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Molecular evolution of stress-response gene Leptin in high-altitude Chinese snub-nosed monkeys (Rhinopithecus genus)

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Chinese Science Bulletin 2010年第36期55卷 4132-4135页

作者： WANG XiaoPing1,2. JIN Wei1,2. YU Li1,2.& ZHANG YaPing1,2.1 laboratory for conservation and {2. of bio-resource, yunnan university, kunming 650091, China 2.State Key laboratory of Genetic resources and Evolution, kunming Institute of Zoology, Chinese Academy of Sciences, kunming 6502.3, China laboratory for conservation and {2. of bio-resource Yunnan University Kunming 650091 China State Key laboratory of Genetic resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China

Chinese snub-nosed monkeys (genus Rhinopithecus, subfamily Colobinae), including R. bieti, R. brelichi and R. roxellana, are well-known as the non-human primates with the highest known altitudinal distribution. They represent an interesting model organism of adaptation to the extreme environmental stresses. However, no study at the molecular level has yet been reported for the high-altitude adaptation in Chinese snub-nosed monkeys. Leptin, as an adipocyte-derived hormone, is believed to play an important role in energy homeostasis in adaptation to high altitude environments. In the present study, we sequenced and compared leptin sequences of the Chinese snub-nosed monkeys (R. bieti and R. roxellana) with their lowland close relative R. avunculus and other Colobines. Unexpectedly, no amino acid changes were observed in the 7 Colobinae species examined, including the 2.Chinese snub-nosed monkeys, indicating no difference in the evolutionary pattern of the Leptin gene between high-altitude monkeys and their lowland counterparts. In contrast to a previous finding of adaptive evolution of Leptin gene in plateau pikas, our study suggests that this gene may not have an important role in high-altitude adaptation of Chinese snub-nosed monkeys. Other nuclear genes associated with energy metabolism, or mitochondrial genes, are most likely to be involved the molecular mechanism underlying adaptation of these monkeys to cold and hypoxia associated with the highland environment.

关键词： Leptin基因金丝猴属瘦素基因压力反应分子进化高空鼻极端环境

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Positive Darwinian selection in human population:A review

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Chinese Science Bulletin 2008年第10期53卷 1457-1467页

作者： WU DongDong1,3 & ZHANG YaPing1,2.1 State Key laboratory of Genetic resources and Evolution, {2. Institute of Zoology, Chinese Academy of Sciences, {2. 6502.3, China 2.laboratory for conservation and utilization of bio-resource, yunnan university, kunming 650091, China 3 Graduate university of Chinese Academy of Sciences, Beijing 100049, China State Key laboratory of Genetic resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Graduate university of Chinese Academy of Sciences Beijing 100049 China laboratory for conservation and {2. of bio-resource Yunnan University Kunming 650091 China

This paper reviews a large number of genes under positive Darwinian selection in modern human populations, such as brain development genes, immunity genes, reproductive related genes, perception receptors. The research on the evolutionary property of these genes will provide important insight into human evolution and disease mechanisms. With the increase of population genetics and comparative genomics data, more and more evidences indicate that positive Darwinian selection plays an indispensable role in the origin and evolution of human beings. This paper will also summarize the methods to detect positive selection, analyze the interference factors faced and make suggestions for further research on positive selection.

关键词：自然选择积极选择达尔文进化论人类学种群遗传

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Application of the phylogenetic analysis in mitochondrial disease study

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Chinese Science Bulletin 2008年第18期53卷 2733-2738页

作者： WANG ChengYe1,2.3, KONG QingPeng1,2.& ZHANG YaPing1,2. 1 State Key laboratory of Genetic resources and Evolution, {2. Institute of Zoology, Chinese Academy of Sciences, {2. 6502.3, China 2.laboratory for conservation and utilization of bio-resource, yunnan university, kunming 650091, China 3 Graduate university of Chinese Academy of Sciences, Beijing 100049, China State Key laboratory of Genetic resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China laboratory for conservation and {2. of bio-resource Yunnan University Kunming 650091 China Graduate university of Chinese Academy of Sciences Beijing 100049 China

Mitochondrial disease currently received an increasing concern. However, the case-control design commonly adopted in this field is vulnerable to genetic background, population stratification and poor data quality. Although the phylogenetic analysis could help solve part of these problems, it has not received adequate attention. This paper is a review of this method as well as its application in mito- chondrial disease study.

