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Correlation of Behavior Changes and BOLD Signal in Alzheimer-like Rat Model

Acta Biochimica et Biophysica Sinica 2004年第12期36卷 803-810页

作者： Zheng-Hui HU#, Xiao-Chuan WANG1#, Li-Yun LI3, Mai-Li LIU3, Rong LIU1, Zhiqun LING1, Qing TIAN1, Xiao-Wei TANG, Yi-Gen WU2*, and Jian-Zhi WANG1* department of physics and Bio-X disciplinary laboratory, Zhejiang university, Hangzhou 310027,china 1 department of Pathophysiology, Tongji Medical College, Huazhong university of Science and Technology, wuhan 430030, china 2institute of High Energy physics and key laboratory of Nuclear Analysis Techniques, chinese academy of sciences, P.O. Box 918, beijing 10003., china 3wuhan institute of physics and mathematics, state key laboratory of magnetic resonance and atomic and molecular physics, chinese academy of sciences, wuhan 43.071, china department of physics and Bio-X disciplinary {2. Zhejiang UniversityHangzhou 310027China department of Pathophysiology Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China wuhan institute of {2. and {3. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan 430071 China institute of High Energy physics and {2. {3. of Nuclear Analysis Techniques Chinese Academy of SciencesP.O. Box 918 Beijing 100039 China

To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2. signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2. signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic {3. imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser3.6/Ser404 and Ser199/Ser2.2.was signifi- cantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2. An AD-like spatial memory retention disturbance was induced at 2. h after isoproterenol injection. (3. A sensitivity threshold of resting T2. signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 3.0}62. These results suggest that resting T2. signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation.

关键词： Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isoproterenol (IP) Morris Water Maze diagnosis

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Experimental and theoretical study of^(13.C shielding tensors in new-style molybdenum complex

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Science china chemistry 2004年第3期47卷 214-221页

作者： HOU Guangjin1,2. WANG Liying2. LU Xiaoming3. ZHENG Anmin2. DENG Feng2.&YE Chaohui1,2.1. department of physics, Huazhong {2. of Science and Technology, wuhan 43.074, china 2. state key laboratory of magnetic resonance and atomic and molecular physics, wuhan institute of physics and mathematics, chi-nese academy of sciences,{13., china 3. department of chemistry, capital normal university, beijing 10003., china 1. department of physics Huazhong University of Science and Technology 430074 Wuhan China 2. chinese {2. of sciences State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics 430071 Wuhan China 3. department of chemistry Capital Normal University 100037 Beijing China

13. 2.-PASS spectra of two new cis-dioxo catecholatomolybdenum complexes (NH2.H2.H2.HCH2.2.H+)3.MovO 2.C6H4O2.2. and (NH2.H2.H2.H2.H2.2.H+)3.Mo(v)O2.(C2.2.2.2. have been obtained by solid-state nuclear magnetic {2. (NMR), in which the spinning sidebands were well-separated. The principal components of the 13. shielding tensors were extracted by theoretically fitting the intensities of 13. spinning sidebands. The effects of counter cations on 13. chemical shift isotropy and shielding tensor of cis-dioxo catecholatomolybdenum complex anion [Mo (v)O2.C6H4O2.2.3. were studied, comparing the 13. CSA of those carbon sites in complex anions with that of the counter cations. Based on the known structure of the molybdenum complex crystal, theoretical values of 13. shielding tensors were calculated by the ainitio GIAO method, in comparison with the experimental results.

关键词： NMR, magic angle spinning, chemical shift anisotropy, shielding tensor, cis-dioxo-monomolybdenum.

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Assisted Cloning and Orthogonal Complementing of an Arbitrary Unknown Two-Qubit Entangled state

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Communications in Theoretical physics 2006年第11期 849-852页

作者： FANG Ming,~1 LIU Yi-Min,~(2,3. LIU Jun,~1 SHI Shou-Hua,~1 and ZHANG Zhan-Jun~(1,3.+) 1 School of physics & Material Science, Anhui university, Hefei 23.03., china 2 {3. of physics, Shaoguan university, Shaoguan 512005, china 3.The state key laboratory of magnetic resonance and atomic and {13. physics, wuhan institute of physics and mathematics, the chinese academy of sciences, wuhan 43.071, china

Based on A.K. Pati’s original idea [Phys. Rev. A 61 (2.00) 02.3.8] on single-qubit-state-assisted clone, very recently Zhan has proposed two assisted quantum cloning protocols of a special class of unknown two-qubit entangled states [Phys. Lett. A 3.6 (2.05) 3.7]. In this paper we further generalize Zhan’s protocols such that an arbitrary unknown two-qubit entangled state can be treated.

