健医学研究会老年内分泌代谢分会北京医学奖励基金会老年医学专业委员会国家老年疾病临床医学研究中心(解放军总医院) 李春霖纪立农潘琦不详解放军总医院第二医学中心内分泌科国家老年疾病临床医学研究中心(解放军总医院)北京100853 北京大学人民医院内分泌科北京100044 北京医院内分泌科国家老年医学中心北京100730

骨质疏松症患病率高、认知率低、诊断治疗率低,其严重并发症骨质疏松性骨折治疗费用高、致残率及病死率高,严重影响老年人的身心健康。建立老年骨质疏松症的三级防控体系,采取预防为主、防治结合、分层诊疗、全周期管理的策略,提高全社... 详细信息

骨质疏松症患病率高、认知率低、诊断治疗率低,其严重并发症骨质疏松性骨折治疗费用高、致残率及病死率高,严重影响老年人的身心健康。建立老年骨质疏松症的三级防控体系,采取预防为主、防治结合、分层诊疗、全周期管理的策略,提高全社会对骨骼健康知识的认知,明确各级医疗机构在骨质疏松防治中的定位,整合医疗资源,降低骨质疏松症及其骨折的危害,对实现健康中国战略具有重大意义。

关键词：骨质疏松老年人三级防控

The sUPER reporting guideline suggested for reporting of surgical technique

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Hepatobiliary surgery and Nutrition 2023年第4期12卷 534-544,I0024-I0026页

作者： Kaiping Zhang Yanfang Ma Jinlin Wu Qianling shi Leandro Cardoso Barchi Marco scarci Rene Horsleben Petersen Calvin s.H.Ng steven Hochwald Ryuichi Waseda Fabio Davoli Robert Fruscio Giovanni Battista Levi sandri Michel Gonzalez Benjamin Wei Guillaume Piessen Jianfei shen Xianzhuo Zhang Panpan Jiao Yulong He Nuria M.Novoa Benedetta Bedetti sebastien Gilbert Alan D.L.sihoe Alper Toker Alfonso Fiorelli Marcelo F.Jimenez Toni Lerut Aung Y.Oo Grace s.Li Xueqin Tang Yawen Lu Hussein Elkhayat Tomaz stupnik Tanel Laisaar Firas Abu Akar Diego Gonzalez-Rivas Zhanhao su Bin Qiu stephen D.Wang Yaolong Chen shugeng Gao Editorial Office AME Publishing CompanyHong KongChina school of Chinese Medicine Hong Kong Baptist UniversityHong KongChina department of Cardiovascular surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Evidence-based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina Lanzhou university Institute of Health Data science LanzhouChina Digestive surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineSão PauloBrazil department of Cardiothoracic surgery Imperial College Healthcare NHS TrustLondonUK department of Cardiothoracic surgery University Hospital of CopenhagenRigshospitaletCopenhagenDenmark The Chinese university of Hong Kong Prince of Wales HospitalShatinNew TerritoriesHong KongChina department of surgical Oncology Roswell Park Cancer InstituteBuffaloNYUSA department of General Thoracic Breast and Pediatric SurgeryFukuoka UniversityFukuokaJapan department of Thoracic surgery AUSL RomagnaS.Maria delle Croci Teaching HospitalRavennaItaly Clinic of Obstetrics and Gynecology University of Milan-BicoccaSan Gerardo HospitalMonzaItaly Division of General surgery and Liver Transplantation S.Camillo HospitalRomeItaly service of Thoracic surgery Lausanne University Hospital(CHUV)LausanneSwitzerland Division of Cardiothoracic surgery Department of SurgeryUniversity of Alabama BirminghamBirminghamALUSA university of Lille CNRSInsermCHU LilleUMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to TherapiesLilleFrance department of Cardiothoracic surgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhaiChina The First school of Clinical Medicine Lanzhou UniversityLanzhouChina Thoracic surgery service University Hospital of SalamancaBiomedical Institute of SalamancaSalamancaSpain department of Thoracic surgery Helios Clinic Bonn/Rhein SiegBonnGermany Division of Thoracic surgery Department of SurgeryThe Ottawa

Background:Existing reporting guidelines pay insufficient attention to the detail and comprehensiveness reporting of surgical *** surgical techniqUe rePorting chEcklist and standaRds(sUPER)aims to address this gap by defining reporting standards for surgical *** sUPER guideline intends to apply to articles that encompass surgical technique in any study design,surgical discipline,and stage of surgical ***:Following the EQUATOR(Enhancing the QUAlity and Transparency Of health Research)Network approach,16 surgeons,journal editors,and methodologists reviewed existing reporting guidelines relating to surgical technique,reviewed papers from 15 top journals,and brainstormed to draft initial items for the *** initial items were revised through a three-round Delphi survey from 2. multidisciplinary Delphi panel experts from 13 countries and *** final sUPER items were formed after an online consensus meeting to resolve disagreements and a three-round wording refinement by all 16 sUPER working group members and five sUPER ***:The sUPER reporting guideline includes 2. items that are considered essential for good and informative surgical technique *** items are divided into six sections:background,rationale,and objectives(items 1 to 5);preoperative preparations and requirements(items 6 to 9);surgical technique details(items 10 to 15);postoperative considerations and tasks(items 16 to 19);summary and prospect(items 2. and 2.);and other information(item 2.).Conclusions:The sUPER reporting guideline has the potential to guide detailed,comprehensive,and transparent surgical technique reporting for *** may also assist journal editors,peer reviewers,systematic reviewers,and guideline developers in the evaluation of surgical technique papers and help practitioners to better understand and reproduce surgical technique.

关键词： surgical technique surgical innovation reporting guideline reporting checklist surgical techniqUe rePorting chEcklist and standaRds(sUPER)