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Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1149-1154页

作者： Li Han Kun Tang xiao-Li Fang Jing-xi Xu xi-Yun Mao Ming Li department of Anorectal Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Anhui HospitalHefei 230001Anhui ProvinceChina Anorectal Center The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230001Anhui ProvinceChina department of Spleen and Stomach Diseases Department of GastroenterologyAffiliated Wuhu Hospital of Traditional Chinese Medicine of Anhui College of Traditional Chinese MedicineWuhu 241000Anhui ProvinceChina

BACKGROUND Ulcer colitis(UC)is a chronic,nonspecific,and noninfectious inflammatory bowel ***,Toll-like receptors(TLRs)have been found to be closely associated with clinical inflammatory *** complete remission in patients with intermittent periods of activity followed by dormancy is ***,no study has explored the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** To explore the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** This prospective clinical study included patients who met the exclusion criteria in 2.2. and *** patients with UC were divided into two groups(control and experimental).The peripheral blood of the experimental and control groups were collected under aseptic *** expression of TLR4 protein,NF-κB,IL-6,and IL-17 was detected in the peripheral blood of patients in the experimental group and control group before and 1 month after taking the *** co rrelation analysis was used to analyze the relationship between the expression level of TLR4 protein and the expression levels of downstream signal NF-κB and inflammatory factors IL-6 and IL-17,and P<0.05 was considered statistically *** There were no significant differences in the patient characteristics between the control and experimental *** results showed that the expression levels of TLR4 and NF-κB in the experimental group were significantly lower than those in the control group(P<0.05).The levels of IL-6 and IL-17 in the experimental group were significantly lower than those in the control group(P<0.05).The TLR4 protein expression in the experimental group was positively correlated with the expression level of downstream signal NF-κB and was positively correlated with the levels of downstream inflammatory cytokines IL-6 and IL-

关键词： Ulcerative colitis TLR4 NF-κB signaling pathway Kuicolong-yu enema

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Microstructure,wear and friction behavior of CoCrAITaY-xCNTs composite coatings deposited by laser-induction hybrid cladding

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Rare Metals 2024年第4期43卷 1815-1827页

作者： Sheng-Feng Zhou Yu Long Yan-Liang Yi Cheng Deng Lian-xi Hu Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan430074China MOE Key Laboratory of New Processing technology for Non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China School of Mechatronics engineering Guangdong Polytechnic Normal UniversityGuangzhou510635China School of Materials Science and engineering Harbin Institute of TechnologyHarbin150001China

To improve the wear performance of CoCrAlYTa coating,part of the carbon nanotubes(CNTs)chemically reacted with Ta to form reinforcement phase(TaC),while the other CNTs were retained as lubrication ***,the CoCrAlYTa-xCNTs(x=0,1,2.and 4;wt%)composite coatings were prepared by laserinduction hybrid cladding(LIHC),and the microstructure and wear resistance of coatings were systematically *** show that the coatings are mainly composed of TaC,y-(Co,Cr)andβ-(Co,Cr)*** the CNTs content increases from 0 wt%to 4 wt%,the volume fraction of TaC increases from 13.11 vol%to 16.12.vol%.Meanwhile,the nano-hardness ofγ-(Co,Cr)andβ-(Co,Cr)Al are improved from 7.49 and 9.72.to 9.3. and 11.19 GPa,*** a result,the microhardness of coating increases from HV53..2. to HV 73..16,the wear rate decreases from3.0}4×10^(-3.to 6.1×10^(-3.mg·m^(-1),and the average friction coefficient decreases from 0.55 to *** good wear performance of the coating is attributed to the formation of TaC and the existence of remained CNTs lubricant film.

关键词： Carbon nanotube MCrAlY coating Friction and wear performance Laser-induction hybrid cladding

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A unified Minorization-Maximization approach for estimation of general mixture models

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 343-362页

作者： HUANG xi-fen LIU Deng-ge ZHOU Yun-peng ZHU Fei School of Mathematics Yunnan Normal UniversityKunming 650092China department of Statistics and Actuarial Science The University of Hong KongHong KongChina

The mixed distribution model is often used to extract information from heteroge-neous data and perform modeling *** the density function of mixed distribution is complicated or the variable dimension is high,it usually brings challenges to the parameter es-timation of the mixed distribution *** application of MM algorithm can avoid complex expectation calculations,and can also solve the problem of high-dimensional optimization by decomposing the objective *** this paper,MM algorithm is applied to the parameter estimation problem of mixed distribution *** method of assembly and decomposition is used to construct the substitute function with separable parameters,which avoids the problems of complex expectation calculations and the inversion of high-dimensional matrices.

