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Exp.ession of hep.titis B vir.s sur.ace antigen in 120 Hodgkin's lymp.oma p.tients

Chinese Jour.al of cancer 2010年第8期29卷 735-740页

作者： Miao-Zhen Qiu1,2, Dan-Yun r.an1,2, Zhi-Qiang Wang1,2, Hui-Yan Luo1,2, Kai-Yuan Teng1,2, Zhong-Jun Xia1,3, Yue Lu1,3, Hui-Qiang Huang1,2, Wen-Qi Jiang1,2, r.i-Hua Xu1,2 1 State Key Labor.tor. of oncology in South china, sun yat-sen university cancer center, guangzhou, guangdong 510060, p. r. china 2 department of medical oncology, sun yat-sen university cancer center, guangzhou, guangdong 510060, p. r. china 3 department of Hematology oncology, sun yat-sen university cancer center, guangzhou, guangdong 510060, p. r. china sun yat-sen university cancer center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Backgr.und and Objective: Little is known about the incidence of hep.titis B vir.s (HBV) infection in Hodgkin's lymp.oma p.tients. This study was to evaluate the imp.ct of HBV infection on the sur.ival of Hodgkin's lymp.oma p.tient. Methods: Clinical data of 120 Hodgkin's lymp.oma p.tients tr.ated at the sun yat-sen university cancer center between Januar. 2004 and October.2007 wer. collected. The imp.ct of p.ognostic factor. including HBV infection on sur.ival was examined by univar.ate and multivar.ate analyses. A log-r.nk test was used for.univar.ate analysis and the Cox p.op.r.ional hazar.s r.gr.ssion model was used for.multivar.ate analysis. r.sults: Of the 120 p.tients, 18 (15.0%) wer. hep.titis B vir.s sur.ace antigen (HBsAg)-p.sitive. The HBsAg-p.sitive p.tients had lower.5-year.sur.ival r.te than did the HBsAg-negative ones (66.9% vs. 91.3%, p.= 0.006). When the p.tients wer. divided into ear.y-stage (Ⅰ+Ⅱ) and advanced-stage (Ⅲ+Ⅳ) gr.up., the 5-year.sur.ival r.te was significantly differ.nt between the HBsAg-p.sitive and -negative p.tients in ear.y-stage gr.up.(64.8% vs. 96.0%, p.r.nt in advanced-stage gr.up.(75.0% vs. 84.8%, p.0.667). Both univar.ate and multivar.ate analyses showed that r.diother.p. and HBV infection wer. indep.ndent p.ognosis factor. for.the p.tients with ear.y-stage Hodgkin's lymp.oma (p.0.006 and 0.014, r.sp.ctively). Conclusions: The incidence of HBV infection is similar.between Hodgkin's lymp.oma p.tients and nor.al p.p.lation. HBV infection is an indep.ndent p.ognosis factor.for.sur.ival in the p.tients with ear.y-stage Hodgkin's lymp.oma.

关键词：乙肝病毒表面抗原淋巴瘤患者乙肝表面抗原多因素分析金病毒感染肝炎病毒

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One p.tient with metastastic color.ctal cancer successfully tr.ated by combination of tar.eted agents after.failur. of chemother.0}y

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Chinese Jour.al of cancer 2010年第12期29卷 1023-1028页

作者： Liang-p.ng Xia1,2, p.i-Hong Wu1,3, Jian-Chuan Xia1,4, Bei Zhang1,2, Zhong-Zhen Guan1,5, De-sen Wan1,6, Gui-Fang Guo1,2, Yi-Xin Zeng1,7 1 State Key Labor.tor. of oncology in South china, guangzhou, guangdong 510060, p. r. china 2 VIp.r.gion, sun yat-sen Univer.ty cancer center, guangzhou, guangdong 510060, p. r. china 3 department of medical Imaging and Inter.entional r.diology, sun yat-sen Univer.ty cancer center, guangzhou, guangdong 510060, p. r. china 4 Biother.p. cancer, sun yat-sen Univer.ty cancer center, guangzhou, guangdong 510060, p. r. china 5 department of medical oncology, sun yat-sen Univer.ty cancer center, guangzhou, guangdong 510060, p. r. china 6 department of Color.ctal cancer,sun yat-sen Univer.ty cancer center, guangzhou, guangdong 510060, p. r. china 7 sun yat-sen Univer.ty cancer center, guangzhou, guangdong 510060, p. r. china VIp.r.gion Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 department of medical Imaging and Inter.entional r.diology Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 Biother.p. cancer Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 department of medical oncology Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 department of Color.ctal cancer Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 sun yat-sen Univer.ty cancer center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060

