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Acta Pharmacologica Sinica 2005年第2期26卷 186-191页

作者： Zhi-jun GE~(1,2),Yin-ming ZENG~1,Yong-fei TAN~2~1jiangsu province key laboratory of anesthesiology,xuzhou medical college,xuzhou 221002,china ~2jiangsu province People's Hospital of Yixing,Yixing 214200,china jiangsu province key laboratory of anesthesiology Xuzhou Medical College Xuzhou 221002 China jiangsu province People's Hospital of Yixing Yixing 214200 China

Aim:To investigate the relationship between spinal cord norepinephrine,α1andα2adrenergic receptors and antinociception of propofol in ***:Kunming mice were *** tests were investigated with the tail-immersion test and the acetic acid-induced writhing *** effects of subcuta-neous（sc）,intrathecal（ith）and intracerebroventricular（icv）injection propofolon pain threshold were *** influences of pretreatment with ith 6-hydroxydopamine,α1R antagonist prazosin,or α2R antagonist yohimbine on theantinociception of propofol were ***:Significant antinociceptionwas produced by propofol（25,50 mg/kg,sc）and propofol（20,40μg,ith）in tail-immersion test and acetic the acid-induced writhing test（P20,and 40 μg）did not produce any effect on pain threshold in mice（P>0.05）.The 6-hydroxydopamine（5 and 10μg）,prazosin（5 and 10μg）,oryohimbine（5 and 10μg）ith alone did not affect basal tai-flick latency（TFL）inconscious mice,but significantly reduced the TFL as measured by tail-immersiontest in propofol（50mg/kg,sc）-treated mice,compared with basal TFL and ve-hicle groups（P2R.

关键词： propofol spinal cord antinociception prazosin yohimbine norepinephrine

Effects of H2S on cerebral arterioles myogenic responses in aging

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Effects of H2S on cerebral arterioles myogenic responses in ...

Regulation of Bcl-2,Bax and caspase-3 expression by shear stress via the PI3K/Akt pathway in mesenteric arterioles of aged rats

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Lei LIU~1,You-Jian QI~1,Dong SUN~2,Chang-Dong YAN~(1,△) 1 Departments of Physiology,xuzhou medical Vollege,xuzhou,jiangsu,221002,Chin 2 jiangsu province key laboratory of anesthesiology,xuzhou medical college,xuzhou,jiangsu,221002,china

Objective:The potential biological significance of hydrogen sulfide(HS) has attracted growing interest in recent *** aim of this study was to illustrate the effect of HS on myogenic response and the role of HS in ***:Responses to changes in intravascular pressure of isolated rat cerebral arterioles were investigated under no-flow *** arterioles of young and old rats were isolated and *** diameters were measured with an image-shearing device and then *** response to step increases in perfusion pressure(from 20 to 120 mmHg,by 20 mmHg steps),arterioles constricted and developed active tone. Results:Isolated cerebral arterioles from young and old rats exhibited myogenic responses through the pressure ranges of 20 to 120 mmHg,and the old rats arterioles decreased their myogenic tones than the arterioles from young *** myogenic tones were reduced by NaHS in both young and old *** young group,glibenclamide the K channel blockers,significantly reduced the HS-induced attenuation of myogenic tones,the blockade of nitric oxide synthase further increased HS-induced attenuation of myogenic tones,and the cAMP synthesis inhibitor SQ22536 did not change the effect of HS,***,in old group,all these inhibitors did not change the effect of HS on myogenic *** of the endothelium significantly reduced NaHS-induced reduction of myogenic response in both young and old ***:Our results demonstrate that the effect of HS on myogenic response is partially mediated through K channel in young rats but not in old rats,and HS can attenuated myogenic tones through the way of endothelial cells.

关键词： cerebral arterioles myogenic reactivity hydrogen sulfide aging

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Regulation of Bcl-2,Bax and caspase-3 expression by shear st...

A novel mechanism of painful signal processing:Propagation failure of unmyelinated fibers in diabetic neuropathy rats

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Yan LIU~(1,2),Yan-Hua CHANG~3,Chang-Dong YAN~1,Hong LIU~(3,*) 1 Department of Physiology xuzhou medical college,xuzhou 221002,china 2 jiangsu province key laboratory of anesthesiology, xuzhou medical college,xuzhou 221002,china 3 Department of Pathology xuzhou medical college,xuzhou 221002,china

