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Early lung injury contributes to lung fibrosis via AT1 receptor in rats

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Acta Pharmacologica Sinica 2007年第2期28卷 227-237页

作者： Fang-ping CHEN~(1,2. Li-kun GONG~1 Ling ZHANG~3 Hui WANG~(1,2. Xin-ming QI~(1,2. Xiong-fei WU~(1,2. Ying XIAO~(1,2. Yan CAI~(1,2. Lin-lin LIU~(1,2. Xiang-hong LI~1 Jin REN~(1,4)1 State Key Laboratory of Drug Research,shanghai Institute of Materia Medica,shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai 2.12.3,china 2.graduate school of the Chinese Academy of Sciences,shanghai Branch,shanghai 2.0031,china 3 shanghai Pulmonary Hospital,shanghai 2.0043,china State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China graduate school of the Chinese Academy of Sciences Shanghai Branch Shanghai China shanghai Pulmonary Hospital Shanghai China

Aim:Angiotensin Ⅱ is believed to play an important role in tissue repair andremodeling in lungs by the angiotensin type I(AT1)receptor via a number ofpotential ***,the role of the AT1 receptor in early lung injuryhas not been ***:Bleomycin-induced pulmonary fibrosis(PF)in rats was utilized to value the treatment with valsartan,an AT1 receptorantagonist,by measurement of body weight,wet weight of the left lung,hydroxy-proline content,mRNA expression of collagen Ⅰ/Ⅲ,and the degree of fibrosis inlung tissues on d *** injury in the early phase was assessed on d 1,3 and7 by apoptosis,malondialdehyde content,myeloperoxidase activity,inflamma-tory cell count and protein *** converting enzyme(ACE)activ-ity and the AT1 receptor in lung tissues were analyzed by biochemistry methodand Western blotting,***:Valsartan ameliorated PF induced bybleomycin in the rats on d *** bleomycin was injected intratracheally,in-creases in the lung AT1 receptor and ACE activity were observed by d 1,3 and *** injury deteriorated in the early *** reduced the increase of theAT1 receptor,ACE activity and lung injury induced by bleomycin in the ***:These observations suggest that angiotensin Ⅱ may play apotent role in early lung injury via the AT1 ***1 receptor antagonistsshould be assessed as potential new therapies for fibrotic lung disease.

关键词： angiotensin II AT1 receptor pulmonary fibrosis lung injury

CO observations of massive star forming regions at different evolutionary phases

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Science china(Physics,Mechanics & Astronomy) 2006年第5期49卷 626-640页

作者： CHEN Xi1,2. XU Ye1,3, SHEN Zhiqiang1,3 & LI Jingjing1,2.1. shanghai Astronomical Observatory, Chinese Academy of Sciences, shanghai 2.0030, {2. 2. graduate school of the Chinese Academy of Sciences, Beijing 100034, {2. 3. Joint Institute for Galaxy and Cosmology, shanghai Astronomical Observatory and the University of Science and Technology of {2., shanghai 2.0030, {2. shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai China graduate school of the Chinese Academy of Sciences Beijing China Joint Institute for Galaxy and Cosmology Shanghai Astronomical Observatory and the University of Science and Technology of China Shanghai China

The 12.O (J=1-0), 13CO (J=1-0) and C18O (J=1-0) emissions in 9 massive star forming regions, which are believed to be at different stages of massive star formation, were mapped with the 13.7 m millimeter wave telescope at Qinghai Station of Purple Mountain Observatory. Of the observed 9 sources, 13CO cores were detected in seven of them, and C18O cores in five of them. And only two sources associated with C18O cores and H2. masers showed the extended structures and strong outflows. This is the first detection of outflow associated with IRAS 2.566+582. in the observing field of S152.S153. The physical parameters of cores and outflows for these sources, derived from Local Thermal Equilibrium (LTE) analysis, are presented. These observing results suggest that the C18O cores will only appear when the gas density is high enough and the probability to have an outflow is very high when the clumps show the C18O and H2. maser simulta- neously.

关键词： star formation cloud core outflow H2. maser

Identification and Characterization of hmr19 Gene Encoding a Multidrug Resistance Efflux Protein from Streptomyces hygroscopicus *** Strain 10-2.

