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A PRELIMILARY STUDY ON FRACTURE GEOCHEMICAL CHARACTERISTICS IN THE MAYANG Cu DEPOSIT, HUNAN

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Geotectonica et Metallogenia 2001年第1期25卷 118-124页

作者： ZENG Qiao song 1, LIU Shi nian 2.and HUANG Man xiang 2.(1. Changsha Institute of Geotectonics, Chinese Academy of Sciences, Changsha 410013, china 2. Institute of Geology, Central South University, Changsha 410083, china) Changsha Institute of Geotectonics Chinese Academy of SciencesChangsha 410013China Institute of Geology Central South UniversityChangsha 410083China

The Mayang Cu deposit, western Hunan is a middle scale sandstone type Cu deposit predominant of native copper. From an angle of geological integrative field, fracture geochemical features are studided and discussed in this paper. In fracture structure, variant regularity and the ratios of element couples participating in metallogensis that their geochemical natures are similar or strongly correlative, reveal changing laws of metallogenic temperature and pressure fields and migrating direction of metallogenic elements. The theoretical study tallies much better with productive practice. They are meaningful to conduct prospecting and exployation.

关键词： Geological integrative field fracture geochemistry Mayang copper deposit,Hunan

Research on Jiuquan-Jiayuguan-Yumen Region's Dynamic Changing of Urbanization Based on Self-Organizing Model

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Chinese Journal of Population,Resources and Environment 2005年第3期3卷 22-28页

作者： Li Ming 1,2.& Fang Chuanglin 2.1 Graduate School of the Chinese Academy of Sciences, Beijing 100039,china 2.Institute of Geographical Sciences and Natural Resources Research, CAS, Beijing 100101, china Graduate School of the Chinese Academy of Sciences Beijing 100039 China Institute of Geographical Sciences and Natural Resources Research CAS Beijing 100101 China

Based on the self-organizing modeling principle in the dissipative structure theory, the paper regards the migration coupling between the regions as the influence factor to create the model of regional urbanization simulation and prediction, which is more practical to simulate the space-time and dynamic evolvement characteristics of regional urbanization level. According to the historical data about the population and urbanization of Jiuquan, Jiayuguan andYumen cities, the past 50 years' dynamic evolvement trend is simulated and the following 50 years' dynamic evolvement trend is predicted with the urbanization dynamic evolvement model based on the self-organizing model. The analysis of effective factors such as economic increase, resources exploitation, ecosystem construction, traffic location, national policies, population migration are given, then the reasons of the dynamic evolvement differences of the three cities' urbanization are drawn. The study suggests that the self-organizing model is fit for the simulation of Jiuquan-Jiayuguan-Yumen regional urbanization level in the past 50 years, and the departure between the stimulant and the actual data is under 5%, so it can be used to predict the urbanization future of the three cities. The predicted results show that the regional population will reach 1.074 million and the regional urbanization level will be 72.56%.

关键词： self-organizing urbanization dynamic evolvement Jiuquan-Jiayuguan-Yumen region

THE PERMIAN SYSTEM OF THE NUJIANG—LANCANGJIANG—JINSHAJIANG AREA, SOUTHWESTERN china

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地学前缘 2000年第S1期7卷 362-362页

作者： Mao Junyi\+1, Zou Guangfu\+2.[WT5,5”BX](1.Regional Geological Surveying, Sichuan Bureau of Geology and Mineral Resources,Chengdu 6102.3, china 2. Chengdu Institute of Geology and Mineral Resources, Chengdu 610082. china)

Permian system is one of the best developed systems in Sanjiang area. In Yidun\|Zhongdian and in Zhiso\|Muli, The Lower Permian is clastics\|carbonates\|volcanics with interbeds of siliceous sediments, Whereas the Upper Permian is composed of lower part of basic volcanics and upper part of clastics\|carbonates with a total thickness of 1000～4000 meters .In Zhongzha (Batang)\|Jingping region, It is mainly carbonates of 2.7～132. meters thick, But in Jingping proper, there occur about 5000 meters thick basalts of early late Permian . From Batang to Benzinan along the Jinshajiang river , the lower Permian is clastics\|volcanics\|carbonates formation with interbeds of siliceous sediments and spilite formation; Whereas the Upper Permian is clastics with volcanic interbeds; The total thickness being 3700 to 7100 meters. In Jiangda—Mangco (Mangkang), It is clastic\|carbonate\|volcanic formation of 1100 to 2.00 meters . In Tuoba (Qamdo)—Haitong (Mankang)—Ximi (Mujiang ), It is mainly clastics\|carbonates formation , the Upper Permian being coal\|bearing clastics sequence and the total thickness being 700～2.00 meters ,In Zhado—Zhasuosuo (Mangkang)—Deqing—Qinggu—Qinghong, It is clastic\|carbonate\|volcanic formation, locally with coal\|bearing clastics of Upper Permian and the total thickness of mainly carbonate formation and clastic formation with coal\|bearing clastic formation of Uppermian, is 800 to 2.00 meters. In the whole area , the Permian strata were slightly metamorphosed, locally more intensively metamorphosed up to amphibolite facies. The fossils found belong to fusulinids, coral, brachiopods,ammonite,bivalve, gastropods, bryozoa,foraminifera, trilobite, algae ,porifera (sponge), and continental plant . Besides the Gondwana cold\|water type components of brachiopods found in Baoshan, the fossils belong mainly to Cathaysian biota, especially to South china type. In some places such as Mangkang, Guxue (Dewong), to South china type. In some places such as Mangkang, Gu

