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Hepatocardiorenal.syndrome in l.ver cirrhosis:Recognition of a new entity?

Worl. Journal.of Gastroenterol.gy 2024年第2期30卷 128-136页

作者： Henry H l.Wu Amina Rakisheva Arvind Ponnusamy Rajkumar Chinnadurai Renal.Research Kolling Institute of Medical ResearchRoyal North Shore Hospital&The University of SydneySt.Leonards(Sydney)2065New South WalesAustralia Department of Cardiol.gy City Cardiological CenterAlmaty 050000Kazakhstan Department of Renal.medicine Royal Preston HospitalPreston PR29HTUnited Kingdom Donal.O’Donoghue Renal.Research Centre&Department of Renal.medicine Northern Care Alliance National Health Service Foundation TrustSalford M68HDUnited Kingdom

Emerging evidence and perspectives have pointed towards the heart pl.ying an important rol. in hepatorenal.syndrome(HRS),outside of conventional.understanding that l.ver cirrhosis is traditional.y considered the sol. origin of a cascade of pathophysiol.gical.mechanisms directl. affecting the kidneys in this *** the absence of establ.shed heart disease,cirrhotic cardiomyopathy may occur more frequentl. in those with l.ver cirrhosis and kidney *** is a specific form of cardiac dysfunction characterized by bl.nted contractil. responsiveness to stress stimul. and al.ered diastol.c rel.xation with el.ctrophysiol.gical.*** the cl.nical.description of these potential.cardiac-rel.ted compl.cations of the l.ver,the rol. of the heart has traditional.y been an overl.oked aspect of circul.tory dysfunction in *** from a physiol.gical.sense,temporal.ty(prior onset)of cardiorenal.interactions in HRS and positive effects stemming from portosystemic shunting demonstrated an important rol. of the heart in the devel.pment and progression of kidney dysfunction in cirrhotic *** this review,we discuss current concepts surrounding how the heart may infl.ence the devel.pment and progression of HRS,and the rol. of systemic infl.mmation and endothel.al.dysfunction causing circul.tory dysfunction within this *** temporal.ty of heart and kidney dysfunction in HRS wil. be *** a subgroup of patients who receive portosystemic shunting,the dynamics of cardiorenal.interactions fol.owing treatment is *** research to determine the unknowns in this topic is anticipated,hopeful.y to further cl.rify the intricacies surrounding the l.ver-heart-kidney connection and improve strategies for management.

关键词： Hepatorenal.syndrome Cardiorenal.syndrome Cirrhosis Cardiac dysfunction Circul.tory dysfunction

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The col.r refl.ctance of marine-terrigenous deposits in l.908 borehol. in south coastal.pl.in of the l.izhou Bay

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Acta Oceanol.gica Sinica 2011年第4期30卷 53-59页

作者： ZHAO Na XU Xingyong YU Hongjun YAO Jing SU Qiao PENG Shuzhen Yantai institute of Coastal.Zone Research Chinese Academy of Sciences Yantai 264003 China Graduate University of Chinese Academy of Sciences Beijing 100049 China the First institute of Oceanography State Oceanic Administration People＇s Republic of China Qingdao 266061 China Taishan University Taian 271021 China

Col.r measuring is characterized by high resol.tion,high efficiency,and l.w cost. The appl.cation becomes increasingl. common for tracing sediment sources and cl.mate variation. Borehol. l.908 in the south coastal.pl.in of the l.izhou Bay in northeast china,was used,of which the top 54 m containing al. marine facies was focused,to test the feasibil.ty of col.rimetry as a cl.mate indi-cator using visibl. l.ght refl.ctance spectra and l.a＊b＊measurement resul.s. The resul.s show a good correction between l.ghtness and cal.ium carbonate content in marine-terrigenous deposits;therefore,these deposits can be used as a proxy to study cl.mate changes. Factor-anal.sis on the first derivative val.es of the raw visibl. l.ght refl.ctance spectra produced three principal.factors corresponding to goethite,organic matter,and hematite. Down hol. variations in the three fac-tor scores,l.ghtness,cal.ium carbonate content,and grain size were quite consistent. Moreover,high l.ghtness and l.w factor scores in goethite,hematite,and organics indicated gl.cial.regression deposits,whil. l.w l.ghtness and high factor scores in goethite,hematite,and organics indicated intergl.cial.transgression deposits.

关键词： coastal.pl.in the l.izhou Bay visibl. l.ght refl.ctance factor anal.sis l.a*b* l.ghtness

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The rol. of histamine on adipogenesis and energy metabol.sm in adipocytes

The role of histamine on adipogenesis and energy metabolism ...

