检索结果-南通市图书馆

Tracheal compliance and limit flow rate changes in a murine model of asthma

Science china(Life Sciences) 2008年第10期51卷 922-931页

作者： TENG ZhongZhao1, WANG YiQin2. LI FuFeng2. YAN HaiXia2.& LIU ZhaoRong3 1 Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA, 01609, USA 2.syndrome laboratory of tcm, shanghai university of traditional chinese medicine, {2. 2.12.3, china 3 Department of Mechanics and Engineering Science, Fudan university, {2. 2.0433, china Department of Mathematical Sciences Worcester Polytechnic Institute Worcester USA syndrome laboratory of {2. Shanghai University of Traditional Chinese Medicine Shanghai China Department of Mechanics and Engineering Science Fudan University Shanghai China

Trachea is the unique passage for air to flow in and out. Its tone is of importance for the respiration system. However, investigation on how tracheal tone changes due to asthma is limited. Aiming at studying how the mechanical property changes due to asthma as well as the compliance and flow limitation, the following methods are adopted. Static and passive pressure-volume tests of rats' trachea of the asthmatic and control groups are carried out and a new type of tube law is formulated to fit the experimental data, based on which changes of compliance and limit flow rate are investigated. In order to give explanation to such changes, histological examinations with tracheal soft tissues are made. The results show that compliance, limit flow rate and material constants included in the tube law largely depend on the longitudinal stretching ratio. Compared with the control group, the tracheal compliance of asthmatic animals decreases significantly, which results in an increased limit flow rate. Histological studies indicate that asthma can lead to hyperplasia/hypertrophy of smooth muscle cells, and increase elastin and collagen fibres in the muscular membrane. Though decreasing compliance increases sta- bility, during the onset of asthma, limit flow rate is much smaller due to the lower transmural pressure. Asthma leads to a stiffer trachea and the obtained results reveal some aspects relevant to asthma-induced tracheal remodelling.

关键词： trachea asthma collapse tube law compliance limit flow rate remodelling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

卫气虚证诊断规范

引用

北京中医药大学学报 2024年第8期47卷 1177-1179页

作者：北京中医药大学福建中医药大学河南中医药大学天津中医药大学第二附属医院广州中医药大学第二附属医院云南中医药大学第三附属医院王天芳不详

1范围本文件规定了卫气虚证诊断标准与卫气虚证严重程度评定。本文件适用于中、西医医疗机构,健康管理机构及中医治未病机构的医务工作者,对18周岁及以上具有卫气虚证表现的亚健康及疾病人群的卫气虚证诊断与程度评定。

关键词：卫气虚证诊断规范

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

traditional chinese {2. Clinical Experience of the Treatment for Irritable Bowel syndrome

引用

chinese Journal of Integrative medicine 2009年第2期15卷 93-94页

作者：唐志鹏 Department of Gastroenterology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Digestive DiseaseShanghai University of Traditional Chinese Medicine

Irritable bowel syndrome (IBS) is a functional bowel disorder that includes abdominal pain or discomfort associated with defecation or a change in bowel habits with features of disordered *** disease lacks morphologic... 详细信息

关键词： IBS traditional chinese {2. Clinical Experience of the Treatment for Irritable Bowel syndrome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relationship between CT grouping and complications of liver cirrhosis

引用

Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 219-223页

作者： Min-Guang Zhang, Xue-Jing Huang, Qiong Zhu, Jian Geng and An-Jun Zhang Department of Radiology, shanghai Hospital of traditional {2. medicine, shanghai 2.0071 , china Department of Radiology, Shuguang Hospital, shanghai university of traditional chinese medicine, shanghai 2.002. , china Department of Radiology Shanghai Hospital of Traditional Chinese Medicine Shanghai 200071 China. mgzhang09@***