关键词： quantum cloning arbitrary two-qubit entangled state two-qubit projective measurement

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强激光场中原子的束缚态和连续态对高次谐波的影响

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物理学报 2001年第10期50卷 1902-1906页

作者：周效信李白文西北师范大学物理系兰州730070 中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室武汉430071

利用基函数展开结合线性最小二乘法方法求解含时薛定谔方程 ,研究了一维原子在强激光场中产生高次谐波过程中 ,束缚态和连续态以及它们的干涉效应对高次谐波的影响 .结果表明 ,低能的高次谐波是由束缚态束缚态之间的相互作用产生的 ,... 详细信息

利用基函数展开结合线性最小二乘法方法求解含时薛定谔方程 ,研究了一维原子在强激光场中产生高次谐波过程中 ,束缚态和连续态以及它们的干涉效应对高次谐波的影响 .结果表明 ,低能的高次谐波是由束缚态束缚态之间的相互作用产生的 ,高能的高次谐波是由束缚态连续态之间的相互作用产生的 ,而截断频率后消失的高次谐波是由于束缚态束缚态与束缚态

关键词：束缚态连续态线性最小二乘法强激光场高次谐波原子物理学量子力学含时薛定谔方程

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直流空心阴极放电中鞘层区电子的输运过程

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物理学报 1994年第6期43卷 950-957页

作者：魏合林刘祖黎华中理工大学物理系中国科学院武汉物理研究所波谱与原子分子物理国家重点实验室

采用蒙特－卡洛方法对空心阴极放电中鞘层区电子的输运过程进行了研究，电子在鞘层区被非均匀电场加速，两次碰撞之间的步长是由电子与中性粒子的碰撞频率确定。模型中三种碰撞截面积是由实验和理论数据拟合而来。研究了电子平均能量、... 详细信息

采用蒙特－卡洛方法对空心阴极放电中鞘层区电子的输运过程进行了研究，电子在鞘层区被非均匀电场加速，两次碰撞之间的步长是由电子与中性粒子的碰撞频率确定。模型中三种碰撞截面积是由实验和理论数据拟合而来。研究了电子平均能量、电子密度和电离系数在径向的分布。电子能量的空间分布结果与实验很好地符合。

关键词：空心阴极放电电子输运过程

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The weakly bound states and resonances of the BeHe2.tri{2. system

The weakly bound states and resonances of the BeHe2 triatomi...

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第十六届全国原子与分子物理学术会议

作者： Hui-li Han~1,Yong Li~2,Ting-yun Shi~1 1 state key laboratory of {3. resonance and atomic and molecular physics,wuhan institute of physics and mathematics,chi{13. academy of sciences,wuhan 43.071,People’s Republic of china 2 department of physics,Huazhong normal university,wuhan 43.079,People’s Republic of china

In the present study we carry out a full search of the bound states and resonances of the HeBe tri{2. system,with its isotopic variants HeBe,HeHeBe and HeBe using the hyperspherical ***-body long-range effects are ...

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A cloud of laser cooled 40Ca+ in a linear ion trap

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Science Bulletin 2010年第Z2期 3094-3097页

作者： ZHOU Fei 1,2,XU YouYang 1,2,XIE Yi 1,2,GUO Bin 1,2,SHU HuaLin 3.LI JiaoMei 1,HUANG XueRen 1 &FENG Mang 11 state key laboratory of {3. resonance and atomic and molecular physics,wuhan institute of physics and mathematics,chi{13. academy of sciences,wuhan 43.071,china 2Graduate university of the chi{13. academy of sciences,beijing 100049,china 3.School of physics and Telecommunication Engineering,South china normal university,Guangzhou 510006,china

A cloud of 40Ca+is successfully trapped and cooled using the radiation of a red-detuned 3.7 nm laser beam and a resonant 866 nm laser beam in our prototype linear ion trap,which was designed and constructed for studying quantum information *** have characterized the size of the ion cloud,estimating the temperature to be in the order of milli-Kelvins.