关键词： MM algorithm mixed distribution model parameter estimation assembly decomposition tech-nology parameter separation

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Tree‑Inspired Structurally Graded Aerogel with Synergistic Water,Salt,and Thermal Transport for High‑Salinity Solar‑Powered Evaporation

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Nano-Micro Letters 2024年第11期16卷 19-37页

作者： xiaomeng Zhao Heng Zhang Kit‑Ying Chan xinyue Huang Yunfei Yang xi Shen department of Aeronautical and Aviation engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Sports Science and technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Solar-powered interfacial evaporation is an energy-efficient solution for water *** requires solar absorbers to facilitate upward water transport and limit the heat to the surface for efficient ***,downward salt ion transport is also desired to prevent salt ***,achieving simultaneously fast water uptake,downward salt transport,and heat localization is challenging due to highly coupled water,mass,and thermal ***,we develop a structurally graded aerogel inspired by tree transport systems to collectively optimize water,salt,and thermal *** arched aerogel features root-like,fan-shaped microchannels for rapid water uptake and downward salt diffusion,and horizontally aligned pores near the surface for heat localization through maximizing solar absorption and minimizing conductive heat *** structural characteristics gave rise to consistent evaporation rates of 2.09 kg m^(-2. h^(-1) under one-sun illumination in a 3.5 wt%NaCl solution for 7 days without *** in a high-salinity solution of 2. wt%NaCl,the evaporation rates maintained stable at 1.94 kg m^(-2. h^(-1) for 8 h without salt crystal *** work offers a novel microstructural design to address the complex interplay of water,salt,and thermal transport.

关键词： Composite aerogel Graded structure Solar-powered evaporation Thermal insulation Salt rejection

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Congruences on ideal nil-extension of completely regular semigroups

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Chinese Science Bulletin 1998年第5期43卷 379-381页

作者： REN Xueming 1, 2.GUO Yuqi 2.and CEN Jiaping (Shum Kar-ping) 3.. department of Mathematics, {3.’an University of Architecture & technology, {3.’an 710055,{2. 2. department of Mathematics, Yunnan University, Kunming 650091,{2. 3. department of department of Mathematics Xi’an University of Architecture & Technology Xi’an China department of Mathematics Yunnan University Kunming China department of Mathematics Chinese University of Hong Kong Hong Kong

Let S be an ideal nil-extension of a completely regular semigroup K by a nil semigroup Q with zero. A concept of admissible congruence pairs (δ,ω) of S is introduced, where δ and ω are a congruence on Q and a congruence on K respectively. It is proved that every congruence on S can be uniquely respresented by an admissible congruence pair (δ,ω) of S. Suppose that ρ K denotes the Rees congruence induced by the ideal K of S. Then it is shown that for any congruence σ on S,a mapping Γ:σ|→(σ Q,σ K) is an order-preserving bijection from the set of all congruences on S onto the set of all admissible congruence pairs of S,where σ K is the restriction of σ to K and σ Q=(σ∨ρ K)/ρ K. Moreover,the lattice of congruences of S is also discussed. As a special case,every congruence on completely Archimedean semigroups S is described by an admissible quarterple of S. The following question is asked: Is the lattice of congruences of the completely Archimedean semigroup a semimodular lattice?

关键词： completely regular semigroups ideal nil-extension congruences.

