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p53、bcl-2.因和雌孕激素受体在乳腺癌表达的临床意义

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上海医学 2003年第S1期26卷 13-15页

作者：韩晶金宗浩党云文同济大学附属同济医院乳腺外科上海200065

目的　探讨 p5 3基因、bcl 2.因、雌激素受体 (ER)及孕激素受体 (PR)在乳腺癌中表达的意义及其相互之间的关系。方法　采用免疫组化SP法检测 116例乳腺癌患者的p5 3、bcl 2.ER及PR。结果　癌组织中p5 3、bcl 2.ER及PR阳性反应检出率... 详细信息

目的　探讨 p5 3基因、bcl 2.因、雌激素受体 (ER)及孕激素受体 (PR)在乳腺癌中表达的意义及其相互之间的关系。方法　采用免疫组化SP法检测 116例乳腺癌患者的p5 3、bcl 2.ER及PR。结果　癌组织中p5 3、bcl 2.ER及PR阳性反应检出率分别为 2.2..4%、48.3 %、73 .3 %和 5 6.9% ;有淋巴结转移的乳腺癌患者p5 3基因表达明显高于无淋巴结转移者 ,ER的表达与p5 3相反。bcl 2.因在病理TNM分期早期乳腺癌中的表达明显高于中、晚期乳腺癌。PR的阳性率表达与患者的年龄、肿块直径、淋巴结转移及TNM分期均呈负相关(P 2.ER和PR均可作为判断乳腺癌预后的指标。p5 3和bcl 2.表达呈负相关 ,bcl 2.ER、PR呈正相关 ,且有协同性。bcl 2.性表达还可作为乳腺癌早期诊断的指标。

关键词：乳腺肿瘤癌基因雌激素受体孕激素受体预后相关性

A new blood supply for human primary gallbladder carcinomas:vasculogenic mimicry,and its correlation with VEGF and significance

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外科研究与新技术 2010年第1期 49-58页

作者：范跃祖孙伟张文忠葛春艳 Department of Surgery Tongji Hospital of Tongji University

Objective To explore if vasculogenic mimicry (VM) exists in human primary gallbladder carcinomas and evaluate the correlation between the VM and expression of vascular epithelial growth factor (VEGF) in gallbladder carcinomas and its significance. MethodsSeventy-four carcinomas, 10 adenomas and 10 chronic inflammatory lesions of the gallbladder underwent operation and confirmed histopathologically were studied. Clinical-pathological data and survival of each patient with gallbladder carcinoma were recorded and followed-up. VM in human gallbladder carcinomas was observed under light microscope by HE staining, CD31 and PAS staining; the expression of VEGF proteins in each paraffin section of each patient in vivo was determined by Envision method of immunohistochemistry; the correlation among the VM, VEGF expression and their clinical significance in the patients with gallbladder carcinomas were analyzed and compared by Kaplan-Meier actuarial survival curves and Cox multiple factors. Results①13.5% (10/74) of human gallbladder carcinomas were found to contain VM, namely intratumoral, tumor cell-lined extracellular matrix (ECM)-rich, PAS-positive and vasculogenic-like network patterns. VM was associated with histological type (χ2.10.2.1,P=0.017), hepatic metastasis (χ2.4.2.8,P=0.042. and poor overall survival (χ2.5.72. 1,P=0.016). ②Expression of VEGF was increased significantly in carcinomas with or without VM than adenomas and inflammatory lesions of the gallbladder (P2.. ③There is positive correlation between expression of VEGF and the gallbladder carcinomas without VM in the cases of Nevin stage (P=0.003 5), invasion depth (P=0.005 9), liver metastases (P=0.037 3) and lymph node metastases (P=0.000 1), the same correlation was only observed between expression of VEGF and the gallbladder carcinomas with VM in the cases of liver metastases (

关键词： gallbladder neoplasm vasculogenic mimicry blood vessels vascular epithelial growth factor prognosis

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副根管的实验观察及其临床意义

同济大学学报（医学版） 2001年第6期22卷 11-12页

作者：朱霞苏静同济大学口腔医学院上海200072 宝山区吴淞地段医院口腔科上海200940

目的　观察副根管的发生率。方法　利用透明标本的制作及 0 .5 %碱性品红在髓室底的渗入情况 ,判断副根管的有无。结果　透明标本与染料渗入法显示第一、二恒磨牙副根管的发生率分别为 12..96 %、2.0 .45 %,经卡方检验 ,两者差异无显著... 详细信息

目的　观察副根管的发生率。方法　利用透明标本的制作及 0 .5 %碱性品红在髓室底的渗入情况 ,判断副根管的有无。结果　透明标本与染料渗入法显示第一、二恒磨牙副根管的发生率分别为 12..96 %、2.0 .45 %,经卡方检验 ,两者差异无显著性。结论　副根管是药物渗漏及致病菌侵犯的通道 ,临床诊疗时应予以考虑。

