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Effects of Intrinsic Nitric Oxide on the Expression of Interleukin-4 and IFN-γ mRNA in the Bronchial and Lung Tissues of Sensitized Rats

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Journal of Huazhong university of Science and Technology(Medical Sciences) 2000年第1期20卷 29-31页

作者：薛建敏徐永健张珍祥 Department of Respiratory Medicine Tongji Hospital Tongji Medical University Wuhan

Summary: To investigate the effects of intrinsic nitric oxide (NO) on the expression of interleukin-4 (IL-4) mRNA and interferon-γ (IFN-γ) mRNA in the airway inflammation of asthma, the rat models of asthmatic inflammation were established by sensitizing and then challenging the animals with ovalbumin. The 2. animals were randomly divided into control group, sensitized group, sensitized and L-Arg-treated group as well as L-NAME-treated group equally. By using in situ hybridization combined with compute physiological quantitative imaging analysis techniques, the influence of intrinsic NO on the expression of IL-4 mRNA and IFN-Y mRNA in the airway inflammatory cells was observed. In situ hybridization study demonstrated that IL-4 mRNA expres- sion was obviously increased as compared with that in the control group, mainly distributed in the inflammatory cells in the submucous of airways in the sensitized group. The increase of intensity of IL-4 mRNA expression was positively correlated with the numbers of eosinophil (Eos) and lymphocyte (both with Pimaging analysis showed that L- NAME could inhibit the expression of IL-4 mRNA (P2.lymphocytes and the expression of IFN-γ mRNA of Th1 lymphocytes and in turn, promote the development of asthmatic airway inflammation.

关键词： asthma nitric oxide interleukin-4 interferon-γ in situ hybridization

Magnetic resonance angiography in the mana-gement of patients with portal hypertension

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 239-243页

作者： Hua Liu, Hui Cao and Zhi-Yong Wu shanghai, china Department of General Surgery, Renji {2., shanghai Second Medical university, shanghai 2.012., china Department of General Surgery Renji Hospital Shanghai Second Medical University Shanghai 200127 China. housman111@***

BACKGROUND: In recent years, MR techniques have been widely used for displaying hepatic vessels and measuring its hemodynamics, especially in the management of the patients with portal hypertension. The aim of this study was to eva- luate the role of magnetic resonance angiography (MRA) in the treatment of patients with portal hypertension. METHODS: A series of 38 patients with portal hypertension and 12.control patients were enrolled in this study. Three dimensional dynamic contrast-enhanced (3D-DCE) MRA and two dimensional phase-contrast (2.-PC) MR were used for the study of portal venous anatomy and its hemo- dynamics, which were compared with those of indirect portal-venography (IPVG) and doppler ultrasonography (DUS). RESULTS: The anatomical imaging of the portal venous system could be displayed clearly in 3D-DCE MRA and the imaging quality of MRA was better than that of IPVG. The hemodynamic information from 2.-PC MR was closely re- lated to that from DUS. CONCLUSIONS: As a non-invasive technique, MRA can display the anatomy of the portal venous system clearly and measure its hemodynamics exactly. It is very useful and can be applied if necessary in the management of patients with portal hypertension.

关键词： portal hypertension clinical application magnetic resonance angiography

中国人群腔内置管溶栓治疗深静脉血栓疗效与安全性的Meta分析

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华中科技大学学报（医学版） 2011年第5期40卷 614-617,622页

作者：李毅清张强周斌梅菲金毕华中科技大学同济医学院附属协和医院血管外科武汉430022 同济大学附属东方医院血管外科上海200120

目的比较腔内置管溶栓(ICDT)和选择性外周静脉溶栓(SPVT)治疗下肢深静脉血栓的优劣。方法通过检索中国学术期刊全文数据库、维普、万方以及EBASE和Pubmed等多个数据库近年的相关文献,运用Meta分析,评价ICDT和SPVT的疗效与安全性。结果... 详细信息