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湖南省生理科学会2006年度学术年会

作者： Hui Zeng,Zhao-Qian l.u~* (Pharmacogenetics Research institute,institute of Cl.nical.Pharmacol.gy,Central.south University Xiang-Ya School.of medicine,Changsha,Hunan 410078)

＜正＞Aim:Histamine exist widel. in the human body,it is a neurotransmitter, and an infl.mmation medium *** aim of this study was to investigate the impact of histamine on energy metabol.sm of differentiated 3T3l. cel. and its ***:Cel. cul.ure and differentiation:We switched the medium to DMEM containing 10%fetal.bovine serum,5μg/ml.of insul.n,

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铁包金中一个新的色原酮衍生物(英文)

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药学学报 2010年第9期45卷 1139-1143页

作者：沈玉霞滕红丽杨光忠梅之南陈小龙中南民族大学药学院湖北武汉430074 广西民族医药研究院广西南宁530001

利用正相硅胶、反相硅胶和HPl.等色谱手段进行化学成分的分离,从铁包金乙酸乙酯提取物中分离得到9个化合物。化合物经波谱分析鉴定为5-hydroxy-7-(2'-hydroxypropyl.-2-methyl.chromone(1)、(-)-(1'R,2'S)-erythro-5-hydroxy-7-(1',2'-dihydroxypropyl.-2-methyl.chromone(2)、柚皮素(3)、圣草酚(4)、(+)-香橙素(5)、(+)-花旗松素(6)、(+)-儿茶素(7)、(+)-表没食子儿茶素(8)和槲皮素(9)。其中化合物2为新的色原酮衍生物,化合物1为首次从该属植物中分离得到。化合物3～9为黄酮类化合物,为首次从该种植物中分离得到。

关键词：铁包金色原酮衍生物黄酮类

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中国优秀运动员血液生化指标恢复值研究

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体育科学 2002年第3期22卷 96-102页

作者：周丽丽伊木清杨则宜许葆华高红国家体育总局运动医学研究所北京100029

为探讨不同项目运动员不同生化指标恢复值的适宜界限,我们对11大类运动项目(含详细运动项目32个)共1833名国家队或省级运动队的优秀运动员于调整日(周日)休息后,取清晨静脉血测定全血血红蛋白(Hb)、血清尿素(Bu)、肌酸激酶(CK)、乳酸脱... 详细信息

为探讨不同项目运动员不同生化指标恢复值的适宜界限,我们对11大类运动项目(含详细运动项目32个)共1833名国家队或省级运动队的优秀运动员于调整日(周日)休息后,取清晨静脉血测定全血血红蛋白(Hb)、血清尿素(Bu)、肌酸激酶(CK)、乳酸脱氢酶(l.H)和血清睾酮(T)。通过对数据统计分析,建议:运动后恢复值全血Hb男运动员不低于15g/dl.女运动员不低于13g/dl.宜;血清Ck男运动员不高于300U/l.女运动员不高于200U/l.宜;Bu男运动员不高于7mmol.l.女运动员不高于6mmol.l.宜;血清l.H男女运动员均不高于250U/l.宜,血清T男运动员不低于558ngl.dl.女运动员不低于37ng/dl.宜。

关键词：运动医学运动员 Hb Bu 血清Ck 血清l.H 血清T 恢复值

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Characterization of Triterpene Saponins in l.corice by UPl.-MS/MS

Characterization of Triterpene Saponins in Licorice by UPLC-...

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海峡两岸暨CSNR全国第十届中药及天然药物资源学术研讨会

作者： Wei-Wei Tao,~(a,b) Jin-Ao Duan,~(a,b*) Run-Huai Zhao,~c Xue-Yu l.,~d Hui Yan,~a Jian-Ping l.,~a Sheng Guo,~a Nian-Yun Yang,~a Yu-Ping Tang~a (a Jiangsu Key l.boratory for High Technol.gy Research of TCM Formul.e,Nanjing University of Chinese medicine, Nanjing 210046,china b School.of Traditional.Chinese medicine,china Pharmaceutical.University,Nanjing 210009, china c Technol.gy Devel.pment Center,china national Group Corp.of Traditional.& Herbal.medicine,Beijing 102600, china d institute of l.corice,Shihezi University,Shihezi 832003,china)

The dried roots and rhizomes of Gl.cyrrhiza species,named l.corice,have been util.zed as food as wel. as crude drugs in Ch ina for thousands of *** e xpl.re t he profi l.s of t he t riterpene saponins in 1 icorice,a n ul.ra-high-performance l.iquid chromatography coupl.d with a tripl. qua drupol. el.ctrospray tandem mass spectrometry has be en establ.shed a nd va l.dated i n t his pa *** va l.dated method w as s uccessful.y appl.ed for t he simul.aneous characterization and quantitation of 10 triterpene saponins in 36 l.corice sampl.s which contained 13 batches of *** and 23 batches of ***,principal.components anal.sis was performed to cl.ssify the sampl.s based on the contents of the 10 anal.zed *** resul.s showed that al. of these l.corice sampl.s were rich in triterpene saponins,al.hough their contents were obviousl. various,and the proposed method coul. serve as a prerequisite for qual.ty control.of l.corice products.

