Preparation and Characterization of Gelatin-Based bFGF-Impregnated Microsphere

作     者：Kangjian WANG1,2,Shiwei XIAO1,2,Yichun YE1,2,Nianhua DAN1,2,Yang HU1,2,Weihua DAN1,2 1 National Engineering Laboratory for Clean Technology of Leather Manufacture,Sichuan University,Chengdu,China,610065 2 Medical Biomaterials Laboratory for the Research Center of Biomedicine Engineering of Sichuan University,Chengdu,China,610065 

会议名称：《加速功能材料自主创新，促进西部战略性新兴产业发展——2011中国功能材料科技与产业高层论坛》

会议日期：2011年

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Science and Technology Bureau of Chengdu(Grant 10GGYB345SW-023) 

关 键 词：gelatin microsphere sustained-release characterization bFGF 

摘      要：The gelatin-based basic fibroblast growth factor(bFGF)-impregnated microspheres were prepared by emulsification and cold-condensation while glutaraldehyde was used as *** electronic microscope(SEM)and laser nano-granulometer were applied to analyze the characters of these ***,the experiments of acute oral toxicity and proliferation of cells were carried *** feasibility of introducing drug sustained-release microsphere system to the field of tissue engineering was discussed,which would establish the foundation for the application of combination use of gelatin/collagen-based wound-rehabilitation membranes as well as the preparation for further study of tissue engineering skin with inducement and regeneration function.