目的比较腔内置管溶栓(ICDT)和选择性外周静脉溶栓(SPVT)治疗下肢深静脉血栓的优劣。方法通过检索中国学术期刊全文数据库、维普、万方以及EBASE和Pubmed等多个数据库近年的相关文献,运用Meta分析,评价ICDT和SPVT的疗效与安全性。结果筛选后获得文献6篇(n=701,2.07～2.10年),其中未见死亡和严重肺栓塞病例报道。ICDT在疗效上相对于SPVT没有显著优势,但其起效时间和早期溶栓的成功率高于SPVT。结论在具备医疗条件的情况下,ICDT是相对有效和廉价的急性深静脉血栓治疗方案。

关键词：深静脉血栓腔内置管溶栓选择性外周静脉溶栓 Meta分析

A study of effects of using low dialysate calcium concentration (1.50 mmol/L) on blood pressure,serum concentrations of calcium,parathyroid hormone and aldosterone in chronic hemodialysis patients

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外科研究与新技术 2011年第3期 229-234页

作者：范凯文许晨朱敏 Dialysis Center Nephrology Department of Tongji Hospital Affiliated to Tongji University

Background: Dialysis centres around the world use different concentrations of calcium in dialysate solution,ranging from 1. 2. to 1. 75 mmol / L. However,a dialysate concentration of 1. 2. mmol / L is recommended. [1] Higher or lower dialysate calcium concentrations are indicated in patients,depending on their co-morbid factors. We explored the effects of using a calcium dialysate solution of 1. 50 mmol / L compared to a 1. 75 mmol / L calcium dialysate solution on the Blood Pressure (BP) ,serum concentrations of Calcium,Parathyroid Hormone (PTH) and Aldosterone in chronic hemodialysis (HD) patients. Method: 42.patients were enrolled in the study. First a 1. 50 mmol / L low calcium dialysate solution (LCDS) was used for 4 hour dialysis,and for the next session of HD,a 1. 75 mmol / L (NCDS) normal calcium dialysate solution was used. Blood pressure was measured at 5 intervals of time: pre HD,at 60,12.,180 and 2.0 minutes into the HD session. Pre and post HD blood samples were taken for serum calcium,PTH and Aldosterone levels. Results: All 42.patients completed the study. With LCDS,the post HD serum calcium levels were (2. 51 ± 0. 14) mmol / L,compared to (2. 85 ± 0. 17) mmol / L for NCDS (P 2. 2. ± 115. 89) pg / ml serum PTH level was noted with NCDS (P 2. ng / L was obtained with LCDS and (165. 50 ± 78. 84) ng / L with NCDS (P 2.. 17 ± 2.. 42. mmHg with LCDS dialysis compared to (132. 50 ± 2.. 32. mmHg for NCDS dialysis (P 2. ±11. 63) mm Hg(P <0. 01) ,respectively. Conclusion: LCDS can more effectively improve hypercalcemic status in dialysis patients than NCDS. Using LCDS stimulates the secretion of PTH more than when using NCDS. LCDS decreases aldosterone l

关键词： dialysate concentration hemodialysis parathyroid hormone calcium aldosterone

Establishment of animal models for chronic pulmonary embolism

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china Medical Abstracts 2009年第1期18卷 73-78页

作者：张鹏王永武葛志如周永新The Department of Thoracic Surgery of tongji hospital of tongji university 2.0065 china 姜格宁 The Department of General Thoracic Surgery of the Pulmonary Disease hospital in shanghai of {2. university 2.0433 China The Department of Thoracic Surgery of tongji hospital of tongji university 2.0065 China The Department of Cardiology of Gongli hospital 2.0135 China