BACKGROUND: Imaging examination is important for hepatic cirrhosis. But the relationship between magnetic resonance (MR), computed tomography (CT) or ultrasound findings and pathological groups, degree, or reserve function of the cirrhotic liver is not clear. In this study, we investigated the relationship between the CT groupings of liver cirrhosis and its complications and clinical conditions. METHODS: The CT findings in 357 patients with liver cirrhosis were grouped. The complications were analyzed, included splenomegaly, varicose collateral veins, ascites, pleurorrhea, primary liver carcinoma, gallbladder stone, etc. Blood routine (BRt), and serum usea nitrogen (SUN), creatinine and uric acid were measured and hypersplenia and liver-kidney syndrome were estimated. RESULTS: Three hundred and fifty-seven patients with cirrhosis were divided into homogeneous group (87 patients, 2..4%), segmental group (41, 11.5%), and nodal group (2.9, 64.2.). The grade of spleen enlargement in the segmental and the nodal groups was significantly greater than that in the homogeneous group (P 2.3%), respectively. Significant difference was observed among the 3 groups ( P 2.patients (79.5%) of the nodal group, in 11 patients (2..8%) of the segmental group and in 9 patients ( 10.3%) of the homogeneous group (P2..7%) in the nodal group had primary liver carcinoma and 1 (2.4%) in the segmental group and 5 (5.8%) in the homogeneous group (P<0.001). The number of patients with decreased concentration of hematoglobin in the nodal group was more than that in the homogeneous group ( P < 0. 001). The mean values of hematoglobin and platelet in the nodal group and the segmental group were significantly lower than those in the homogeneous group ( P < 0. 05 ). The number of

关键词： grouping cirrhosis complication computed tomography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lipopolysaccharide “Two-hit” Induced Refractory Hypoxemia Acute Respiratory Distress Model in Rats

引用

Journal of Huazhong university of Science and Technology(Medical Sciences) 2009年第4期29卷 470-475页

作者：李玉梅卫洪昌 Department of Pathology College of Basic MedicinesShanghai University of Traditional Chinese Medicine

To establish a stable and reliable model of refractory hypoxemia acute respiratory distress syndrome （ARDS） and examine its pathological mechanisms, a total of 144 healthy male Wistar rats were randomized into 4 groups： group Ⅰ （saline control group）, group Ⅱ （LPS intravenous ＂single-hit＂ group）, group Ⅲ （LPS intratracheal ＂single-hit＂ group） and Group IV （LPS ＂two-hit＂ group）. Rats were intravenously injected or intratracheally instilled with a large dose of LPS （10 mg/kg in 0.5 mL） to simulate a single attack of ARDS, or intraperitoneally injected with a small dose of LPS （1 mg/kg） followed by tracheal instillation with median dose of LPS （5 mg/kg） to establish a ＂two-hit＂ model. Rats in each group were monitored by arterial blood gas analysis and visual inspection for three consecutive days. Arterial blood gas values, lung wet/dry weight ratio and pathological pulmonary changes were analyzed to determine the effects of each ALI/ARDS model. Concentrations of TNF-α, IL-1 and IL-10 in the bronchoalveolar lavage fluid （BALF） and blood plasma were meastired by using enzyme-linked immunosorbent assays （ELISA）. Our resulsts showed that single LPS-stimulation, whether through intravenous injection or tracheal instillation, could only induce ALl and temporary hypoxemia in rats. A two-hit LPS stimulation induces prolonged hypoxemia and specific pulmonary injury in rats, and is therefore a more ideal approximation of ARDS in the animal model. The pathogenesis of LPS two-hit-induced ARDS is associated with an uncontrolled systemic inflammatory response and inflammatory injury. It is concluded that the rat ARDS model produced by our LPS two-hit method is more stable and reliable than previous models, and closer to the diagnostic criteria of ARDS, and better mimics the pathological process of ARDS.

关键词： acute respiratory distress syndrome (ARDS) acute lung injury (ALl) lipopolysaccharide (LPS) rat animal model systemic inflammatory response syndrome (SIRS) tumor necrosis factor-α (TNF-α) IL- 1 IL- 10

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Back to the future of oridonin: again,compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo

