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The results and prognosis of different treatment modalities for solitary metastatic lung tumor from nasopharyngeal carcinoma:a retrospective study of 105 cases

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chinese Journal of Cancer 2010年第9期29卷 787-795页

作者： Jun Ma1,2. Zhe-Sheng Wen1,2. Peng Lin1,2. Xin Wang1,2. Fang-Yun Xie1,3 1 State Key Laboratory of Oncology in South china, guangzhou, Guangdong 510060, P.R.{2. 2.Department of Thoracic Oncology, Sun Yat-sen University Cancer center, guangzhou, Guangdong 510060, P.R.{2. 3 Department of Radiation Oncology, Sun Yat-sen University Cancer center, guangzhou, Guangdong 510060, P.R.{2. Department of Thoracic Surgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi 030012. P.R.{2. Department of Thoracic Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060 Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Background and Objective:Nasopharyngeal carcinoma (NPC) is known for its propensity for distant *** metastasis is one of the most important causes of death for patients with *** metastatic lung tumor from NPC is a distinctive group associated with a better *** study was to find a more effective treatment modality and prognostic factors for the ***:Clinical data of 105 cases of solitary metastatic lung tumor from NPC were retrospectively *** rate was calculated by the Kaplan-Meier *** difference of survival between the patients treated by different modalities was evaluated by the log-rank *** Cox univariate and multivariate analyses of gender, age, pathologic type, stage, adjuvant chemotherapy, evaluation of treatment for NPC, disease-free interval, size of metastatic tumor, pulmonary hilar and/or mediastinal lymph node metastasis, treatment modalities, recurrent distant metastases and/or relapse of NPC were ***:The local control rate was 53.8% in chemotherapy group, 88.0% in radiotherapy +/-chemotherapy group, and 96.4% in operation +/-chemotherapy group (Pression-free survival (PFS) and overall survival (OS) were obtained with operation +/-chemotherapy and followed by radiotherapy +/-*** of them showed much better efficacy than chemotherapy (Precurrent distant metastases and/or relapse of NPC affected the survival (OR=2.087, 95% CI=1.2.7-3.410, P=0.003).The T stage of NPC, size of metastatic tumor, hilar and/or mediastinal lymph node metastasis, and the treatment modality were independent prognostic ***:Operation +/-chemotherapy and radiotherapy +/-chemotherapy are better treatment of solitary metastatic lung tumor from NPC, which could improve the local control and prolong the PFS and *** is recommended for patients with higher T stage of NPC, size of metastatic tu

关键词：治疗方式鼻咽癌预后孤立全国人民代表大会肺疗效评价多因素分析

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基于裂解气质联用分析的生物质逐级热解研究

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燃料化学学报 2010年第2期38卷 168-173页

作者：吴选民赵增立吴文强李海滨中国科学院广州能源研究所中国科学院可再生能源与天然气水合物重点实验室广东广州510640 中国科学院研究生院北京100049

为探究生物质快速热解反应历程,利用裂解气质联用仪对生物质进行逐级热解实验,考察在不同温度区间热解液体产物组分的分布规律。实验结果表明,生物质的化学组成和热解温度区间对热解液体产物都有重要影响。桉木在2.℃~400℃热解液体产... 详细信息

为探究生物质快速热解反应历程,利用裂解气质联用仪对生物质进行逐级热解实验,考察在不同温度区间热解液体产物组分的分布规律。实验结果表明,生物质的化学组成和热解温度区间对热解液体产物都有重要影响。桉木在2.℃~400℃热解液体产物较少,主要是吡喃和芳香类化合物,其中5,6-二氢-4-羟基-吡喃-2.酮相对峰面积随温度升高而降低;在450℃~500℃热解液体产物种类和产量均较多,主要以酮类和芳香类化合物为主。玉米芯热解规律和桉木的相似,但在2.℃~350℃主要以呋喃类化合物为主,主要热解液体产物是2.3-二氢-苯并呋喃和2.甲氧基-4-乙烯基苯酚,在400℃~450℃热解液体产物以酮类化合物为主。生物质主要化学组分在不同温度区间热解得到不同液体产物,对其进行选择性热解,能够有效实现生物质资源的综合利用。

关键词：生物质逐级热解裂解气质联用

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Interferon-α enhances sensitivity of human osteosarcoma U2.S cells to doxorubicin by p53-dependent apoptosis

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Acta Pharmacologica Sinica 2007年第11期28卷 1835-1841页

