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Relation of coronary vulnerable plaque instability to serum levels of C-reactive protein and B-type natriuretic peptide in ACS.

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上海医学 2007年第S1期30卷 88-88页

作者： JIANG Jin-fa , QIAN Qi , DENG Liang , DU Lei. department of Cardiology, tongji {2. of tongji university, shanghai 200065, china

Objective To explore the relationship between coronary vulnerable plaque instability and serum C-reactive protein(CRP) , B-type natriuretic peptide(BNP) levels in 85 patients with coronary heart disease. Methods Eighty-five patients( aged 63.16,M= 52.) were divided into two *** control group was 2. patients with stable angina pectoris (SAP). The study group was 57 patients with acute coronary syndrome (ACS) .which were further divided into 2. patients with non ST elevated myocardial infarction (NSTEMI) and 3. patients with unstable angina pectoris (UAP). Plasma BNP and CRP were measured as well as coronary angiography made for all 85 patients. Plaques of coronary culprit arteries were classified as I -III three types according to Ambrose classification. Results (1). BNP and CRP levels of NSTEMI and UAP groups were significant higher than in SAP group. (2..The levels of BNP and CRP correlated with Ambrose classification, especially positively with Ambrose II type ,but no relation with coronary narosis. (3.. The levels of BNP was much higher in patients of left anterior descending or multiple coronary artery diseases .(4). The Plaques of coronary culprit arteries in high risk of NSTEMI and UAP patients were mostly Ambrose II or III type. Conclusions The prevalence of higher levels of plasma BNP and CRP in patients with ACS ,when compared with those of SAP, was associated with the instability of coronary vulnerable plaques (ie, Ambrose II type). The level of BNP was much higher in patients of left anterior descending or multiple complicated coronary diseases. So, BNP and CRP are not only markers of vulnerable plaques, but also indicators of ACS prognosis.

关键词： natriuretic vulnerable plaque instability pectoris descending angina unstable arteries classified

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人工晶体瞳孔夹持的分析

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上海医学 2003年第4期26卷 262-264页

作者：王惠英荣翱同济大学附属同济医院眼科上海200065

目的　分析后房型人工晶体植入术后发生瞳孔夹持的原因 ,并探讨其防治方法。方法　回顾性分析 11例人工晶体术后发生瞳孔夹持患者的临床资料。早期发生瞳孔夹持 5例 ,行非手术治疗。迟发的 6例中 ,2.患者的视力受影响较小 ,且无其他并... 详细信息

目的　分析后房型人工晶体植入术后发生瞳孔夹持的原因 ,并探讨其防治方法。方法　回顾性分析 11例人工晶体术后发生瞳孔夹持患者的临床资料。早期发生瞳孔夹持 5例 ,行非手术治疗。迟发的 6例中 ,2.患者的视力受影响较小 ,且无其他并发症 ,未予处理 ;4例行手术复位。结果　 5例经非手术方法治疗后均复位成功。 4例手术复位的患者中 ,3.术后复位 ,并发症消失 ;1例因葡萄膜炎导致复位失败。结论　选择合适的人工晶体、撕囊口位置居中、人工晶体植入囊袋内和术毕缩小瞳孔等方法可有效地预防或减少瞳孔夹持的发生。术后早期发现瞳孔夹持 ,其非手术复位的成功率高。

关键词：人工晶体瞳孔夹持房型人工晶体植入术防治手术治疗治疗白内障

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Transumbilical endoscopic surgery:History,present situation and perspectives

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World Journal of Gastrointestinal Endoscopy 2011年第6期3卷 107-109页

作者： Jiang-Fan Zhu,department of Minimally Invasive Surgery,East hospital of {2. {3.,shanghai 2.012.,china Jiang-Fan Zhu Department of Minimally Invasive Surgery East Hospital of Tongji University Shanghai 200120 China.

