检索结果-南通市图书馆

遗传学进步与人口健康高峰论坛

作者： Jia Zhang~1 Li Xiao~2 Lideng Liu~2 Hanlin Gao~(2,3) Kai Li~(2,3) (1.Functional Genomics Institute of Norvatis,San Diego,CA92121,USA 2.clinical molecular diagnostic center,the second affiliated hospital.suzhou university,suzhou,china 3.Human Genetics,City of Hope National Cancer center,Duarte,CA 91010,USA)

Incidences of small indels decay rapidly according to the size of inserted or deleted *** analysis of small indels revealed that the decay of small insertions/deletions is proportional with the square of the number of base pairs inserted or deleted,which is described as M=M×*** type of decay has been observed in randomly occurred genetic alterations including inherited mutations,somatic mutations,and small gaps from sequence alignment within or between

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma

引用

Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 289-294页

作者： Research center of clinical Medicine,affiliated hospital of Nantong university,Nantong 226001,china (Yao M,Yao DF,Qiu LW,Wu W,Sai WL,Yang JL and Zhang HJ) Department of Oncology,Yancheng First People’s hospital,Yancheng 224001,china (Bian YZ) Department of Oncology,second affiliated hospital,Nanjing Medical university,Nanjing 210011,china (Zhang CG) Research center of clinical Medicine Affiliated Hospital of Nantong University Nantong 226001 China Department of Oncology Yancheng First People's Hospital Yancheng 224001 China Department of Oncology Second Affiliated Hospital Nanjing Medical University Nanjing 210011 China

BACKGROUND:Hepatocellular carcinoma (HCC) is characterized by a multi-cause,multi-stage and multi-focus process of tumor *** prognosis is poor and early diagnosis is of utmost *** study was undertaken to investigate the dynamic expression of oncofetal antigen glypican-3 (GPC-3) and GPC-3 mRNA in hepatocarcinogenesis and to explore their early diagnostic value for ***:A hepatoma model was induced in male Sprague-Dawley rats with 0.05% 2-fluorenylacetamide and confirmed by hematoxylin and eosin staining and gamma-glutamyltransferase (GGT) *** RNA was purified and transcribed into cDNA by reverse *** of the GPC-3 gene were amplified by nested RT-PCR,and confirmed by ***-3 was analyzed by immunohistochemistry,Western blotting or ***:Positive GPC-3 expression showed as brown granule-like staining localized in the *** examination of hepatocytes revealed three morphological stages of granule-like degeneration,atypical hyperplasia (precancerous),and cancer formation,with a progressive increase of liver total RNA and GGT *** incidence of liver GPC-3 mRNA and GPC-3,and serum GPC-3 was 100%,100% and 77.8% in the HCC group,100%,100%,and 66.7% in the precancerous group,83.3%,83.3%,and 38.9% in the degeneration group,and no expression in the liver or blood of the control group,*** was a positive correlation between liver GPC-3 mRNA and total RNA level (r=0.475,Pmolecular markers for early diagnosis of HCC.

关键词： hepatocellular carcinoma glypican-3 immunohistochemistry nested RT-PCR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Nuclear Medicine Consensus on the clinical Use of Amyloid Positron Emission Tomography in Alzheimer’s Disease

引用

Phenomics 2023年第4期3卷 375-389页

作者： Mei Tian Chuantao Zuo Ali Cahid Civelek Ignasi Carrio Yasuyoshi Watanabe Keon Wook Kang Koji Murakami Valentina Garibotto John OPrior Henryk Barthel Yihui Guan Jiaying Lu Rui Zhou Chentao Jin Shuang Wu Xiaohui Zhang Yan Zhong Hong Zhang molecular Imaging-Based Precision Medicine Task Group of A3(china-Japan-Korea)Foresight Program PET center Huashan HospitalFudan UniversityShanghai 200235China Human Phenome Institute Fudan UniversityShanghai 201203China Department of Nuclear Medicine and PET center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China National center for Neurological Disorders and National clinical Research center for Aging and Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Radiology and Radiological Science Division of Nuclear Medicine and Molecular ImagingJohns Hopkins MedicineBaltimore 21287USA Department of Nuclear Medicine Hospital Sant PauAutonomous University of BarcelonaBarcelona 08025Spain Laboratory for Pathophysiological and Health Science RIKEN Center for Biosystems Dynamics ResearchKobeHyogo 650‑0047Japan Department of Nuclear Medicine Seoul National University College of MedicineSeoul 03080Korea Department of Radiology Juntendo University HospitalTokyo 113‑8431Japan diagnostic Department University Hospitals of Geneva and NIMTlabUniversity of GenevaGeneva 1205Switzerland Department of Nuclear Medicine and molecular Imaging Lausanne University HospitalLausanne 1011Switzerland Department of Nuclear Medicine Leipzig University Medical CenterLeipzig 04103Germany Key Laboratory of Medical molecular Imaging of Zhejiang Province Hangzhou 310009China The College of Biomedical Engineering and Instrument Science of Zhejiang university Hangzhou 310007China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310007China 不详

Alzheimer’s disease(AD)is the main cause of dementia,with its diagnosis and management remaining *** positron emission tomography(PET)has become increasingly important in medical practice for patients with *** integrate and update previous guidelines in the field,a task group of experts of several disciplines from multiple countries was assembled,and they revised and approved the content related to the application of amyloid PET in the medical settings of cognitively impaired individuals,focusing on clinical scenarios,patient preparation,administered activities,as well as image acquisition,processing,interpretation and *** addition,expert opinions,practices,and protocols of prominent research institutions performing research on amyloid PET of dementia are *** the increasing availability of amyloid PET imaging,a complete and standard pipeline for the entire examination process is essential for clinical *** international consensus and practice guideline will help to promote proper clinical use of amyloid PET imaging in patients with AD.

关键词： Positron emission tomography(PET) Alzheimer’s disease Amyloid Brain imaging Expert consensus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于骨髓样本的多发性骨髓瘤微小残留病检测中国专家共识(2024年版)

引用

中华血液学杂志 2024年第6期45卷 534-541页

作者：中华医学会血液学分会实验诊断学组、浆细胞疾病学组中国医师协会多发性骨髓瘤专业委员会吴德沛黄晓军陈苏宁常英军傅琤琤路瑾朱明清姚利不详国家血液系统疾病临床医学研究中心江苏省血液研究所苏州大学附属第一医院苏州215006 国家血液系统疾病临床医学研究中心北京大学人民医院北京大学血液病研究所造血干细胞移植治疗血液病北京市重点实验室北京100044 苏州大学附属第一医院北京大学人民医院

多发性骨髓瘤(MM)是血液系统第二大常见恶性肿瘤,标准的整体治疗模式及以新药为主的方案极大地改善了MM患者的生存,但微小残留病(MRD)导致大多数患者复发。因此,需要在传统血清学疗效评估的基础上联合MRD检测,以更精准地评估患者的疾病... 详细信息

多发性骨髓瘤(MM)是血液系统第二大常见恶性肿瘤,标准的整体治疗模式及以新药为主的方案极大地改善了MM患者的生存,但微小残留病(MRD)导致大多数患者复发。因此,需要在传统血清学疗效评估的基础上联合MRD检测,以更精准地评估患者的疾病状态。目前,二代流式细胞术(NGF)和二代测序(NGS)是基于骨髓样本检测MRD的主流技术。为使MRD检测标准化和规范化,专家组讨论制订了在MM患者中应用NGF和NGS技术进行骨髓MRD检测的中国专家共识。

关键词：多发性骨髓瘤微小残留病二代流式细胞术二代测序

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：