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Intrathecal administration of Cav3.2 and Cav3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion

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Acta Pharmacologica Sinica 2006年第12期27卷 1547-1552页

作者： Xian-jie WEN~(1,2)Zhang-jun LI~2 Zhi-xin CHEN~2 Zhi-yuan FANG~3 Chen-xiang YANG~1 Heng LI~1 Yin-ming ZENG~(2,4)1 Department of anesthesiology,the First People's Hospital of FoShan & Affiliated FoShan Hospital of Sun-Yat Sen University,Foshan 528000,china 2 jiangsu province institute of anesthesiology,xuzhou medical college,xuzhou 221002,china 3 Department of anesthesiology,the Municipal Hospital of Suzhou,Suzhou 215002,china 1Department of anesthesiology the First People s Hospital of FoShan &#38 Affiliated FoShan Hospital of Sun-Yat Sen University Foshan 528000 China 2Jiangsu Province Institute of Anesthesiology Xuzhou Medical College Xuzhou 221002 China 2jiangsu province institute of anesthesiology Xuzhou Medical College Xuzhou 221002 China 2jiangsu province institute of anesthesiology Xuzhou Medical College Xuzhou 221002 China 3Department of anesthesiology the Municipal Hospital of Suzhou Suzhou 215002 China 1Department of anesthesiology the First People s Hospital of FoShan &#38 Affiliated FoShan Hospital of Sun-Yat Sen University Foshan 528000 China 1Department of anesthesiology the First People s Hospital of FoShan &#38 Affiliated FoShan Hospital of Sun-Yat Sen University Foshan 528000 China 2jiangsu province institute of anesthesiology Xuzhou Medical College Xuzhou 221002 China

Aim:The present study aimed to elucidate the role of T-subtype calcium channels（Cav3.1,Cav3.2,and Cav3.3）in the pathogenesis of neuropathic pain at spinal ***:The chronic compression of the dorsal root ganglion（CCD）rat modelwas *** antisense oligonucleotide of Cav3.1,Cav3.2,and Cav3.3 or nor-mal saline（NS）were intrathecally administered twice per day from the first day tothe fourth day after *** mechanical withdrawal threshold and pawthermal withdrawal latency were measured to evaluate the tactile allodynia andthermal hyperalgesia,***:CCD rats developed reliable tactileallodynia and thermal hyperalgesia after *** administration ofantisense oligonucleotide of Cav3.2 and Cav3.3 significantly relieved tactileallodynia and thermal hyperalgesia in CCD rats,but not ***:Cav3.2and Cav3.3 subtype calcium channels in the spinal cord may play an important rolein the pathogenesis of neuropathic pain,which may contribute to the manage-ment of the neuropathic pain.

关键词： T-type calcium channels neuropathic pain spinal cord antisense oligonucleotide

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Synergistic Dual Dynamic Bonds in Covalent Adaptable Networks

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CCS Chemistry 2024年第1期6卷 41-56页

作者： Jun Zhao Zhaoming Zhang Chunyu Wang xuzhou Yan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai

Covalent adaptable networks(CANs),comprising polymer networks crosslinked by dynamic covalent bonds(DCBs),have garnered considerable attention as sustainable *** the stress relaxation of CANs is essential for controlling their viscoelastic *** unexpected acceleration of stress relaxation has been observed in CANs containing dual dynamic *** dynamic behavior of the second dynamic bonds can accelerate stress relaxation and lower the relaxation activation energy of dual dynamic CANs compared to analogous CANs that rely on only one type of *** findings complement current approaches that utilize catalysts or adjust network *** this minireview,we summarize the synergistic acceleration effects in various CANs containing dual dynamic *** classify these effects based on the second dynamic bonds,including noncovalent bonds,mechanical bonds,and the second *** also discuss the mechanisms behind this ***,we highlight the challenges and offer perspectives on harnessing the synergistic effects of these dual dynamic systems to expand the chemistry and applications of CANs.

关键词： covalent adaptable networks dynamic covalent bonds dynamic materials stress relaxation synergistic effect

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End-to-End Paired Ambisonic-Binaural Audio Rendering

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 502-513页

作者： Yin Zhu Qiuqiang Kong Junjie Shi Shilei Liu xuzhou Ye Ju-Chiang Wang Hongming Shan Junping Zhang Shanghai Key Laboratory of Intelligent Information Processing School of Computer ScienceFudan UniversityShanghai 200433China Beijing ByteDance Technology Co.Ltd. Shanghai 201102China. Chinese University of Hong Kong Hong KongChina IEEE institute of Science and Technology for Brain-Inspired Intelligence and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433 Shanghai Center for Brain Science and Brain-Inspired Technology Shanghai 200031China