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Triboelectric nanogenerator integrated with a simple controlled switch for regularized water wave energy harvesting

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Nano Research 2024年第8期17卷 7585-7592页

作者： Hongbo Yang xi Liang Junwu Kan Zhong Lin Wang Tao Jiang Zhanyong Hong College of engineering Zhejiang Normal UniversityJinhua 321004China Beijing Key Laboratory of Micro-Nano Energy and Sensor Center for High-Entropy Energy and SystemsBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China The Beijing Key Laboratory for Nano-Photonics and Nano-Structure Department of PhysicsCapital Normal UniversityBeijing 100048China Guangzhou Institute of Blue Energy Guangzhou 510555China Georgia Institute of technology AtlantaGA 30332-0245USA Yonsei Frontier Lab Yonsei UniversitySeoul 03722Republic of Korea

Ocean is full of low-frequency,irregular,and widely distributed wave energy,which is suitable as the energy source for maritime Internet of Things(IoTs).Utilizing triboelectric nanogenerators(TENGs)to harvest ocean wave energy and power sensors is proven to be an effective ***,in random ocean waves,the irregular electrical energy output by general TENGs restricts the *** present,achieving regularized water wave energy harvesting relies on rather complex mechanical structure designs,which is not conducive to *** this work,we proposed a novel mechanical controlled TENG(MCTENG)with a simple controlled switch to realize the regularization *** structural parameters of the MC-TENG are optimized,and the optimal output voltage,output current,and transferred charge respectively reach 1684.2.V,85.4μA,and 3.9.9 nC,generating a peak power density of 3..46 W·m^(−3.·Hz^(−1).Under real water wave environment,the output of the MC-TENG is regularized and keeps stable regardless of any wave ***,the potential applications of the MC-TENG are demonstrated in powering environmental temperature,humidity,and wind speed *** work renders a simple approach to achieve effective regularized ocean wave energy harvesting,promoting the TENG industrialization toward practical application of maritime IoTs.

关键词： water wave energy harvesting triboelectric nanogenerators random excitation mechanical control regular output

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Development and parentage analysis of SNP markers for Chestnut-vented Nuthatch(Sitta nagaensis)based on ddRAD-seq data

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Avian Research 2024年第2期15卷 271-278页

作者： Qingmiao Yuan xi Lu Ruixin Mo xianyin Xu Xu Luo Yubao Duan Key Laboratory for Conserving Wildlife with Small Populations in Yunnan Southwest Forestry UniversityKunming 650224China Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of china Ministry of EducationSouthwest Forestry UniversityKunming 650224China Key Laboratory of Forest Disaster Warning and Control of Yunnan Province Southwest Forestry UniversityKunming 650224China College of Forestry Southwest Forestry UniversityKunming 650224China Administration of Zixi Mountain Provincial Nature Reserve Chuxiong 675008China

Extra-pair paternity(EPP)is commonly found in socially monogamous birds,especially in small passerine birds,and there are interspecific and intraspecific variations in the extent of *** Chestnut-vented Nuthatch(Sitta nagaensis)is a socially monogamous passerine bird,and verifying whether this species has EPP relies on parentage *** is not known to have *** this study,we developed SNP markers of this species that are informative for parentage analysis from double digest restriction site-associated DNA sequencing(ddRAD-seq)data.A panel consisting of 50 SNP markers,with a mean heterozygosity of 0.3.3.was used to resolve 95% of nestlings to *** combined exclusion probabilities for the first parent and second parent were 0.991 and 0.9999,*** panel of SNP markers is a powerful tool for parentage assignments in *** addition,we found that three offspring(7.9%)from three nests(2..1%)were the result of extra-pair fertilization out of 3. offspring in 13.*** study provided information on parentage analysis that has not been reported before in *** also supplemented the understudied EPP behavior of birds in Asia,contributing to a general understanding of the EPP behaviors of birds.

关键词： Chestnut-vented Nuthatch ddRAD sequencing Extra-pair paternity Parentage analysis SNPs

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DMPP mitigates N_(2.O and NO productions by inhibiting ammonia-oxidizing bacteria in an intensified vegetable field under different temperature and moisture regimes

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Pedosphere 2024年第3期34卷 652-663页

作者： xi ZHANG xintong XU Chenyuan WANG Qianqian ZHANG Yubing DONG Zhengqin xiONG Jiangsu Key Laboratory of Low Carbon Agriculture and GHGs Mitigation College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095(China) department of Soil Science of Temperate Ecosystems Department of Agricultural Soil ScienceGeorg-August University of GottingenGottingen 37077(Germany) State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300(China) Huaiyin Institute of Agricultural Sciences of Xuhuai Region in Jiangsu Jiangsu Academy of Agricultural SciencesHuai’an 223001(China)