关键词： Permian sedimentary characteristic regional stratigraphy the Nujiang—Lancangjiang—Jinshajiang area Southwestern china

Neural precursors derived from human embryonic stem cells

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Science china(Life Sciences) 2005年第3期48卷 295-299页

作者： Peng Hongmei 1,2.& Chen Gui’an 1 1. Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, china 2. Department of Obstetrics and Gynecology, General Hospital of PLA, Beijing 100853, china Department of Obstetrics and Gynecology Peking University Third Hospital Beijing100083 China Department of Obstetrics and Gynecology General Hospital of PLA Beijing100853 China Department of Obstetrics and Gynecology Peking University Third Hospital Beijing100083 China

Human embryonic stem (hES) cells provide a promising supply of specific cell types for transplantation therapy. We presented here the method to induce differentiation of purified neural precursors from hES cells. hES cells (Line PKU-1 and Line PKU-2. were cultured in sus- pension in bacteriological Petri dishes, which differentiated into cystic embryoid bodies (EBs). The EBs were then cultured in N2.medium containing bFGF in poly-L-lysine-coated tissue culture dishes for two weeks. The central, small cells with 2.3 short processes of the spreading out- growth were isolated mechanically and replated. The resulting neurospheres were cultured in suspension for 10 days, then dissociated into single cell suspension with a Pasteur pipette and plated. Cells grew vigorously in an attached way and were passed every 4―5 days. Almost all the cells were proved nestin positive by immunostaining. Following withdrawal of bFGF, they differentiated into neurons expressing β-tubulin isotypeIII, GABA, serotonin and synaptophysin. Through induction of PDGF-AA, they differentiated into astrocytes expressing GFAP and oli- godendrocytes expressing O4. The results showed that hES cells can differentiate into typical neural precursors expressing the specific marker nestin and capable of generating all three cell types of the central nervous system (CNS) in vitro.

关键词： human embryonic stem cell, differentiation, neural precursor.

Application of Cell Penetrating Peptide in Magnetic Resonance Imaging of Bone Marrow Mesenchymal Stem Cells

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Acta Biochimica et Biophysica Sinica 2006年第12期38卷 865-873页

作者： Min LIU~1 You-Min GUO~1 Jun-Le YANG~1 Peng WANG~1 Lin-Yu ZHAO~2.Nian SHEN~2.Si-Cen WANG~3 Xiao-Juan GUO~1 Qi-Fei WU~2. 1 Imaging Center,the 2.d Affiliated Hospital of Medical School,Xi'an Jiaotong University,Xi'an 710004,china 2.Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education,Xi'an Jiaotong University,Xi'an 710061,china 3 Department of Pharmacy,Medical School,Xi'an Jiaotong University,Xi'an 710061,china Imaging Center the 2nd Affiliated Hospital of Medical School Xi'an Jiaotong UniversityXi'an 710004 China Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi'an Jiaotong UniversityXi'an 710061 China Department of Pharmacy Medical School Xi'an Jiaotong UniversityXi'an 710061 China

Tracking the distribution and differentiation of stem cells by high-resolution imaging techniqueswould have significant clinical and research *** this study,a model cell-penetrating peptide wasused to carry gadolinium particles for magnetic resonance imaging (MRI) of mesenchymal stem cells (MSCs).MSCs were isolated from rat bone marrow and identified by osteogenic differentiation in *** cell-penetrating peptide labeled with fluorescein-5-isothiocyanate (FITC) and gadolinium was synthesized by asolid-phase peptide synthesis *** imaging analysis confirmed that this new peptide couldinternalize into the cytoplasm and nucleus at room temperature,4℃ and 37℃.Gadolinium were efficientlyinternalized into mesenchymal stem cells by the peptide in a time or concentration-dependent manner,resulting in intercellular shortening of longitudinal relaxation enhancements,which were obviously detectedby 1.5 Tesla Magnetic Resonance *** assay and flow cytometric analysis showed thatthe intercellular contrast medium incorporation did not affect cell viability at the tested *** vitro experiment results suggested that the new constructed peptides could be a vector for trackingMSCs.