Binaural rendering is of great interest to virtual reality and immersive media. Although humans can naturally use their two ears to perceive the spatial information contained in sounds, it is a challenging task for machines to achieve binaural rendering since the description of a sound field often requires multiple channels and even the metadata of the sound sources. In addition, the perceived sound varies from person to person even in the same sound field. Previous methods generally rely on individual-dependent head-related transferred function(HRTF)datasets and optimization algorithms that act on HRTFs. In practical applications, there are two major drawbacks to existing methods. The first is a high personalization cost, as traditional methods achieve personalized needs by measuring HRTFs. The second is insufficient accuracy because the optimization goal of traditional methods is to retain another part of information that is more important in perception at the cost of discarding a part of the information. Therefore, it is desirable to develop novel techniques to achieve personalization and accuracy at a low cost. To this end, we focus on the binaural rendering of ambisonic and propose 1) channel-shared encoder and channel-compared attention integrated into neural networks and 2) a loss function quantifying interaural level differences to deal with spatial information. To verify the proposed method, we collect and release the first paired ambisonic-binaural dataset and introduce three metrics to evaluate the content information and spatial information accuracy of the end-to-end methods. Extensive experimental results on the collected dataset demonstrate the superior performance of the proposed method and the shortcomings of previous methods.

关键词： Ambisonic attention binaural rendering neural network

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Strengthening and toughening styrene-butadiene rubber by mechanically interlocked cross-links

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Science china Chemistry 2024年第10期67卷 3414-3422页

作者： Yuanhao Wang Li Yang Lin Cheng Jun Zhao Ruixue Bai Wenbin Wang Shaolei Qu Zhaoming Zhang Wei Yu xuzhou Yan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China

Styrene-butadiene rubber(SBR)is an indispensable material in modern society,and the necessity for enhanced mechanical properties in SBR persists,particularly to withstand the rigors of challenging environmental *** surmount the limitations of conventional cross-linking modes,mechanical bonds stabilized by host-guest recognition are incorporated as the cross-linking points of SBR to form mechanically interlocked networks(MINs).Compared with covalently cross-linked network,the representative MIN exhibits superior mechanical performance in terms of elongation(1392%)and breaking strength(4.6 MPa),whose toughness has surged by 17 *** of host-guest recognition and subsequent sliding motion provide an effective energy dissipation mechanism,and the release of hidden length is also beneficial to enhance ***,the introduction of the rotaxane cross-links made the network more pliable and possess damping and elastic properties,which can return to initial state with one minute rest *** aspire that this direct introduction method can serve as a blueprint,offering valuable insights for the enhancement of mechanical properties in conventional commercial polymer materials.

关键词： mechanically interlocked molecules host-guest chemistry styrene-butadiene rubber mechanical properties dynamic materials

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Stretchable poly[2]rotaxane elastomers

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Fundamental Research 2024年第2期4卷 300-306页

作者： Kai Liu Xinhai Zhang Dong Zhao Ruixue Bai Yongming Wang Xue Yang Jun Zhao Hao Zhang Wei Yu xuzhou Yan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China college of Chemistry and Chemical Engineering National Engineering Research Center for Dyeing and Finishing of TextilesDonghua UniversityShanghai 201620China

Mechanically interlocked polymers(MIPs)are promising candidates for the construction of elastomeric materials with desirable mechanical performance on account of their abilities to undergo inherent rotational and translational mechanical movements at the molecular ***,the investigations on their mechanical properties are lagging far behind their structural fabrication,especially for linear polyrotaxanes in ***,we report stretchable poly[2]rotaxane elastomers(PREs)which integrate numerous mechanical bonds in the polymeric backbone to boost macroscopic mechanical ***,we have synthesized a hydroxyfunctionalized[2]rotaxane that subsequently participates in the condensation polymerization with diisocyanate to form *** from the peculiar structural and dynamic characteristics of the poly[2]rotaxane,the representative PRE exhibits favorable mechanical performance in terms of stretchability(∼1200%),Young’s modulus(24.6 MPa),and toughness(49.5 MJ/m^(3)).Moreover,we present our poly[2]rotaxanes as model systems to understand the relationship between mechanical bonds and macroscopic mechanical *** is concluded that the mechanical properties of our PREs are mainly determined by the unique topological architectures which possess a consecutive energy dissipation pathway including the dissociation of host−guest interaction and consequential sliding motion of the wheel along the axle in the[2]rotaxane motif.

