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Multiple dose pharmacokinetics of risperidone and 9-hydroxyrisperidone in Chinese female patients with schizophrenia

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Acta Pharmacologica Sinica 2006年第3期27卷 381-386页

作者： Zhi-ling ZHOU~2 Xin LI~3 Huai-yan PENG~4 Xi-yong YU~2 Ming YANG~2 Feng-li SU~1 Feng WANG~1 Rong-hua ZHU~1 Chun-yu DENG~2 Qiu-xiong LIN~2 Chuan-yue WANG~5 Wen-biao LI~5 Shu-guang LIN~2 Huan-de LI~(1,6) ~1Clinical Pharmacy Research Institute,Xiangya Second Hospital,Central South University,Changsha 410011,china ~2Research center of Medical Science,guangdong Provincial People's Hospital,guangzhou 510080,china ~3Vascular Surgery Department,Xiangya Second Hospital,Central South University,Changsha 410011,china ~4Department of Clinical Laboratory,Third Xiangya Hospital,Central South University,Changsha 410013,china ~5Affiliated Beijing An Ding Hospital,Capital University of Medical Science,Beijing 100088,china ClinicalPharmacyResearchInstitute XiangyaSecondHospitalCentralSouthUniversityChangsha410011China ResearchcenteroJMedicalScience GuangdongProvincialPeople'sHospitalGuangzhou510080China

Aim:To study the multiple dose clinical pharmacokinetics of risperidone and itsmain active metabolite,9-hydroxyrisperidone,in Chinese female patients ***:The subjects were 23 Chinese female inpatients aged18-65 years who met the CCMD-Ⅲ（third revision of the Chinese Criteria of Men-tal Disorders）criteria for *** were tested after 17 d of treat-ment with 2 mg risperidone twice *** concentrations of risperidone and9-hydroxy-risperidone were assayed by using validated high performance liquidchromatography-mass spectrometry（HPLC-MS）***:Risperidonewas rapidly absorbed(Tmaxwas 1.6 h)and its T1/2in plasma was short（3.2 h）.9-hydroxy-risperidone was quickly metabolized from the parent drug with a meanTmaxof 2.5 *** had a long half-life of 24.7 *** Cavssof risperidone and 9-hydroxy-risperidone were 36.9±33.1 and 110.6±30.5 μg·h·L-1,respectively,and the AUC0-12sswere 443.2+397.4 and 1327.2±402.3 μg·h·L-1,***/F and V/F ofrisperidone were 8.7±6.2 L/h and 34.1±24.3 L,*** varia-tions for pharmacokinetic parameters were quite large for *** 23 sub-jects experienced high prolactin levels when treated with *** was no correlation between prolactin level and the concentration ofrisperidone,9-hydroxy-risperidone,or the active ***:Risperidoneshowed large interindividual variations in *** ofrisperidone resulted in high serum prolactin *** results indicate that sys-temic exposure to risperidone and 9-hydroxy-risperidone in female Chinese schizo-phrenic patients is higher relative to published data for white Caucasian *** studies regarding the PK/PD relationship may be required to develop areasonable clinical dosage regimen for Chinese female patients.

关键词： pharmacokinetics risperidone 9-hydroxyrisperidone schizophrenia

Model-Based Verifying and Design of Autonomous Airship

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Model-Based Verifying and Design of Autonomous Airship

中国自动化学会中南六省（区）2010年第28届年会

作者： Yu Liu,Yilin Wu,Guangjun Liao,Yueming Hu1. Engineering Research center of Precision Electronic Manufacturing Equipments,Ministry of Education,South china University ofTechnology,guangzhou 510641,china2. Department of Computer Science,guangdong Institute of Education,guangzhou 510310,china3. guangdong Police College,guangzhou 510232,china

Based on the Kirchhoff equations,Newton-Euler laws,boundary layer theory and mass definition,the six degrees offreedom dynamic model of airship complete with aerodynamic forces,wind effect and coupling between the airship and internalmass is presented. Then,the nonlinear dynamic model is divided into three group equations by restricting airship motion indifferent planes respectively. The motion characteristics of airship,including stability,mode and the effect of ballast position,are studied using linearized model. The results of simulation verify the correctness of the theoretical analysis and airship model.

关键词： Autonomous Airship Dynamic Modelling Internal Mass Linearization Motion Characteristic

Implementation Method for Region Vector of IP Mode Multi-sensor Cooperated Measurement Based on Synergetics

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Implementation Method for Region Vector of IP Mode Multi-sen...

