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The Relations Among Various Markov Chains

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wuhan university Journal of Natural Sciences 2001年第3期6卷 643-648页

作者： Hu Di\|he college of Mathematics and Statistics,wuhan {2., wuhan 430072. china college of Mathematics and Statistics Wuhan University Wuhan China

Some basic equations and the relations among various Markov chains are established. These works are the bases in the investigation of the theory of Markov chain in random environment.

关键词： Hopf Markov chain Markov chain in random environment skew product Markov chain sample Markov chain in random environment

A Recovery Algorithm for Self-Stabilizing Communication Protocols

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Journal of Systems Engineering and Electronics 2000年第1期11卷 38-46页

作者： Li Layuan & Li Chunlin (Department of Computer Science & technology, wuhan nansportation {2., 430063, P. R. china) Department of Computer Science & technology Wuhan Transportation University 430063 P. R. China

This paper presents a recovery algorithm for self-stabilizing communication protocols. It first describes some concepts and a formal description method for the algorithm. Then it proposes the algorithm procedures, proves its correctness and analyses its complexity. Finally, it also verifies the availability and efficiency of the algorithm by illustrating an example protocol with multi-processes.

关键词： Computer networks Communication protocols Recovery algorithm Self-stabilization Multimedia communication networks.

Alterations of placental cytochrome P450 1A1 and P-glycoprotein in tobacco-induced intrauterine growth retardation in rats

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Acta Pharmacologica Sinica 2005年第11期26卷 1387-1394页

作者： You-e YAN~2. Hui WANG~(2.3), Ymg-hong FENG~2.~2.Department of Pharmacology, Medical college of wuhan {2., wuhan 430071, china Department of Pharmacology Medical College of Wuhan University Wuhan China

Aim: To investigate the alterations of placental P-glycoprotein (P-gp) and cytochrome P450 1 Al (CYPlAl) at different gestational days (GD), and to explore the possible significance of placental P-gp and CYPlAl in tobacco smoke-induced intrauterine growth retardation (IUGR) in rats. Methods: An IUGR model was produced by passive tobacco smoking from GD 7 to parturition (GD 2.) and predicted using fetal development parameters. Placental structure and function were monitored by observing pathological alteration and antioxidative function, including the content of malondialdehyde and the activities of superoxide dismutase and catalase (CAT). The expressions of CYPlAl and P-gp (mdr la and mdr lb) were detected using a reverse transcription polymerase chain reaction and immunohistochemistry. Results: Placental pathological changes occurred and the malondialdehyde content increased, whereas the activities of superoxide dismutase and CAT lowered, when compared to their controls. In the rat placenta of the tobacco group, the level of CYPlAl mRNA increased significantly; the level of mdr1a mRNA increased significantly at GD 2. but not at GD 14, whereas the level of mdr1b mRNA in different term remained stable; the expression of P-gp increased significantly only in full-term placenta. Conclusion: The expression of placental CYPlAl and P-gp increased in tobacco-induced IUGR. Overexpression of placental CYPlAl can attribute to the metabolism of tobacco and the generation of reactive metabolites, which can trigger IUGR. As a compulsory mechanism, upregulation of P-gp might decrease tobacco exposure to a developing fetus with IUGR

关键词： intrauterine growth retardation tobacco placenta cytochrome P450 1A1 P-glycoprotein rats

Permian carbonates of Baoshan block, Western Yunnan and their paleoclimatic implications

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Science china Earth Sciences 2004年第5期47卷 385-392页

作者： YAN Jiaxin1, LIANG Dingyi1 & WU Ming2.1. Faculty of Earth Sciences, china university of Geosciences, {2. 430074, china 2. college of Chemistry and Life Sciences, South-Central university for Nationalities, {2. 430074, china Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China college of Chemistry/Life Sciences South-Central Univ./Nationalities Wuhan 430074 China

