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Circ_0004592.An auxiliary diagnostic biomarker for gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2757-2768页

作者： Shan kong Yan-Hua Xu Ming Zheng Shao-Qing Ju Heng-Chuan Shi department of Laboratory Medicine Jiangsu Province Official HospitalNanjing 210000Jiangsu ProvinceChina department of Laboratory Medicine Northern Jiangsu People’s HospitalYangzhou 225000Jiangsu ProvinceChina department of Laboratory Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)has a high mortality rate,and robust diagnostic biomarkers are currently ***,the clinical relevance of circular RNAs(circRNAs)as GC biomarkers remains largely *** To evaluate the potential of novel circRNA circ_0004592.in the early screening and prognosis of *** High-throughput sequencing of circRNAs was performed to screen for potential target ***_0004592.expression was examined in GC tissues,cells,and *** samples were collected from healthy subjects’patients,as well as from patients with benign lesions,precancerous lesions,and GC,whereafter the diagnostic accuracy of circ_0004592.was *** correlation between circ_0004592.levels in plasma and clinicopathological data of patients with GC was further *** Circ_0004592.was upregulated in both the tissue and plasma of patients with ***,circ_0004592.expression was higher in patients with precancerous lesions than in healthy controls while being highest in patients with *** the same patient,the postoperative plasma level of circ_0004592.was lower than that in the preoperative ***,circ_0004592.level was significantly correlated with tumor differentiation,tumor depth,and lymph node *** area under the curve(AUC)of plasma circ_0004592.exhibited high sensitivity and specificity for differentiating patients with GC from healthy *** based on circ_0004592.carcinoembryonic antigen,and cancer antigen 199 achieved a superior AUC and was highly *** Plasma circ_0004592.may represent a potential non-invasive auxiliary diagnostic biomarker for patients with GC.

关键词： Biomarker Circular RNA Diagnosis Gastric cancer Plasma

Partitioning series-parallel multigraphs into υ*-excluding edge covers

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Science china mathematics 2006年第8期49卷 1082-1093页

作者： LIU Guizhen, DENG Xiaotie & XU Changqing School of mathematics and System Science, Shandong university, Jinan 2.0100, {2. department of Computer Science, City university of hong kong, Kowloon, hong kong, {2. department of Applied mathematics, Hebei university of Technology, Tianjin 300130, {2. School of mathematics and System Science Shandong University Jinan 250100 China department of Computer Science City University of Hong Kong Kowloon Hong Kong Hong Kong department of Applied mathematics Hebei University of Technology Tianjin 300130 China

We prove that, for any given vertexν* in a series-parallel graph G, its edge set can be partitioned into k= min{k′(G) + 1,δ(G)} subsets such that each subset covers all the vertices of G possibly except forν*, whereδ(G) is the minimum degree of G and k′(G) is the edge-connectivity of G. In addition, we show that the results in this paper are best possible and a polynomial time algorithm can be obtained for actually finding such a partition by our proof.

关键词： series-parallel graph, edge-connectivity, edge cover coloring, min-max theorem.

Spatial pattern of land cover change in china's semiarid environment

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Journal of Arid Land 2009年第1期1卷 16-25页

作者： BaoLin LI1 and QiMing ZHOU2.1 State Key Laboratory of Environment and Resources Information System, Institute of Geographical Sciences and Resources Research, Chinese Academy of Sciences, Beijing 100101, china 2.department of Geography, {2., Kowloon Tong, hong kong, china hong kong baptist Univ Dept Geog Kowloon Tong Hong Kong Peoples R China Chinese Acad Sci State Key Lab Environm & Resources Informat Syst Inst Geog Sci & Resources Res Beijing 100101 Peoples R China