关键词： Polyrotaxanes Mechanically interlocked polymers Mechanically interlocked molecules Dynamic materials Elastomers

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GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats

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Acta Pharmacologica Sinica 2004年第12期25卷 53-59页

作者： Qin-yun WANG2,3, Jun-li CAO2, Yin-ming ZENG2, Ti-jun DAI2,4 2jiangsu institute of anesthesiology, jiangsu province Key Laboratory of anesthesiology, xuzhou, 221002, china 3Department of anesthesiology, the1st Affiliated Hospitalof Soochow University, Suzhou 215006, china jiangsu institute of anesthesiology Jiangsu Province Key Laboratory of Anesthesiology Department of anesthesiology the 1st Affiliated Hospital of Soochow University

AIM: To observe effects of propofol on nociceptive response at superspinal and spinal level in rats. METHODS: Two hundreds and fifty-eight Sprague-Dawley male rats were randomized into thirty-two groups. Propofol and bicuculline were microinjected into lateral ventricle (icv), ventrolateral periaqueductal gray (vlPAG), intrathecal (ith), and intraperitoneal (ip). The noxious responses were evaluated by hot plate and formalin test. RESULTS: In hot-plate test, systemic and superspinal administration of propofol (40 mg·kg-1 ip, 100 μg in 10 μL, icv, and 4 μg in 0.4 μL vlPAG microinjection) produced hyperalgesia (P2 %, 98.8 % at 10, 20, and 30 min by microinjection of bicuculline (10 ng in 0.4 μL, vlPAG) (P20, 30 and 40 min by ith bicuculline (P<0.05). In formalin test, systemic and superspinal administration of propofol (40 mg·kg-1 ip, 4 μg in 0.4 μL, vlPAG) also produced hyperal- gesia (P<0.01). The increased formalin pain scores were antagonized about 57.1 % by bicuculline (10 ng, vlPAG) (P<0.05) at 60 min after formalin injection. The decreased formalin pain scores induced by ith propofol (100 μg in 10 μL) were antagonized about 66.7 % at 30 min by ith bicuculline (P<0.05) after formalin injection. Hyperalgesia produced by ip propofol in both hot plate and formalin test could not be antagonized by vlPAG administration of bicuculline. CONCLUSION: GABAA receptor partly mediated propofol-induced hyperalgesia at superspinal and analgesia at spinal cord in rats.

关键词： GABA receptors propofol pain ventrolateral periaqueductal gray spinal cord

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Mechanically robust and dynamic supramolecular polymer networks enabled by [an]daisy chain backbones

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Science china Chemistry 2024年

作者： Yongming Wang Yi Ding Yuhang Liu Shaolei Qu Wenbin Wang Wei Yu Zhaoming Zhang Feng Liu xuzhou Yan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong University State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft Matter School of Materials Science and Engineering Xi'an Jiaotong University

Supramolecular polymer networks（SPNs） have garnered significant research interest due to their dynamic properties. However,while current developments primarily focus on managing supramolecular crosslinks, the role of polymer backbones—equally crucial to SPN properties—has not yet been sufficiently explored. Herein, we utilize mechanically interlocked [an]daisy chain as backbone to prepare a class of SPNs, where the force-induced motion of successive mechanical bonds toughens and reinforces the networks. In specific, the [an]daisy chain backbones connect with polynorbornene chains through quadruple H-bonding in the SPN networks. Compared to the control with non-slidable backbone, The representative SPN-2 exhibits a robust feature in tensile tests with high maximum stress（14.7 vs. 7.89 MPa） and toughness（83.8 vs. 48.6 MJ/m3）. Moreover, it also has superior performance in energy dissipation benefitting from the [an]daisy chain backbones as well as supramolecular crosslinks. Additionally, the SPN-2 displayed exceptional self-healing and reprocessing capabilities due to their dynamic quadrable H-bonding crosslinkers. These findings demonstrate the untapped potential of [an]daisy chain as a polymer skeleton to develop SPNs and open the door to design mechanically robust supramolecular materials with diverse smart functions.

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Isoflurane preconditioning protects against ischemia-reperfusion injury partly by attenuating cytochrome c release from subsarcolemmal mitochondria in isolated rat hearts

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Acta Pharmacologica Sinica 2005年第7期26卷 813-820页

作者： Li-ping QIAN Shan-shan ZHU~2 Jun-li CAO Yin-ming ZENG jiangsu Provincial Key Lab of anesthesiology,jiangsu institute of anesthesiology,xuzhou medical college,xuzhou 221002,china jiangsu Provincial Key Lab of anesthesiology Jiangsu Institute of Anesthesiology Xuzhou Medical College Xuzhou 221002 China

