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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan ding Xiaoming Liu Haiqin Chen Jianxin Zhao r.Paul ross Catherine Stanton Shilong Jiang Wei Chen Bo Yang Nutrition and Metabolism research division， Innovation center， Heilongjiang Feihe dairy Co.， Ltd. National Engineering research center for Functional Food， Jiangnan University State Key Laboratory of Food Science and Technology， Jiangnan University PKUHSC-china Feihe Joint research Institute of Nutrition and Healthy Lifespan development APC Microbiome Ireland， University College Cork School of Food Science and Technology， Jiangnan University International Joint research center for Probiotics & Gut Health， Jiangnan University Teagasc Food research Centre

This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the CCFM1078 group (administration B. breve CCFM1078， 3 × 109CFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/CrEB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve CCFM1078 were different with age and gender dependent. This finding suggests B. breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.

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Seasonal variance of salinity tolerance of a copepod drepanopus bispinosus in an Antarctic littoral saline lake (Burton lake)

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Acta Oceanologica Sinica 1989年第1期8卷 137-144页

作者： d.S.Eslake H.r.Burton Antarctic division HobartAustraliaAntarctic DivisionHobartAustralia

In Burton lake (an Antarctic littoral saline lake), as one of the overwinter species, the female drepanopus bispinosus reach adult form in autumn. and early *** the subsequent life period of more than eight months, the animals experience such changing environment as increasing salinities from approximately 33 (in May) to 39 (in November). There is a considerable difference of salinity tolerance of female adults between summer and winter *** collected copepods survived lower salinities than summer collected copepods in this experiment. The upward shift in their salinity tolerance range is related to the development of field acclimation to salinity. respiration rates of the summer animals showed a visible increase over those of winter copepods in simitar salinity and temperature conditions, thus supporting the above conclusion.

关键词： Burton lake Seasonal variance of salinity tolerance of a copepod drepanopus bispinosus in an Antarctic littoral saline lake

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陆封型大西洋鲑的全人工繁殖

水产学杂志 2004年第1期17卷 34-38页

作者：陆九韶刘成刚秦文启夏重志中国水产科学研究院黑龙江水产研究所黑龙江哈尔滨150070 中国水产科学研究院鲟鱼繁育技术工程中心北京100034

本文报道了陆封型大西洋鲑全人工繁殖的实验结果。 2 0 0 0年 1月从美国缅因州格兰特湖增殖站引进的陆封型大西鲑发眼卵 ,在北京房山中国水产科学研究院鲟鱼繁育技术工程中心进行了发眼卵孵化、苗种培育 ,亲鱼养成实验研究。结果表明 :... 详细信息

本文报道了陆封型大西洋鲑全人工繁殖的实验结果。 2 0 0 0年 1月从美国缅因州格兰特湖增殖站引进的陆封型大西鲑发眼卵 ,在北京房山中国水产科学研究院鲟鱼繁育技术工程中心进行了发眼卵孵化、苗种培育 ,亲鱼养成实验研究。结果表明 :引进的发眼卵经 930d ( 1 1 783度日 )培育成产卵亲鱼 ,雌、雄亲鱼成熟系数分别为 42 7%、 4 2 3% ;怀卵量为 1 0 98～ 362 1粒 /尾 (叉长 36～ 5 5cm) ,平均卵径 5 4mm (吸水膨胀前 )、 6 2mm(吸水后 ) ;平均卵重 8 5粒 /g (吸水后 )、 7 5粒 /g (吸水前 ) ;精液浓度 2 0 0亿个 /ml,精子寿命 70～ 90s,精子快速运动时间为 2 0～ 40s;个体繁殖率E (粒 )与叉长 (L)的相关公式为E =1 32 5L - 3671 8,相关系数r=0 89。受精卵在水温 6～ 1 1℃进行孵化 ,达到发眼所需积温为 2 64 5℃·d ;达到破膜所需 483℃·d ;仔鱼上浮所需 880℃·d。试验亲鱼雌、雄按 2比 1配组 ,1 0 75尾雌鱼共采卵 90 47万粒 ,受精率为 89 88%、发眼率为77 83%。产卵后 ( 3个月后 )存活率分别为雌鱼 30 % ,雄鱼 1 0 %。

关键词：陆封型大西洋鲑人工繁殖苗种培育

别嘌呤醇对新生大鼠缺氧缺血性脑损伤的保护作用

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复旦学报（医学版） 2004年第4期31卷 347-350,F002页

作者：胡勇邵肖梅张旭东复旦大学附属儿科医院新生儿科上海200032

目的　探讨别嘌呤醇 (ALLO)对新生大鼠缺氧缺血性脑损伤 (HIBd)的影响。方法　将新生 7日龄Sd大鼠 14 3只随机分为别嘌呤醇治疗组、缺氧缺血对照组和假手术组 ,缺氧缺血后即刻、2 4和 4 8h分别腹腔注射ALLO或生理盐水 ,然后观察ALLO对H... 详细信息