This study seeks a routine to quantify spatial pattern of land cover changes in semiarid environment of china based on post-classification comparison method. The method consists of three major steps: (1) the image classification and unification of classified results based on two-level land cover classification themes, (2. the establishment of land cover change classes based on an unification land cover classification theme, (3) the reclassification and mapping of land cover change classes with three overall classes including no-change, gain and loss based on the unification land cover class. This method was applied to detect the spatial pattern of land cover changes in Yinchuan Plain, one of famous irrigation agricultural zones of the Yellow River, china. The results showed the land cover had undergone a remarkable change from 1991 to 2.02.in the study area (the changed area was over 30%). Rapid increase of cropland (12.5%), built-up area (131.4%) and rapid decrease of bare ground (51.7%) were alarming. The spatial pattern of land cover changes showed clear regional difference in the study area and was clearly related to human activities or natural factors. Thus, it obtained a better understanding of the human impact on the fragile ecosystem of china’s semiarid environment.

关键词： change detection spatial pattern land cover semiarid zone of china remote sensing human activities

Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2.Low Expression in Chinese Patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： kong Zi Qing LIU Li Qun HUANG De Qin WANG Yu Tong LI Jing Jie ZHANG Zheng WANG Xi Xi LIU Chuan Ling ZHANG Ya Di SHAO Jia Kang ZHU Yi Min CHEN Yi Meng LIU Mei ZHAO Wei hong Medical School of Chinese PLA Beijing 100853China department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai university School of Medicine Tianjin 300071China department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2.HER2.-low early breast cancer(BC)and HER2.IHC0 *** Patients diagnosed with HER2.negative BC(N=999)at our institution between January2.11 and December 2.15 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2.low,and evolution of HER2.immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2.IHC0 and HER2.low *** HER2.low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2.IHC0 BC group(P2.low status increased with increasing ER expression levels(Mantel-Haenszelχ^(2.test,P2.low BC group than in HER2.IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2.IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2.low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2.low Breast cancer Estrogen receptor Trastuzumab deruxtecan

METTL5 promotes cell proliferation,invasion,and migration by up-regulating Toll-like receptor 8 expression in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2006-2017页

作者： Ling-Shang kong Ran Tao Yi-Fan Li Wen-Bin Wang Xue Zhao department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina department of Vascular Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230002Anhui ProvinceChina department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230012Anhui ProvinceChina department of Scientific Research Anhui Public Health Clinical CenterHefei 230012Anhui ProvinceChina department of Scientific Research The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND N6-methyladenosine(m6A)modification represents the predominant alteration found in eukaryotic messenger RNA and plays a crucial role in the progression of various ***,despite its significance,the comprehensive investigation of METTL5,a key m6A methyltransferase,in colorectal cancer(CRC)remains *** To investigate the role of METTL5 in *** We assessed METTL5 expression levels in clinical samples obtained from CRC patients as well as in CRC cell *** elucidate the downstream targets of METTL5,we performed RNA-sequencing analysis coupled with correlation analysis,leading us to identify Toll-like receptor 8(TLR8)as a potential downstream *** vitro functional assessments of METTL5 and TLR8 were conducted using CCK-8 assays,scratch assays,as well as assays measuring cell migration and *** Our findings reveal a pronounced upregulation of METTL5 expression in both CRC cells and tissues,which correlated significantly with an unfavorable *** vitro experiments unequivocally demonstrated the oncogenic role of METTL5,as evidenced by its promotion of CRC cell proliferation,invasion,and ***,we identified TLR8 as a downstream target of METTL5,and subsequent down-regulation of TLR8 led to a significant inhibition of CRC cell proliferation,invasion,and tumor *** The heightened expression of METTL5 in CRC is strongly associated with clinicopathological features and a poor prognosis,thereby underscoring its potential utility as a critical marker for facilitating early diagnosis and prognostication in CRC.

