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A functional MRI study of mental calculation-a comparison between abacus mental experts and nonexperts

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A functional MRI study of mental calculation-a comparison be...

3.-CTA在周围动静脉畸形诊治中的初步应用

中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Chen Fei-yan, Zhao Xiao-hu, He Hong-jian, Yang Zhen-yan, Hu Zheng-hui Bio-X Laboratory, Zhejiang university, Hangzhou 3.002. tongji {2. Affiliated, tongji university, shanghai 200065

＜正＞Abacus mental calculation is a method of mental calculation based on the principles of manipulating abacus calculation, opposite to the usual algorithm. Abacus mental experts have demonstrated extraordinary potential of mental calculation. The neurophysiological mechanism underlying such superior mental calculation capability remains unknown, although some efforts have been done. In the present study, we investigated the neural correlates of mental calculation in children abacus mental experts and nonexperts, employing a functional magnetic resonance imaging （fMRI） to measure the subjects’ brain activities engaged in simple serial addition （SSA, one-digit numbers） and complex serial addition （CSA, two-digit numbers for control, four-digit numbers for experts）. Eight right-handed healthy children abacus mental experts and. ten children nonexperts aged between 10 and 15 years, volunteered to participate in this study with informal written consent by their parents.

关键词： mental calculation fMRl neural correlate childr

来源： cnki会议评论

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上海口腔医学 2004年第1期13卷 2-5页

作者：陈达林晓曦范新东毛青姚振威李伟上海第二医科大学附属第九人民医院整复外科上海200011 上海第二医科大学附属第九人民医院放射科上海200011 上海第二医科大学附属第九人民医院神经外科上海200011 复旦大学附属华山医院放射科上海200040

目的:观察比较16层螺旋CT血管造影(3.-CTA)和数字减影血管造影技术(DSA)在周围动静脉畸形中的应用价值。方法:16例周围动静脉畸形(AVM)病人,分别进行DSA和CTA检查。进行畸形病灶、各级供应动脉、经济学等指标的比较。有关数据利用SPSS1... 详细信息

目的:观察比较16层螺旋CT血管造影(3.-CTA)和数字减影血管造影技术(DSA)在周围动静脉畸形中的应用价值。方法:16例周围动静脉畸形(AVM)病人,分别进行DSA和CTA检查。进行畸形病灶、各级供应动脉、经济学等指标的比较。有关数据利用SPSS10.0软件进行t检验。结果:以DSA为诊断的阳性对照,CTA对畸形血管团诊断准确率为100%,对畸形血管团的第1、2.供应动脉诊断的准确率达86%,对第3.供应动脉的确诊率低。CTA平均费用为800元;;同时进行三维重建后的CTA图像,有助于对AVM和周围组织的关系判断。结论:多层3.-CTA作为一种微创、高分辨率的血管造影技术,在AVM的诊断中具有重要的价值,而且有助于手术方案的制定。

关键词：周围动静脉畸形诊断血管造影数字减影血管造影 16层螺旋CT 血液流体力学 3.-CTA

头颈部恶性肿瘤颈淋巴结隐匿性转移的MRI诊断

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上海口腔医学 2001年第1期10卷 13-13页

作者：顾云峰邱蔚六罗济程同济大学附属同济医院口腔外科上海200065 上海第二医科大学附属第九人民医院口腔医学院口腔颌面外科上海200011

目的确定磁共振 (MRI)诊断口腔癌的颈淋巴结隐匿性转移的效率。方法 41例临床触诊检查颈部淋巴结转移阴性的头颈部恶性肿瘤病人 ,术前行MRI颈部扫描 ,了解颈淋巴结转移阳性和阴性的情况 ,并在术后同病理诊断对照。结果 41例病人被手... 详细信息

目的确定磁共振 (MRI)诊断口腔癌的颈淋巴结隐匿性转移的效率。方法 41例临床触诊检查颈部淋巴结转移阴性的头颈部恶性肿瘤病人 ,术前行MRI颈部扫描 ,了解颈淋巴结转移阳性和阴性的情况 ,并在术后同病理诊断对照。结果 41例病人被手术切除的颈淋巴清扫标本内有 12.经病理证实为颈淋巴结转移 ,其中MRI发现 9例 ,其敏感性为 75 % ,特异性为 87% ,3.假阴性 ,主要是转移的淋巴结体积小 ,形态无明显变化 ,其内部信号变化不明显。结论 MRI技术可作为临床诊断颈淋巴结隐匿性转移的有效手段之一。