关键词： ion trap laser cooling quantum information processing

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Different response patterns of local field potentials of the olfactory bulb in awake and anesthetized rats

Different response patterns of local field potentials of the...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： An-An LI~1,Min LIU~2,Lei ZHANG~2,Qing LIU~1,Ling GONG~1,Fu-Qiang XU~(1,3.*) 1 wuhan MRC,state key {3. of magnetic resonance and atomic and molecular physics,wuhan institute of physics and mathematics,the {13.nese academy of sciences,wuhan 43.071,china 2 department of chemistry and Life Science,Hubei university of Education,wuhan 43.205,china 3.wuhan National {3. for Optoelectronics,wuhan 43.074,china

＜正＞The olfactory bulb（OB）,an important odor information processing center in olfactory system,not only has heavy intermutual neural projections with brain areas related to olfaction,including piriform cortex,amygdala, hippocampus and striatum,but also receives regulatory affections from other brain regions such as raphe nuclei and locus *** of these projections provide the possible modulation of the activity in the OB by brain *** awake and anesthetized states are two different brain conditions and are both used extensively in electrophysiological studies of ***,the activity patterns of OB local field potentials（LFP）in responding to odor stimulation at different brain states are *** clarify this question,the LFP oscillations at granule cell layer of the OB in awake and anesthetized animals were *** found that the LFP responses induced by odor in awake state were complex,with different frequency bands showed different patterns:13.3. Hz,increased significantly;3.-60 Hz,almost no response;and 60-90 Hz,decreased *** addition,the increased response of 13.3. Hz was transient, whereas the decreased response of 60-90 Hz was ***,when the animals were anesthetized by chloral hydrate,all of the three frequency bands showed significantly increased and long-lasting ***, the activity patterns of OB LFP in responding to odor stimulation are significantly different when the animals are under awake and anesthetized states,reflecting different neural mechanisms involved in the odor information processing under the two brain states.

关键词： brain states local field potential olfactory bulb odor

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Expression pattern of clusterin in the mouse olfactory bulb

Expression pattern of clusterin in the mouse olfactory bulb

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Rui-Qi WU~(1,3.,Zhi-Xiang XU~(1,3.,Xiao-Ping RAO~(1,3.,Fu-Qiang XU~(1,2,*) 1 wuhan MRC,state key {3. of magnetic resonance and atomic and molecular physics,wuhan institute of physics and mathematics,the {13.nese academy of Science,wuhan 43.071,china 2 wuhan National {3. for Optoelectronics,wuhan 43.074,china 3.Graduate {23. of {13.nese academy of Science,beijing 100049,china

＜正＞Objective Clusterin is an enigmatic multifunctional glycoprotein expressed in most mammalian tissues. Some possible roles of clusterin in central nervous system（CNS）have been *** olfactory system is important in CNS for emotional responses,reproductive functions,neuroendocrine regulation,aggressive behavior, *** olfactory bulb（OB）is the center for the coding and processing of the peripheral information,and the hub for the distribution of the processed information in the olfactory *** In order to better understand the functions of this protein in the CNS,we examined the detailed distribution of clusterin in normal and anosmic mouse OB by immunohistochemical *** We found that the signals located in cell bodies at postnatal day 6 （P6）,in nerve fibers at P18,and then in neurofibrils after *** addition,less clusterin protein expression was observed for anosmic mouse,except for the high level in the olfactory nerve layer（ONL）.Conclusion The dynamic expression in OB at different ages and the increased expression in ONL for anosmic mice may provide important hints toward the potential functions of this protein.

关键词： clusterin olfactory bulb neuronal immunohistochemistry

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Oscillator strengths between low-lying ro-vibrational states of HD+

Oscillator strengths between low-lying ro-vibrational states...

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第十六届全国原子与分子物理学术会议

作者： Quan-Long Tian~1,Li-Yan Tang~1,Zong-Chao Yan~2.Ting-Yun Shi~1 1 state key {2. of magnetic resonance and atomic and molecular physics, wuhan institute of physics and mathematics,chinese academy of {12.,wuhan 43.071,china and 2.department of physics,university of New Brunswick,Fredericton,New Brunswick,Canada, E3. 5A3

The molecular hydrogen ions(MHI) are the simplest stable *** several decades,the high precision spectroscopy of MHI have attracted much attention, aiming to determine fundamen-tal constants and test bound state *** is

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