作者： Xiang-wei YUAN~2.Xiao-feng ZHU~(3,5),Xiu-fang HUANG~4,Pu-yi SHENG~2.Ai-shan HE~2.Zi-bo YANG~2.Rong DENG~3,Gong-kanFENG~3,Wei-ming LIAO~(2.5)~2.Department of Orthopedic Surgery,The First Affiliated Hospital,Sun Yat-sen University,guangzhou 510080,china ~3 State Key Laboratoryof Oncology in South{2.,Cancer center,Sun Yat-sen University,guangzhou 510060,china ~4 Department of Pathology,The AffiliatedJiangmen Hospital,Sun Yat-sen University,Jiangmen 52.030,china Department of Orthopedic Surgery The First Affiliated Hospital Sun Yat-sen University Guangzhou China State Key Laboratory of Oncology in South china Cancer Center Sun Yat-sen University Guangzhou China Department of Pathology The Affiliated Jiangmen Hospital Sun Yat-sen University Jiangmen China

Aim:To determine whether interferon-α(IFNα) can enhance doxorubicinsensitivity in osteosarcoma cells and its molecular ***:Cellviability was evaluated using 3-(4,5-dimethylthiazol-2.yl)-2.5-diphenyltetrazoliumbromide *** was studied using Flow cytometry analysis,Hoechst332.8 staining,DNA fragmentation assay,as well as the activation ofcaspase-3 and poly (ADP-ribose) *** expression was detectedby Western *** dependence of p53 was determined using ***:IFNα increased doxorubicin-induced cytotoxicity to a muchgreater degree through apoptosis in human osteosarcoma p53-wild U2.S cells,but not p53-mutant MG63 ***α markedly upregulated p53,Bax,Mdm2.andp2.,downregulated Bcl-2.and activated caspase-3 and PARP cleavage in re-sponse to doxorubicin in U2.S ***,the siRNA-mediated silencing ofp53 significantly reduced the IFNα/doxorubicin combination-induced cytotoxic-ity and PARP ***:IFNα enhances the sensitivity of humanosteosarcoma U2.S cells to doxorubicin by p53-dependent *** propercombination with IFNα and conventional chemotherapeutic agents may be a ra-tional strategy for improving the treatment of osteosarcoma with functional p53.

关键词： Interferon-α doxorubicin apoptosis p53 osteosarcoma

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煤与生物质热重分析及动力学研究

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燃料化学学报 2009年第5期37卷 538-545页

作者：武宏香李海滨赵增立中国科学院广州能源研究所中国科学院可再生能源与天然气水合物重点实验室广东省新能源和可再生能源研究开发与应用重点实验室广东广州510640 中国科学院研究生院北京100049

利用热重分析仪对稻秆、麦秆、木屑和煤单独及混合热解特性进行了研究。通过对不同混合比例热解与单独热解对比表明,混合热解中不同生物质起始热解温度、生物质挥发分最大析出温度、煤挥发分最大析出温度随着煤混合比例的变化呈规律性... 详细信息

利用热重分析仪对稻秆、麦秆、木屑和煤单独及混合热解特性进行了研究。通过对不同混合比例热解与单独热解对比表明,混合热解中不同生物质起始热解温度、生物质挥发分最大析出温度、煤挥发分最大析出温度随着煤混合比例的变化呈规律性变化。对混合热解实验数据与单独热解参数按混合比例后特性参数分析表明,混合热解导致固体产物产率提高。实验通过对稻秆两种方式的脱灰及脱挥发分处理后混合热解分析,脱挥发分稻秆与脱灰分稻秆对煤的热解都起到了促进作用,证明了生物质中的碱/碱土金属能促进煤在较低温度下热解,硅元素对热解速率起抑制作用。推测生物质与褐煤的共热解中存在协同作用。

关键词：生物质褐煤共热解

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Expression of hepatitis B virus surface antigen in 12. Hodgkin's lymphoma patients

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chinese Journal of Cancer 2010年第8期29卷 735-740页