关键词：磁共振成像颈淋巴结隐匿性转移准确率头颈部恶性肿瘤诊断

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肝脏局灶性结节增生的MRI诊断

复旦学报（医学版） 2003年第5期30卷 444-447页

作者：林江严福华李钦复旦大学附属中山医院放射科上海200032

目的　分析和研究肝脏局灶性结节增生 (FNH)的MRI表现及诊断价值。方法　回顾性分析 2.4例 3.个经手术病理证实的FNH的平扫及动态增强扫描图像。 2.4例中有 4例又行肝特异性造影剂检查 ,包括 2.锰福地匹三钠 (Mn DPDP)和 2.超顺磁性... 详细信息

目的　分析和研究肝脏局灶性结节增生 (FNH)的MRI表现及诊断价值。方法　回顾性分析 2.4例 3.个经手术病理证实的FNH的平扫及动态增强扫描图像。 2.4例中有 4例又行肝特异性造影剂检查 ,包括 2.锰福地匹三钠 (Mn DPDP)和 2.超顺磁性氧化铁 (SPIO)增强扫描。结果　 2.2.为单发FNH ,2.为多发。大小为 1.0～ 6 .0cm。 2.4个病灶在T1WI上呈典型的等或略低信号 ,4个呈低信号 ,2.为略高信号。 2.5个病灶在T2.I呈典型的等或略高信号 ,5个呈高信号。 2.9个病灶的实质部分在动脉期明显强化 ,在门脉期和延迟期呈等或略高信号。 1个病灶的实质部分在动脉无强化 ,而在延迟期变成等信号。 2.病灶在延迟期出现增强的假包膜。 2.1个病灶MRI平扫和动态增强扫描显示瘢痕 ,9个均未显示。瘢痕为T1WI低信号或等信号 ,T2.I高信号 ,增强后延迟强化 ,4个病灶动态增强扫描动脉期显示供血动脉影。使用Mn DPDP后病灶为等或略高信号。使用SPIO后 ,病灶呈等信号。结论　多数FNH有典型MRI征象 ,综合使用平扫和动态增强扫描是正确诊断的关键。肝特异性造影剂对FNH的诊断有帮助。

关键词：肝脏局灶性结节增生磁共振成像诊断肝肿瘤 MRI

大剂量阿糖胞苷治疗时血浆和脑脊液中药物浓度测定的研究

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上海医学 2005年第3期28卷 220-223页

作者：谢晓恬李本尚李莉廖雪莲石苇同济大学附属同济医院小儿血液肿瘤专科上海200065

目的　测定初治儿童急性淋巴细胞白血病(ALL)和Ⅳ期非霍奇金淋巴瘤(NHL)在接受大剂量阿糖胞苷(HD AraC)和常规剂量阿糖胞苷(SD -AraC)治疗时血浆和脑脊液中的药物浓度,了解HD AraC的体内药物代谢规律,并验证其疗效优越性。方法　予HD Ar... 详细信息

目的　测定初治儿童急性淋巴细胞白血病(ALL)和Ⅳ期非霍奇金淋巴瘤(NHL)在接受大剂量阿糖胞苷(HD AraC)和常规剂量阿糖胞苷(SD -AraC)治疗时血浆和脑脊液中的药物浓度,了解HD AraC的体内药物代谢规律,并验证其疗效优越性。方法　予HD AraC(2.0 g/m2.治疗时,在特定时间点分次采集对侧肘静脉血,并于血药浓度高峰时(静脉滴注12. min)采集脑脊液标本。采用高效液相色谱法(HPLC)和Ara- C、Ara- U标准品测定血和脑脊液标本的Ara- C和Ara- U浓度,并绘制血浓度变化曲线。结果　应用HD- AraC治疗时,Ara -C平均高峰血药浓度为(49.94±2..03.μmol/L,Ara -U平均高峰血药浓度为(162.10±108.06)μmol/L,分别达到SD AraC治疗时血药浓度(1.07μmol/L和6.81μmol/L)的近50倍和2.倍。脑脊液中Ara C和Ara- U的浓度均值在血药浓度达到峰值(静滴滴注12. min)时分别为(5.93.4.01)和(2..98±10.41)μmol/L。同时发现,Ara -U浓度明显高于Ara -C浓度;药物浓度也存在明显的个体差异。结论　应用HD- AraC治疗可明显提高药物血浓度,脑脊液中也能维持较高的药物浓度水平,是达到显著临床疗效的药理学基础。但药物浓度存在明显的个体差异,尚需进一步进行药物代谢相关研究,为今后个体化治疗创造条件。