＜正＞Objective:To investigate whether shear stress would regulate the expression of Bcl-2,Bax and Caspase-3 via the PI3K/Akt pathway in arterioles of aged ***:Second-order mesenteric arterioles of young（6 months） and aged（24 months） male SD rats were selectively ligated to elevate blood flow in first-order arterioles as high blood flow（HF）.A 3rd to 5th first-order arteriole proximal to the HF arteriole was selected as the normal blood flow （NF）.Three weeks after surgery,the arterioles were isolated and measured by vascular perfusion *** changes of arteriolar wall elasticity and the wall thickness of the first-order arterioles with HF and NF were *** expression of Akt,p-Akt,Bcl-2,Bax and Caspase-3 in NF and HF of young and aged rats were determined by western ***:（1） Compared with young rats,the content of arteriolar collagen fiber was increased,whereas the elasticity of arterioles was reduced in aged *** increased intravascular fluid shear stress,the elasticity of arterioles was increased and the function of arterioles was improved,however,there was no significant change in arteriolar morphology.（2） Western blot analysis showed that shear stress increased expression of p-Akt and Bcl-2,while decreased expression of Bax and Caspase-3 in NF arterioles of both *** aged rats,shear stress regulated p-Akt,Bcl-2 and Caspase-3 production in HF arterioles to a level similar to NF arterioles of young ***:Shear stress increased phosphorylated Akt production and played a key role in the regulation of Bcl-2,Bax and *** it can increase the flexibility and state of rat *** results suggest that shear stress acts as an efficient stimulus to improve function of mesenteric arterioles in aged rats via the PI3K/Akt pathway.

关键词： shear stress mesenteric arterioles aged Akt Bcl-2 Bax caspase-3

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A novel mechanism of painful signal processing:Propagation f...

Water-Driven Malleable,Weldable and Eco-Friendly Recyclable Carbon Fiber Reinforced Dynamic Composites

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xiu-Chao WANG~1,Wei SUN~1,Bei MIAO~(1,2),Wen-Ting WANG~1,Ceng LUO~1,Yi-Hui LIU~1,Fang KUANG~1,Jun-Ling XING~1, Hui XU~1,Gong JU~1,Xue-Jun SONG~2,San-Jue HU~(1,*) 1 Institute of Neuroscience,the Fourth Military medical University,Xi’an 710033,china 2 jiangsu province key laboratory of anesthesiology,xuzhou medical college,xuzhou 221002,china

Objective The precise mechanism of painful diabetic neuropathy(PDN) in unmyelinated fibers(C-fibers) remains unclear despite of the finding of hyper-responsivity in some subset of *** previous work found that conduction failures(CF) of main axon in C-fibers are one of adaptation phenomenon and information processing in peripheral *** present study is to investigate the roles of CF and it’s mechanisms in *** Streptozotocin (STZ,70mg/kg) diabetic model was induced with SD male *** injecting STZ 3-4 weeks,the behavioral responses to mechanical and heat stimulations were tested to the appearance of diabetic neuropathy *** single C fibers discharge was induced by mechanical and electrical stimulations for testing the changes of CF degree in C fibers within the coccygeal *** cell patch clamp recording in whole dorsal root ganglion(DRG) neurons was used to explore the excitability change and the intensity of sodium current in *** channel expression alterations were tested in DRG and C fibers of coccygeal nerve in control and NPD ***(1) A rat model of PDN induced by STZ has been set up. (2) The discharge numbers of single C-fiber in PDN were significantly higher than the control group in mechanical stimulations(100 g).High frequency firing(>3Hz) was found in about 1/3 of C-fibers in *** degree of PDN was distinctly lower than that of control ***,low dose TTX(100nM) could increase CF degree in partial PDN.(3) The threshold of action potential in PDN was lower than control *** its half width of action potential also was faster than control.(4) Sodium current of PDN was larger than control group.(5) Immunochemistry data showed that the numbers of Nav 1.7 cell,Nav 1.8 and Nav 1.9 in PDN were higher than *** the fluorescence intensities of Nav 1.7, Nav 1.8 and Nav1.9 in PDN also increased in coccygeal *** The results demonstrat that CF of the axon of C fibers is weakened during P

关键词： conduction failure unmyelinated fibers persistent sodium channel diabetic painful neuropathy dorsal root ganglion

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Chinese Journal of Chemistry 2024年第5期42卷 516-522页

作者： Ping Yu Qirui Huang Yi Wang Wan Peng Zichen Jia Haiyue Wang Juanjuan Ma Chunyu Wang xuzhou Yan School of Environmental and Chemical Engineering Jiangsu Key Laboratory of Function Control Technology for Advanced MaterialsJiangsu Ocean UniversityLianyungangJiangsu222005 China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai200240 China

Traditional carbon fiber-reinforced polymers based on thermoset matrix have been extensively used in the fields of wind turbine blades,automotive sector,and aerospace,among many ***,there is still a major challenge of recycling those polymers due to the high cost and adverse impacts on the *** this work,we apply a polyimine network as matrix,which possess considerable tensile and thermal properties,to prepare the carbon fiber reinforced polyimine materials with trifluoromethyl diphenoxybenzene units(CFRFP)using a prepreg-based compression molding *** CFRFP can be reshaped or reprocessed by heat or with water rapidly,and exhibited multifunction,including welding,chemical recycling,*** unique findings gained from our study will facilitate the manufacturing capability and enrich the types of fiber-reinforced composites.