Recently, much attention has been paid to the climatic significance of carbonates originating in shallow water. Permian carbonates of shallow shelf origin are present in the upper part of the Dingjiazhai Formation, the upper part of the Yongde Formation, and the Shazipo Formation on the Baoshan block of Western Yunnan. Their skeleton and non-skeleton grain as-sociations have been investigated in this study. The carbonates of the Dingjiazhai Formation indicate a Bryonoderm (bryozoans-echinoderm) association without non-skeleton grains. The carbonates of Yongde and Shazipo formations show Chloroforam (green algae-foraminifers) association with peloids. Oolites develop in the Shazipo Formation. Based on the comparisons of grain association with coeval carbonates formed in different paleolatitudes (i.e. various paleo-climatic zones), the carbonates of the Dingjiazhai Formation were thought to have been accu-mulated in shelf environments of warm-temperate zone, and those of the Yongde and Shazipo formations in shelf environments of warm-water.

关键词： Early Permian, carbonate, paleoclimate, Western Yunnan.

Poly(N-isopropylacrylamide), Poly(methacrylic acid) and Their Copolymers for Oral Colon-specific Drug Delivery

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Journal of wuhan university of technology(Materials Science) 2009年第4期24卷 571-574页

作者：高玉香 School of Chemical Engineering Wuhan University of Technology

A series of cross-linked gels of Poly（N-isopropylacrylamide） [P（NIPAAm）] and Poly（methacr-ylic acid）[P（MAA）] homopolymers and P（NIPAAm-co-MAA） random copolymers were synthesized based on NIPAAm and MAA using 4,4-Bis-（methacryloylamino） azobenzene （BMAAB） as a cross-linker. The swelling behavior of these hydrogels in different pH buffer solutions was studied. The influential factors of the gels including composition of NIPAAm and MAA, pH and temperature upon swelling behavior were investigated. The obtained gels not only hold pH and thermometrical sensitivity, but also take on enzymatic sensitivity due to the cross-linker could be degraded by enzymes of colon. Swelling equilibrium degree of copolymers was very low in acidic medium, which could avoid drug releasing due to biggish swelling of carder in stomach. Hydrogels would partly swell owing to higher pH value in small intestine. When arrived in colon, hydrogels completely swelled, meanwhile, azoenzymes located would degrade azo-bonds of polymeric network and then drug released in colon.

关键词： pH sensitivity therrnometrical sensitivity colon-specific

A Java-Based Approach for Developing Web Application System

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Journal of Systems Engineering and Electronics 1999年第3期10卷 15-21页

作者： Li Chunlin(Dept. of Computer Science and Engineering, wuhan transportation {2., 430063, P. R. china )(Received) Dept. of Computer Science and Engineering Wuhan Transportation University 430063 P. R. China

This paper adopts server-side Java programming model: mod e 1- view-cont roller to construct welybased shopping system framework. Using servlets, Java server pages (JSPs) and JavaBeantechnologies, we provide a standard, open, robust and cross-platform architecture. It can guarantee system- independence. Presented framework provides a clean separation of presentation from business logic which meets user's taste by changing user interface frequenctly, and enables more functions to be conventiently added in future.

关键词： Web application system Java Electronic shopping system

The Study on BCR/ABL Fusion Gene in Adult Acute Lymphoblastic Leukemia

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wuhan university Journal of Natural Sciences 2001年第3期6卷 742-746页

作者： Li Hui yu 1,2.,Zuo Guo Lin 1, ,Zuo Ping 2.1.college of Life Science, wuhan {2.,wuhan 430072.china 2.Union Hospital,Tongji Medical college,Huazhong {2. of Science and technology,wuhan 43002.,china college of Life Science Wuhan University Wuhan China Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

In order to assess the significance of BCR/ABC fusion gene in adult acute lymphoblastic Leukemia (ALL), 2. patients who were diagnosed as ALL were enrolled to detect BCR/ABC gene using nested-RT-PCR. The results showed that 9 cases (31.2.%) were BCR/ABL positive, and expressed P2.0 subtype. Among them 7 cases were B-ALL, and one was T-ALL. The diagnosis was proved by monoclonal antibodies recognition by indirect immunofluorescence. Adult patients with BCR/ABL positive ALL were significantly older (p0.05). The induction failure rate was high in BCR/ABL positive patients and those who achieved complete remission usually relapsed earlier. In conclusion, adult ALL patients with BCR/ABL-positive have poorer prognosis.