关键词：大剂量阿糖胞苷药物浓度测定急性淋巴细胞白血病(ALL) 血浆 Ara-C mol/L 非霍奇金淋巴瘤高效液相色谱法血药浓度脑脊液标本个体差异药理学基础个体化治疗常规剂量代谢规律体内药物肘静脉血静脉滴注变化曲线

Effects of 2.APB on Store-operated Ca^(2.) Channel Currents of Hepatocytes after Hepatic Ischemia/Reperfusion Injury in Rats

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Journal of Huazhong university of Science and Technology(Medical Sciences) 2005年第1期25卷 39-41页

作者：黄昌州张宗明裘法祖 department of Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 43003 China department of Surgery The First Affiliated Hospital Qinghua University Beijing 100016 China

The effects of hepatic ischemia/reperfusion (I/R) injuries on hepatocellular viability and store-operated calcium current (Isoc) in isolated rat hepatocytes and the effects of 2.APB on store-operated calcium current (Isoc) in isolated rat hepatocytes after hepatic ischemia/reperfusion injuries were studied. Hepatic ischemia and reperfusion injury model was established and whole cell patch-clamp techniques were used to investigate the effects of 2.APB on Isoc. The results showed that ischemia/reperfusion injuries could significantly reduce hepatocellular viability and further increase Isoc in hepatocytes and 2.APB (2., 40, 60, 80, 100 μmol/L) produced a concentration-dependent decrease of Isoc with IC 50 value of 64.63.10.56 μmol/L (n=8). It was concluded that ischemia/reperfusion injuries could reduce hepatocellular viability, probably through increased Isoc in hepatocytes and 2.APB had a protective effect on ischemia/reperfusion-induced liver injury, probably though inhibiting Isoc.

关键词： hepatic ischemia/reperfusion injuries hepatocytes store-operated calcium current store-operated calcium channel calcium channel blockers

Concurrent hyperglycemia does not influence the long-term prognosis of unresectable hepatocellular carcinomas

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World Journal of Gastroenterology 2003年第8期9卷 1848-1852页

作者： Xiao-Ping Li Zhen Chen Zhi-Qiang Meng Wen-Xia Huang Lu-Ming Liu, department of Liver Neoplasms, Cancer hospital, Fudan {2., {3. 2.003.2} china Xiao-Ping Li Zhen Chen Zhi-Qiang Meng Wen-Xia Huang Lu-Ming Liu Department of Liver Neoplasms Cancer Hospital Fudan University Shanghai 200032 China

AIM: The association has been established between the disorder of carbohydrate metabolism and liver ***, little is known regarding the impact of concurrent hyperglycemia on prognosis of hepatocellular carcinoma (HCC). The present study aimed at solving this ***: A total of 2.5 patients included in this study,were admitted from January 1998 to December 2.01 for an unresectable HCC proven by histological and imaging examinations. Most of the patients received interventional treatment, radiation and biotherapy. Response was evaluated by computerized tomography (CT) scan conducted 4-6 weeks following completion of the treatment, and then every 3.onths, Survival was calculated from the beginning of treatment using the Kaplan-Meier method. Pretreatment,treatment and follow-up variables with possible prognostic significance were analyzed. A stepwise multivariate analysis was performed using the Cox regression model, and a prognostic index was ***: No differences were observed in survival parameters between the patients with and without hyperglycemia, median survival times of the patients were being 2.±3.46 months and 2..5±2.04 months, respectively, and the 3.year survival rate was 8.3.%and 9.62., respectively. The univariate analysis indicated that there were several survival-associated variables including serum AFP level, clinical stage, Child-Pugh grade,method of treatment, size and number of tumor nodule (s).However, only the clinical stage, Child-Pugh grade and the treatment procedure were proved to be independent prognostic factors in the multivariate ***: This study indicates that hyperglycemia does not influence the long-term prognosis of HCC, and concurrent hyperglycemia should not be considered as an unfavorable prognostic factor during the treatment of patients with HCC.

