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Cleaner production for continuous digester processes based on hybrid Pareto genetic algorithm

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Journal of Environmental Sciences 2003年第1期15卷 129-135页

作者： JIN Fu\|jiang, WANG Hui, LI Ping (institute of Industrial Process Control, zhejiang university, hangzhou 310027, china. institute of Industrial Process Conlnil Zhejiang University Hangzhnu 310027

Pulping production process produces a large amount of wastewater and pollutant emitted, which has become one of the main pollution sources in pulp and paper industry. To solve this problem, it is necessary to implement cleaner production by using modeling and optimization technology. This paper studies the modeling and multi\|objective genetic algorithms for continuous digester process. First, model is established, in which environmental pollution and saving energy factors are considered. Then hybrid genetic algorithm based on Pareto stratum\|niche count is designed for finding near\|Pareto or Pareto optimal solutions in the problem and a new genetic evaluation and selection mechanism is proposed. Finally using the real data from a pulp mill shows the results of computer simulation. Through comparing with the practical curve of digester,this method can reduce the pollutant effectively and increase the profit while keeping the pulp quality unchanged.

关键词： cleaner production multi\|objective optimization genetic algorithm Pareto stratum concentration of residual alkali Kamyr continuous digester

Inhibitory effect of leflunomide on hepatic fibrosis induced by CCl4 in rats

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Acta Pharmacologica Sinica 2004年第7期25卷 69-74页

作者： Hong-wei YAO2,3, Jun LI3,4, Ji-qiang CHEN2, Shu-yun XU3 2 zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of china, School of medicine, zhejiang university, hangzhou 310031 3institute of Clinical Pharmacology, Anhui Medical university, Hefei 230032, china 浙江大学国家食品药品监督管理局呼吸药物研究实验室 Hangzhou 310031 institute of Clinical Pharmacology Anhui Medical University Hefei

AIM: To study the effect of leflunomide on CCl4-induced hepatic fibrosis in rats. METHODS: Hepatic fibrosis was induced by subcutaneous injection with 50 % CCl4 in Sprague-Dawley rats. The amount of CCl4 administered was 1 mg/kg. The alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitric oxide (NO) levels in plasma and hydroxyproline (Hyp) contents in liver tissue were assayed by spectrophotometry. The hyaluronic acid (HA) and procollagen III (PC III) were assessed by radioimmunoassay. The transforming growth factor-β1 (TGF-β1) in serum was determined by ELISA. The nuclear factor-kappa B (NF-κB) in liver tissue was examined by immunohistochemistry. Liver samples collected after 12 weeks of CCl4 treatment were stained with hematoxy- lin and eosin. RESULTS: Leflunomide (1, 3, and 9 mg/kg) significantly decreased indices of liver and spleen, the serum transaminase (AST, ALT) activities, HA and PC III levels, and Hyp contents in liver tissue in rats of hepatic fibrosis. Histopathological examination showed leflunomide had inhibitory effect on fibrogenesis and formation of pseudolobulus. Furthermore, leflunomide significantly inhibited NF-κB expression in liver tissue, and reduced elevated serum TGF-β1 and NO levels in rats of hepatic fibrosis. CONCLUSION: Leflunomide showed inhibitory action on hepatic fibrosis induced by CCl4 in rats.

关键词： leflunomide hepatic fibrosis nuclear factor-kappa B transforming growth factor-beta nitric oxide

The Cauchy Integral Operator on Weighted Hardy Space

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Chinese Annals of Mathematics,Series B 2010年第4期31卷 461-472页

作者： Jianmiao RUAN Jiecheng CHEN Department of Mathematics Zhejiang University Hangzhou 310027 China Department of Mathematics Zhejiang Education Institute Hangzhou 310012 China

The authors show that the Cauchy integral operator is bounded from Hωp(R1) to hωp(R1) (the weighted local Hardy space). To prove the results, a kind of generalized atoms is introduced and a variant of weighted "Tb t... 详细信息

关键词： Cauchy integral Calder6n-Zygmund operator Weighted Hardy space Weighted local Hardy space

Cloning and Alternative Splicing Analysis of Bombyx mori Transformer-2 Gene using Silkworm EST Database

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Acta Biochimica et Biophysica Sinica 2005年第11期37卷 728-736页