第二十七届中国控制会议

作者： Hong Xiaobin 1,Liu Guixiong 1,Du Xipeng 1,Chen Taobo 2 1.Department of Mechanical Engineering,South china University of Technology,guangzhou,guangdong 510640,P.R.china 2.Automation Engineering R&M center,guangdong Academy of Sciences,guangzhou,guangdong 510070,P.R.china

According to synergetics,the mechanism model of multi-sensor cooperated measurement is established,which evolutionary process was based on cooperation-competition-harmony *** cooperated learning in the mechanism model is a pivotal *** the IP mode multi-sensor measuring samples are all trained to finish associative memory,they will make attraction domains of mechanism model disordered highly,so the acquisition of region vector is the precondition of implementing the *** the methods and technologies of some key problems to obtain region vectors were espe-cially discussed,including the selection of clustering criterion function,the conversion rules of samples based on proportion and the confirmation of region vector *** order to validate the practicability of mechanism model and realizing meth-ods of region vector based on proportional clustering,the application of IP mode coordinated measuring＆controlling system of modern greenhouse was *** the use of networked measuring＆controlling strategy of modern greenhouse,the experimental results were shown out at the same *** results indicate that the realization of region vector reduces greatly disordered degree,decreases computational quantity and time,increases the reliability of IP mode measuring＆controlling *** methods can be applied to the decision making of other complex systems in similar fields.

关键词： Region vector Synergetics Cooperated measurement IP Mode

The Impact on Environmental Kuznets Curve by Trade and Foreign Direct Investment in china

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Chinese Journal of Population,Resources and Environment 2005年第2期3卷 14-19页

作者： Yang Haisheng 1, Jia Jia 2, Zhou Yongzhang 1& Wang Shugong 1,31 center for Earth Environment & Resources, Zhongshan University, guangzhou, 5102752 Lingnan College, Zhongshan University, guangzhou, 5102753 Institute of Environmental Science, Zhongshan University, guangzhou, 510275 center for Earth Environment and Resources Zhongshan University Guangzhou 510275 China Lingnan College Zhongshan University Guangzhou 510275 China Institute of Environmental Science Zhongshan University Guangzhou 510275 China

Based on data of trade, foreign directinvestment (FDI), economic development andenvironmental conditions in china’s 30 provincesbetween 1990-2002, this paper deals with the impacton Environmental Kuznets Curve (EKC) of tradeand FDI in china. The results show no direct impacton EKC of trade, on the one hand. However, tradecontributes significantly to economic growth, andhas played a positive role in introducing advancedpollution prevention technology and environmentalmanagement methodology to china. Therefore, aproactive trade policy will help solve the environmentalpollution problem brought by economic growth. Onthe other hand, there is a positive correlation betweenFDI and pollutant emission, which proves that FDIdoes have some negative influence on environmentin china due to hasty introduction of foreign capitaland inadequate environmental management systemin china.

关键词： Environmental economy free trade FDI Environmental Kuznets Curve econometricmodel Sustainable development

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Screening and identification of siRNA to suppress the oxidized LDL-receptor 1(OLR1) gene expression

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Screening and identification of siRNA to suppress the oxidiz...

第9届中国南方国际心血管病学术会议

作者： SHAN Zhixin,LIN Qiuxiong,YU Xiyong,DENG Chunyu, ZHOU Zhiling,FU Yongheng,TAN Honghong,LIN Shuguang (Research center of Medical Sciences,guangdong Provincial People’s Hospital,guangdong Provincial Cardiovascular Institute,guangzhou 510080,china)

Objectives To study the suppression of OLR1 expression by siRNA targeting OLR1 mRNA,and screen the siRNA which can effectively inhibit OLR1 *** 3 candidate siRNAs targeting OLR1 mRNA and 1 control siRNA were designed,the siRNA DNA templates were annealed and cloned into the siRNA expression vector pSilencer-4.1-neo,and the recombinant plasmids were identified by DNA sequencing by using the specific primer complementary to the vector pSilencer- *** using Lipofectamine2000 reagent,the 4 recombinant plasmids were transformed into human umbilical vascular endothelial cells(HUVECs) with the green fluorescent protein(GFP) expression vector pN-EGFP as transformation marker.12 hours later,the HUVECs were incubated with 1μg/ml lipopolysaccharide(LPS) for 12 hours,then the HUVECs were changed to incubate with complete Dulbecco’s modified Eagle’s medium(DMEM) for more 24 *** total RNA and total protein of HUVECs were extracted,and the OLR1 mRNA and protein expressions were detected by real-time quantitative PCR and Western-blotting assays with the GAPDH as internal control,*** The results of DNA sequencing showed that the 4 recombinant plasmids were correctly *** 60%～70%HUVECs were transformed with plasmids being indicated by GFP expression. Comparing with the control siRNA,OLR1 mRNA expression was obviously suppressed by OLR1 siRNA2,siRNA3 at the rate of 85 %and 82%(P2,siRNA3 at the rate about 70%(P2 and siRNA3 were found to suppress OLR1 expression efficiently.