关键词：肝细胞癌并发症高血糖症预后

Methodological study on real-time three-dimensional echo-cardiography and its application in the diagnosis of complex congenital heart disease

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Chinese Medical Journal 2006年第14期119卷 1190-1194页

作者： CHEN Guo-zhen, HUANG Guo-ying, LIANG Xue-cun, MA Xiao-jing, CHEN Wei-da, TAO Zi-yu and LIN Qi-shan Pediatric Heart Center, Children’s hospital of Fudan university {2. of Pediatrics, {3. Medical College, {3. 2.003.2} china china） 200032

Background Real-time three-dimensional echocardiography （RT-3.E） has made revolutionized improvements of cardiac imaging during the past few years. However, there is no standard examination method for RT-3.E so far. This study aimed to establish the diagnostic method of RT-3.E and evaluate its application in the diagnosis of complex congenital heart diseases （CHD）. Methods Fifty patients with complex CHD were examined by RT-3.E with modes of Live 3.E and Full Volume. A series of novel volumetric views combined with Van Praagh sequential segmental approach were introduced to reveal the pathological morphology of the hearts, which were compared with the findings of two-dimensional echocardiography （2.E）, angiography and cardiac surgery. Results In 50 patients, 190 image acquisitions of Full Volume were performed at several acoustic windows including subcostal, apical and parasternal regions. Among them, 94.2. （179/190） of image acquisitions were successful. Most sectional volumetric views could be clearly displayed in 92.6% of the successful image acquisitions. However, sectional volumetric views could not be clearly displayed in 7.4%, which was mainly due to poor perspective conditions of examination location, improper instrument multi-parameter setting and insufficient information of whole heart captured in Full Volume acquisitions. As compared with surgical findings and angiography, RT-3.E made correction to the diagnoses in 2.cases including 1 with corrected transposition of the great arteries and the other with single atrium and mitral cleft. The diagnoses initially made by 2.E for these 2.patients were double outlet right ventricle with transposition of the great arteries and complete atrio-ventricular septal defect. Conclusions RT-3.E can clearly display the pathological morphology of complex CHD by a series of novel volumetric views combined with sequential segmental approach through providing more spatial informative cardiovascular structures, which pro

关键词： congenital heart disease three-dimensional echocardiography real-time imaging

术后发生重症肺栓塞的急诊导管及导丝碎栓治疗

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上海医学 2003年第11期26卷 834-835页

作者：王乐民魏林孙政育李晓光刘雅君同济大学附属同济医院心内科上海200065 哈尔滨医科大学第四临床医学院心内科

目的　探讨急诊导管、导丝治疗术后重症肺栓塞的可行性。方法　 6例术后发生急性重症肺栓塞患者均采用肺动脉造影及导管、导丝碎栓术。结果　 6例患者经造影证实其肺动脉内均有大块状血栓栓塞 ,经导管、导丝碎栓治疗后 ,5例患者痊愈。... 详细信息

目的　探讨急诊导管、导丝治疗术后重症肺栓塞的可行性。方法　 6例术后发生急性重症肺栓塞患者均采用肺动脉造影及导管、导丝碎栓术。结果　 6例患者经造影证实其肺动脉内均有大块状血栓栓塞 ,经导管、导丝碎栓治疗后 ,5例患者痊愈。结论　通过急诊肺动脉造影和直接导管介入治疗 ,可使术后大面积肺栓塞患者的血流动力学迅速得到改善。

关键词：术后并发症重症肺栓塞急诊导管碎栓术导丝碎栓术治疗血流动力学