Either.cetuximab or.bevacizumab can imp.ove the sur.ival of p.tients with metastastic color.ctal cancer (mCr.) if administer.d combided with cytotoxic agents. However. the effect of two or.mor. tar.et agents in combination is uncer.ain in these p.tients. Her., we r.p.r.ed a p.tient with mCr. successfully tr.ated by a combination of tar.et agents after.the failur. of chemother.p.. The p.tient r.ceived p.lliative r.section of p.imar. tumor.followed by 9 cycles of p.stop.r.tive XELOX r.gimen, cytokine-induced killer.cell (CIK)-based biother.p., tr.ditional Chinese medicine, p.r.icle imp.antation in the lung metastatic lesions. The tumor.p.ogr.ssed 20 months after.the standar. tr.atments. Then, the r.gimen cetuximab, bevacizumab and cefitinib was ap.lied. Dur.ng the tr.atment with tar.eted agents, gr.de IV acne-like r.sh and r.latively sever. p.r.onychia of the toes occur.ed. Both of them r.cover.d smoothly. The p.T-CT r.examination at 40 days after.the tar.et tr.atment showed that the metabolism of mediastinal lymp. nodes basically r.cover.d to a nor.al level. The combination of multip.e tar.eted agents obtained a p.ogr.ssion-fr.e sur.ival(p.S) of 11 months and the p.tient with a good quality of life dur.ng this p.r.od.

关键词：药物治疗结直肠癌转移性患者大肠细胞毒性靶向药物不确定性

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Antiangiogenic ther.p.:a novel ap.r.ach to over.ome tumor.hyp.xia

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Chinese Jour.al of cancer 2010年第8期29卷 715-720页

作者： Fang p.ng1,2, Ming Chen1,2 1 State Key Labor.tor. of oncology in South china, guangzhou, guangdong 510060, p. r. china 2 department of r.diation oncology, sun yat-sen university cancer center, guangzhou, guangdong 510060, p. r. china department of r.diation oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Hyp.xia is a common p.enomenon in solid tumor.. r.sistance of hyp.xic tumor.cells to r.diation is a significant r.ason of failur. in the local contr.l of tumor.. The gr.wth and metastasis of solid tumor. r.ly on blood vessels. Antiangiogenic agents mainly tar.et tumor.blood vessels, and r.diation ther.p. mainly tar.ets tumor.cells. Combination of antiangiogenic tr.atment and r.diation exhibits syner.istic effect, which imp.oves the r.sp.nse of tumor. to r.diation ther.p.. The mechanisms of inter.ction between antiangiogenic agents and ionizing r.diation ar. comp.ex and involve inter.ctions between tumor.cells and tumor.micr.envir.nment, including tumor.oxygenation, str.ma, and vasculatur.. The or.ginal mechanism of antiangiogenesis is to induce ischemia and hyp.xia in tumor., ther.by, "star.e" the tumor.. However. r.cently, emer.ing data suggest that antiangiogenic agents could r.duce the p.op.r.ion of hyp.xic cells thr.ugh nor.alizing tumor.vasculatur., decr.asing oxygen consump.ion, and other.mechanisms. The use of antiangiogenic agents p.ovides a new ap.r.ach to over.ome the hyp.xia p.oblem, and ultimately imp.oves the efficacy of r.diation ther.p.. In this r.view, we discuss tumor.hyp.xia, tumor.angiogenesis and its r.gulation, mechanisms of antiangiogenic ther.p. combined with r.diation ther.p., and how antiangiogenic ther.p. over.omes tumor.hyp.xia.

关键词：抗血管生成肿瘤细胞抗缺氧疗法放射治疗电离辐射肿瘤血管生成相互作用

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Adjuvant inter.er.n ther.p. for.malignant melanoma:the debate

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Chinese Jour.al of cancer 2010年第11期29卷 907-913页

作者： Qiang Zhou1,2, Xiao-Shi Zhang1,2 1 State Key Labor.tor. of oncology in South china, guangzhou, guangdong 510060, p. r. china 2 Biother.p. center, sun yat-sen university cancer center, guangzhou, guangdong 510060, p. r. china Biother.p. center Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Based on the r.sults of the Kir.wood high-dose inter.er.n alp.a-2b (HDI) adjuvant ther.p. tr.al of the Easter. Coop.r.tive oncology Gr.up.1684, the US Food and Dr.g Administr.tion (FDA) ap.r.ved HDI as the p.stop.r.tive adjuvant ther.p. for.high-r.sk melanoma. Unfor.unately, contr.ver.ies continue r.gar.ing the use of inter.er.n (IFN) as adjuvant ther.p. for.melanoma owing to the inconsistent r.sults of subsequent tr.als. Numer.us tr.als of adjuvant inter.er.n ther.p. demonstr.ted a benefit in ter.s of r.lap.e-fr.e sur.ival (r.S), but without confir.ed significant effect on over.ll sur.ival (OS). The op.imal timing, dose, and typ. of inter.er.n ar. not yet defined. Ther.for., adjuvant inter.er.n tr.atment is p.efer.ntially ap.lied in the r.ndomized clinical tr.als in sp.cialized centers. Decisions about the ap.r.p.iateness of adjuvant inter.er.n alfa-2b tr.atment for.p.tients should be made on an individual basis, after.discussion with the p.tient, including an exp.anation of the p.tential benefits and side effects of inter.er.n ther.p.. Mor.over. we also need to use available r.gimens r.asonably, seek feasible and p.edictable p.ognostic factor. to ser.e p.tients with individualized ther.p..

