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Effect of Excip.ents on Stability and Str.ctur. of r.CuZn-SOD Encap.ulated in p.GA Micr.sp.er.s

Chemical r.sear.h in Chinese universities 2004年第3期20卷 323-327页

作者： LIU Ling 1,2.,GE Yu 1 and YUAN Qin-sheng 1 1. State Key Labor.tor. of Bior.actor.Engineer.ng and Institute of Biochemistr.,East china univer.ity of Science and Technology,Shanghai 2.02.7,{2. 2. p.blic health School,nanjing medical univer.ity,nanjing 2.002.,{2. E china Univ Sci & Technol State Key Lab Bioreactor Engn Shanghai 200237 Peoples R China E china Univ Sci & Technol Inst Biochem Shanghai 200237 Peoples R China nanjing Med Univ Sch Publ Hlth Nanjing 210029 Peoples R China

When a p.otein is encap.ulated into p.ly( DL -lactide-co-glycolide)(p.GA) micr.sp.er.s by means of the double-emulsion method,the har.h micr.sp.er.s for.ation p.ocess including ultr.sonification,exp.sur. to an or.anic solvent and a p.lymer.may cause the denatur.tion of the p.otein. In this study,we investigated the enzymatic activity change and the effect of the excip.ents on the stability of r.combinant human Cu,Zn-sup.r.xide dismutase(r.Cu,Zn-SOD) dur.ng the emulsification. The sp.cific activity r.cover. was found to be concentr.tion dep.ndent and the excip.ents involved such as p.G 600 and Tween 2.,and tr.halose wer. shown to incr.ase the stability of r.Cu,Zn-SOD. The p.otein str.ctur.l integr.10} within the micr.sp.er.s was analyzed by FTIr. The str.ctur. of r.Cu,Zn-SOD within p.GA micr.sp.er.s containing tr.halose was found to be similar.to that of the native solid state,wher.as the p.otein encap.ulated dur.ng the p.ep.r.tion in the absence of any excip.ent changed due to the p.ssible hydr.p.obic inter.ction with the p.lymer. The r.sults suggest that a r.tional stability str.tegy for.p.otein to be encap.ulated into micr.sp.er.s should aim at differ.nt p.ocesses.

关键词： p.ly( DL -lactide-co-glycolide)(p.GA) micr.sp.er. r.combinant human Cu Zn-sup.r.xide dismutase(r.Cu Zn-SOD) Four.er.tr.nsfor. infr.r.d(FTIr. sp.ctr.scop. p.otein stability Excip.ent

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Hear. failur. in china:ep.demiology and cur.ent management

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Jour.al of Ger.atr.c Car.iology 2024年第6期21卷 631-641页

作者： Sheng-Shou HU the Wr.ting Committee of the r.p.r. on Car.iovascular.health and Diseases in china Fuwai Hosp.tal National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The Annual r.p.r. on Car.iovascular.health and Diseases in china(2.2.)intr.cate landscap. of car.iovascular.1} in *** connection with the p.evious section,this sixth section of the r.p.r. offer. a comp.ehensive analysis of hear. failur.(HF)in *** is one of the most imp.r.ant car.iovascular.disease in the 2.st *** mor.ality is equivalent to that of *** is an imp.r.ant p.blic health p.oblem that ser.ously affects the health of Chinese *** r.cent year.,with the deep.ningof under.tanding,the change of tr.atment p.incip.es,the innovation of tr.atment methods and the up.ate of tr.atment guidelines,the in-hosp.tal mor.ality of HF p.tients has declined,and the long-ter. p.ognosis is also ***,ther. ar. stilldiffer.nces in the management level of HF among differ.nt hosp.tals in *** to imp.ove the standar.ized diagnosis andtr.atment level of HF in china r.mains an imp.r.ant challenge.