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Acta Biochimica et Biophysica Sinica 2004年第8期36卷 519-528页

作者： Lei QIN , Heng-An WANG1 , Zhong-Qin WU, Xiao-Feng ZHANG, Mei-Lei JIN,Zi-Xin DENG2. and Guo-Ping ZHAOshanghaiResearch Center of Biotechnology, shanghai Institute for Biological Sciences, Chinese Academy of Sciences,{2. school of the Chinese Academy of Sciences, shanghai 2.02.3, china 1school of Agriculture and Biology, shanghai Jiaotong University, shanghai 2.1101, china 2.3} of Life Science and Biotechnology, shanghai Jiaotong University, shanghai 2.0030, china shanghai Research Center of Biotechnology Shanghai Institute for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200233 China school of Agriculture and Biology Shanghai Jiaotong UniversityShanghai 201101 China school of Life Science and Biotechnology Shanghai Jiaotong UniversityShanghai 200030 China

The hmr19 gene was cloned from Streptomyces hygroscopicus subsp. yingchengensis strain 10- 2., a bacterium strain producing agricultural antibiotics. Sequence similarity comparison indicates that hmr19 gene may encode a predicted protein with 14 putative transmembrane α-helical spanners, belonging to the drug:H+ antiporter-2.family of the major facilitator superfamily. The expression of hmr19 in the mycelium of strain 10-2. was detected by Western blotting analysis. Gene replacement technology was employed to construct an hmr19 disruption mutant. The growth inhibition test against different antibiotics indicated that the mutant strain was 5–2. fold more susceptible to tetracycline, vancomycin and mitomycin C than the parental wild type strain. The mutant took up tetracycline much faster and accumulated more antibiotics than the wild type strain 10-2.. While with the addition of an energy uncoupler, carbonyl cyanide m- chlorophenylhydrazone, the characteristics of the accumulation of [3H]tetracycline in these two strains were almost the same. It was thus concluded that hmr19 encoded a multidrug resistance efflux protein.

关键词： multidrug resistance (MDR) gene replacement (knockout) Streptomyces Streptomyces hygroscopicus subsp. yingchengensis strain 10-2.

Parentage determination of an isolated Yangtze finless porpoise population Neophocaena phocaenoides asiaeorientalis in the Yangtze Tian-e-Zhou Baiji National Natural Reserve based on molecular data

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Progress in Natural Science:Materials International 2005年第2期15卷 54-61页

作者： XIA Junhong 1,2. ZHENG Jinsong 1,2. XU Limei 1,2.and WANG Ding1*(1. Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072. china 2. graduate {2. of the Chinese Academy of Sciences, Beijing 100039, china) Inst. of Hydrobiology Chinese Acad. of Sciences Wuhan 430072 China graduate Sch. Chinese Acad. of Sciences Beijing 100039 China

Reproductive behaviors are poorly known for the Yangtze finless porpoise Neophocaena phocaenoides asiaeorientalis. In this study, the parentage of an isolated Yangtze finless porpoise population inhabiting the Yangtze Tian-e-Zhou Baiji National Natural Reserve is determined by analysis of microsatellite loci and mitochondrial DNA (mtDNA) control region sequences, and the porpoise's reproductive behaviors are studied. Overall 4 full parentage assignments and additional 3 single parentage assignments were determined for the population of 2. individuals. The analysis shows that their estimated reproductive cycle is shorter than that reported previously and there probably exists an overlapping between gestation and lactation period. The study also shows that the female does not show fidelity to a particular male for breeding and vice versa, the oldest males did not monopolize mating and the dominance rank could not be so strict for the porpoise society. Moreover, the porpoise's mating pattern and relatedness among candidate parents are discussed here. These results provide important information for making guidelines of management and conservation for this protected population.