引用

Cell Research 2007年第4期17卷 274-276页

作者： Guang-Biao Zhou~(1,2. Sai-Juan Chen~1 Zhen-Yi Wang~1 Zhu Chen~1 ~1State Key laboratory of Medical Genomics and shanghai Institute of Hematology,Ruijin Hospital Affiliated to shanghai Jiao Tong university School of medicine,197 Ruijin Road II,shanghai 2.002.,china ~2.uangzhou Institute of Biomedicine and Health,chinese Academy of Sciences,Guangzhou Science Park,Guangzhou 510663,china State Key laboratory of Medical Genomics and shanghai Institute of Hematology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences Guangzhou Science Park Guangzhou China

traditional chinese {2.(tcm)has been widelyand successfully used in treating illnesses ranging frominflammation to cancer,and compounds from medicinalherbs and minerals are playing more and more importantroles in taming various kinds of diseases[1],exemplifiedby artemisinin and arsenic trioxide(ATO).Artemisinin(or Qinghaosu in chinese)is isolated from a plant calledsweet wormwood(Artemisia annua;or Qinghao in Chi-nese)which has been used as an antipyretic remedy formore than 1500 years in *** has impressiveparasiticidal properties in vitro and in vivo,and is now oneof the most important class of antimalarial agents[2.3].ATO is a common,naturally occurring substance whichhad been used in china for a long time as a therapeuticagent for some severe diseases with the ancient philosophyof'treating an evil with a toxic'[4].In 1990s,ATO wasshown to be able to cause partial differentiation at low doseand apoptosis at high concentration of acute promyelocyticleukemia(APL)cells[5],and induce complete remissionin 90% of patients with relapsed or refractory APL[6-8].

关键词： AML Back to the future of oridonin again,compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A novel evaluation method for the synchronicity of drug release based on the mathematics set for preparation of a tcm drug delivery system

A novel evaluation method for the synchronicity of drug rele...

引用

2.12.中国药学大会暨第十二届中国药师周

作者： Lan SHEN 1,2,Yu ZHAI 1,Wenjuan CONG 2,Xiao LIN 1,2,Shiyu MA 1,Yi FENG 2,Kefeng RUAN 2 1 School of traditional chinese medicine,shanghai university of traditional chinese medicine,shanghai 2.12.3,P.R.china 2 Engineering Research Center of Modern Preparation Technology of traditional chinese medicine of Ministry of Education,shanghai university of traditional chinese medicine,shanghai 2.12.3,P.R. china.

The quantitative characterization and evaluation of the synchronization of multi component release behavior are urgently needed to solve bottlenecks in multicomponent release kinetics and the quality control of traditional chinese {2. （tcm）.Existing research of tcm drug delivery systems （tcmDDS） has been confined to studying the release characteristics of a single or a few components,but the correlation of active ingredients and efficacy is not ***,the reported evaluation method is too macroscopic,and unable to specifically identify the components which caused the integral *** a result,this evaluation method cannot provide a valid foundation for the design of *** this paper,a novel evaluation method for the synchronicity of drug release based on the mathematics set for tcmDDS has been *** Fang was selected as the model drug and this new evaluation method utilized to guide the optimization of the release unit types and the dose ratio of Fuzhenghuayu *** method was shown to be highly sensitive,stable and reproducible,providing a quantitative assessment of drug release characteristics of multicomponent ***,it may guide the optimal combination of release units,thus providing a basis for the construction of a scientific tcmDDS.

关键词： mathematics set evaluation method of the synchronicity fingerprint chromatography traditional chinese {2. drug delivery system

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A LINEAR DYNAMIC MODEL DESCRIBING LYMPH CIRCULATION

引用

Journal of Hydrodynamics 2009年第1期21卷 118-123页

作者： YAO Wei WANG Sheng-zhang DING Guang-hong SHEN Xue-yong Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China shanghai Research Center of Acupuncture and Meridian Shanghai 201203 China Acupuncture Department of shanghai university of traditional chinese medicine Shanghai 200032 China

The lymph circulation plays an important role in interstitial fluid balance, protein transport, and immune system. However, its mechanism is poorly understood, and associated pathologies are mostly untreatable. By following Sungawa＇s method of discussing the heart output, a hemodynamic model of lymph circulation was set up. The model was used to demonstrate how the lymphatic fluid formation, investigate the relationship between the lymph flow rate QL and physiological parameters, and explore how local massage influences QL Computer simulation results show that QL is linearly proportional to the interstitial fluid pressure P~, which is similar to experimental observations. Comparing the simulated value of QL during the massage of different frequency with the experimental data from Ikomi shows that they are identical, which indicates that the presented model is rational to explain the mechanism of massage treatment in traditional chinese {2. （tcm）.