关键词：线粒体疾病分析单元型种群分布

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Pitfalls in the analysis of ancient human mtDNA

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Chinese Science Bulletin 2003年第8期48卷 826-830页

作者： YAO Yonggang1,3 & ZHANG Yaping1,2.1. laboratory of Molecular Evolution and Genome Diversity, kunming Institute of Zoology, Chinese Academy of Sciences, kunming 6502.3, China 2. laboratory for conservation and utilization of bio-resource, yunnan university, kunming 650091, China 3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China Correspondence should be addressed to Zhang Yaping (e-mail: zhang- yp1@***) laboratory of Molecular Evolution and Genome Diversity Kunning Institute of Zoology Chinese Academy of Sciences China Graduate School of the Chinese Academy of Sciences China laboratory for conservation and {2. of bio-resource Yunnan University China

The retrieval of DNA from ancient human specimens is not always successful owing to DNA deteriora-tion and contamination although it is vital to provide new insights into the genetic structure of ancient people and to reconstruct the past history. Normally, only short DNA fragments can be retrieved from the ancient specimens. How to identify the authenticity of DNA obtained and to uncover the information it contained are difficult. We employed the ancient mtDNAs reported from Central Asia (including Xin-jiang, China) as an example to discern potentially extraneous DNA contamination based on the updated mtDNA phylog-eny derived from mtDNA control region, coding region, as well as complete sequence information. Our results demon-strated that many mtDNAs reported are more or less prob-lematic. Starting from a reliable mtDNA phylogeney and combining the available modern data into analysis, one can ascertain the authenticity of the ancient DNA, distinguish the potential errors in a data set, and efficiently decipher the meager information it harbored. The reappraisal of the mtDNAs with the age of more than 2.00 years from Central Asia gave support to the suggestion of extensively (pre)historical gene admixture in this region.

关键词：古代人类遗传构造 DNA 脱氧核糖核酸

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Genomic organization and sequence analysis of the vomeronasal receptor V2. genes in mouse genome

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Chinese Science Bulletin 2007年第3期52卷 336-342页

作者： YANG Hui1,2.& Zhang YaPing1,3 1 laboratory of Cellular and Molecular Evolution, kunming Institute of Zoology, Chinese Academy of Sciences, kunming 6502.3, China 2.Graduate university of the Chinese Academy of Sciences, Beijing 100049, China 3 laboratory for conservation and utilization of bio-resources, yunnan university, kunming 650091, China laboratory of Cellular and Molecular Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Graduate university of the Chinese Academy of Sciences Beijing 100049 China laboratory for conservation and {2. of bio-resources Yunnan University Kunming 650091 China

Two multigene superfamilies, named V1R and V2., encoding seven-transmembrane-domain G-protein coupled receptors (GPCRs) have been identified as pheromone receptors in mammals. Three V2. gene families have been described in mouse and rat. Here we screened the updated mouse genome se- quence database and finally retrieved 63 putative functional V2. genes including three newly identified genes which formed a new additional family. We described the genomic organization of these genes and also characterized the conservation of mouse V2. protein sequences. These genomic and se- quence information we described are useful as part of the evidence to speculate the functional domain of V2.s and should give aid to the functionality study in the future.

关键词：大白鼠基因组犁鼻受体2 多基因超家族序列分析

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Evolutionary implications of Avian Infectious Bronchitis Virus(AIBV)analysis

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Cell Research 2006年第3期16卷 323-327页

作者： Peng Shi~(1,2. Li Yu~2.Yun-xin Fu~3 Jing-Fei Huang~1 Ke-Qin Zhang~2.Ya-ping Zhang~(1,2.1 laboratory of Cellular and Molecular Evolution,and Molecular biology of Domestic Animals,{2. lnstitute of Zoology,Chinese Academy of Sciences,{2. 6502.3,China 2.laboratory for conservation and utilization of bio-resource,yunnan university,{2. 650091,China 3 Human Genetics Center,university of Texas at Houston,Houston,Texas 77030,USA laboratory of Cellular and Molecular Evolution and Molecular Biology of Domestic Animals Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China.

For developing efficient vaccines,it is essential to identify which amino acid changes are most important to the sur-vival of the *** investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus (AIBV)antigenic domain of a vaccine serotype (DE072. and a virulent viral strain (GA98) to better understand adaptive evo-lution of *** addition,the SARS Coronavirus (SARS-CoV) was also analyzed in the same *** is interestingto find that extreme comparability exists between AIBV and SARS in amino acid substitution *** suggests thatamino acid changes that result in overall shift of residue charge and polarity should be paid special attention to duringthe development of vaccines.