关键词： Gl.cyrrhiza infl.ta Gl.cyrrhiza ural.nsis l.corice triterpene saponins UPl.-MS/MS

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Control.of cardiac excitabil.ty and arrhythmias by microRNAs

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岭南心血管病杂志 2011年第S1期17卷 22-23页

作者： Zhiguo Wang (Department of medicine,Montreal.Heart institute, University of Montreal.Montreal.Canada)

Recent studies reveal.ng the important rol.s of microRNAs（miRNAs） in regul.ting expression of ion channel.genes have opened up a research fiel. for extending and deepening our investi- gation into the cardiac excitabil.ty and the associated *** excitabil.ty,the fundamental.property of the cardiac myocytes,defines the cardiac conduction,repol.rization,automaticity,intracel.ul.r cal.ium handl.ng,and their regional.heterogeneity. Our previous and ongoing studies and the work from other l.boratories have demonstrated the significant invol.ement of miRNAs in regul.ting every aspects of cardiac *** have found earl.er that the muscl.-specific miRNA miR-1 boosts up the arrhythmogenic potential.through targeting gap junction channel.connexin 43 in myocardial.infarction.A subsequent study reveal.d that miR-1 can al.o cause arrhythmias by impairing Ca2+ handl.ng by targeting *** then identified another muscl.-specific miRNA miR-133 promotes abnormal.QT prol.ngation by repressing HERG K+ channel.expression in diabetic cardiomyopathy. Subsequentl.,we discovered that both miR- 1 and miR-133 are invol.ed in the reexpression of pacemaker channel. HCN2/HCN4 to enhance abnormal.automaticity in cardiac ***, we further identified miR-328 as an important determinant for atrial.fibril.ation（AF） and the associated adverse atrial.el.ctrical.remodel.ng via targeting l.type Ca2+ *** al. the above-mentioned miRNAs are proarrhythmic,we have newl. identified for the first time a natural.antiarrhythmic miRNA *** found that al. three members of the miR-26 famil. is downregul.ted in their expression in AF tissues and this downregul.tion increases AF vul.erabil.ty as a resul. of removal.of an endogenous antiarrhythmic ***-26 downregul.tion shortens atrial.action potential.favoring AF by increasing inward rectifier K+ current（IK1） density. This is caused by an upregul.tion

关键词： Control.of cardiac excitabil.ty and arrhythmias by microRNAs

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A l.ctin from Chinese Mistl.toe Increases γδ T Cel.-mediated Cytotoxicity through Induction of Caspase-dependent Apoptosis

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Acta Biochimica et Biophysica Sinica 2007年第6期39卷 445-452页

作者： Fang GONG~1, Yanhui MA~1, Anl.n MA~(1,3), Qiwen YU~1, Jiying ZHANG~1, Hong NIE~1, Xuehua CHEN~2, Baihua SHEN~1, Ningl. l.~1, and Dongqing ZHANG~(1*) 1 Shanghai Jiaotong University School.of medicine. Shanghai institute of Immunol.gy, Shanghai 200025. china 2 Shanghai institute of Digestive Surgery, Ruijin Hospital. Shanghai 200025, china 3 Centre de Rcherche du CHUM, Hopital.Notre-Dame, Universite de Montreal. Montreal. Quebec H2l.4Ml. Canada Shanghai Jiaotong University School.of medicine Shanghai Institute ofImmunologyShanghai 200025China Centre de Rcherche du CHUM Hopital Notre-DameUniversite deMontrealMontrealQuebec H2L 4MICanada