作者： Bao-Long NIU Zhi-Qi MENG Yue-Zhi TAO Shun-Lin LU Hong-Biao WENG Li-Hua HE Wei-Feng SHEN Sericultural Research institute,zhejiang Academy of Agricultural Sciences,hangzhou 310021,china Department of Sericulture and Apiculture,College of Animal Sciences,zhejiang university,hangzhou 310029,china Sericultural Research institute Zhejiang Academy of Agricultural SciencesHangzhou 310021 China Department of Sericulture and Apiculture College of Animal Sciences Zhejiang UniversityHangzhou 310029 China

We have identified Bombyx mori transformer-2 gene(Bmtra-2)cDNA by blasting the ESTdatabase of *** was expressed in the whole life of the male and female silkworm and was observed asa band of 1.3 kb by Northern blot *** comparing corresponding ESTs to the Bmtra-2 DNA sequence,it was revealed that there were eight exons and seven introns,and all splice sites of exons/introns conformedto the GT/AG ***-2 pre-mRNA can produce multiple mRNAs encoding six distinct isoforms ofBmTRA-2 protein using an alternative splicing pathway during *** types of Bmtra-2 cDNAclones were identified by reverse transcription-polymerase chain *** isoforms of BmTRA-2 proteincontain two arginine/serine-rich domains and one RNA recognition motif,showing striking organizationalsimilarity to Drosophila TRA-2 proteins.

关键词： EST database transformer-2 gene Bmtra-2 alternative splicing gene clone Bombyxmori

Dynamic behavior of polymer surface and the time dependence of contact angle

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Science china Chemistry 2005年第6期48卷 553-559页

作者： WANG Xinping1, CHEN Zhifang1 & SHEN Zhiquan2 1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Education Ministry, Department of Applied Chemistry, zhejiang institute of Science and Technology, hangzhou 310033, china 2. Department of Polymer Science and Engineering, zhejiang university, hangzhou 310027, china Department of Applied Chemistry Zhejiang Institute of Science and Technology Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Education Ministry Hangzhou China Department of Polymer Science and Engineering Zhejiang University Hangzhou China

Time-dependent contact angles were measured by depositing sessile drops of wa-ter on the polymer surfaces and monitoring the drop shape as a function of time. It was found that contact angles decreased sharply with contact time and the equilibrium contact angle was finally attained after a certain time. Values of starting (θ s) and equilibrium contact angles (θ e) obtained by the sessile drop method depend on polymer properties. The Wilhelmy plate technique was used to measure advancing and receding contact angles. The variations of starting (θ s) and equilibrium contact angles (θ e), advancing (θ a) and receding contact angles (θ r) have been studied on the oxidized surface of polymers containing polybutadiene block to explore the cause of time-dependence in contact angle measurement and the meaning of θ s and θ e. The results showed the linear relationships between starting (θ s) and advancing contact angles (θ a), the equilibrium (θ e) and receding contact angles (θ r). The similar relationship was also established between the contact angle hysteresis (θ a?θ r) and differences (θ s ?θ e) in starting contact angles and equilibrium contact angles. Therefore, time-dependence in contact angle measurement was mainly attributed to the surface reconstruction when water drops were deposited on polymer surfaces. The starting contact angle was contributed by the hydrophobic component on polymer surface and the equilibrium contact angle mainly by the hydrophilic component of polymer. These results not only demonstrated the interdependency between two contact angle measurements, the sessile drop method and the Wilhelmy plate technique, but also provided the experimental evidence to explain the cause of time-dependent contact angle. This may also provide a new method to study dynamic behavior of polymer surface.

关键词： contact angle, surface dynamic behavior, polymer surface, dynamic contact angle, time-dependence.

P systems based multi-objective optimization algorithm

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Progress in Natural Science:Materials International 2007年第4期17卷 458-465页

作者： Huang Liang, He Xiongxiong, Wang Ning and Xie Yi ( National Laboratory of Industrial Control Technology, institute of Advanced Process Control, zhejiang university, hangzhou 310027, china zhejiang university of Technology, hangzhou 310033, china) National Laboratory of Industrial Control Technology Institute of Advanced Process Control Zhejiang University Hangzhou 310027 China zhejiang university of Technology Hangzhou 310033 China

Based on P systems, this paper proposes a new multi-objective optimization algorithm (PMOA). Similar to P systems, PMOA has a cell-like structure. The structure is dynamic and its membranes merge and divide at different stages. The key rule of a membrane is the communication rule which is derived from P systems. Mutation rules are important for the algorithm, which has different ranges of mutation in different membranes. The cooperation of the two rules contributes to the diversity of the population, the conquest of the muhimodality of objective function and the convergence of algorithm. Moreover, the unique structure divides the whole population into several sub populations, which decreases the computational complexity. Almost a dozen popular algorithms are compared using several test problems. Simulation results illustrate that the PMOA has the best performance. Its solutions are closer to the true Pareto-optimal front

关键词： P systems evolutionary algorithm multi-objective optimization Pareto optimality.