Objective： To establish the animal model for the chronic pulmonary embolism and do some research on it. Methods： Pulmonary arteriography by DSA were performed in 6 goats and the stent was released in the infer-pulmonary arterary. Arterial blood gas analysis and right heart catheterization were done. After 3 days of embolism, pulmonary arteriography were performed again. After the animal was sacrificed, the right and left infer-pulmonary tissues were prepared and pathologically studied. Results： Stents were smoothly released in 6 animals. Compared with that before embolism, the arterial blood gas showed no difference 10 minutes later and 3 days later of the stent released. The pulmonary angiography showed that the right infra pulmonary artery was partly blocked and the blood could still pass by. 3 d of the embolism later, the stent was placed well and the right pulmonary artery was completely blocked. Compared with that before embolism,the right atrial pressure, ventricular pressure and the pulmonary pressure in 10 rain after embolism did not change much （ P 〉 0.05 ）, while 3 d after embolism, the pressures were obviously changed（P 〈 0.05 ）. There was no atelectasis ,pleural effusion in the right infra lobe in the experimental group. The wall of blood capillary among the alve- olar wall were significantly dilated. Hyperemia and edema were also observed. Lots of monocyte infiltrated. Localized exudates appeared in alveolar. Conclusion： By releasing stent in the pulmonary, the chronic pulmonary embolism model could be established in the animal experiment, and it should have great potential value in the following study.

关键词： pulmonary embolism chronic animal model

Application of Color Doppler Ultrasonic Examination in Deep Vein Valvular Incompetence in Lower Limbs

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Journal of Huazhong university of Science and Technology(Medical Sciences) 1997年第1期17卷 49-53页

作者：吴亚群薛新波覃修福汪元芳张青萍 Department of Surgery Tongji Hospital Tongji Medical University Wuhan

By use of color Doppler Flow imaging (CDFI), the morphologic and hemodynamic parameters such as the diameters of femoral and popliteal veins,blood flow velocity and the reflux 0f valve area were examined in lower extremity deep valvular incompetence (DVI) and normal control gr0ups. The purpose was to evaluate the value of CDFI in the diagnosis of DVI. The results demonstrated that the parameters between the two groups had a very significant difference (P<0. 001), indicating that the CDFI is non-invasive, cost-effective and safe and it might serve as a practical tool in the diagnosis of lower extremity deep va1vular incompetence.

关键词： color Doppler flow imagingl diagnosis lower extremity deep valvular incompetence

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人工晶体瞳孔夹持的分析

上海医学 2003年第4期26卷 262-264页

作者：王惠英荣翱同济大学附属同济医院眼科上海200065

目的　分析后房型人工晶体植入术后发生瞳孔夹持的原因 ,并探讨其防治方法。方法　回顾性分析 11例人工晶体术后发生瞳孔夹持患者的临床资料。早期发生瞳孔夹持 5例 ,行非手术治疗。迟发的 6例中 ,2.患者的视力受影响较小 ,且无其他并... 详细信息

目的　分析后房型人工晶体植入术后发生瞳孔夹持的原因 ,并探讨其防治方法。方法　回顾性分析 11例人工晶体术后发生瞳孔夹持患者的临床资料。早期发生瞳孔夹持 5例 ,行非手术治疗。迟发的 6例中 ,2.患者的视力受影响较小 ,且无其他并发症 ,未予处理 ;4例行手术复位。结果　 5例经非手术方法治疗后均复位成功。 4例手术复位的患者中 ,3例术后复位 ,并发症消失 ;1例因葡萄膜炎导致复位失败。结论　选择合适的人工晶体、撕囊口位置居中、人工晶体植入囊袋内和术毕缩小瞳孔等方法可有效地预防或减少瞳孔夹持的发生。术后早期发现瞳孔夹持 ,其非手术复位的成功率高。

关键词：人工晶体瞳孔夹持房型人工晶体植入术防治手术治疗治疗白内障

The anatomical research of the structure of orbital bone based on CT images

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The anatomical research of the structure of orbital bone bas...

