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核开关:一个新的基因调控元件,一类潜在的药物靶点

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生物化学与生物物理进展 2004年第8期31卷 684-687页

作者：骆迎峰陈跃磊浙江大学生命科学学院

核开关是一类通过结合小分子代谢物调控基因表达的mRNA元件 .它位于特定的mRNA区域 ,可以不依赖任何蛋白质因子而直接结合小分子代谢物 ,继而发生构象重排 ,影响该mRNA的活动 .核开关在特定细菌中 ,参与调控包括维生素B12.和甲硫氨酸生... 详细信息

核开关是一类通过结合小分子代谢物调控基因表达的mRNA元件 .它位于特定的mRNA区域 ,可以不依赖任何蛋白质因子而直接结合小分子代谢物 ,继而发生构象重排 ,影响该mRNA的活动 .核开关在特定细菌中 ,参与调控包括维生素B12.和甲硫氨酸生物合成等在内的代谢途径 .核开关的发现 ,尤其是其可以特异性紧密结合特定配体 ,从而精确调控生物基本代谢途径的特征 ,使人们开始关注它在科研和医学上的应用潜力 .核开关的研究进展。

关键词：核开关基因表达调控蛋白质因子配体药物靶点

准二维电荷密度波导体钾紫青铜K_xMo_6O_(17)单晶样品的制备

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物理学报 2004年第3期53卷 895-899页

作者：王俊峰熊锐余恒李慧汤五丰余祖新石兢田德诚田明亮张裕恒武汉大学物理科学与技术学院武汉430072 中国科学技术大学结构分析中心合肥230026

采用碳酸盐替代高钼酸盐电解还原的方法成功制备出了准二维电荷密度波导体钾紫青铜单晶 .通过x射线衍射、透射电子显微术等方法对单晶进行结构分析表明 :晶胞参数a =b =0 5 5 4 0nm ,c =1 3. 0 8nm ,单晶为三角晶系 ,对称群为P3. .电... 详细信息

采用碳酸盐替代高钼酸盐电解还原的方法成功制备出了准二维电荷密度波导体钾紫青铜单晶 .通过x射线衍射、透射电子显微术等方法对单晶进行结构分析表明 :晶胞参数a =b =0 5 5 4 0nm ,c =1 3. 0 8nm ,单晶为三角晶系 ,对称群为P3. .电阻温度关系曲线的测量显示 :钾紫青铜KxMo6 O1 7单晶在

关键词：钾紫青铜电荷密度波 Peierls相变钼酸钾单晶 X射线衍射结构分析晶胞参数

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敏捷制造系统的基于Agent的混合调度

系统仿真学报 2009年第12期21卷 3763-3767页

作者：李应杨善林郑家强合肥工业大学管理学院合肥230009 合肥通用机械研究所合肥230001

针对敏捷制造调度环境的不确定性和动态性,研究了基于分布式多Agent的敏捷制造系统控制结构及混合调度策略。首先,提出多Agent制造控制结构,该结构兼有Agent的自治性和递阶组织(或动态逻辑单元)的协调性。接着,研究了结合模糊规划与模... 详细信息

针对敏捷制造调度环境的不确定性和动态性,研究了基于分布式多Agent的敏捷制造系统控制结构及混合调度策略。首先,提出多Agent制造控制结构,该结构兼有Agent的自治性和递阶组织(或动态逻辑单元)的协调性。接着,研究了结合模糊规划与模糊合同网的混合作业车间调度方案。该方法具有静态调度方法的精确性和合同网方法的动态、灵活性。最后设计算例仿真并验证了方法的可行性与效率。

关键词：多Agent系统调度模糊规划模糊合同网

VORTEX INDUCED VIBRATIONS OF FINNED CYLINDERS

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Journal of Hydrodynamics 2008年第2期20卷 195-201页

作者： SHA Yong WANG Yong-xue Postdoctoral Programme Technology Research Department CNOOC Research Beijing 100027 China State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024China

This article presents the results of a numerical simulation on the vortex induced vibration of various fumed cylinders at low Reynolds number. The non-dimensional, incompressible Navier-Stokes equations and continuity equation were adopted to simulate the fluid around the cylinder. The cylinder （with or without fins） in fluid flow was approximated as a mass-spring system. The fluid-body interaction of the cylinder with fins and uniform flow was numerically simulated by applying the displacement and stress iterative computation on the fluid-body interfaces. Both vortex structures and response amplitudes of cylinders with various arrangements of fins were analyzed and discussed. The remarkable decrease of response amplitude for the additions of Triangle60 fins and Quadrangle45 fins was found to be comparable with that of bare cylinder. However, the additions of Triangle00 fins and Quadrangle00 fins enhance the response amplitude greatly. Despite the assumption of two-dimensional laminar flow, the present study can give a good insight into the phenomena of cylinders with various arrangements of fins.

关键词： vortex induced vibration cylinder with fins fluid-body interaction

research on Multiple Pattern Matching Technology Based on TCAM

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Research on Multiple Pattern Matching Technology Based on TC...

微波消解-原子荧光光谱法测定番茄不同部位中微量汞

2.11 IEEE International Conference on Information Theory and Information Security(ICITIS 2.11)

作者： Lei Guo 1) Yadi Wang 1) Qinrang Liu 2. Ke Zhu 2. 1) Zhengzhou Information Science and Technology Institute Zhengzhou china 2. National Digital Switching System Engineering & Technological research {2. Zhengzhou china

This paper studied on Deep Packet Inspection and the core technology multiple-pattern matching *** the basis of these algorithms,the paper proposed a new multiple-pattern matching algorithm which could accelerate based on *** full advantage of the property of TCAM,the algorithm could achieve better performance,and achieve the demand for line-speed when multiple pattern real time *** the algorithm has lower cost than similar algorithms.