关键词： ep.demiology diagnosis tr.atment

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Car.iovascular.r.sk Factor. in china

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Jour.al of Ger.atr.c Car.iology 2024年第2期21卷 153-199页

The Annual r.p.r. on Car.iovascular.health and Diseases in china(2.2.) intr.cate landscap. of car.iovascular.health in china. This section dissects car.iovascular.r.sk factor. in china which including hyp.r.ension, dyslip.demia, diabetes mellitus, chr.nic kidney disease, metabolic syndr.me and air.p.llution. Hyp.r.ension p.evalence has steadily incr.ased in china,with effor.s to contr.l it facing challenges in achieving op.imal r.tes, esp.cially in r.r.l ar.as. Inter.entions like salt substitutes and intensive blood p.essur. contr.l show p.omise but need imp.ovement. Abnor.al lip.d levels, indicative of dyslip.demia,have r.sen significantly, p.sing a r.sk for.car.iovascular.diseases. Desp.te effor.s, many p.tients str.ggle to achieve tar.et lip.d levels, necessitating imp.oved tr.atment str.tegies. Both typ. 1 and typ. 2.diabetes mellitus affect millions of adults in china,with long-ter. comp.ications adding to the disease bur.en. Ear.y inter.ention and effective management ar. cr.cial to mitigate its imp.ct. p.evalent among older.adults, chr.nic kidney disease is associated with diabetes mellitus, hyp.r.ension, and car.iovascular.diseases, necessitating comp.ehensive management ap.r.aches. The p.evalence of metabolic syndr.me, char.cter.zed by a cluster.of r.sk factor., has incr.ased in both adults and adolescents, calling for.lifestyle modifications and p.blic health inter.entions. Ambient and household air.p.llution r.main significant envir.nmental r.sk factor., desp.te some imp.ovements in air.quality. Continued effor.s to r.duce emissions ar. essential for.mitigating associated health r.sks. Addr.ssing these r.sk factor. r.quir.s a multifaceted ap.r.ach, including p.blic health initiatives, p.licy inter.entions, and individual-level str.tegies to p.omote healthy lifestyles and r.duce envir.nmental exp.sur.s. Sur.eillance and r.sear.h effor.s ar. cr.cial for.monitor.ng tr.nds and develop.ng effective str.tegies to lessen the bur.en of car.iovascular.diseases in

关键词： landscap. adding sp.te

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Community-based p.evention and tr.atment of car.iovascular.diseases

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Jour.al of Ger.atr.c Car.iology 2024年第3期21卷 315-322页

作者： Sheng-Shou HU The Wr.ting Committee of the r.p.r. on Car.iovascular.health and Diseases in china Fuwai Hosp.tal National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The Annual r.p.r. on Car.iovascular.health and Diseases in china(2.2.)intr.cate landscap. of car.iovascular.health in *** is the thir. section of the r.p.r. with a sp.cific focus on community-based p.evention and tr.atment of car.iovascular.diseases(CVD).This section of the r.p.r. under.cor.s the imp.r.ance of initiatives outlined in the"healthy china 2.30 p.an,"emp.asizing the comp.ehensive p.evention and contr.l str.tegy for.chr.nic diseases.A key asp.ct of this p.an involves the establishment of national demonstr.tion ar.as aimed at comp.ehensive p.evention and contr.l of chr.nic *** 2.2.,488 such ar.as had been set up.acr.ss china,sur.0}ssing the initial tar.et and cover.ng a significant p.op.r.ion of counties and *** r.p.r. highlights the successful imp.ementation of these str.tegies in Lishan distr.ct,Anshan city,wher. demonstr.tion ar.as for.comp.ehensive p.evention and contr.l of chr.nic diseases wer. launched in *** the cour.e of seven year.,the number.of healthy units incr.ased substantially,leading to imp.ovements in managing r.sk factor. for.CVD among *** r.ductions in p.evalence r.tes of over.eight,obesity,smoking,p.ssive smoking,and dr.nking wer. obser.ed,along with the develop.ent of healthier.behavior. among ***,Qiaokou distr.ct in Wuhan City,designated as a national demonstr.tion ar.a in 2.14,imp.emented comp.ehensive {12. health p.omotion ***,sp.cial clinics for.hyp.r.ension inter.ention wer. established,contr.buting to an incr.ase in self-r.p.r.ed r.tes of hyp.r.ension,a slight decr.ase in p.evalence,and a r.mar.able imp.ovement in the contr.l r.te among tr.ated ***,these effor.s under.cor. the effectiveness of community-based ap.r.aches in dr.ving p.sitive health outcomes and advancing the comp.ehensive p.evention and contr.l of chr.nic diseases,p.r.icular.y car.iovascular.diseases,in china.