目的　探讨别嘌呤醇 (ALLO)对新生大鼠缺氧缺血性脑损伤 (HIBd)的影响。方法　将新生 7日龄Sd大鼠 14 3只随机分为别嘌呤醇治疗组、缺氧缺血对照组和假手术组 ,缺氧缺血后即刻、2 4和 4 8h分别腹腔注射ALLO或生理盐水 ,然后观察ALLO对HIBd模型鼠缺氧缺血 (HI)后 4 2h脑含水量、72h脑神经元凋亡(TUNEL法 )及超微结构改变、14d体质量增长率、脑病理改变 (海马神经元死亡率 )、30d学习分辨能力和记忆保持能力 (三臂迷宫试验 )等的影响。结果　脑含水量 :治疗组缺血侧 [( 84 .75± 4 .5 2 ) % ]含水量较对照组[( 92 .32± 3.75 ) % ]明显减少 (P 2h缺血侧脑组织可见较多凋亡细胞。治疗组缺血侧皮质凋亡细胞数明显低于对照组 [分别为 ( 93.6± 10 .8)和 ( 110 .5± 16 .9)个 / 30 0 0个细胞 ,P 2± 11.5 )和 ( 94 .2± 12 .3)个 / 30 0 0个细胞 ,P d体质量增长百分率 (WIP) :治疗组 [( 16 7.0± 33.6 ) % ]较对照组 [( 135 .6±4 7.5 ) % ]无显著性差异 (P >0 .0

关键词：别嘌呤醇新生大鼠缺氧缺血性脑损伤保护作用别嘌呤醇

lakeS IN THE MIddLE KEKEXILI rEGION

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Scientia Geologica Sinica 1994年第4期 479-486页

作者： Han Chunyu(center for International Scientific Exchanges, Chinese Academy of Sciences, beijing 100864)Murayama Haruta(department of Chemistry, Faculty of Education, Yokohama National University, 156 Tokiwadai,Kodogaya-ku, Yokohama, Japan 240)

ＬＡＫＥＳＩＮＴＨＥＭＩＤＤＬＥＫＥＫＥＸＩＬＩＲＥＧＩＯＮＨａｎＣｈｕｎｙｕ（ＣｅｎｔｅｒｆｏｒＩｎｔｅｒｎａｔｉｏｎａｌＳｃｉｅｎｔｉｆｉｃＥｘｃｈａｎｇｅｓ，ＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＳｃｉｅｎｃｅｓ，Ｂ...

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地塞米松不同给药方式治疗大鼠放射性直肠炎疗效观察

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肿瘤预防与治疗 2011年第5期24卷 221-224页

作者：敖睿孙岚刘浩涂琳莉四川省人民医院肿瘤科成都610072 四川大学华西医院肿瘤中心成都610041

目的:比较地塞米松分别采用腹腔注射及灌肠方式治疗大鼠放射性直肠炎的疗效。方法:32只Sd大鼠随机分为4组:未放疗+生理盐水灌肠组(A组);放疗+生理盐水灌肠组(B组);放疗+地塞米松灌肠组(C组);放疗+地塞米松腹腔注射组(d组)。每组8只大鼠,... 详细信息

目的:比较地塞米松分别采用腹腔注射及灌肠方式治疗大鼠放射性直肠炎的疗效。方法:32只Sd大鼠随机分为4组:未放疗+生理盐水灌肠组(A组);放疗+生理盐水灌肠组(B组);放疗+地塞米松灌肠组(C组);放疗+地塞米松腹腔注射组(d组)。每组8只大鼠,除A组外所有大鼠盆腔均接受16.5Gy剂量的放疗。放疗10天后处死所有大鼠。直肠标本进行HE染色病理检查,并行肿瘤坏死因子-α(TNF-α)mrNA的rT-PCr检测,处死大鼠前抽大鼠静脉血行血清TNF-α的ELISA检测。结果:地塞米松灌肠并没有显示出治疗大鼠放射性直肠炎的作用,而地塞米松腹腔注射可以明显减轻大鼠直肠放射性炎症,并可以减少直肠局部TNF-α及血清TNF-α的表达。结论:地塞米松全身给药治疗放射性直肠炎是正确的给药方式。

关键词：放射性直肠炎地塞米松灌肠腹腔注射

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注射用硫普罗宁治疗药物性肝损害

寄生虫病与感染性疾病 2003年第2期1卷 62-64页

作者：江南陈道邦唐荣珍四川省人民医院感染科四川成都610072 四川大学华西医学中心四川成都610041

目的了解硫普罗宁 (商品名凯西莱 ,tiopronin)静脉注射剂对药物性肝损害的治疗效果。方法采用随机数字表方法对 3 0对药物性肝损害病人进行分组治疗 (年龄在 2 5～ 60岁之间 )。对照药品为国产还原性谷胱甘肽 (泰特 )。用法硫普罗宁 (批... 详细信息