Aim:To examine if isoflurane preconditioning can attenuate ischemia/reperfusioninjury by reducing cytochrome c release from inner mitochondrial ***:Isolated hearts of Sprague-Dawley rats were perfused on *** were randomly assigned to a non-treated group(CON group,n=12)or three isoflurane preconditioning groups(0.5% ISC group,1.0% ISC group,and 2.0% ISC group;n=12).In the latter three groups,isoflurane was given atconcentrations of 0.5%,1.0%,and 2.0% for 15 min with 15-rain washout before30-min *** mitochondria of the myocardium were isolatedafter 60-min *** of the each heart was recorded,infarctsize of the hearts and contents of cytosolic cytochrome or mitochondrial cyto-chrome c were measured at the end of *** of isolated mito-chondria in the four groups was evaluated,***:Compared withthe CON group,cytosolic cytochrome c in 0.5% ISC group,1.0% ISC group,and2.0% ISC group were significantly decreased along with a significant increase ofmitochondrial cytochrome *** size of the hearts in the four groups were56%±12%,41%±12%,32%±7% and 33 %±11%,*** values of thethree isoflurane preconditioning groups were significantly lower than that of theCON group(P2.0% isofluraneon reducing cytochrome c release were more remarkable than 0.5% and 1.0%concentrations of ***:Myocardioprotective effects ofisofluranc preconditioning were associated with attenuation of cytochrome c lossfrom the inner membrane of subsarcolemmal mitochondria.

关键词： isoflurane reperfusion injury cytochromec mitochondria

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Implementation of the Fredkin gate with a three-qubit mixed-spin Heisenberg model

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Science china(Physics,Mechanics & Astronomy) 2010年第7期53卷 1276-1280页

作者： FAN QiuBo college of Mathematics and Physics,xuzhou institute of Technology,xuzhou 221008,china 1. college of Mathematics and Physics Xuzhou Institute of Technology Xuzhou 221008 China

We show that a local unitary(LU) equivalent Fredkin gate can be obtained from the free evolution of three mixed-spin qubits by virtue of numerical simulation with only one *** spin-1 qubit acts as the control qubit,and two spin-1/2 qubits,which interact with the spin-1 qubit via the first neighbor spin interaction,respectively,play the role of target *** also examine the imperfect Fredkin gate operation by considering the effects of nonidentical coupling constants,uniform and inhomogeneous magnetic fields.

关键词： Fredkin gate mixed spin quantum computation

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Activation of ERK/CREB pathway in spinal cord contributes to chronic constrictive injury-induced neuropathic pain in rats

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Acta Pharmacologica Sinica 2005年第7期26卷 789-798页

作者： Xue-song SONG~2 Jun-li CAO~(3,4,5) Yan-bing XU~3 Jian-hua HE~3 Li-cai ZHANG~3 Yin-ming ZENG~(3,4)2 Department of anesthesiology,First Clinical college of N.Bethune Centre of Health Sciences,Jilin University,Changchun 130021,china 3 Department of anesthesiology,Affiliated Hospital of xuzhou medical college,xuzhou 221002,china 4 jiangsu institute of anesthesiology,xuzhou 221002,china Departmentofanesthesiology FirstClinicalCollegeofN.BethuneCentreofHealthSciencesJilinUniversityChangchun130021China

Aim:To investigate whether activation and translocation of extracellular signal-regulated kinase(ERK)is involved in the induction and maintenance of neuro-pathic pain,and effects of activation and translocation of ERK on expression ofpCREB and Fos in the chronic neuropathic ***:Lumbar intrathecalcatheters were chronically implanted in male Sprague-Dawley *** left sciaticnerve was loosely ligated proximal to the sciatica's trifurcation at approximately 1.0mm intervals with 4-0 silk *** mitogen-activated protein kinase kinase(MEK)inhibitor U0126 or phosphorothioate-modified antisense oligonucleotides(ODN)were intrathecally administered every 12 h,1 d pre-chronic constrictioninjury(CCI)and 3 d *** and mechanical nociceptive thresholdswere assessed with the paw withdrawal latency(PWL)to radiant heat and vonFrey *** expression of pERK,pCREB,and Fos were assessed by bothWestern blotting and immunohistochemical ***:Intrathecal injec-tion of U0126 or ERK antisense ODN significantly attenuated CCI-induced me-chanical allodynia and thermal *** significantly increased the ex-pression of p-ERK-IR neurons in the ipsilateral spinal dorsal horn to injury,not inthe contralateral spinal dorsal *** time courses of pERK expression showedthat the levels of both cytosol and nuclear pERK,but not total ERK,were in-creased at all points after CCI and reached a peak level on postoperative d *** significantly increased the expression of pCREB and ***-CREB-positive neurons were distributed in all laminae of the bilateral spinal cord and Foswas expressed in laminae I and II of the ipsilateral spinal dorsal *** of U0126 or ERK antisense ODN markedly suppressed the increase ofCCI-induced pERK,pCREB and c-Fos expression in the spinal ***:The activation of ERK pathways contributes to neuropathic pain in CCI rats,andthe function of pERK may partly be accomplished via the cAMP

关键词： extracellular signal-regulated kinases cyclic AMP-response DNA-binding protein pain hyperalgesia spinal cord

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