关键词： Key words BCR/ABL gene acute lymphoblastic leukemia nested RT PCR

Production of male flowers does not decrease with plant sizein insect-pollinated Sagittaria trifolia,contrary to predictionsof size-dependent sex allocation

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Journal of Systematics and Evolution 2011年第5期49卷 379-385页

作者： Bing HAN Xiao-Fan WANG Shuang-Quan HUANG(college of Life Sciences,wuhan {2.,wuhan 430072.china) (college of Life Sciences Wuhan University Wuhan 430072 China)

It has been proposed that relative allocation to female function increases with plant size in animalpollinated *** investigations in several monoecious Sagittaria species seem to run contrary to the prediction of size-dependent sex allocation(SDS),throwing doubt on the generalization of *** size,phenotypic gender,and flower production were measured in experimental populations of an aquatic,insect-pollinated herb Sagittaria trifolia(Alismataceae) under highly different *** comparison of ramets produced clonally can reduce confounding effects from genetic and environmental *** the high-density population,48% of ramets were male without female flowers,but in the low-density population all ramets were *** observed allometric growth in reproductive allocation with ramet size,as evident in biomass of reproductive structures and number of ?***,within both populations female and male flower production were isometric with ramet size,in contrast to an allometric growth in femaleness as predicted by *** gender was not related to ramet size in either *** results indicated that large plants may increase both female and male function even in animal-pollinated plants,pointing towards further studies to test the hypothesis of size-dependent sex allocation using different allocation currencies.

关键词： Alismataceae clonal reproduction ?ower production insect-pollinated monoecious Sagittaria trifolia size-dependent sex allocation.

SOLUTION PROPERTIES OF ANTITUMOR CARBOXYMETHYLATED DERIVATIVES OF α-(1→3)-D-GLUCAN FROM GANODERMA LUCIDUM

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Chinese Journal of Polymer Science 2001年第3期19卷 283-289页

作者： Li-na Zhang Mei Zhang Jing-hua Chen Fan-bo Zeng Department of Chemistry wuhan university, wuhan 430072. china Pharmacy college, Tongji Medical university, wuhan 430072. china 武汉大学湖北武汉同济医科大学湖北武汉

Fractions of a water insoluble α-(1→3)-D-glucan (GL) extracted from Ganoderma lucidum were carboxy-methylated (CM) to obtain water-soluble carboxymethylated derivatives (CM-GL) having a degree of substitution (DS) of0.38～0.51. Weight-average molecular weight M_w and intrinsic viscosity [η] of the samples CM-GL were measured by gelpermeation chromatography combined with laser light scattering (GPC-LLS) and viscometry. The CM-GL exhibits a stifferchain in aqueous solution at 2.℃ than the original glucan, The antitumor activities against Ehrlich ascites carcinoma (EAC,5×10~6) of the carboxymethylated derivatives from the α-glucan and curdlan, a β-glucan, are significantly higher than thoseof the original glucans. The effects of the relatively low molecular weight, expanded chains and better water-solubility of theCM-GL on the enhancement of antitumor activity could not be neglected. The chain stiffness decreased speedily withincrease of temperature from 40 to 60℃ or NaOH concentration from 0.1 to 0.4 in the solution, respectively, and the changeof the chain stiffness is reversible.

关键词： Solution properties Antitumor activity Carboxymethylated derivative α-D-glucan Ganoderma lucidum