关键词： METTL5 Toll-like receptor 8 Colorectal cancer

Swimmer with submerged SiO_(2./Al/LiNbO_(3) surface acoustic wave propulsion system

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Biomimetic Intelligence & Robotics 2024年第2期4卷 71-77页

作者： Deqing kong Ryo Tanimura Fang Wang Kailiang Zhang Minoru Kuribayashi Kurosawa Manabu Aoyagi department of Engineering Muroran Institute of TechnologyMuroran 050-8585Japan Tianjin Key Laboratory of Film Electronic and Communication Devices School of Integrated Circuit Science and EngineeringTianjin University of TechnologyTianjin 300384China School of Engineering Tokyo Institute of TechnologyYokohama 226-8501Japan

Acoustic propulsion system presents a novel underwater propulsion approach in small scale *** study introduces a submerged surface acoustic wave(SAW)propulsion system based on the SiO_(2./Al/LiNbO_(3) *** 19.2. MHz,the SAW propulsion system is proposed and investigated by the propulsion force calculation,PIV measurements and propulsion measurements.3.3 mN propulsion force is measured at 2..6 V_(pp).To evaluate the miniature swimmer,the SAW propulsion systems with multiple frequencies are *** 2.2.W,the submerged SAW propulsion system at 38.45 MHz demonstrates 0.83 mN/mm^(2. propulsion *** 96.13 MHz and 2. V_(pp),the movements of miniature swimmer with a fully submerged SAW propulsion system are recorded and analyzed to a maximum of 177 mm/*** of miniaturization,high power density,and simple structure,the SAW propulsion system can be expected for some microrobot applications,such as underwater drone,pipelinerobotand intravascularrobot.

关键词： Acoustofluidics Surface acoustic wave Swimmer Underwater propulsion system

Ability of Agrogyron elongatum to accumulate the single metal of cadmium, copper, nickel and lead and root exudation of organic acids

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Journal of Environmental Sciences 2001年第3期13卷 368-375页

作者： YANG hong 1, Jongathan W.C.Wong 2. YANG Zhi min\+1, ZHOU Li xiang 1(1. College of Science, Nanjing Agricultural university, Nanjing\ 2.0095, {2.. 2. department of Biology, hong kong baptist university, {2.) College of Science Nanjing Agricultural University Nanjing 210095 China.

Agrogyron elongatum were grown in nutrient solution containing moderate to high amounts of separate heavy metal of Cd, Cu, Ni and Ph in a greenhouse for a 9 - day. Cd, Cu, Ni and Ph generally led to decrease in the elongation of roots although the length of seedlings exposed to Cd and Ph at 0.05 and 0.5 mg/L showed to be slightly greater than that of controls. Of the four metals in the experiment, Ph was absorbed and accumulated to the highest level, with the concentrations of 92.54 mg/kg dry weight (DW) in roots and 11683 mg/kg DW in shoots. Cd was moderately accumulated in Agrogyron elongatum, but the maximum bioaccumulation coefficients (BCs) for roots and shoots were observed. The patterns for Cu and Ni uptake and distribution in plants differed from those of Ph and Cd, as it was showed that the shoot accumulation of Cu and Ni was significantly higher than in roots. A. elongation had the highest Ni concentration in shoots (302.1 mg/kg DW) at the external concentration of 2.0 mg/L. Cu ranked second, with a shoot concentration of 12.30 mg/kg DW when 50 mg/L Cu in solution was applied. For the four trace elements tested, the highest concentrations in shoots decreased by the order of Ni > Cu > Ph > Cd (mg/kg DW), and those in roots were Ph > Cd > Ni > Cu (mg/kg DW). Malic, oxalic and citric acids exuded by roots exposed to 1 and 50 mg/L of the metals were detected. Release of organic acids from plants significantly differed among the metal treatments. Cu was most effectively in inducing root exudation of the three types of organic acids. Cd, and Ni were also the inducers of secretion of malic and oxalic acids. With reference of Pb, a small amounts of malic and oxalic acids were detected in the root exudates, but few quantities, of citric acid were. found. However, no correlation between alternations in root exudation of organic acids and metal accumulation could be established.