关键词： p.evention distr.ct tr.atment

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p.lmonar. embolism and deep.venous thr.mbosis in china

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Jour.al of Ger.atr.c Car.iology 2024年第8期21卷 775-778页

The Annual r.p.r. on Car.iovascular.health and Diseases in china(2.2.) intr.cate landscap. of car.iovascular.health in *** connection with the p.evious section,this eighth section of the r.p.r. offer. a comp.ehensive analysis of p.lmonar. embolism and deep.venous *** r.cent year.,r.sear.h in the field of p.lmonar. vessel in china has made gr.at p.ogr.ss.A number.of nationwide multi-center.r.gistr. r.sear.h r.sults have filled the gap. in the ep.demiology,diagnosis and tr.atment of p.lmonar. hyp.r.ension and venous *** typ.s of p.lmonar. hyp.r.ension still need attention to the identification of r.sk factor. and/or.r.sk str.tification,and venous thr.mboembolism needs attention in the p.evention and the over.ll management inside and outside *** the futur.,we look for.ar. to the p.blication of mor. high-quality r.sear.h in china,which could be able to imp.ove r.levant guidelines for.p.lmonar. vascular.diseases both domestically and inter.nationally.

关键词： ep.demiology p.evention diagnosis

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Intuitionistic fuzzy hier.r.hical cluster.ng algor.thms

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Jour.al of Systems Engineer.ng and Electr.nics 2009年第1期20卷 90-97页

作者： Xu Zeshui1,2.1. Coll. of Economics and Management, Southeast Univ., nanjing 2.0096, p. r. china 2. Inst. of Sciences, p.A Univ. of Science and Technology, nanjing 2.0007, p. r. china Coll. of Economics and Management Southeast Univ. Nanjing 210096 P. R. China Inst. of Sciences PLA Univ. of Science and Technology Nanjing 210007 P. R. China

Intuitionistic fuzzy set （IFS） is a set of 2.tup.e ar.uments, each of which is char.cter.zed by a member.hip.degr.e and a nonmember.hip.degr.e. The gener.lized for. of IFS is inter.al-valued intuitionistic fuzzy set （IVIFS）, whose comp.nents ar. inter.als r.ther.than exact number.. IFSs and IVIFSs have been found to be ver. useful to descr.be vagueness and uncer.ainty. However. it seems that little attention has been focused on the cluster.ng analysis of IFSs and IVIFSs. An intuitionistic fuzzy hier.r.hical algor.thm is intr.duced for.cluster.ng IFSs, which is based on the tr.ditional hier.r.hical cluster.ng p.ocedur., the intuitionistic fuzzy aggr.gation op.r.tor. and the basic distance measur.s between IFSs： the Hamming distance, nor.alized Hamming, weighted Hamming, the Euclidean distance, the nor.alized Euclidean distance, and the weighted Euclidean distance. Subsequently, the algor.thm is extended for.cluster.ng IVIFSs. Finally the algor.thm and its extended for. ar. ap.lied to the classifications of building mater.als and enter.1}ises r.sp.ctively.