关键词： Yangtze finless porpoise isolated population reproductive behavior parentage

Wet-chemical synthesis and characteristics of Au nanoshell

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Science china Chemistry 2005年第5期48卷 431-435页

作者： LIU Zhongxin1,2. SONG Hongwei1, YU Lixin1,2. YANG Linmei1,2.& PAN Guohui1,2.1. Key Laboratory of Excited State Physics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, china 2. graduate {2. of the Chinese Academy of Sciences, Beijing 100039, china Key Laboratory of Excited State Physics Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun China graduate school of the Chinese Academy of Sciences Beijing China

Gold nanoshells were prepared by an easy wet-chemical method, with Ag nanoparticles used as the templates. Transmission electron microscopy (TEM) indicated that the shells were sphere in shape, the size was homogenous, being about 2. nm, and no hard ag-glomerates were observed. The plasma resonance absorption of gold was tuned from visible to near-infrared (NIR) with the increased volume of HAuCl4. The temperature grads (?T) of the gold nanoshell hydrosol under the exposure of an 808-nm optical fiber laser with different power den-sities were measured. The highest ?T was 30℃ (5 W/cm2. irradiation area was 2.cm2.. This kind of gold nanoshell hydrosol is a promising material to be used in biomedicine such as photo-thermal cancer therapy, and its special photothermal convert property will photothermally trigger drug release.

关键词： wet-chemical synthesis, Au, nanoshell, NIR absorption, photothermal conversion.

The relation between black hole masses and Lorentz factors of the jet components in blazars

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Research in Astronomy and Astrophysics 2009年第3期9卷 293-301页

作者： Ming Zhou1,2.3 and Xin-Wu Cao1,2.1 shanghai Astronomical Observatory, Chinese Academy of Sciences, shanghai 2.0030, {2. 2.Joint Institute for Galaxy and Cosmology (JOINGC) of SHAO and USMC, shanghai 2.0030, {2. 3 graduate school of the Chinese Academy of Sciences, Beijing 100049, {2. shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Joint Institute for Galaxy and Cosmology (JOINGC) of SHAO and USMC Shanghai 200030 China graduate school of the Chinese Academy of Sciences Beijing 100049 China

We explore the relationship between black hole mass (MBH) and the motion of the jet components for a sample of blazars. The Very Long Baseline Array (VLBA) 2.cm Survey and its continuation: Monitoring of Jets in active galactic nuclei (AGNs) with VLBA Experiments (MOJAVE) have observed 2.8 radio-loud AGNs, of which 146 blazars have reliable measurements of their apparent velocities of the jet components. We calculate the minimal Lorentz factors for these sources from their measured apparent velocities, and their black hole masses are estimated with their broad-line widths. A sig- nificant intrinsic correlation is found between black hole masses and the minimal Lorentz factors of the jet components. The Eddington ratio is only weakly correlated with the min- imal Lorentz factor, which may imply that the Blandford-Znajek (BZ) mechanism may dominate over the Blandford-Payne (BP) mechanism for the jet acceleration (at least) in blazars.

关键词： black hole physics — galaxies: active — galaxies: jets — galaxies: nuclei

Identification and Categorization of Horizontally Transferred Genes in Prokaryotic Genomes

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Acta Biochimica et Biophysica Sinica 2005年第8期37卷 561-566页

作者： Shuo-Yong SHI~1 Xiao-Hui CAI~1 and Da-fu DING~(1,2.) Key Laboratory of Proteomics.Institute of Biochemistry and Cell Biology.shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,graduate {2. of the Chinese Academy of Sciences.shanghai 2.0031,china ~2.{2. of Life Science & Technology.shanghai Jiaotong University.shanghai 2.0030.china Key Laboratory of Proteomics Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China school of Life Science & Technology Shanghai Jiaotong UniversityShanghai 200030 China

Horizontal gene transfer(HGT),a process through which genomes acquire genetic materialsfrom distantly related organisms,is believed to be one of the major forces in prokaryotic genome ***,systematic investigation is still scarce to clarify two basic issues about HGT:(1) what types ofgenes are transferred:and(2.what influence HGT events over the organization and evolution of ***-scale investigations of these two issues will advance the systematical understanding ofHGT in the context of prokaryotic genome *** investigated 82.genomes,we constructed anHGT database across broad evolutionary *** identified four function categories containing a highproportion of horizontally transferred genes:cell envelope,energy metabolism,regulatory functions,andtransport/binding *** biased function distribution indicates that HGT is not completely random;instead,it is under high selective pressure,required by function restraints in ***,wemapped the transferred genes onto the connectivity structure map of organism-specific pathways listed inKyoto Encyclopedia of Genes and Genomes(KEGG).Our results suggest that recruitment of transferredgenes into pathways is also selectively constrained because of the tuned interaction between original *** organization structures still conserve well through evolution even with the recruitment ofhorizontally transferred ***,in pathways whose organization were significantly affected byHGT events,the operon-like arrangement of transferred genes was found to be *** resultssuggest that operon plays an essential and directional role in the integration of alien genes into pathways.