关键词： heavy metal organic acid Agrogyron elongation hyperaccumulation

Computerized cognitive remediation therapy on cognitive impairment and social function in patients with chronic schizophrenia

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World Journal of Psychiatry 2024年第6期14卷 884-893页

作者： Jian-Jun Hu Xi-Rong Sun Shuang-Ming Ni Yan kong department of Psychiatry Shanghai Pudong New Area Mental Health Center(Mental Health Center of Tongji UniversityShanghai Pudong New Area Psychological Counseling Center)Shanghai 200124China

BACKGROUND Patients with schizophrenia may have various disease manifestations,most of which gradually tend toward incurable chronic decline,leading to mental *** basic symptoms of the disease can impair social function,whereas long-term hospitalization produces hospitalization syndrome,causing serious damage to social *** To investigate the effects of Computerized Cognitive Remediation Therapy(CCRT)on cognitive and social functioning in patients with chronic *** A retrospective analysis of 12. patients with chronic schizophrenia in Shanghai Pudong New Area Mental Health Center was *** were divided into an intervention group(60 cases treated with CCRT combined with conventional medication)and a control group(60 cases treated with conventional medication).After treatment,effects on cognitive function and social roles were observed in both *** Positive and Negative Syndrome Scale(PANSS)was used to assess the patients'psychiatric *** Wisconsin Card Sorting Test(WCST)was used to assess the patients'cognitive functioning,and the Social Functioning Scale for Psychiatric Inpatients(SSPI)was used to assess the social functioning of the inpatient psychiatric *** No significant differences were observed in the PANSS,WCST,and SSPI intergroup scores before treatment(P>0.05).After 2.4,and 6 wk of therapy,general psychopathological factors,positive symptoms,negative symptoms,and total PANSS scores of PANSS in the intervention group were lower than in the control group(P2.4,and 6 wk of treatment,the number of false responses,number of persistent bugs,and total responses in the WCST were significantly lower in the intervention group than in the control group(P2.4,and 6 wk of therapy,the SSPI scores were significantly greater than those of the controls(P<0.05).After 6 wk of treatm

关键词： Computerized cognitive correction therapy Schizophrenia Cognitive function Social function Psychopathological factors

Multifunctional high-performance pressure/proximity/temperature sensors enabled by hybrid resistive-supercapacitive response

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Nano Research 2024年第6期17卷 5604-5613页

作者： Huijun kong Zhongqian Song Meichun Ding Changxiang Shao Jiahui Yu Baolei Wang Weiyan Li Chenwei Li Li Niu School of Chemistry and Pharmaceutical Engineering Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China College of Artificial Intelligence and Big Data for Medical Sciences Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

The issue of sensitivity attenuation in high-pressure region has been a persistent concern for pressure-sensitive electronic *** order to tackle such trade-off between sensitivity and linear range,herein,a hybrid piezoresistive-supercapacitive(HRSC)strategy is proposed via introducing a piezoresistive porous aerogel layer between the charge collecting electrodes and iontronic films of the pressure ***,the HRSC-induced impedance regulation and supercapacitive behavior contribute to significant mitigation in sensitivity attenuation,achieving high sensitivity across wide linear range(44.58 kPa^(−1)from 0 to 3 kPa and 2..6 kPa^(−1)from 3 to 12.kPa).The HRSC pressure sensor exhibits a low detection limit of 1 Pa,fast responsiveness(~130 ms),and excellent cycling stability,allowing to detect tiny pressure of air flow,finger bending,and human ***,the HRSC sensor exhibits exceptional perception capabilities for proximity and temperature,broadening its application scenarios in prosthetic perception and electronic *** proposed HRSC strategy may boost the ongoing research on structural design of high-performance and multimodal electronic sensors.

关键词： multimodal sensor pressure sensor high sensitivity MXene/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)aerogel structural design