关键词： lymph circulation pressure-volume circle equivalent elastance massage treatment in tcm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中医治疗血液病名家学术观点撷菁Ⅳ

引用

北京中医药大学学报 2024年第6期47卷 813-817页

作者：中华中医药学会血液病分会中华中医药学会血液病创新研究与转化平台王金环(整理) 侯丽不详黑龙江中医药大学附属第一医院中华中医药学会血液病分会北京中医药大学东直门医院

为更好地传承与发展名老中医学术思想,中华中医药学会血液病分会、中华中医药学会血液病创新研究与转化平台对陶淑春、顾振东、吴志奎、虞荣喜、周仲瑛5位教授的学术思想与临床诊疗经验进行总结。其中,陶淑春教授遵循病机,结合脏腑及部... 详细信息

为更好地传承与发展名老中医学术思想,中华中医药学会血液病分会、中华中医药学会血液病创新研究与转化平台对陶淑春、顾振东、吴志奎、虞荣喜、周仲瑛5位教授的学术思想与临床诊疗经验进行总结。其中,陶淑春教授遵循病机,结合脏腑及部位诊治,在临证中重视活血化瘀法的应用;顾振东教授创立急性白血病辨证体系并总结脉证规律,提倡中西医结合治疗本病;吴志奎教授提出地中海贫血的病机及治法,应用益髓生血颗粒治疗本病,取得较好疗效;虞荣喜教授提出白血病的中医辨证体系,实现中西医结合治疗本病;周仲瑛教授完善中医内科学辨证论治体系,创立中医病机辨证学说,应用“瘀热”学说及“癌毒论”治疗血液病。本研究的目的是培养和提高中医血液病学后备人才的能力、推动学科建设,同时,为中医药事业的传承与发展提供宝贵的财富。

关键词：中医血液病名老中医学术思想诊疗经验传承

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SCAP gene polymorphisms decrease the risk of non-alcoholic fatty liver disease in female metabolic syndrome subjectsr

SCAP gene polymorphisms decrease the risk of non-alcoholic f...

引用

第二十一次全国中西医结合肝病学术会议

作者： Shanshan Sun 1,Miao Wang (1,2),Haiyan Song 1,Tao Wu (1,3),Huafeng Wei (1,2),Songhua He 2,Zhaoguo Ding 5,Guang Ji (1,4) 1.Institute of Digestive Disease,Longhua Hospital,shanghai university of traditional chinese medicine, shanghai 200032,china 2.Department of Internal medicine of traditional chinese medicine,Longhua Hospital,shanghai university of traditional chinese medicine,shanghai 200032,china 3.Center of chinese medicine therapy and systems biology,shanghai university of traditional chinese medicine, shanghai 2.12.3,china 4.E-institute of shanghai Municipal Education Commission,shanghai university of traditional chinese medicine,shanghai 2.12.3,china 5.Department of Statistics,Uppsala university,Uppsala,Sweden.

Background:The prevalence of Nonalcoholic fatty liver disease(NAFLD)in metabolic syndrome(MS) population is much higher than that in non-MS,NAFLD is recognized as the hepatic additional and specific manifestation of *** variants in the human SREBF-1,SREBF-2.and SCAP genes have been demonstrated to associate with dyslipidemia,meanwhile metabolism of cholesterol and fatty acids plays an important role in the pathogenesis of NAFLD,so we hypothesized that some variants in these genes may be associated with NAFLD. Method:A total of 363 unrelated individuals were enrolled in this study,in which 100 were healthy control subjects and 2.3 diagnosed as MS(160 complicated with NAFLD,103 without NAFLD).In total,14 tag SNPs of SREBF-1,SREBF-2.and SCAP were chosen for our study. Result:The rs2.012.7 of SCAP was significantly different between MS+NAFLD group and MS-NAFLD group,but the statistical significance was only observed in *** with the GG genotype, the variant genotypes GA/GG of rs2.012.7 were associated with a significantly decreased risk for NAFLD(adjusted OR,0.2.1;95%CI,0.061-0.664;P=0.009/adjusted OR,0.184;95%CI, 0.053-0.640;P=0.008)in female *** neither the lipid levels nor BMI were significant differences among GG,GA and AA genotypes. Conclusion:The present study demonstrates SCAP rs2.012.7 A allele might decrease the risk of NAFLD in female MS *** studies are warranted to replicate this finding in independent and larger populations.

关键词： genetic polymorphism Nonalcoholic fatty liver disease,SCAP

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：