作者： Miao-Zhen Qiu1,2. Dan-Yun Ruan1,2. Zhi-Qiang Wang1,2. Hui-Yan Luo1,2. Kai-Yuan Teng1,2. Zhong-Jun Xia1,3, Yue Lu1,3, Hui-Qiang Huang1,2. Wen-Qi Jiang1,2. Rui-Hua Xu1,2.1 State Key Laboratory of Oncology in South china, Sun Yat-sen University Cancer center, {2., Guangdong 510060, P. R. china 2.Department of Medical Oncology, Sun Yat-sen University Cancer center, {2., Guangdong 510060, P. R. china 3 Department of Hematology Oncology, Sun Yat-sen University Cancer center, {2., Guangdong 510060, P. R. china Sun Yat-sen University Cancer center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Background and Objective: Little is known about the incidence of hepatitis B virus (HBV) infection in Hodgkin's lymphoma patients. This study was to evaluate the impact of HBV infection on the survival of Hodgkin's lymphoma patient. Methods: Clinical data of 12. Hodgkin's lymphoma patients treated at the Sun Yat-sen University Cancer center between January 2.04 and October 2.07 were collected. The impact of prognostic factors including HBV infection on survival was examined by univariate and multivariate analyses. A log-rank test was used for univariate analysis and the Cox proportional hazards regression model was used for multivariate analysis. results: Of the 12. patients, 18 (15.0%) were hepatitis B virus surface antigen (HBsAg)-positive. The HBsAg-positive patients had lower 5-year survival rate than did the HBsAg-negative ones (66.9% vs. 91.3%, P = 0.006). When the patients were divided into early-stage (Ⅰ+Ⅱ) and advanced-stage (Ⅲ+Ⅳ) groups, the 5-year survival rate was significantly different between the HBsAg-positive and -negative patients in early-stage group (64.8% vs. 96.0%, P rent in advanced-stage group (75.0% vs. 84.8%, P=0.667). Both univariate and multivariate analyses showed that radiotherapy and HBV infection were independent prognosis factors for the patients with early-stage Hodgkin's lymphoma (P=0.006 and 0.014, respectively). Conclusions: The incidence of HBV infection is similar between Hodgkin's lymphoma patients and normal population. HBV infection is an independent prognosis factor for survival in the patients with early-stage Hodgkin's lymphoma.

关键词：乙肝病毒表面抗原淋巴瘤患者乙肝表面抗原多因素分析金病毒感染肝炎病毒

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Correlation analysis between loss of heterozygosity at chromosome 18q and prognosis in the stage-Ⅱ colon cancer patients

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chinese Journal of Cancer 2010年第8期29卷 761-767页

作者： Wei Wang1,2. Yuan-Fang Li1,2. Xiao-Wei Sun1,2. Gong Chen1,3, You-Qing Zhan1,2. Chun-Yu Huang1,2. De-Sen Wan1,3, Zhi-Zhong Pan1,3, Zhi-Wei Zhou1,2.1 State Key Labortary of Oncology in South china, guangzhou, Guangdong 510060, P. R. china 2.Department of gasrtic and Pancreatic Surgery, Sun Yat-sen University Cancer center, guangzhou, Guangdong 510060, P. R. china 3 Department of Colorectal Surgery, Sun Yat-sen University Cancer center, guangzhou, Guangdong 510060, P. R. china Department of gasrtic and Pancreatic Surgery Sun Yat-sen University Cancer Center State Key Labortary of Oncology in South China Guangdong Guangzhou 510060 Department of Colorectal Surgery Sun Yat-sen University Cancer Center State Key Labortary of Oncology in South China Guangdong Guangzhou 510060

Background and Objective: Colorectal cancer is one of the most common malignant cancers in the world. Although the clinicopathologic staging is the golden criterion for the prognosis at present, the optimum prognostic criteria for colorectal cancer should be a combination of the clinicopathologic staging and the molecular markers. However, there are currently no molecular markers available for the prognosis of colorectal cancer. Several tumor-suppressor genes associated with colorectal cancer have been mapped at the 18q2.-2. region. In this study we detected the frequency of loss of heterozygosity (LOH) at chromosome 18q and investigated the relationship between LOH and clinicopathologic features and its prognostic value for patients with stage Ⅱ colon cancer. Methods: A total of 106 samples of tumor tissues and corresponding normal mucosa from patients with sporadic stage-Ⅱ colon cancer were included in this study. All the samples were formalin-fixed and paraffin-embedded. DNA was extracted from tumor tissues and LOH of D18S474, D18S55, D18S58, D18S61 and D18S64 at chromosome 18q was analyzed using polymerase chain reaction (PCR), polyacrylamide gel-electrophoresis, and DNA sequencing method. Multivariate analysis for association between LOH and prognosis in colon cancer patients was performed with Cox proportional hazards regression model. results: The median follow-up time was 68 months. For 106 patients, 5-year survival rate was 83.6%, which was associated with age and gross tumor type (P = 0.011 and 0.034, respectively). Among 102.patients who were eligible for LOH information, the overall frequency of LOH is 49.0% (50/102., and that of LOH at 5 microsatellite loci of D18S474, D18S55, D18S58, D18S61, and D18S64 was 30.2. (2./86), 2..4% (18/77), 2..6% (2./70), 35.0% (2./80), and 2..8%(15/72., respectively. The occurrence of LOH was significantly associated with tumor location and histopathologic grade (P = 0.02., 0.016 and 0.005, respectively). LOH was more freq