关键词：磨牙根管副根管

Relationship between CT grouping and complications of liver cirrhosis

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 219-223页

作者： Min-Guang Zhang, Xue-Jing Huang, Qiong Zhu, Jian Geng and An-Jun Zhang Department of Radiology, shanghai hospital of Traditional Chinese Medicine, shanghai 2.0071 , china Department of Radiology, Shuguang hospital, shanghai university of Traditional Chinese Medicine, shanghai 2.002. , china Department of Radiology Shanghai Hospital of Traditional Chinese Medicine Shanghai 200071 China. mgzhang09@***

BACKGROUND: imaging examination is important for hepatic cirrhosis. But the relationship between magnetic resonance (MR), computed tomography (CT) or ultrasound findings and pathological groups, degree, or reserve function of the cirrhotic liver is not clear. In this study, we investigated the relationship between the CT groupings of liver cirrhosis and its complications and clinical conditions. METHODS: The CT findings in 357 patients with liver cirrhosis were grouped. The complications were analyzed, included splenomegaly, varicose collateral veins, ascites, pleurorrhea, primary liver carcinoma, gallbladder stone, etc. Blood routine (BRt), and serum usea nitrogen (SUN), creatinine and uric acid were measured and hypersplenia and liver-kidney syndrome were estimated. RESULTS: Three hundred and fifty-seven patients with cirrhosis were divided into homogeneous group (87 patients, 2..4%), segmental group (41, 11.5%), and nodal group (2.9, 64.2.). The grade of spleen enlargement in the segmental and the nodal groups was significantly greater than that in the homogeneous group (P 2.3%), respectively. Significant difference was observed among the 3 groups ( P 2.patients (79.5%) of the nodal group, in 11 patients (2..8%) of the segmental group and in 9 patients ( 10.3%) of the homogeneous group (P2..7%) in the nodal group had primary liver carcinoma and 1 (2.4%) in the segmental group and 5 (5.8%) in the homogeneous group (P<0.001). The number of patients with decreased concentration of hematoglobin in the nodal group was more than that in the homogeneous group ( P < 0. 001). The mean values of hematoglobin and platelet in the nodal group and the segmental group were significantly lower than those in the homogeneous group ( P < 0. 05 ). The number of

关键词： grouping cirrhosis complication computed tomography

Retroperitoneal laparoscopic nephropexy:a report of 2. cases

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Retroperitoneal laparoscopic nephropexy:a report of 28 cases

Effects of 2.APB on Store-operated Ca^(2.) Channel Currents of Hepatocytes after Hepatic Ischemia/Reperfusion Injury in Rats

第十五届全国泌尿外科学术会议

作者： ZHENG Jun-hua1,PENG Bo1,XU Dan-feng2. GO Yi2.(Department of Urology, shanghai 10th People’s hospital, {2. university, shanghai 2.0072.

Objective: To discuss the procedures and clinical effect of retroperitoneal laparoscopic nephropexy (RLN). Methods: From August 2.01 to June 2.06, RLN was performed on 2. female patients (aged 2.-45 years old, mean 34...

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Journal of Huazhong university of Science and Technology(Medical Sciences) 2005年第1期25卷 39-41页

作者：黄昌州张宗明裘法祖 Department of Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 43003 China Department of Surgery The First Affiliated Hospital Qinghua University Beijing 100016 China

The effects of hepatic ischemia/reperfusion (I/R) injuries on hepatocellular viability and store-operated calcium current (Isoc) in isolated rat hepatocytes and the effects of 2.APB on store-operated calcium current (Isoc) in isolated rat hepatocytes after hepatic ischemia/reperfusion injuries were studied. Hepatic ischemia and reperfusion injury model was established and whole cell patch-clamp techniques were used to investigate the effects of 2.APB on Isoc. The results showed that ischemia/reperfusion injuries could significantly reduce hepatocellular viability and further increase Isoc in hepatocytes and 2.APB (2., 40, 60, 80, 100 μmol/L) produced a concentration-dependent decrease of Isoc with IC 50 value of 64.63±10.56 μmol/L (n=8). It was concluded that ischemia/reperfusion injuries could reduce hepatocellular viability, probably through increased Isoc in hepatocytes and 2.APB had a protective effect on ischemia/reperfusion-induced liver injury, probably though inhibiting Isoc.

