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中国遗传学会“发育、遗传和疾病”研讨会

作者： Qiang Wang~1 Zheng Huang~2 Huiling Xue~2 Chengcheng Jin~1 Xiu-Li Ju~3 Jing-Dong J.Han~2 Ye-Guang Chen~(1#) 1 State key laboratory of Biomembrane and Membrane Biotechnology,Department of Biological sciences and Biotechnology,Tsinghua University,Beijing 100084,china 2.cas key laboratory of molecular developmental biology and center for molecular systems biology,institute of genetics and developmental biology,the chinese academy of sciences,beifing 100101, china 3 Department of Pediatrics,Qilu Hospital of Shandong University,Jinan 250012,china

MicroRNAs have been suggested to modulate a variety of cellular *** we report that miR-24 regulates erythroid differentiation by influencing the expression of human activin type I receptor ALK4(bALK4).Ectopic expression of miR-24 reduces the mRNA and protein levels of bALK4 by targeting its 3'-untranslated region and interferes with activin-induced Smad2 phosphorylation and reporter ***,miR-24 represses the activin-mediated accumulation of hemoglobin,an erythroid differentiation marker,in erythroleukemic K562 cells and decreases erythroid colony-forming and burst-forming units of CD34+ hematopoietic progenitor ***4 expression is reversely correlated with miR-24 expression during erythroid ***,our findings define a regulation mode of miR-24 on erythropoiesis by impeding ALK4 expression.

关键词： ALK receptor ALK4 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type miR

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MicroRNA miR-24 Inhibits Erythropoiesis through Targeting Activin Type Ⅰ Receptor ALK4

MicroRNA miR-24 Inhibits Erythropoiesis through Targeting Ac...

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中国细胞生物学学会第九次会员代表大会暨青年学术大会

作者： Qiang Wang~1 Zheng Huang~2 Xue Hui-Ling~2 Xiu-Li Ju~3 Jing-Dong J.Han~2 Ye-Guang Chen~1 1 State key laboratory of Biomembrane and Membrane Biotechnology,Department of Biological sciences and Biotechnology,Tsinghua University,Beijing 100084,china 2.cas key laboratory of molecular developmental biology and center for molecular systems biology,institute of genetics and developmental biology,the chinese academy of sciences,Beijing 100101,china 3 Department of Pediatrics,Qilu Hospital of Shandong University,Jinan 250012,china

关键词： microRNA miR-24 activin ALK4 erythopoiesis

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Genome-wide Analysis of Smad Targets Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination

Genome-wide Analysis of Smad Targets Reveals the Role of BMP...

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第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Teng Fei 1# ,Kai Xia 2# ,Zhang Chen 2 ,Hua Chen 1 ,Zhongwei Li 1 ,Jianping Zhang 1 ,Bing Zhou 2 ,Huasheng Xiao 3 ,Jing-Dong J.Han 2* ,Ye-Guang Chen 1* 1The State key laboratory of Biomembrane and Membrane Biotechnology, Department of Biological sciences and Biotechnology,Tsinghua University,Beijing 100084,china 2cas key laboratory of molecular developmental biology and center for molecular systems biology,institute of genetics and developmental biology,the chinese academy of sciences,Beijing 100101,china 3National Engineering center for Biochip at Shanghai,Zhangjiang Hi-Tech Park, Shanghai,201203,china

＜正＞Embryonic stem（ES）cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling *** external

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molecular Cytogenetic Characterization of a New T2BL·1RS Wheat-Rye Chromosome Translocation Line Resistant to Stripe Rust and Powdery Mildew

Molecular Cytogenetic Characterization of a New T2BL·1RS Wh...

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中国遗传学会植物遗传和基因组学专业委员会2009年学术研讨会

作者： Chunmei Wang~(1*),Qi Zheng~(2*),Lihui Li~3,Yongchun Niu~4,Haibo Wang~5,Bin Li~2,Xiaotian Zhang~1,Yunfeng Xu~1,and Diaoguo An~(1**) 1 center for Agricultural Resources Research,institute of genetics and developmental biology(IGDB), chinese academy of sciences(cas),Shijiazhuang 050021 2 The State key laboratory of Plant Cell and Chromosome Engineering,IGDB,cas,Beijing 100101 College of Life sciences,china Genetic and molecular Breeding University,Beijing 100000 3 The National key Facility for Crop Gene Resources and Genetic Improvement,institute of Crop Science, chinese academy of Agricultural sciences(CAAS),Beijing 100081 4 institute of Plant Protection,CAAS,Beijing 100193 5 institute of genetics and Physiology,Hebei academy of Agriculture and Forestry sciences,Shijiazhuang, 050051

Wheat(Triticum aestivum) genotypes with rye(Secale cereale) 1RS chromosomal translocations are widely used in wheat breeding programs because 1RS carries genes for resistance to several ***,some of the pathogens have ... 详细信息

关键词： Wheat rye translocation line GISH and FISH wheat stripe rust and powdery mildew

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Gene expression and metabolite profiles of cotton fiber during cell elongation and secondary cell wall synthesis

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Cell Research 2007年第5期17卷 422-434页

作者： Jin-Ying Gou1,2,3 Ling-Jian Wang1,2 Shuang-Ping Chen4 Wen-Li Hu1,2 Xiao-Ya Chen1,2 1 National key laboratory of Plant molecular genetics, institute of Plant Physiology and Ecology, Shanghai institutes for Biological sciences, chinese academy of sciences, 300 Fenglin Road, Shanghai 200032, china 2.cas center of Shanghai Chenshan Botanical Garden, 300 Fenglin Road, Shanghai 200032, china 3 Graduate School of chinese academy of sciences, Shanghai 200032, china 4 Department of Computer Science and Technology, University of Science and Technology of china, Hefei 230026, china NationalkeylaboratoryofPlantmoleculargenetics InstituteofPlantPhysiologyandEcologyShanghaiInstitutesforBiologicalSciencesChineseAcademyofSciences300FenglinRoadShanghai200032China

Cotton fibers elongate rapidly after initiation of elongation, eventually leading to the deposit of a large amount ofcellulose. To reveal features of cotton fiber cells at the fast elongation and the secondary cell wall synthesis stages, wecompared the respective transcriptomes and metabolite profiles. Comparative analysis of transcriptomes by cDNA arrayidentified 633 genes that were differentially regulated during fiber development. Principal component analysis (PCA)using expressed genes as variables divided fiber samples into four groups, which are diagnostic of developmental *** grouping results are also found if we use non-polar or polar metabolites as variables for PCA of developingfibers. Auxin signaling, wall-loosening and lipid metabolism are highly active during fiber elongation, whereas cellulosebiosynthesis is predominant and many other metabolic pathways are downregulated at the secondary cell wall synthesisstage. Transcript and metabolite profiles and enzyme activities are consistent in demonstrating a specialization process ofcotton fiber development toward cellulose synthesis. These data demonstrate that cotton fiber cell at a certain stage has itsown unique feature, and developmental stages of cotton fiber cells can be distinguished by their transcript and metaboliteprofiles. During the secondary cell wall synthesis stage, metabolic pathways are streamed into cellulose synthesis.

关键词： cotton fiber transcriptome metabolite profile auxin cell elongation cellulose synthesis

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