关键词：大肠癌染色体杂合性预后患者相关分析聚丙烯酰胺凝胶电泳临床病理

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Nd isotope as the tracer of seawater evolution of early Miocene in the eastern Pacific Ocean

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chinese Science Bulletin 2003年第B6期48卷 106-110页

作者： LIU Jihua~(1,2.3), CHEN Lirong~1, WANG Yingxi~4 & HAN Jianxiu~5 1. Institute of Oceanology, chinese Acadcmy of ences, Qingdao 2.6071. china 2. Key Lab of Marine Sedimentology and Environmental Geology, First Institute of Oceanograpgy, State Oceanic Administration, Qingdao 2.6061. china 3. Graduate School, chinese academy of sciences, Beijing 100039. china 4. Modern Analysis center, Nanjing University. Nanjing 2.0093. china 5. guangzhou Marine Investigation Bureau, guangzhou 510760. china Institute of Oceanology Chinese Academy of Sciences Qingdao China Key Lab of Marine Sedimentology and Environmental Geology First Institute of Oceanograpgy State Oceanic Administration Qingdao China Graduate School Chinese Academy of Sciences Beijing China Modern Analysis center Nanjing University Nanjing China guangzhou Marine Investigation Bureau Guangzhou China

Fifty-six samples of nannofossil ooze were collected from Core PC5794 in the northern equatorial Pacific at 5 cm intervals. With the methods of mass spectrometer (VG354) and ICP, the Nd isotopic compositions (εNd(t)), Mn contents and Mg/Sr ratios of carbonate phase have been analyzed. CaCO3 contents of bulk sediments were obtained by dissolution of 0.5 mol/L HCl. Based on these data, the high-resolution εNd(t) profile of seawater in early Miocene with core depth(or time) have been established. The values of εNd(t) range from -6.2.to -2.97 and 4 fluctuation cycles existed during 2..06-2..02.Ma. 4 low εNd(t) values (about -6.4) correspond to high CaCO3 contents, which implicates that there were 4 cold epochs or 4 times of Antarctic Bottom Water activity. They occurred at the time of 2..06 Ma, 2..85 Ma,2..88 Ma and 2..2. Ma, respectively. High εNd(t) values correspond to the high Mn contents and high values of Mg/Sr ratio, which indicates the existence of 4 intense hydrothermal activity periods during 2..06-2. Ma, the durations of them are 4.05-2..98 Ma, 2..69-2..15 Ma, 2..74-2..37 Ma and 2..06-2..02.Ma, respectively.

关键词：同位素钕示踪原子海水演化中新世太平洋微化石分光计持续期海水样品

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Diversity, distribution, and new phylogenetic information of calcareous dinoflagellates from the china Sea

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Journal of Systematics and Evolution 2011年第2期49卷 126-137页

作者： 1 Hai-Feng GU 1 Zhao-He LUO 2.Yan WANG 1 Dong-Zhao LAN 1 (Third Institute of Oceanography, Xiamen 361005, china) 2.(research {2. for Harmful Algae and Aquatic Environment, College of Life Science and Technology, Jinan University, guangzhou 510632. china) (Third Institute of Oceanography Xiamen 361005 China) (research center for Harmful Algae and Aquatic Environment College of Life Science and Technology Jinan University Guangzhou 510632 China)

Calcareous dinoflagellates have been recorded from subarctic to tropical areas, inhabiting both neritic and oceanic regions. In the present study we analyse 12.sediment samples from the china Sea to establish the existence of calcareous dinoflagellates in this area. A total of 11 calcareous dinoflagellate species were recorded, among them, three genera (Calciodinellum, Leonella, Posoniella) and seven species (Calciodinellum albatrosianum, C. levantinum, C. operosum, Leonella granifera, Posoniella tricarinelloides, Scrippsiella irregularis, and S. regalis) were reported from the china Sea for the first time. Cysts of S. irregularis and S. precaria are identical, with a mesoepicystal a{2.eopyle, representing the loss of 2.4 and 1–3a paraplates; however, their thecal plates vary slightly and differ from each other in 78 positions of the internal transcribed spacer sequence. Scrippsiella trochoidea is dominant in coastal areas, whereas Calciodinellum albatrosianum is the most abundant offshore. Scrippsiella irregularis is distributed widely along the coast of china, whereas S. precaria is recorded only in northern china. Leonella granifera is the second most abundant species offshore, comprising 15–40% of the cyst assemblage.