关键词： genome evolution horizontal gene transfer function and pathway analysis

Cytotoxicity of carbon nanotubes

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Science china Chemistry 2008年第11期51卷 1021-1029页

作者： ZHU Ying1,2.& LI WenXin1 1 Laboratory of Nano-biology and Medicine, shanghai Institute of Applied Physics, Chinese Academy of Sciences, shanghai 2.1800, {2. 2.graduate school of Chinese Academy of Sciences, Beijing 100049, {2. Laboratory of Nano-biology and Medicine Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai China graduate school of Chinese Academy of Sciences Beijing China

With large-scale production and application at large scale, carbon nanotubes (CNTs) may cause ad-verse response to the environment and human health. Thus, study on bio-effects and safety of CNTs has attracted great attention from scientists and governments worldwide. This report briefly summa-rizes the main results from the in vitro toxicity study of CNTs. The emphasis is placed on the descrip-tion of a variety of factors affecting CNTs cytotoxicity, including species of CNTs, impurities contained, lengths of CNTs, aspect ratios, chemical modification, and assaying methods of cytotoxicity. However, experimental information obtained thus far on CNTs' cytotoxicity is lacking in comparability, and some-times there is controversy about it. In order to assess more accurately the potential risks of CNTs to human health, we suggest that care should be taken for issues such as chemical modification and quantitative characterization of CNTs in cytotoxicity assessment. More importantly, studies on physical and chemical mechanisms of CNTs' cytotoxicity should be strengthened; assaying methods and evaluating criteria characterized by nanotoxicology should be gradually established.

关键词： carbon nanotubes (CNTs) cell bio-security

Microcosmic analysis of ductile shearing zones of coal seams of brittle deformation domain in superficial lithosphere

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Science china Earth Sciences 2004年第5期47卷 393-404页

作者： JU Yiwen1,2. WANG Guiliang2. JIANG Bo2.& HOU Quanlin1 1. graduate school, Chinese Academy of Sciences, Beijing 100039, {2. 2. College of Mineral Resources and Geosciences, {2. University of Mining & Technology, Xuzhou 2.1008, {2. graduate school Chinese Academy of Sciences Beijing 100039 China College of Mineral Resources/Geosci. China University of Mining/Technol. Xuzhou 221008 China

The ductile shearing zones of coal seams in a brittle deformation domain in super-ficial lithosphere are put forward based on the study on bedding shearing and ductile rheology of coal seams. The macrocosmic and microcosmic characteristics include wrinkle fold, mymonitized zones and ductile planar structure of coal seams, etc., while the microcosmic characteristics may also include different optic-axis fabrics and the anisotropy of vitrinite reflectance as well as the change of chemical structure and organic geochemistry components. The forming mechanism is analyzed and the strain environment of ductile shearing zones of coal seams discussed. The result indicates that, in the superficial brittle deformation domain, the coal seams are easy to be deformed, resulting in not only brittle deformation but also ductile shearing deformation under the action of force. Because of simple shearing stress, the interlayer gliding or ductile rheology may take place between coal seams and wall rocks. Therefore, many ductile shearing zones come into being in superficial lithosphere (<5 km). The research on ductile shearing zone of brittle de-formation domain in superficial lithosphere is significant not only theoretically for the study of ductile shearing and ductile rheology of the lithosphere but also practically for the structural movement of coal seams, the formation and accumulation of coal-bed methane, and the preven-tion and harness of gas burst in coal mine.

关键词： brittle deformation domain, interlayer gliding, ductile rheology, ductile shearing zones of coal seams, coal mymonite, vitrinite reflectance anisotropy.