关键词： Avian Infectious Bronchitis Virus SARS Coronavirus positive selection adaptive evolution vaccine development

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The role of MC1R gene in buffalo coat color

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Science China(Life Sciences) 2010年第2期53卷 267-272页

作者： MIAO YongWang1,2.WU GuiSheng3,WANG Lei2.LI DaLin4,TANG ShouKun5,LIANG JianPing2.MAO HuaMing2.LUO HuaiRong3 & ZHANG YaPing1,6 1 laboratory for conservation and {2. of bio-resource,yunnan university,kunming 650091,China 2.Faculty of Animal Science and Technology,yunnan Agricultural university,kunming 6502.1,China 3 kunming Institute of Botany,Chinese Academy of Sciences,kunming 6502.4,China 4 yunnan Institute of Buffalo Science and Technology,kunming 65002.,China 5 Animal Husbandry and Veterinary Station of Luxi city,Luxi 678400,China 6 State Key laboratory of Genetic resources and Evolution,kunming Institute of Zoology,Chinese Academy of Sciences,kunming 6502.3,China laboratory for conservation and {2. of bio-resource Yunnan University Faculty of Animal Science and Technology Yunnan Agricultural University kunming Institute of Botany Chinese Academy of Sciences

Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many *** investigate if the MC1R gene is associated with coat color in water buffalo,the coding region of MC1R gene of 2.6 buffalo samples was sequenced,which included 49 black river buffalo (Murrah and Nili-Ravi),136 swamp buffalo (Dehong,Diandongnan,Dechang,Guizhou,and Xilin) with white and gray body,and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp *** the three variation sites found,SNP684 was synonymous,while SNP310 and SNP384 were nonsynonymous,leading to p.S104G and p.I12.M changes,*** Individuals carrying homozygote EBR/EBR were *** genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele EBR or the allele carrying the amino acid p.104S was important for the full function of *** in silico functional analysis showed that the amino acid substitutions p.G104S and p.M12.I had significant impact on the function of *** results indicate that the allele EBR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo.

关键词： Buffalo coat color MC1R

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Molecular diversity of arbuscular mycorrhizal fungi colonizing the valley-type savanna,southwest China

Molecular diversity of arbuscular mycorrhizal fungi colonizi...

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2.08年中国微生物学会学术年会

作者： Li Tao,Zhao Zhi-Wei~* (laboratory of conservation and {2. for bio-resources,yunnan university,kunming 650091,

The communities of arbuscular mycorrhizal(AM) fungi colonizing the roots and the rhizosphere soils of Heteropogon contortus and Dodonaea viscose were characterized in a valley-type savanna,southwest *** large subunit ribosomal RNA genes were subjected to nested-PCR,sequencing and phylogenetic ***,547 AM fungal sequences were screened from PCR products and four clone libraries were

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A Novel Method For Synthesis of Titanium Silicalite-2.TS-2.

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分子催化 1998年第6期 4-5页

作者： ZHOU Jicheng 2. WANG Xiangsheng (Open laboratory of Comprehensive utilization For Carbon {2. Dalian university of Technology Dalian 116012.

Ｉｎ１９９０Ｒｅｄｄｙｅｔａｌ［１］ｆｏｒｔｈｅｆｉｒｓｔｔｉｍｅｒｅｐｏｒｔｅｄｔｈｅｓｙｎｔｈｅｓｉｓｏｆｔｉｔａｎｉｕｍｓｉｌｉｃａｌｉｔｅ－２（ＴＳ－２）ｗｈｉｃｈｐｏｓｓｅｓｓｅｓｓｉｌｉｃａｌｉｔｅ－２（... 详细信息

Ｉｎ１９９０Ｒｅｄｄｙｅｔａｌ［１］ｆｏｒｔｈｅｆｉｒｓｔｔｉｍｅｒｅｐｏｒｔｅｄｔｈｅｓｙｎｔｈｅｓｉｓｏｆｔｉｔａｎｉｕｍｓｉｌｉｃａｌｉｔｅ－２（ＴＳ－２）ｗｈｉｃｈｐｏｓｓｅｓｓｅｓｓｉｌｉｃａｌｉｔｅ－２（ＭＥＬ）ｓｔｒｕｃｔｕｒｅｉｎｔｈ...

关键词： Titanium Silicalite 2 TS 2 Synthesis Propylene epoxidation

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捕食线虫菌物玻片标本制作方法

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微生物学通报 2004年第1期31卷 92-95页

作者：刘雪峰张克勤云南大学云南省生物资源保护与利用国家重点实验室培育基地

采用玻片培养———棉蓝染色法解决了食线虫菌物永久玻片制作中存在的一些问题 ;小室培养加盖玻片的方法解决了捕食器不能用高倍镜和油镜观察的难题 ,并且可以拍摄到高质量的显微图象 ;刮片法改进了临时玻片的制作方法。

关键词：捕食线虫菌物玻片制作方法

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