关键词： Dynamic chemistry Green chemistry Fiber-reinforced composites Fluoropolyimine Welding Reshaping Recycling Renewable resources

Effects of intrathecal NMDA and AMPA receptors agonists or antagonists on antinociception of propofol

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Acta Pharmacologica Sinica 2004年第1期 11-16页

作者： Ai-jun XU, Shi-ming DUAN, Yin-ming ZENGjiangsu province key laboratory of anesthesiology, xuzhou medical college, xuzhou 221002, china

AIM: To study the effects of intrathecal (it) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors and NMDAR1 antisense oligodeoxynucleotides (AS ODN) on the antinociception of propofol. METHODS: Hot-plate test (HPPT) and acetic acid-induced writhing test were used to measure the nociceptive thresholds in mice. The effects of intrathecal NMDA,

关键词： N-methyl-D-aspartate receptors AMPA receptors spinal injections antinociception propofol

GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats

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Acta Pharmacologica Sinica 2004年第12期25卷 53-59页

作者： Qin-yun WANG2,3, Jun-li CAO2, Yin-ming ZENG2, Ti-jun DAI2,4 2jiangsu Institute of anesthesiology, jiangsu province key laboratory of anesthesiology, xuzhou, 221002, china 3Department of anesthesiology, the1st Affiliated Hospitalof Soochow University, Suzhou 215006, china jiangsu Institute of anesthesiology Jiangsu Province Key Laboratory of Anesthesiology Department of anesthesiology the 1st Affiliated Hospital of Soochow University

AIM: To observe effects of propofol on nociceptive response at superspinal and spinal level in rats. METHODS: Two hundreds and fifty-eight Sprague-Dawley male rats were randomized into thirty-two groups. Propofol and bicuculline were microinjected into lateral ventricle (icv), ventrolateral periaqueductal gray (vlPAG), intrathecal (ith), and intraperitoneal (ip). The noxious responses were evaluated by hot plate and formalin test. RESULTS: In hot-plate test, systemic and superspinal administration of propofol (40 mg·kg-1 ip, 100 μg in 10 μL, icv, and 4 μg in 0.4 μL vlPAG microinjection) produced hyperalgesia (P2 %, 98.8 % at 10, 20, and 30 min by microinjection of bicuculline (10 ng in 0.4 μL, vlPAG) (P20, 30 and 40 min by ith bicuculline (P<0.05). In formalin test, systemic and superspinal administration of propofol (40 mg·kg-1 ip, 4 μg in 0.4 μL, vlPAG) also produced hyperal- gesia (P<0.01). The increased formalin pain scores were antagonized about 57.1 % by bicuculline (10 ng, vlPAG) (P<0.05) at 60 min after formalin injection. The decreased formalin pain scores induced by ith propofol (100 μg in 10 μL) were antagonized about 66.7 % at 30 min by ith bicuculline (P<0.05) after formalin injection. Hyperalgesia produced by ip propofol in both hot plate and formalin test could not be antagonized by vlPAG administration of bicuculline. CONCLUSION: GABAA receptor partly mediated propofol-induced hyperalgesia at superspinal and analgesia at spinal cord in rats.

关键词： GABA receptors propofol pain ventrolateral periaqueductal gray spinal cord

Role of PI3-K/Akt pathway and its effect on glial cell line-derived neurotrophic factor in midbrain dopamine cells

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Acta Pharmacologica Sinica 2007年第2期28卷 166-172页

作者： Hong-jun WANG Jun-ping CAO Jing-kao YU Dian-shuai GAO~2 Research Centre of Neurobiology,xuzhou medical college,xuzhou 221002,china Research Centre of Neurobiology Xuzhou Medical College

Aim:To explore the intracellular mechanisms underlying the survival/differentia-tion effect of the glial cell line-derived neurotrophic factor(GDNF)on dopamine(DA)***:Midbrain slice culture and primary cell culture wereestablished,and the cultures were divided into 3 groups:control group,GDNFgroup,and the phosphatidylinositol 3-kinase/Akt(PI3-K/Akt)*** the expression of tyrosine hydroxylase(TH)was detected byimmunostaining as well as Western ***:GDNF treatment inducedan increase in the number of TH-immunoreactive(ir)cells and the neurite numberof TH-ir cells,as well as in the level of TH expression in cultures(Number of TH-ir cells in the slice culture:control group,8.76±0.75;GDNF group,18.63±*** of TH-ir cells and neurite number of TH-ir cells in cell culture:controlgroup,3.65±0.88 and 2.49±0.42;GDNF group,6.01±0.43 and 4.89±0.46).Meanwhile,the stimulation of cultured cells with GDNF increased the phosphorylation of Akt,which is a downstream effector of PI3-K/*** effects of GDNF were specifi-cally blocked by the inhibitor of the PI3-K/Akt pathway,wortmannin(Number ofTH-ir cells in slice culture:PI3-K/Akt pathway-inhibited group,6.98±***-ber of TH-ir cells and neurite number of TH-ir cells in cell culture:PI3-K/Aktpathway-inhibited group,3.79±0.62 and 2.50±0.25,respectively).Conclusion:The PI3-K/Akt pathway mediates the survival/differentiation effect of GDNF onDA cells.