Transumbilical endoscopic surgery or laparo-endoscopic single site(LESS)surgery has become an exciting area of surgical development as innovation continues to move in the 2.st century to minimally invasive *** history,present situation and perspectives are reviewed and the nomenclature of this technique is discussed in this *** range of this technique has been applied in almost all abdominal diseases,surgeries for morbid obesity,hernia and so on,in recent *** is estimated that 50%-80%of traditional laparoscopic surgery could be performed transumbilically in the next five years according to the LESSCAR *** the concept of transumbilical laparoscopic surgery is gaining traction rapidly and the instruments have been improved greatly, we should not advocate for slightly improved cosmetic value over ***,randomized and clinical trials are necessary to further elucidate the safety and efficiency of this new *** that examines the efficacy of the new instruments on the market may be helpful to simplify the confusing landscape of new and novel products designed for this purpose.

关键词： Transumbilical Laparoscopy Surgery Transumbilical endoscopic surgery Minimally invasive surgery

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Using the rPatlak plot and dynamic FDG-PET to generate parametric images of relative local cerebral metabolic rate of glucose

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Science Bulletin 2012年第Z2期 3811-3818页

作者： WU YiGen 1,2.,ZHOU Yun 3.BAO ShangLian 2.,HUANG SungCheng 4,ZHAO XiaoHu 5 & LI Jun 2.1 School of Physics and Optoelectronic Engineering,Nanjing {3. of Information Science and Technology,Nanjing 2.0044,china 2.Beijing City Key Laboratory of Medical Physics and Engineering,Peking {3.,Beijing 100871,china 3.The Russell H.Morgan department of Radiology and Radiological Science,School of Medicine,Johns Hopkins {3.,Baltimore,MD 2.2.7,USA 4 department of Molecular and Medical Pharmacology,UCLA David Geffen School of Medicine,{3. of California in Los Angeles,Los Angeles,CA 90095,USA 5 imaging department of tongji hospital of tongji {3.,shanghai 200065,china

Local cerebral metabolic rate of glucose(LCMRGlc) is an important index for the description of neural *** 18 F-fluoro-2.deoxy-D-glucose(FDG) positron emission tomography(PET) has been used for quantitative imaging of LCMRGlc in humans,but is seldom used routinely because of the difficulty in obtaining the input function noninvasively.A reference tissue-based Patlak plot model(rPatlak) was proposed to generate parametric images of LCMRGlc in a quantitative dynamic FDG-PET study without requiring blood *** emission scans(4×0.5,4×2.and 10×5 min) were acquired simultaneously with an IV bolus injection of 155 MBq of *** blood samples were collected during the scans via a catheter placed in the radial *** data were also generated using the same scan *** last ten scan data sets were used in a graphical analysis using the Patlak *** ratio of LCMRGlc estimated from the original Patlak(oPatlak,using plasma input) was used as the gold standard,and the standardized uptake value ratio(SUVR) was also calculated for *** different tissues including white matter,gray matter,and whole brain were chosen as reference tissues for *** of the reference region used,the slopes in the linear regression between oPatlak and rPatlak were closer to unity than the regression slopes between oPatlak and *** intercepts for the former were also closer to 0 than those for the latter *** squared correlation coefficients were close to 1.0 for both *** showed that the results of rPatlak were in good agreement with those of oPatlak,however,SUVR exhibited more *** simulation study also showed that the relative variance and bias for rPatlak were less than those for *** images obtained with rPatlak were very similar to those obtained with oPatlak,while there were differences in the relative spatial distribution between the images of SUVR and *** study validates that the rPatl

关键词： quantification local cerebral metabolic rate of glucose FDG-PET rPatlak method SUVR noninvasive parametric imaging

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肾素-血管紧张素系统与血管紧张素转换酶基因多态性的关系

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上海医学 2003年第11期26卷 805-807页

作者：王宏保邓兵邓南伟同济大学附属同济医院心内科上海200065

目的　了解血管紧张素转换酶 (ACE)基因多态性对肾素血管紧张素系统 (RAS)的影响。方法　 6 8例高血压患者给予口服氯沙坦钾 5 0～ 10 0mg/d ,共 2.0周。采用外周血白细胞抽提基因组DNA、体外PCR基因扩增的方法检测ACE基因第 16内含... 详细信息