关键词： calcareous dinoflagellates Calciodinellum china Sea Leonella Posoniella Scrippsiella.

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Efficient transformation and expression of gfp gene in the edible mushroom Pleurotus nebrodensis

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Progress in Natural Science:Materials International 2008年第7期18卷 819-824页

作者： Junfang Lin a,b, Mingyao Zheng a, Jie Wang a,b, Wei Shu c, Liqiong Guo a,b,* a Department of Biotechnology, College of Food sciences, South china Agricultural University, {2. 510640, china b Institute of Biomass research, South china Agricultural University, {2. 510640, china c Test and Experimental center, South china Agricultural University, {2. 510640, china Department of Biotechnology College of Food Sciences South China Agricultural University Guangzhou 510640 China Institute of Biomass research South China Agricultural University Guangzhou 510640 China Test and Experimental center South China Agricultural University Guangzhou 510640 China

An efficient transformation method mediated by PEG-protoplasts was developed for the newly commercial edible mushroom Pleu- rotus nebrodensis. Two plasmids were used to co-transform protoplasts of P. nebrodensis. One plasmid is pAN7-1 containing a positive selectable marker gene hph conferring hygromycin B resistance. Another plasmid is pBlue-GFP containing a reporter gene gfp conferring green fluorescent protein. PCR and Southern blot analysis showed that hph gene or/and gfp gene were integrated into the genome of P. nebrodensis transformants. The transformation efficiency of the positive selectable marker gene hph was 3 transformants per microgram of plasmid pAN7-1 DNA, which was about 30 times higher than that previously reported in thoroughly studied Pleurotus species such as Pleurotus ostreatus. The transformation efficiency of the reporter gene gfp was 9 transformants per microgram of plasmid pBlu-GFP DNA. The co-transformation efficiency was 2..68%. This is the first report that a "reporter" gene, green fluorescent protein gene can be successfully stably expressed in this Pleurotus species.

关键词： Pleurotus nebrodensis Protoplast-mediated transformation Green fluorescent protein GFP expression

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Layer-block tectonics of Cenozoic basements and formation of intra-plate basins in Nansha micro-plate, southern South china Sea

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Acta Oceanologica Sinica 2009年第3期28卷 26-39页

作者： LIU Hailing XIE Guofa LIN Qiujin ZHENG Hongbo LIU Yingchun Key Laboratory of Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of Sciences Guangzhou 510301 China Brigade 2.1 Bureau of Nuclear Geology Jiangxi Province Yingtan 335001 China

Layer-block tectonics （LBT） concept, with the core of pluralistic geodynamic outlook and multilayer-sliding tectonic outlook, is one of new keys to study 3-dimensional solid and its 4-dimensional evolution history of global tectonic system controlled by global geodynamics system. The LBT concept is applied to study the lithospheric tectonics of the southern South china Sea （SCS）. Based on the analysis of about 30 000 km of geophysical and geological data, some layer-blocks in the Nansha micro-plate can be divided as Nansha ultra-crustal layer-block, Zengmu crustal layer-block, Nanwei （Rifleman bank）-Andu （Ardasier bank） and Liyue （reed bank） North Palawan crustal layer-blocks, Andu-Bisheng and Liyue-Banyue basemental layer-blocks. The basic characteristics of the basemental layer-blocks have been dicussed, and three intra-plate basin groups are identified. The intra-plate basins within Nansha micro-plate can be divided into three basin groups of Nanwei- Andu, Feixin-Nanhua, and Liyue-North Palawan based on the different geodynamics. In the light of pluralistic geodynamic concept, the upheaving force induced by the mid-crust plastic layer is proposed as the main dynamical force which causes the formation of the intra-plate basins within the Nansha micro-plate. Finally, models of a face-to-face dip-slip detachment of basemental layerblock and a unilateral dip-slip-detachment of basemental layer-block are put forward for the forming mechanisms of the Nanwei Andu and Liyue-North Palawan intra-plate basin groups, respectively.

关键词： layer-block tectonics forming mechanism of intra-plate basin Nansha micro-plate South china Sea oil and gas gas hydrate

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