目的了解硫普罗宁 (商品名凯西莱 ,tiopronin)静脉注射剂对药物性肝损害的治疗效果。方法采用随机数字表方法对 3 0对药物性肝损害病人进行分组治疗 (年龄在 2 5～ 60岁之间 )。对照药品为国产还原性谷胱甘肽 (泰特 )。用法硫普罗宁 (批号 :0 2 1 0 0 1 -3 ) 0 .2 g加 5 %葡萄糖液 ( GS) 2 5 0 ml静脉滴注 ( iv gtt)每 d1次 ,共 1月。泰特 (批号 :0 2 0 72 7) 1 .2 g加 5 % GS2 5 0 ml( iv gtt)共 1月。观察 :1用药前后谷丙转氨酶 ( ALT)、谷草转氨酶( AST)、血清总胆红素 ( TBIL)的变化。 2硫普罗宁用于药物性肝损害治疗的不良反应。结果 1硫普罗宁治疗药物性肝损害其 ALT复常时间短于国产还原性谷胱甘肽 ( P0 .0 5 )。 2硫普罗宁治疗药物性肝损害仅 2例病人出现丘疹样皮疹 ,停药后消失。结论 1硫普罗宁治疗药物性肝损害 ,其肝细胞膜修复或保护肝细胞作用及减少药物对肝细胞的第二次打击方面 ,可能优于国产还原性谷胱甘肽。 2硫普罗宁治疗药物性肝损害有效。

关键词：药物性肝损害硫普罗宁还原性谷胱甘肽临床疗效

Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica d.Eisner Li Xie Minhu Chen department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda development center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA china Medical Team Takeda ChinaBeijing 100027China Hoffmann-La roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from china,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI2 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

Treating 630 Cases of Cerebral Stroke with defibrase made in china

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Treating 630 Cases of Cerebral Stroke with Defibrase made in...

中国毒理学会生物毒素毒理专业委员会第4次、中国生物化学与分子生物学会毒素专业组第5次学术研讨会

作者： Prof,Yang Jinghua, dr,Chang Xiaojinresearch Cooperative Group of Clinical application of snake venom. china dep & Treating research center of Thrombo-diseases Kunnming General Hospital 650223

20 years ago. We treated acute ischemic Cerebral stroke with purified thrombin-likeenzyme separated from Agkistrodon snake venom and gained apparent effect. The drug isconsisted of 4 *** May 1997 to May 1999, our cooperating research group consisted of 17hospitals used defibrase, a drug made of simple peak and made in china to treated 630cases, of ischemic cerebral stroke, study subjects were allotted into defibrase Group A,Batrocobin Group B and Control, Group C. For Group A and Group B, We used 10 or 5b.u intravenous drip in 250ml normal saline over 3 hours for 4-5 times. Every other day,altogether 10 days. For Group C We used Nimotop, Ginado and Notoginseng I. d daily for10 days, After the treatments above, mentioned. We used other medicines, exceptanticoagulative and thrombolytic agents, during the next 10 days, then decide therapeuticeffect.

关键词： Treating 630 Cases of Cerebral Stroke with defibrase made in china snake

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一种从蛇毒中纯化神经生长因子的新工艺

色谱 2004年第1期22卷 1-4页

作者：吴鹏杨晓燕边六交西北大学生命科学学院基因工程药物研究开发中心陕西西安710069

为了能从中华眼镜蛇蛇毒中简单快速地分离纯化神经生长因子 (一种治疗各种神经性损伤和神经退行疾病的药物 ,简称NGF) ,采用不同的色谱柱联用的方式对NGF的纯化工艺进行了研究。结果表明 ,采用dEAE SepharoseF F 和SephadexG 5 0二步柱... 详细信息

为了能从中华眼镜蛇蛇毒中简单快速地分离纯化神经生长因子 (一种治疗各种神经性损伤和神经退行疾病的药物 ,简称NGF) ,采用不同的色谱柱联用的方式对NGF的纯化工艺进行了研究。结果表明 ,采用dEAE SepharoseF F 和SephadexG 5 0二步柱色谱工艺可以从蛇毒中快速分离得到神经生长因子。经十二烷基硫酸钠聚丙烯酰胺凝胶电泳和反相高效液相色谱分析 ,证明所得到的NGF为单一组分 ,相对分子质量约为 2 90 0 0。对 8d龄鸡胚背根神经节采用体外培养法 ,结果证明 ,所得NGF具有明显的促进神经纤维生长的生物活性。

关键词：蛇毒神经生长因子分离纯化阴离子交换色谱-凝胶排阻色谱