关键词： intuitionistic fuzzy set inter.al-valued intuitionistic fuzzy set hier.r.hical cluster.ng intuitionisticfuzzy aggr.gation op.r.tor distance measur..

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Synthesis and Lubr.cation of p.osp.or.lcholine Der.vative

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Jour.al of Bionic Engineer.ng 2010年第3期7卷 254-258页

作者： Zhenliang Qiao~1, Dangsheng Xiong~1, Lude Lu~2. p.ngju Jiang~2.1. Dep.r.ment of Mater.als Science and Engineer.ng, nanjing univer.ity of Science and Technology, nanjing 2.0094, p.r. china 2. School of Chemical Engineer.ng, nanjing univer.ity of Science and Technology, nanjing 2.0094, p. r. china [a] Dep.r.ment of Mater.als Science Engineer.ng Nanjing University of Science Technology Nanjing 210094 P.R. China [b] School of Chemical Engineering Nanjing University of Science Technology Nanjing 210094 P. R. China

The monomer.of p.osp.or.lcholine der.vative, O-(5-（2.methacr.loxy）-3, 3-dimethyl-3-azap.ntyl)-O’-（ω-hydr.xy-octyl）-p.osp.atequater.ar. ammonium salt, was designed and synthesized successfully. It was char.cter.zed by the sp.ctr. ofHNMr.and Mass sp.ctr. （ESI+）, and ever. signal was assigned. Then the lubr.cating char.cter.stics of the p.osp.or.lcholineder.vative wer. investigated on the tr.bological setup.of ball-oh-flat. The Ultr.-High Molecular.Weight p.lyethylene（UHMWp.） flat was r.tated against a stainless steel ball with 6 mm diameter. The load was 2.3 N, which cor.esp.nded to amaximal Her.z contact p.essur. of 2. Mp.. Water. p.osp.or.lcholine der.vative, and Acr.lic Acid （AA） solution wer. used aslubr.cants, r.sp.ctively. Comp.r.d with AA, the p.osp.or.lcholine der.vative shows significant lubr.cation. It can be str.nglyhydr.ted under.water.due to the char.ed segment in chemical str.ctur.. The thick water.layer. within the chains ser.es asboundar. lubr.cants, and this is thought to be the molecular.or.gins of lubr.cating behavior.

关键词： ar.ificial joint ar.icular.car.ilage molecular.lubr.cation mechanism p.osp.or.lcholine synthesis UHMWp.

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New typ. of adap.ive contr.l for.a class of distr.buted time-delay systems with adap.ation r.gar. to delay p.r.meter

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Jour.al of Systems Engineer.ng and Electr.nics 2010年第6期21卷 1054-1062页

作者： Lin Chai1, 2. Shumin Fei1, 2. Haiyan Jin1, 2. r.imin Wang1, 2. and Yanhong Li1, 2.1. Key Labor.tor. of Measur.ment and Contr.l of Comp.ex Systems of Engineer.ng, Southeast univer.ity, nanjing 2.0096, {2. 2. School of Automation, Southeast univer.ity, nanjing 2.0096, {2. Key Labor.tor. of Measur.ment and Contr.l of Comp.ex Systems of Engineer.ng Southeast UniversityNanjing 210096P.R.China School of Automation Southeast UniversityNanjing 210096P.R.China

The p.oblem on stabilization for.the system with distr.buted delays is r.sear.hed. The distr.buted time-delay under.consider.tion is assumed to be a constant time-delay, but not known exactly. A design method is p.op.sed for.a memor. p.op.r.ional and integr.l （p.） feedback contr.ller.with adap.ation to distr.buted time-delay. The feedback contr.ller.with memor. simultaneously contains the cur.ent state and the p.st distr.buted infor.ation of the addr.ssed systems. The design for.adap.ation law to distr.buted delay is ver. concise. The contr.ller.can be der.ved by solving a set of linear.matr.x inequalities （LMIs）. Two numer.cal examp.es ar. given to illustr.te the effectiveness of the design method.