关键词：恶性黑色素瘤干扰素α 辅助治疗治疗试验人类发展指数美国食品临床试验合理利用

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Cor.elation analysis between loss of heter.zygosity at chr.mosome 18q and p.ognosis in the stage-Ⅱ colon cancer p.tients

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Chinese Jour.al of cancer 2010年第8期29卷 761-767页

作者： Wei Wang1,2, Yuan-Fang Li1,2, Xiao-Wei sun1,2, Gong Chen1,3, You-Qing Zhan1,2, Chun-Yu Huang1,2, De-sen Wan1,3, Zhi-Zhong p.n1,3, Zhi-Wei Zhou1,2 1 State Key Labor.ar. of oncology in South china, guangzhou, guangdong 510060, p. r. china 2 department of Gasr.ic and p.ncr.atic Sur.er., sun yat-sen university cancer center, guangzhou, guangdong 510060, p. r. china 3 department of Color.ctal Sur.er., sun yat-sen university cancer center, guangzhou, guangdong 510060, p. r. china department of Gasr.ic and p.ncr.atic Sur.er. Sun Yat-sen University Cancer Center State Key Labortary of Oncology in South China Guangdong Guangzhou 510060 department of Color.ctal Sur.er. Sun Yat-sen University Cancer Center State Key Labortary of Oncology in South China Guangdong Guangzhou 510060

Backgr.und and Objective: Color.ctal cancer is one of the most common malignant cancers in the wor.d. Although the clinicop.thologic staging is the golden cr.ter.on for.the p.ognosis at p.esent, the op.imum p.ognostic cr.ter.a for.color.ctal cancer should be a combination of the clinicop.thologic staging and the molecular.mar.er.. However. ther. ar. cur.ently no molecular.mar.er. available for.the p.ognosis of color.ctal cancer. Sever.l tumor.sup.r.ssor.genes associated with color.ctal cancer have been map.ed at the 18q21-23 r.gion. In this study we detected the fr.quency of loss of heter.zygosity (LOH) at chr.mosome 18q and investigated the r.lationship.between LOH and clinicop.thologic featur.s and its p.ognostic value for.p.tients with stage Ⅱ colon cancer. Methods: A total of 106 samp.es of tumor.tissues and cor.esp.nding nor.al mucosa fr.m p.tients with sp.r.dic stage-Ⅱ colon cancer wer. included in this study. All the samp.es wer. for.alin-fixed and p.r.ffin-embedded. DNA was extr.cted fr.m tumor.tissues and LOH of D18S474, D18S55, D18S58, D18S61 and D18S64 at chr.mosome 18q was analyzed using p.lymer.se chain r.action (p.r., p.lyacr.lamide gel-electr.p.or.sis, and DNA sequencing method. Multivar.ate analysis for.association between LOH and p.ognosis in colon cancer p.tients was p.r.or.ed with Cox p.op.r.ional hazar.s r.gr.ssion model. r.sults: The median follow-up.time was 68 months. For.106 p.tients, 5-year.sur.ival r.te was 83.6%, which was associated with age and gr.ss tumor.typ. (p.= 0.011 and 0.034, r.sp.ctively). Among 102 p.tients who wer. eligible for.LOH infor.ation, the over.ll fr.quency of LOH is 49.0% (50/102), and that of LOH at 5 micr.satellite loci of D18S474, D18S55, D18S58, D18S61, and D18S64 was 30.2% (26/86), 23.4% (18/77), 28.6% (20/70), 35.0% (28/80), and 20.8%(15/72), r.sp.ctively. The occur.ence of LOH was significantly associated with tumor.location and histop.thologic gr.de (p.= 0.023, 0.016 and 0.005, r.sp.ctively). LOH was mor. fr.q

关键词：大肠癌染色体杂合性预后患者相关分析聚丙烯酰胺凝胶电泳临床病理

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Exp.ession of calr.ticulin is associated with infiltr.tion of T-cells in stage ⅢB colon cancer

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Wor.d Jour.al of Gastr.enter.logy 2010年第19期16卷 2428-2434页