目的　了解血管紧张素转换酶 (ACE)基因多态性对肾素血管紧张素系统 (RAS)的影响。方法　 6 8例高血压患者给予口服氯沙坦钾 5 0～ 10 0mg/d ,共 2.0周。采用外周血白细胞抽提基因组DNA、体外PCR基因扩增的方法检测ACE基因第 16内含子、长度为 2.87bp的片段插入 /缺失 (I/D)多态性 ,并将患者分为DD、ID、II这 3.基因型。采用放射免疫分析法检测治疗前后患者血浆肾素活性 (PRA)、血管紧张素Ⅱ (AⅡ )、血清醛固酮 (ALD)的变化。结果　口服氯沙坦钾2.0周后 ,6 8例患者ALD明显下降 ,PRA和AⅡ明显升高 ,但基因型不同其变化明显不同。结论　ACE基因I/D多态性对RAS有明显的影响。

关键词：肾素-血管紧张素系统血管紧张素转换酶基因多态性氯沙坦钾放射免疫分析法检测高血压

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The Association between the Gene Polymorphism of ApoE, ACE and Cognitive Function

The Association between the Gene Polymorphism of ApoE, ACE a...

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2.05年中国神经心理学学术会议

作者： FANG Fang, WU Wen-yuan, LI Chun-bo, et al. Psychosomatic department, tongji {2. oftongji university, shanghai 200065, china

＜正＞Objective To explore the relationship between cognitive function and the genetic polymorphism of Apolipoprotein E （ApoE） and Angiotensin-converting enzyme （ACE）. Methods Using polymerase chain reaction（PCR）-based technique, polymorphism of ApoE and ACE were determined in 3.1 community elderly aged 65 years or over. All were assessed by Neuropsychological Test Battery for Elderly （NTBE）. Results Controlling age and educational level, group with ApoEe4 allele was better on the scores of some sub-test （auditory verbal learning and delayed recall, naming recall, visual recognition, verbal fluency about first names, mini-token, motor, finished time of Cancellation test of red circle） than the group without e4 , the difference were significant. The difference of construction test and number of near-misses of color trials 2.test between two groups had significant tendency （P=0.06）. The group with ACE D allele were better on the scores of some sub-test (auditory verbal learning and delayed recall, sorting, mini-token, finished time of color trials 1 and 2.than the group without D, the difference were significant. The difference of motor test between two groups had significant tendency （.P=0.08）. Conclusions Cognitive function correlates to the genetics polymorphism of ApoE and ACE. Screening and detecting elderly with potential high risk on cognition impairment in advance through identifying these genetic individuals will contribute to early intervention of successful aging.

关键词： genes Polymorphism(genetics) Angiotensin-convertingenzyme Apolipoprotein E Cognitive function Neuropsychological tests

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Subacute Thyroiditis as Seen Initially in ENT department—— A Reportof3. Cases

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Journal of Huazhong university of Science and Technology(Medical Sciences) 2002年第1期22卷 82-83页

作者： WANG Zhibin (王志斌) department of Otolaryngology Tongji Hospital Tongji Medical College Huazhong University of Science and Technolog y Wuhan 430030

To assess the pharyngeal presentations and the diagnostic value of thyroid SPECT and thyroid fine needle aspiratory biopsy (FNAB) in subacute thyroiditis (SAT) as seen initially in ENT department, 3. patients, during the course of SAT, were examined for pharyngeal symptoms and tested for serum T 3. T 4 level. The thyroid SPECT imaging or thyroid FNAB were performed. Our results showed that, of the 3. patients, 2. had sore throat of various degrees, and 9 had abnormal sensation of throat. Six were diagnosed as having SAT by only SPECT, in the remaining 2., the final diagnoses was established by SPECT combined with FNAB. Two of them were finally diagnosed as having SAT by trial treatment with oral prednisone. It is concluded that sore throat and abnormal sensation of pharynx are the important presentations of SAT, and thyroid SPECT imaging and thyroid FNAB are valuable in diagnosing SAT.

关键词： subacute thyroiditis sore throat abnormal sensation of pharynx

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Era of diagnostic and interventional ultrasound

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World Journal of Radiology 2011年第5期3卷 141-146页

作者： Hui-Xiong Xu,department of Medical Ultrasound,shanghai Tenth People’s {2. and the Tenth People’s {2. of tongji university,shanghai 2.0072.china Hui-Xiong Xu Department of Medical Ultrasound Shanghai Tenth People's Hospital and the Tenth People's Hospital of Tongji University Shanghai 200072 China.