关键词： mesenchymal stem cells cell-penetrating peptide gadolinium fluorescein magnetic resonance imaging

Small interfering RNA of cyclooxygenase-2.induces growth inhibition and apoptosis independently of Bcl-2.in human myeloma RPMI82.6 cells

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Acta Pharmacologica Sinica 2007年第7期28卷 1031-1036页

作者： Qiu-bai LI Zhi-chao CHEN Yong YOU Ping ZOU Department of Hematology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,wuhan 43002.,china Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To investigate the effects of small interfering RNA of cyclooxygenase-2.COX-2. on the proliferation and apoptosis of human multiple myeloma RPMI82.6cells and its relation with the Bcl-2.family in ***:Transcription andexpression of COX-2.in human myeloma RPMI82.6 cells were checked by RT-PCRand Western blot analysis,*** COX-2.siRNA fragment targetingexon 5 of COX-2.gene was transfected into the cells with the Amaxa *** inhibition of cell growth was detected by 3-(4,5-dimethyl-2.thiazolyl)-2.5-diphenyl-2.-tetrazolium (MTT) *** was estimatedby Annexin-V/propidium iodide double-labeled cytometry and confirmed by termi-nal deoxynucleotidyl transferase-mediated dUTP nick end-labeling ***-2.nd Bax expression was evaluated by Western blot ***:The COX-2.iRNA fragment could be successfully transfected into RPMI82.6 cells,whichresulted in the significant inhibition of transcription and expression of COX-2.inthe myeloma *** of the transfected cells was inhibited andapoptosis was induced (6.52.±0.32.,12.53%±2.52.,2..39%±3.51% and36.48%±4.96% for 0,12.2.,and 48 h,respectively) in a time-dependent manner(P2.and Bax in the RPMI82.6 cells had nosignificant changes after ***:COX-2.siRNA transfectioncan suppress COX-2.expression in human myeloma RPMI82.6 cells,which leadsto growth inhibition and apoptosis independent of Bcl-2.

关键词： RPMI82.6 small interfering RNA apoptosis proliferation

Pretreatment with insulin enhances anticancer functions of 5-fluorou racil in human esophageal and colonic cancer cells

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Acta Pharmacologica Sinica 2007年第5期28卷 721-730页

作者： Ke ZOU~(1,2.,Ji-hang JU~(1,2.,Hong XIE~(1,3)~1 Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 2.0031,china ~2.Graduate School of the Chinese Academy of Sciences,Beijing,100049,china Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Graduate School of the Chinese Academy of Sciences Beijing China

Aim:To investigate the effects of insulin on enhancing 5-fluorouracil (5-FU) anti-cancer functions and its mechanisms in the human esophageal cancer cell line(Eca 109) and human colonic cancer cell line (Ls-174-t).Methods:The effect ofinsulin/5-FU combination treatment on the growth of Eca 109 and Ls-174-t cellswas evaluated by 3-(4,5-dimethylthiazol-2.yl)-2.5-diphenyl-tetrazolium bromide(MTT) *** insulin treatment or insulin/5-FU treatment,cell cycle distri-bution of both cell lines was analyzed by flow *** blot assay wasused to assess the expression of caspase-3 and thymidylate synthase (TS).Apoptosis was detected by flow cytometry,DNA fragmentation assay,and termi-nal transferase dUTP nick end labeling assay (TUNEL).Moreover,the changes of5-FU uptake after insulin pretreatment were detected by HPLC assay and Westernblot ***:We found that insulin enhanced the inhibitory effect of 5-FU on cell proliferation when Eca 109 cells and Ls-174-t cells were pretreated withinsulin for the appropriate *** increased the cell number of the S phaseand the uptake of ***/5-FU treatment enhanced apoptosis of tumor cellsand upregulated the expression of cleaved caspase-3 compared with 5-FU ***,insulin/5-FU treatment induced the changes of free TS and the TSternary complex level compared with 5-FU treatment in Eca 109 and Ls-174-t ***:These data suggest that insulin enhances anticancer functions of 5-FU when it is treated before 5-FU for the appropriate time in human esophagealand colonic cancer cell lines.

关键词： apoptosis cell cycle 5-fluorouracil insulin

Arsenic emission of high-arsenic coal combustion from southwestern Guizhou,china

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Acta Geochimica 2006年第S1期 49-50页

作者： Junying ZHANG1, Yongchun ZHAO1, Wenchun HUANG1, Yang LI1, Dangyu SONG1, Shifeng DAI2. Fenghua ZHAO2. Chuguang ZHENG1 1 State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, wuhan 430074, china 2.hina University of Mining and Technology (Beijing), Beijing 10083, china

Application of Wavelet Analysis toInterference Elimination for Geochemical Hydrocarbon Exploration

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Journal of Earth Science 2000年第1期19卷 91-93页

作者： Zhang Liuping Ruan Tianjian Faculty of Earth Resources, china University of Geosciences, wuhan 430074

Interference in the data of geochemical hydrocarbon exploration is a large obstacle for anomaly recognition. The multiresolution analysis of wavelet analysis can extract the information at different scales so as to provide a powerful tool for information analysis and processing. Based on the analysis of the geometric nature of hydrocarbon anomalies and background, Mallat wavelet and symmetric border treatment are selected and data pre-processing (logarithm-normalization) is established. This approach provide good results in Shandong and Inner Mongolia, china. It is demonstrated that this approach overcome the disadvantage of backgound variation in the window (interference in window), used in moving average, frame filtering and spatial and scaling modeling methods.

关键词： geochemical exploration petroleum exploration interference elimination wavelet analysis data processing anomaly recognition.