关键词： distr.buted delay linear.matr.x inequality (LMI) adap.ive contr.l time-delay systems memor. p. feedback.

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Inter.ctive gr.up.decision making p.ocedur. based on uncer.ain multip.icative linguistic p.efer.nce r.lations

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Jour.al of Systems Engineer.ng and Electr.nics 2010年第3期21卷 408-415页

作者： Zeshui Xu1,2.1.College of Economics and Management,Southeast univer.ity,nanjing 2.0096,p.r.{2. 2.Institute of Sciences,univer.ity of Science and Technology of the p.A,nanjing 2.0007,p.r.{2. College of Economics and Management Southeast UniversityNanjing 210096P.R.China Institute of Sciences University of Science and Technology of the PLANanjing 210007P.R.China

Gr.up.decision making p.oblems ar. investigated with uncer.ain multip.icative linguistic p.efer.nce *** unbalanced multip.icative linguistic label set is intr.duced,which can be used by the exp.r.s to exp.ess their.linguistic p.efer.nce infor.ation over.*** uncer.ain linguistic weighted geometr.c mean op.r.tor.is utilized to aggr.gate all the individual uncer.ain multip.icative linguistic p.efer.nce r.lations into a collective one,and then a simp.e ap.r.ach is develop.d to deter.ine the exp.r.s＇ weights by utilizing the consensus degr.es among the individual uncer.ain multip.icative linguistic p.efer.nce r.lations and the collective uncer.ain multip.icative linguistic p.efer.nce ***,a p.actical inter.ctive p.ocedur. for.gr.up.decision making is p.op.sed based on uncer.ain multip.icative linguistic p.efer.nce r.lations,in which a p.ssibility degr.e for.ula and a comp.ementar. matr.x ar. used to r.nk the given ***,the p.op.sed p.ocedur. is ap.lied to solve the gr.up.decision making p.oblem of a manufactur.ng comp.ny sear.hing the best global sup.lier.for.one of its most cr.tical p.r.s used in assembling p.ocess.

关键词： gr.up.decision making uncer.ain multip.icative linguistic p.efer.nce r.lations unbalanced multip.icative linguistic label set consensus degr.e inter.ction.

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p.esent Status and Futur. Develop.ent of Mobile Inter.et

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china Communications 2009年第1期6卷 113-118页

作者： Wang Jian1, Bi Houjie2.1nanjing univer.ity, nanjing 2.0093, china 2.0} univer.ity of p.sts and Telecommunications, nanjing 2.0003, china nanjing univer.ity Nanjing 210093 China nanjing univer.ity of p.sts and Telecommunications Nanjing 210003 China

With the integr.tion of telecommunications networ. and Inter.et, mobile Inter.et is bound to r.se. Mobile Inter.et br.ngs not only high-quality business exp.r.ence; but also enor.ous challenges to telecommunications. The cur.ent status and hier.r.hical str.ctur. of the mobile Inter.et ar. p.esented. Technological advances and mar.et demand ar. p.omoting develop.ent of mobile Inter.et, and ter.inals, networ.s and businesses ar. thr.e elements of the develop.ent of the mobile Inter.et. Mobile Ip.technique and r.lated p.otocols ar. descr.bed systematically, which ar. designed to allow mobile ter.inal and the mobile sub-networ. to r.am within the Inter.et. Then the Ip.Multimedia Subsystem (IMS) and its ar.hitectur.l fr.mewor. ar. exp.unded, which ar. designed by (3Gp.). The cr.dible and r.liable Ip.networ. ar.hitectur. with Quality of Ser.ice (QoS) based on IMS is discussed to meet the needs of the next gener.tion of mobile Inter.et. Finally, the hotsp.ts such as p.2}/ Multicast/ Secur.0} ar. p.inted out within the mobile Inter.et.

关键词： Mobile Inter.et mobile Ip IMS networ. conver.ence

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