关键词： RNAi siRNA Oxidized LDL-receptorl(OLR1) Human umbilical vascular endothelial cell

HBV resistant to lamivudine: experimental and clinical studies

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Hepatobiliary & Pancreatic Diseases International 2002年第4期1卷 519-522页

作者： Dong-Yao Zhou Yong-Jian Cao Lian-Ying Lin Hong Wang Jian-Sheng Huang the Department of Clinical Laboratory Medicine, guangdong Provincial Hospital of Traditional Chinese Medicine, guangzhou 510120, china Institution of Molecular Biology Diagnostic center, First Military Medical University, guangzhou 510515, china Department of Clinical Lab. Medicine Guangdong Prov. Hosp. Trad. Chinese Guangzhou 510120 China Inst. of Molec. Biol. Diagnost. Ctr. First Military Medical University Guangzhou 510515 China

Objective: To identify the impact of lamivudine on HBV e antigen (HBeAg) seroconversion and HBV DNA level, and the appearance of Tyr-Met-Asn-Asp (YMDD) resistants. Methods: Forty-seven hepatitis B patients were trea- ted with oral lamivudine. ALT level and HBeAg were detected in the treatment on the zero, 3rd, 6th and 9th month respectively. The levels of HBV DNA and YMDD resistants were analyzed with PCR mi- croplate hybridization-ELISA. Results: After 9 months of treatment, HBV DNA be- came negative and ALT level was normal in 74% pa- tients. Among these patients, 17% patients had HBeAg converted to negative and anti-HBe antibody positive, whereas another 15% patients showed HBeAg negative. YMDD resistants appeared in 19 % patients (9/47). One, three and five resistants were detected in the treatment on the 3rd, 6th and 9th month respectively. Conclusions: Most HBV DNA in serum became nega- tive after 9 months of treatment, and the rate of HBeAg seroconversion was 17% (HBV DNA level was lower than 100 pg/ml before treatment). YMDD resistants appeared in 19% patients.

关键词： lamivudine Tyr-Met-Asn-Asp mutants microplate hybridization HBeAg seroconversion

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鸭淀粉样变病的发病学研究

畜牧兽医学报 1989年第S1期20卷 118-123页

作者：凌育燊广东省家禽科学研究所

用致病性大肠杆菌(Ec)和鼠伤寒沙门氏杆菌(St)的菌体粗提物径静脉反复处理本地麻鸭和松香黄鸭以人工诱发鸭淀粉样变病,其诱发率分别是:麻鸭15/30(Ec+St)和9/30(St);松香黄鸭16/40(St)、30/40(Ec)和20/40(Ec+St)。实验结果表明,细菌内毒... 详细信息

用致病性大肠杆菌(Ec)和鼠伤寒沙门氏杆菌(St)的菌体粗提物径静脉反复处理本地麻鸭和松香黄鸭以人工诱发鸭淀粉样变病,其诱发率分别是:麻鸭15/30(Ec+St)和9/30(St);松香黄鸭16/40(St)、30/40(Ec)和20/40(Ec+St)。实验结果表明,细菌内毒素在本病的发生上可能起着重要的作用。

关键词：松香黄鸭淀粉样变病麻鸭细菌内毒素致病性大肠杆菌粗提物发病学继发性淀粉样变无菌检查普通光镜

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Tannin inhibits HIV-1 entry by targeting gp41

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Acta Pharmacologica Sinica 2004年第2期 87-92页

作者： Lin Lü2, Shu-wen LIU2,3, Shi-bo JIANG3, Shu-guang WU2,4 2Institute of Pharmaceutical Sciences of the First Medical University of PLA, Key Lab of GD for Screening of New Drug, guangzhou, guangdong 510515, china Lindsley F Kimball Research Institute, New York Blood center, New York, NY 10021, USA

AIM: To investigate the mechanism by which tannin inhibits HIV-1 entry into target cells. METHODS: The inhibitory activity of tannin on HIV-1 replication and entry was detected by p24 production and HIV-1-mediated cell fusion, respectively. The inhibitory activity on the gp41 six-helix bundle formation was determined by an improved sandwich ELISA. RESULTS: Tannins from different sources showed potent inhibitory activity on HIV-1 replication, HIV-1-mediated cell fusion, and the gp41 six-helix bundle formation. CONCLUSION: Tannin inhibits HIV-1 entry into target cells by interfering with the gp41 six-helix bundle formation, thus blocking HIV-1 fusion with the target cell.

关键词： tannin drug dose-response relationship enzyme-linked immunosorbent assay HIV envelope pro- tein gp41 phenols plant extracts medical plants

Problems Exiting in the Work Safety Training and Discussion on the Result of the Work Safety Training

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Problems Exiting in the Work Safety Training and Discussion ...

2006国际安全生产培训研讨会

作者： Zou Lin Work Safety Propaganda and Education center of guangdong Province guangzhou

＜正＞Based on the analysis to problems exist in the process of safety training in china, some measures have been put forward to obtain higher efficiency in safety training, which will do practical benefit to the upco...

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