关键词： glial cell line-derived neurotrophic factor phosphatidylinositol 3-kinase/Akt dopa mine cells survival/differentiation

Changes in Dietary Patterns and Certain Nutrition-related Diseases in Urban and Rural Residents of jiangsu province,china,During the 1990s

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Biomedical and Environmental Sciences 2002年第4期15卷 271-276页

作者： WANG CAN-NAN , LIANG ZHI , WEI PING , LIU PEI , YD JiA-Xr, ZHANG DAN-MEI, AND MA FENG-LOUFaculty of Public Health, xuzhou medical college, xuzhou, jiangsu 221002, china Bureau ofHealth, jiangsu Provincial Government, Nanjing, jiangsu 210008, china Statistical Bureauof jiangsu Provincial Government Nanjing, jiangsu 210026, china Health andAnti-epidemic Station of xuzhou, xuzhou. jiangsu 221002, china ’ School of PublicHealth, Nanjing medical University, Nanjing, jiangsu 210029, china Faculty of Public Health Xuzhou Medical College 江苏 Xuzhou 221002 Bureau of Health Jiangsu Provincial Government 江苏 Nanjing 210008 Faculty of Public Health Xuzhou Medical Colleg 江苏 Xuzhou 221002 Health and Anti-epidemic Station of xuzhou 江苏 Xuzhou 221002 School of Public Health Nanjing Medical University 江苏 Nanjing 210029

Objective To investigate into the changes of dietary patterns and their impacts on health of urban and rural residents in jiangsu province, china during the 1990s. Methods On the basis of the results of food consumption survey, the calorie intake was calculated according to the balanced diet method and the quality of diet was assessed by scores of desirable dietary pattern (DDP). Results It was found that food consumption and dietary patterns changed remarkably during the 1990s. Grain consumption was decreasing year by year, but the consumption of animal food was markedly increasing. Although the score of desirable dietary pattern (DDP) in urban residents was more than 90, the deducted score due to over-consumption of animal food increased. The mortality from infectious diseases evidently decreased in the whole province, while the death rates of some chronic diseases, such as diabetes, hypertension, colorectal cancer and breast cancer, were increasing rapidly in urban areas. Conclusions Sufficient attention should be paid to the negative effects of change in dietary patterns on people's health, especially in the urban residents.

关键词： Dietary patterns Nutrition-related diseases

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Calculation of maximum ground movement and deformation caused by mining

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中国有色金属学会会刊：英文版 2011年第S3期21卷 562-569页

作者： LI Pei-xian1, 2, TAN Zhi-xiang1, 2, DENG Ka-zhong1, 2 1. key laboratory for Land Environment and Disaster Monitoring of State Bureau of Surveying and Mapping, china University of Mining and Technology, xuzhou 221116, china 2. jiangsu key laboratory of Resources and Environmental Information Engineering, china University of Mining and Technology, xuzhou 221116, china [a] key laboratory for Land Environment and Disaster Monitoring of State Bureau of Surveying and Mapping China University of Mining and Technology Xuzhou 221116 China [b] jiangsu key laboratory of Resources and Environmental Information Engineering China University of Mining and Technology Xuzhou 221116 China

In order to know the maximum mining ground deformation of arbitrary surface point, directions of the maximum surface tilt, curvature,horizontal displacement and horizontal deformation caused by multi-working faces were deduced based on probability integral method. The distribution forms of surface deformations in all direction φ∈[0, 2π] were obtained and also equations of maximum deformations were given based on calculation of mining ground deformation in direction φ. A mining subsidence analysis system was developed with VB6.0. The system implements the probability integral mining subsidence prediction with direct integration method, and it can avoid errors of arbitrary shaped working face subdivision of traditional method, and accuracy of mining subsidence prediction can be improved with the direct integral method. The system implements the contour chart and profile chart and also data analysis automation by manipulation of the SURFER kernel function and it complements the defect of existing subsidence prediction software. Calculation of maximum deformations caused by multi-working faces mining in a coal mine of xuzhou, china was shown as application example. Engineering application indicates that maximum deformation of mining ground surface can be calculated and analyzed by the system. The research provides a theoretical basis and calculation tool for mining subsidence prediction and analysis.

关键词： mining subsidence probability integral method movement and deformation system development

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