关键词： DPI multiple-pattern matching TCAM

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分析测试学报 2005年第1期24卷 89-92页

作者：朱芳刘翅杨中艺中山大学化学与化学工程学院广东广州510275 中山大学测试中心广东广州510275 中山大学生命科学学院广东广州510275

在汞污染的土壤上种植不同品种番茄 ,采用微波溶样技术和原子荧光光谱法 ,测定番茄不同部位的汞含量 ,初步研究了汞在番茄植株各个部位的分布情况 ,同时确定了微波消解该类样品的最佳条件 ,优化了原子荧光光谱仪的工作参数。该方法具有... 详细信息

在汞污染的土壤上种植不同品种番茄 ,采用微波溶样技术和原子荧光光谱法 ,测定番茄不同部位的汞含量 ,初步研究了汞在番茄植株各个部位的分布情况 ,同时确定了微波消解该类样品的最佳条件 ,优化了原子荧光光谱仪的工作参数。该方法具有快速、简便、准确等特点 ,汞含量在0.01～2.μg/L范围内线性良好 ,相关系数r=0.9998。研究结果还表明 ,汞含量在番茄各部位中的分布规律是根叶>茎果实 ,只有1/10的供试番茄品种在汞胁迫下果实中汞含量超标。

关键词：微波消解原子荧光光谱法番茄汞

Association between apolipoprotein E promoter-2.9G/T polymorphism and total cholesterol level in patients with Alzheimer disease

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Neural Regeneration research 2006年第9期1卷 841-843页

作者： Fang Liu1,2. Xiao Sun1, Jing Wang1, Yan Kong1, Li Cui1, Xiangdang Shi2.1Department of Neurology, Fengtian Hospital, Shenyang Medical College, Shenyang 11002., Liaoning Province, {3. 2.edical university of South Carolina, SC, U.S.A Department of Neurology Fengtian Hospital Shenyang Medical College Shenyang 110024 Liaoning Province China Medical university of South Carolina Charleston SC United States

BACKGROUND: Many researches have suggested that apolipoprotein E (APOE) and total cholesterol metabolism are closely related with dementia. In the supposed theory, 2.9 site of APOE promoter region is near gene coding region, so its polymorphism may result in the abnormality of APOE gene and protein expression, and finally lead to dementia. OBJECTIVE: To observe the association between APOE promoter-2.9G/T polymorphisms with serum total cholesterol in patients with Alzheimer disease, and compare it with non-dementia people. DESIGN: Case-control, comparative observation. SETTING: Department of Neurology, Fengtian Hospital of Shenyang Medical College. PARTICIPANTS: Fifty-five dementia patients including 2. males and 2. females aged (66±3. years and treated in the Department of Neurology, Fengtian Hospital were selected from January 2.02.to December 2.05 as the Alzheimer disease group. They all diagnosed according to the DSM-Ⅳdiagnostic criteria of Alzheimer disease instituted by American Psychiatry Association in 1994. Meanwhile, 44 none-dementia patients including 2. males and 2. females aged (66±3. years were selected from other clinical departments of Fengtian Hospital as control group. All the participants were informed the detection and agreed. METHODS: Genomic DNA was extracted from the peripheral blood of all subjects, then 'NEST'PCR, DNA sequence and enzyme digestion were adopted to detect the expression of APOE promoter-2.9 polymorphism, following by biomedical statistics analysis based on the clinical total cholesterol level. MAIN OUTCOME MEASURES: Polymorphism of APOE promoter-2.9 G/T and total cholesterol level. RESULTS: All 55 dementia patients and 44 non-dementia ones were involved in the result analysis. ①Allele and genotype frequency: The T allele frequency of the Alzheimer disease group was significantly higher than that in the control group [88.2. (97/110), 54.5% (48/88)], while G allele frequency was remarkably lower than that in the control group [1

关键词： Association between apolipoprotein E promoter-2.9G/T polymorphism and total cholesterol level in patients with Alzheimer disease APO DSM than

Preparation and Characterization of Gelatin-Based bFGF-Impregnated Microsphere

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Preparation and Characterization of Gelatin-Based bFGF-Impre...

A Survey of Stickiness of Agriculture Knowledge Acquisition in china

加速功能材料自主创新，促进西部战略性新兴产业发展——2.11中国功能材料科技与产业高层论坛

作者： Kangjian WANG1,2.Shiwei XIAO1,2.Yichun YE1,2.Nianhua DAN1,2.Yang HU1,2.Weihua DAN1,2.1 National Engineering Laboratory for Clean Technology of Leather Manufacture,Sichuan university,Chengdu,china,610065 2.Medical Biomaterials Laboratory for the {2. center of Biomedicine Engineering of Sichuan university,Chengdu,china,610065

The gelatin-based basic fibroblast growth factor(bFGF)-impregnated microspheres were prepared by emulsification and cold-condensation while glutaraldehyde was used as *** electronic microscope(SEM)and laser nano-granulometer were applied to analyze the characters of these ***,the experiments of acute oral toxicity and proliferation of cells were carried *** feasibility of introducing drug sustained-release microsphere system to the field of tissue engineering was discussed,which would establish the foundation for the application of combination use of gelatin/collagen-based wound-rehabilitation membranes as well as the preparation for further study of tissue engineering skin with inducement and regeneration function.

关键词： gelatin microsphere sustained-release characterization bFGF

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A Survey of Stickiness of Agriculture Knowledge Acquisition ...