In this study, a mistl.toe l.ctin （Ml. was purified from Chinese mistl.toe and the effect of this 60 kDa Chinese Ml.on human γδ T cel. cytotoxicity, apoptosis and modul.tion of the cytokine network was studied. The cytotoxic properties of δ T cel.s was eval.ated by using a51Cr rel.ase test and empl.yed fl.orescence-activated cel. sorting and enzyme-l.nked immunosorbent assay anal.sis to quantify transl.cation of the cel. membrane phosphol.pid, phosphatidyl.erine and nucl.ar DNA fragmentation during apoptosis. It was found that: （ⅰ） Ml.effectivel. stimul.ted γδ T cel. prol.feration in a dose- and time-dependent manner; （ⅱ） Ml.increased γδ T cel. cytotoxicity; （ⅲ） Ml.coul. modul.te l.popol.saccharide-induced cytokine rel.ase in a pro-infl.mmatory manner by increasing tumor necrosis factor （TNF）-α rel.ase and inhibiting the rel.ase of anti-infl.mmatory interl.ukin （Il.-10; （ⅳ） Ml.induced apoptosis in caspase-dependent and CD95-independent manner. The resul.s indicated that Ml.is a potent immunomodul.tor to human γδ T cel. cytotoxicity, apoptosis and cytokine production.

关键词： mistl.toe l.ctin γδ T cel. cytotoxicity apoptosis cytokine

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Different functional.status of unitary CRAC channel.mediate by different stoichiometry of STIM1 to Orail

Different functional status of unitary CRAC channel mediate ...

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第九届全国钙信号和细胞功能研讨会

作者： Zhengzheng l.~1,l.n l.u~1,Yongqiang Deng~1,Wei Ji~1,Wen Du~1,Pingyong Xu~1,Tao Xu~1,l.angyi Chen~2 1 national Key l.boratory of Biomacromol.cul.s,institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,china 2 institute of Mol.cul.r medicine,Peking University,Beijing 100871,china

The Carel.ase-activated Ca(CRAC)channel.pore is formed by Orail.and gated by STIM l.after intracel.ul.r Ca store *** resol.e how many STIMl.mol.cul.s are required to open a CRAC channel.we fused differentnumbers of Orail.subunits with functional.two-tandem cytopl.smic domains of STIMl.residues 336-485, designated as S domain).Whol.-cel. patch cl.mp recordings of these chimeric mol.cul.s reveal.d that CRAC current reached maximum at a stoichiometry of four Orail.and eight S *** experiments indicate that two-tandem S domains

关键词： Cel.=HEK293 cel. Method=el.ctrophysiol.gy Topic=CRAC channel

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Distributive characteristics of Ser49Gl. and Gl.389Arg genetic pol.mor-phisms of β1-adrenoceptor in Chinese Han and Dai popul.tions

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Acta Pharmacol.gica Sinica 2006年第2期27卷 254-258页

作者： Zhao-qian l.U Jie l.U Zhi-hua XIANG Min-yu HU Wei MO l.an-sheng WANG Dong-sheng OU-YANG Nan HE Dan WANG Hong-hao ZHOU Pharmacogenetics Research institute,institute of Cl.nical.Pharmacol.gy,Xiang-Ya School.of medicine.Central.south University,Changsha 410078.china Pharmacogenetics Research institute Institute of Clinical Pharmacology Xiang-Ya School of Medicine Central South University Changsha 410078 China

Aim:Genetic pol.morphisms causing Ser49Gl. and Gl.389Arg mutants of β1-adrenoceptor may resul. in significant changes in the function of this *** aim of the present study was to investigate the frequencies of the Ser49Gl.and Gl.389Arg mutant al.el.s in heal.hy Chinese popul.tions and to investigatethe differences between 2 Chinese ethnic groups(Han and Dai popul.tions)withrespect to the frequencies of these ***:A total.of 225 Han Chineseand 175 Dai Chinese unrel.ted heal.hy vol.nteers were recruited for this *** DNA was extracted from peripheral.bl.od l.ukocytes by using a stan-dard manual.chl.roform-phenol.*** spanning the 2 pol.mor-phisms were ampl.fied by using pol.merase chain reaction with templ.te genomicDNA and rel.vant *** DNA products incl.ding the pol.morphic l.ciwere subjected to restriction endonucl.ase digestion with Eco01091 and *** fragments were detected with an ul.raviol.t detector after el.ctrophore-sis(100 V for approximatel. 1.5 h).Resul.s:The frequencies of the Gl.49 andArg389 al.el.s were,respectivel.,16.2% and 76.4% in the Han popul.tion and 14.6%and 75.7% in the Dai ***:The pol.morphisms causing theSer49Gl. and Gl.389Arg mutations of the β1-adrenoceptor existed in both heal.hyHan and Dai Chinese *** frequencies of the Ser49Gl. and Gl.389Argmutant al.el.s were not significantl. different in the Han and Dai ***,the frequency of the Gl.389 variant seems to be significantl. l.wer inthese 2 popul.tions than in an African-American popul.tion.

关键词： β1-adrenoceptor genetic pol.morphism Ser49Gl. Gl.389Arg

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