关键词： hepatic ischemia/reperfusion injuries hepatocytes store-operated calcium current store-operated calcium channel calcium channel blockers

VEGF stimulates lymphangiogenesis in colorectal cancer and the treatment via anti-lymphangiogenesis

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china Medical Abstracts 2006年第1期15卷 78-81,87页

作者：贡海兵张国锋范跃祖 Department of Surgery Tongji HospitalTongji UniversityShanghai 200065China

Lymph node metastasis is the most common and basic way in the extending of colorectal tumor. It is an important reason for the difficulty of curing the tumor and the tumor＇s high mortality. And it is also an important factor that effects surgery treatment. Vascular endothelial growth factor（VEGF） family is a group of factors which specificly act on endothelial cell. VEGF has been shown to be an important regulator of turnour angiogenesis, but its effect on lymphangiogenesis is not so clear. In this review,we discussed VEGF＇s effect on lymphangiogenesis, the colorectal microenvironment＇s effect on the factors expression and the therapeutics via antilymphangiogenesis by inhibiting VEGFR-3 signaling.

关键词： lymphangiogenesis VEGF VEGFR metastasis

Differential levels of cytokines and soluble FasL between tuberculous and malignant effusions

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Differential levels of cytokines and soluble FasL between tu...

维持性血液透析患者外周血单个核细胞核因子κB活性与微炎症、氧化应激状态及心血管疾病的关系

中华医学会结核病学分会2.10年学术年会

作者： HaiYan Cui,Qing Zang,Bo Su,Wei Li,ShenJie Tang~* Department of TB,shanghai Pulmonary hospital,{2. university School of Medicine,shanghai,2.0433, china

Tuberculosis(TB) remains the major infectious cause of death *** pleurisy(TBP) is a common manifestation of extra-pulmonary TB,still difficult to *** is regarded as a positive response to Mtb infection,characterized by an extensive inflammatory exudate in the pleural *** effort has been devoted to clarify the immunity mechanism of TB and identification of immunologically important factors in TBP. This study compared the differences of 3 cytokines(IFN-γ,IL-2.IL-4) and soluble Fas ligand(sFasL) both in serum and pleural effusion between TBP and MP,using an enzyme-linked immunosorbent assay(ELISA).In addition,we also evaluated the relationship between sFasL and *** and pleural effusion samples were collected from 36 patients with tuberculous pleurisy,30 patients with malignant pleurisy caused by lung cancer and 30 healthy *** data showed in both groups,the levels of cytokines and sFasL were significantly higher in pleural effusion than in serum;the levels of IFN-γboth in serum and pleural effusion was significantly higher in TBP than MP;the levels of sFasL were significantly higher in TBP than MP;pleural sFasL concentrations correlated with IFN-γin TBP patients,R=0.588,P<*** summary,we show that serum and pleural effusion levels of cytokines and sFasL differ in TBP and MP *** this study is limited by the small number of patients investigated,our findings might advance our understanding of the immune mechanism of tuberculosis.

关键词： tuberculosis pleurisy cytokine sFasL apoptosis

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肾脏病与透析肾移植杂志 2011年第6期20卷 506-511页

作者：徐雁邹建洲刘中华徐少伟沈波晋玮滕杰丁小强上海市同济医院肾内科上海200065 复旦大学附属中山医院肾内科血液净化中心

目的:探讨维持性血液透析(MHD)患者外周血单个核细胞(PBMC)核因子κB(NF-κB)活性与微炎症、氧化应激状态及心血管疾病(CVD)的关系。方法:选取MHD治疗3个月以上的患者(32.),以体检健康者(12.)为对照组。采用ELISA法检测受试者PBMC的NF... 详细信息

目的:探讨维持性血液透析(MHD)患者外周血单个核细胞(PBMC)核因子κB(NF-κB)活性与微炎症、氧化应激状态及心血管疾病(CVD)的关系。方法:选取MHD治疗3个月以上的患者(32.),以体检健康者(12.)为对照组。采用ELISA法检测受试者PBMC的NF-κB活性,比色法检测血清总抗氧化能力(TAOC)及丙二醛(MDA)。Pearson相关和线性回归分析PBMC的NF-κB活性与其他指标的相关性。二分类Logistic回归分析NF-κB活性与CVD的关系。结果:MHD患者PBMC的NF-κB活性[(1142.4±413.0)ng/mg核蛋白vs(2.8.3±39.5)ng/mg核蛋白,P2.g/Lvs0.5mg/L,P2..9±6.6)U/mlvs(15.7±2.3)U/ml,P2.76.5±690.1)ng/mg核蛋白vs(1142.2.413.0)ng/mg核蛋白,P2..9±6.6)U/ml,P1170.0ng/mg核蛋白)是CVD的独立危险因素(OR=8.47,P<0.05)。结论:MHD患者PBMC的NF-κB活性显著升高,且与微炎症、氧化应激状态及CVD相关,可作为患者的炎症标志物。

关键词：血液透析核因子κB 炎症氧化应激心血管疾病