Non-paraxial Elliptical Gaussian Beam

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Chinese Journal of Lasers 2001年第6期10卷 33-39页

作者： WANG Zhaoying LIN Qiang NI Jie (institute of Optics, Department of Physics, zhejiang university, hangzhou 310028, china) 浙江大学物理系光学所浙江杭州 310028

By using the methods of Hertz vector and angular spectrum transormation, the exact solution of non-paraxial elliptical Gaussion beam with general astigmatism based on Maxwell′s equations is obtained. We discussed its propagation characteristics. The results show that the orientation of the elliptical beam spot changes continuously as the beam propagates through isotropic media. Splitting or coupling of beam spots may occur for different initial spot size. This is very different from that of paraxial elliptical Gaussian beam.

关键词： non-paraxial elliptical Gaussian beam propagation

Effect of primary iris and ciliary body cyst on anterior chamber angle in patients with shallow anterior chamber

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Journal of zhejiang university-Science B(Biomedicine & Biotechnology) 2012年第9期13卷 723-730页

作者： Bing-hong WANG Yu-feng YAO Department of Ophthalmology Sir Run Run Shaw Hospital School of MedicineZhejiang UniversityHangzhou 310016China Sir Run Run Shaw institute of Clinical medicine of zhejiang university Hangzhou 310016China

Objective:To evaluate the prevalence of primary iris and/or ciliary body cysts in eyes with shallow anterior chamber and their effect on the narrowing of the anterior chamber ***:Among the general physical check-up population,subjects with shallow anterior chambers,as judged by van Herick technique,were recruited for further *** biomicroscope(UBM) was used to detect and measure the cysts located in the iris and/or ciliary body,the anterior chamber depth(ACD),the angle opening distance at 500 μm(AOD500),and the trabecular-iris angle(TIA).A-scan ultrasonography was used to measure the ocular biometry,including lens thickness,axial length,lens/axial length factor(LAF),and relative lens position(RLP).The effect of the cyst on narrowing the corresponding anterior chamber angle and the entire angle was evaluated by the UBM images,ocular biometry,and gonioscopic *** eye with unilateral cyst was compared with the eye without the cyst for further ***:Among the 727 subjects with shallow anterior chamber,primary iris and ciliary body cysts were detected in 250(34.4%) patients;among them 96(38.4%) patients showed unilateral single cyst,21(8.4%) patients had unilateral double cysts,and 42(16.8%) patients manifested unilateral multiple and multi-quadrants *** iris configuration was found in 140 of 361(38.8%) eyes with *** mean size of total cysts was(0.6547±0.2319) *** evaluation of the effect of the cyst size and location on narrowing the corresponding angle to their position,the proportion of the cysts causing corresponding angle narrowing or closure among the cysts larger than 0.8 mm(113/121,93.4%) was found to be significantly higher than that of the cysts smaller than 0.8 mm(373/801,46.6%),and a significant higher proportion was also found in the cysts located at iridociliary sulcus(354/437,81.0%) than in that at the pars plicata(131/484,27.1%).In evaluating the effect of the cyst on the entire anterior ch

关键词： Iris and ciliary body cyst Ultrasound biomicroscope Shallow anterior chamber

Linguistic granular model: design and realization

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Progress in Natural Science:Materials International 2005年第8期15卷 749-756页

作者： YUE Shihong 1,2*, LI Ping2 and SONG Zhihuan2(1. institute of Industrial Process Control, zhejiang university, hangzhou 310027, china 2. School of Electric Engineering and Atomization, Tianjin university, Tianjin 300072, china) institute of Industrial Process Control Zhejiang University Hangzhou 310027 China School of Electric Engineering and Atomization Tianjin University Tianjin 300072 China

A new linguistic granular model is proposed and the effect of its parameters on the output is analyzed. The design of the model consists of two stages: using conditional fuzzy clustering for information granular, and integrating all information granules to final output. The integrating tool is fuzzy integral based on fuzzy measure, and the generalization of fuzzy integral increases flexibility of the linguistic granular model greatly. A heuristic algorithm to determine the parameters in the fuzzy integral is used to realize the linguistic model. Two experiments verify the feasibility of the proposed model.

关键词： linguistic model granular fuzzy clustering fuzzy integral.