Vegetable soils with high nitrogen input are major sources of nitrous oxide(N_(2.O)and nitric oxide(NO),and incorporation of the nitrification inhibitor 3.4-dimethylpyrazole phosphate(DMPP)into soils has been documented to effectively reduce ***,the efficiency of DMPP in terms of soil N_(2.O and NO mitigations varies greatly depending on soil temperature and moisture ***,further evaluations of DMPP efficiency in diverse environments are required to encourage widespread application.A laboratory incubation study(2. d)was established to investigate the interactive effects of DMPP,temperature(15,2.,and 3.?C),and soil moisture(55% and 80% of water-holding capacity(WHC))on net nitrification rate,N_(2.O and NO productions,and gene abundances of nitrifiers and denitrifiers in an intensive vegetable *** showed that incubating soil with 1%DMPP led to partial inhibition of the net nitrification rate and N_(2.O and NO productions,and the reduction percentage of N_(2.O production was higher than that of NO production(69.3.vs.3..2.)regardless of temperature and soil moisture *** increased temperatures promoted the net nitrification rate but decreased soil N_(2.O and NO *** moisture influenced NO production more than N_(2.O production,decreasing with the increased moisture level(80%).The inhibitory effect of DMPP on cumulative N_(2.O and NO productions decreased with increased temperatures at 55%***,the inhibitory effect of DMPP on cumulative N_(2.O production increased with increased temperatures at 80%*** on the correlation analyses and automatic linear modeling,the mitigation of both N_(2.O and NO productions from the soil induced by DMPP was attributed to the decreases in ammonia-oxidizing bacteria(AOB)amoA gene abundance and NO_(2.^(-)-N ***,our study indicated that DMPP reduced both N_(2.O and NO productions by regulating the associated AOB amoA gene abundance and NO_(2.^(-)-N concentra

关键词： 3.4-dimethylpyrazole phosphate environment condition gene abundance nitrification inhibitor nitrite accumulation soil water content

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pH-sensitive KHA/CMC-Fe^(3.)@CS hydrogel loading and the drug release properties of riboflavin

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Particuology 2024年第3期86卷 13-23页

作者： Jie Song xi Li Yuhua Niu Lijun Chen Zhiqiang Wei Yidan Li Youqian Wang Shaanxi University of Science&technology Xi'an710021China

To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3.))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3.as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball *** tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3.)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal *** stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3.))@CS hydrogel spheres were *** results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2..The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.

关键词： Potassium humate Hydrogel spheres pH-sensitive Drugsustained-release Drug release model

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Pyruvate kinase M in germ cells is essential for sperm motility and male fertility but not spermatogenesis

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Asian Journal of Andrology 2024年第2期26卷 212-219页

作者： Gao-Qing Qian xiao-Chen Wang xi Zhang Bin Shen Qiang Liu State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical UniversityNanjing 211166China Shanghai Key Laboratory of Reproductive Medicine Department of HistoembryologyGenetics and Developmental BiologyShanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China

Male germ cells employ specific metabolic pathways throughout their developmental *** a previous study,we discovered heightened expression of pyruvate kinase M(PKM),a pivotal glycolytic enzyme,in spermatogonia and *** gain deeper insights into PKM's roles in spermatogenesis,sperm function,and male fertility,we engineered a conditional-knockout mouse model(Pkm-vkO mice)to selectively disrupt the Pkm gene within germ *** maintaining regular testicular histology and sperm morphology,the male Pkm-vko mice were infertility,characterized by significant impairments in sperm motility and adenosine triphosphate(ATP)*** addition,Pkm-null spermatozoa exhibited similar deficits in protein tyrosine phosphorylation linked to capacitation,as well as compromised performance in in vitro fertilization *** conclude,PKM's presence is not obligatory for the entirety of spermatogenesis in male germ cells;however,it emerges as a critical factor influencing sperm motility and overall male fertility.

关键词： glycolysis male fertility pyruvate kinase M sperm motility spermatogenesis

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