Using the rPatlak plot and dynamic FDG-PET to generate parametric images of relative local cerebral metabolic rate of glucose

2.04年上海市口腔医学学术年会

作者： Y.L HUANG, XING ZHANG shanghai East hospital, {2. university

＜正＞ Objective: The purpose of this study was to analyze and investigate the anatomical structure of orbital implant areas with template technology and computed tomography （CT） images. Date can be used for preoperative design of the orbital implant surgery to make the implant fixedness and avoid the complication. Methods: Twelve skull specimens with template scanned with Spiral CT （GE LightSpeed Ultra）. The original data was transmitted to the AW 4.0 CT workstation, reedited by Volume Analysis Voxtool 3.0 with MPVR, analyzed by ez-DICOM. The developed researches included established the methodology of orbital CT scan, design and fabricate orbital template and the research of the structure of the orbital implant areas. Result: Data extracted from Spiral CT scans are reliable and accurate can be used to preoperative design of the orbital implant surgery. The quality and quantity of paries lateralis orbital bone are better than paries medialis orbitae. Right orbital seven o’clock and eleven o’clock position have more bone （mean 13.62.m and 17.2.mm） than other positions. On left orbital, however, there are one o’clock and five o’clock （mean 16.12.m and 12.73mm）. The density of bone have no obvious different in two sides of paries lateralis orbital. Conclusion: Orbital template technology combine with the Spiral CT scan and computer assisted analyze can not only well evaluate the structure of the orbital implant areas, but accomplish the preoperative design. It is also the base of the further research for cranio-maxillofacial implant surgical computer-assisted design system.

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Science Bulletin 2012年第Z2期 3811-3818页

作者： WU YiGen 1,2.,ZHOU Yun 3,BAO ShangLian 2.,HUANG SungCheng 4,ZHAO XiaoHu 5 & LI Jun 2.1 School of Physics and Optoelectronic Engineering,Nanjing university of Information Science and Technology,Nanjing 2.0044,china 2.Beijing City Key Laboratory of Medical Physics and Engineering,Peking university,Beijing 100871,china 3 The Russell H.Morgan Department of Radiology and Radiological Science,School of Medicine,Johns Hopkins university,Baltimore,MD 2.2.7,USA 4 Department of Molecular and Medical Pharmacology,UCLA David Geffen School of Medicine,university of California in Los Angeles,Los Angeles,CA 90095,USA 5 imaging Department of tongji hospital of tongji university,shanghai {12.,china

Local cerebral metabolic rate of glucose(LCMRGlc) is an important index for the description of neural *** 18 F-fluoro-2.deoxy-D-glucose(FDG) positron emission tomography(PET) has been used for quantitative imaging of LCMRGlc in humans,but is seldom used routinely because of the difficulty in obtaining the input function noninvasively.A reference tissue-based Patlak plot model(rPatlak) was proposed to generate parametric images of LCMRGlc in a quantitative dynamic FDG-PET study without requiring blood *** emission scans(4×0.5,4×2.and 10×5 min) were acquired simultaneously with an IV bolus injection of 155 MBq of *** blood samples were collected during the scans via a catheter placed in the radial *** data were also generated using the same scan *** last ten scan data sets were used in a graphical analysis using the Patlak *** ratio of LCMRGlc estimated from the original Patlak(oPatlak,using plasma input) was used as the gold standard,and the standardized uptake value ratio(SUVR) was also calculated for *** different tissues including white matter,gray matter,and whole brain were chosen as reference tissues for *** of the reference region used,the slopes in the linear regression between oPatlak and rPatlak were closer to unity than the regression slopes between oPatlak and *** intercepts for the former were also closer to 0 than those for the latter *** squared correlation coefficients were close to 1.0 for both *** showed that the results of rPatlak were in good agreement with those of oPatlak,however,SUVR exhibited more *** simulation study also showed that the relative variance and bias for rPatlak were less than those for *** images obtained with rPatlak were very similar to those obtained with oPatlak,while there were differences in the relative spatial distribution between the images of SUVR and *** study validates that the rPatl

关键词： quantification local cerebral metabolic rate of glucose FDG-PET rPatlak method SUVR noninvasive parametric imaging