The results and prognosis of different treatment modalities for solitary metastatic lung tumor from nasopharyngeal carcinoma:a retrospective study of 105 cases

作     者：Jun Ma1,2, Zhe-Sheng Wen1,2, Peng Lin1,2, Xin Wang1,2, Fang-Yun Xie1,3 1 State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P.R.China 2 Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R.China 3 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R.China Department of Thoracic Surgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi 030012, P.R.China 

作者机构：Department of Thoracic Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060 Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060 

出 版 物：《Chinese Journal of Cancer》 (CHINESE JOURNAL OF CANCER)

年 卷 期：2010年第29卷第9期

页      面：787-795页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：治疗方式 鼻咽癌 预后 孤立 全国人民代表大会 肺 疗效评价 多因素分析 

摘      要：Background and Objective:Nasopharyngeal carcinoma (NPC) is known for its propensity for distant *** metastasis is one of the most important causes of death for patients with *** metastatic lung tumor from NPC is a distinctive group associated with a better *** study was to find a more effective treatment modality and prognostic factors for the ***:Clinical data of 105 cases of solitary metastatic lung tumor from NPC were retrospectively *** rate was calculated by the Kaplan-Meier *** difference of survival between the patients treated by different modalities was evaluated by the log-rank *** Cox univariate and multivariate analyses of gender, age, pathologic type, stage, adjuvant chemotherapy, evaluation of treatment for NPC, disease-free interval, size of metastatic tumor, pulmonary hilar and/or mediastinal lymph node metastasis, treatment modalities, recurrent distant metastases and/or relapse of NPC were ***:The local control rate was 53.8% in chemotherapy group, 88.0% in radiotherapy +/-chemotherapy group, and 96.4% in operation +/-chemotherapy group (P0.01).The most promising progression-free survival (PFS) and overall survival (OS) were obtained with operation +/-chemotherapy and followed by radiotherapy +/-*** of them showed much better efficacy than chemotherapy (P0.001).The Cox multivariate analysis showed that recurrent distant metastases and/or relapse of NPC affected the survival (OR=2.087, 95% CI=1.277-3.410, P=0.003).The T stage of NPC, size of metastatic tumor, hilar and/or mediastinal lymph node metastasis, and the treatment modality were independent prognostic ***:Operation +/-chemotherapy and radiotherapy +/-chemotherapy are better treatment of solitary metastatic lung tumor from NPC, which could improve the local control and prolong the PFS and *** is recommended for patients with higher T stage of NPC, size of metastatic tu