It is an era of diagnostic and interventional ultrasound (US).Various new techniques such as three-dimensional US(3. US),interventional US,and contrastenhanced US(CEUS)have been introduced into clinical *** and his colleagues have taken advantage of these techniques and carried out a series of relevant *** use of 3. US in the liver,gallbladder,liver tumor volumetry,guidance for ablation,and 3. CEUS has widened the application of 3. US in the *** found that prognosis in patients with hepatocellular carcinoma(HCC)after thermal ablation with curative intent was determined by treatment response to ablation,pretreatment serum AFP,and liver function *** response to treatment was the most predictive factor for long-term *** compared the use of percutaneous microwave ablation and radiofrequency ablation for the treatment of HCC and found that both are effective methods in treating *** local tumor control,complications related to treatment, and long-term survival were equivalent for the two *** first compared the enhancement patterns of HCC and intrahepatic cholangiocarcinoma(ICC)and proposed the diagnostic clues for ICC,liver angiomyolipoma(AML),gallbladder cancer,renal carcinoma,and renal AML,which have greatly enhanced the role ofCEUS in the *** also evaluated the diagnostic performance of CEUS in characterizing complex cystic focal liver lesions and the agreement between two investigators with different experience levels;and found that CEUS is especially useful for the young *** assessed the effect of anti-angiogenic gene therapy for HCC treated by microbubble-enhanced US exposure and concluded that gene therapy mediated by US exposure enhanced by a microbubble contrast agent may become a new treatment option for HCC.

关键词： Ablation Cancer Contrast-enhanced ultrasound Interventional ultrasound Liver Three-dimensional ultrasound

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尿激酶与链激酶治疗下肢深静脉血栓形成的比较

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上海医学 2003年第S1期26卷 66-67页

作者：黄道景龚凯范跃祖同济大学附属同济医院普外科上海200065

目的　探讨国产尿激酶与重组链激酶溶栓治疗下肢非急性期深静脉血栓形成的早期疗效。方法　非急性期深静脉血栓形成患者 43. ,分为 2.。尿激酶组 ( 2.2. )予国产尿激酶 5 0万U ,重组链激酶组 ( 2.1例 )予链激酶 5 0万U。两药均溶于 5... 详细信息

目的　探讨国产尿激酶与重组链激酶溶栓治疗下肢非急性期深静脉血栓形成的早期疗效。方法　非急性期深静脉血栓形成患者 43. ,分为 2.。尿激酶组 ( 2.2. )予国产尿激酶 5 0万U ,重组链激酶组 ( 2.1例 )予链激酶 5 0万U。两药均溶于 5 0 0ml 5 %葡萄糖注射液中 ,每日 1次静脉滴注 ,连用 5d。两组常规治疗相同。结果　两组症状缓解率中 ,重组链激酶组下肢周径缩小的程度和血管部分再通率明显优于尿激酶组 (P <0 .0 5 )。结论　重组链激酶治疗下肢非急性期深静脉血栓形成的早期疗效优于国产尿激酶 ,但药物不良反应较多。

关键词：尿激酶重组链激酶深静脉血栓形成

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A new formula for estimation fetal of weights less than 2.00 g by using ultrasound scanning

A new formula for estimation fetal of weights less than 2500...

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中华医学会第十次全国超声医学学术会议

作者： Ping Chen~1,Jinhua Yu~2.and Yuehua Song~1 1 shanghai First Maternity and Infant Health hospital,{2. university,shanghai,china 2.department of Electronic Engineering,Fudan university,shanghai,china

Objective:To develop a new formula to estimate fetal weight in fetuses of less than ***:A new formula was developed from 2.0 low weight(≤2.00g) fetuses,singleton fetuses,examined within 3.days before birth *** regression analysis was used to develop the new formula with BPD HC AC and FL *** another 94 fetuese whose birth weitht were lower than 2.00g the new formula was tested and compared with other three published ***:The new estimated weight formula was:EFW=-

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