作者： r.i-Qing p.ng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Labor.tor. of oncology in South china, Biother.p. center, cancer center, sun yat-sen university, 651 Dongfeng r.E, guangzhou 510060, guangdong p.ovince, china Ying-Bo Chen, Zhi-Wei Zhou, State Key Labor.tor. of oncology in South china, department of Gastr.c and p.ncr.atic oncology, cancer center, sun yat-sen university, 651 Dongfeng r.E, guangzhou 510060, guangdong p.ovince, china r.ng Zhang, State Key Labor.tor. of oncology in South china, department of Endoscop., cancer center, sun yat-sen university, 651 Dongfeng r.E, guangzhou 510060, guangdong p.ovince, china Xing-Juan Yu, Yi-Xin Zeng, State Key Labor.tor. of oncology in South china, department of Exp.r.mental r.sear.h, cancer center, sun yat-sen university, 651 Dongfeng r.E, guangzhou 510060, guangdong p.ovince, china State Key Labor.tor. of oncology in South china Biotherapy Center Sun Yat-sen University 651 Dongfeng R E Guangzhou 510060 Guangdong Province China.

AIM: To investigate the cor.elation between exp.ession of calr.ticulin and infiltr.tion of lymp.ocytes in stage ⅢB colon cancer. METHODS: Sixty-eight p.thologically-confir.ed sp.ci-mens wer. obtained fr.m stage ⅢB (T3N1M0) colon cancer p.tients who under.ent r.dical r.section between Januar. 1999 and May 2002 at the cancer center of sun yat-sen university, guangzhou, china. Immuno-histochemical analysis was p.r.or.ed to show infiltr.tion of lymp.ocytes and exp.ession of calr.ticulin in colon cancer. Association between calr.ticulin exp.ession, infiltr.tion of lymp.ocytes, and 5-year.sur.ival r.te of p.tients was assessed. r.SULTS: The exp.ession level of calr.ticulin was lower.in cancer nest than in its adjacent nor.al ep.thelium since 61.8% (42/68) of the samp.es wer. stained with calr.ticulin in colon cancer. The exp.ession of calr.ticulin in colon cancer was associated with the infi ltr.tion of CD45r.+ cells r.ther.than with that of CD3+ cells. In addition, the str.nger.exp.ession of calr.ticulin and the higher.infiltr.tion of CD3+ and CD45r.+ cells in colon cancer wer. associated with the higher.5-year.sur.ival r.te of p.tients. CONCLUSION: Exp.ession of calr.ticulin is associated with infiltr.tion of T-cells, which imp.ies that a low exp.ession level of molecular.mar.er.may r.p.esent a new mechanism under.ying immune escap. in colon cancer.

关键词： Calr.ticulin Tumor.infiltr.ting lymp.ocyte Colon cancer Immune escap.

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p.r.utaneous r.diofr.quency ablation ap.r.ach thr.ugh the sp.een:initial case r.p.r. for.p.ncr.atic tail gastr.noma

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Chinese Jour.al of cancer 2010年第9期29卷 836-841页

作者： p.i-Hong Wu1,2, Chang-Chuan p.n1,2, Zi-Lin Huang1,2, Wang Li1,2, Ming Zhao1,2, Zhi-Wei Zhou1,3 1 State Key Labor.tor. of oncology in South china, guangzhou, guangdong 510060, p.r.china 2 department of medical Imaging & Inter.entional r.diology, sun yat-sen university cancer center, guangzhou, guangdong 510060, p.r.china 3 department of Abdominal oncology, sun yat-sen university cancer center, guangzhou, guangdong 510060, p.r.china department of medical Imaging& Inter.entional r.diology Sun Yat-s en University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060 department of Abdominal oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Gastr.noma has a low incidence, and the p.ncr.as-or.ginated gastr.noma is *** gastr.noma p.tients with liver.metastases have p.or.p.ognosis and shor. *** tr.atment to r.duce the tumor.bur.en help. to imp.ove symp.oms and slows down tumor.p.ogr.ssion for.p.tients with unr.sectable *** r.p.r. a case of p.ncr.atic tail gastr.noma with unr.sectable liver.*** p.tient r.ceived a comp.ehensive minimally invasive inter.entional tr.atment, that is, chemoembolization and r.diofr.quency ablation for.liver.metastases, and p.r.utaneous tr.nsp.enic r.diofr.quency ablation combined with r.dioactive 125I seed imp.antation for.p.ncr.atic tail *** p.tient was followed up.for.mor. than 20 months, and showed no clear.evidence of tumor.*** exp.or.d the safety and feasibility of p.r.utaneous tr.nsp.enic r.diofr.quency ablation for.unr.sectable p.ncr.atic tail *** tr.nsp.enic ap.r.ach allow mor. indications for.minimally invasive ther.p. and p.ovides a new tr.atment op.ion not only for.p.tients with unr.sectable p.ncr.atic tail tumor.but also for.p.tients r.fusing sur.er..

关键词：射频消融胃泌素病例报告尾部局部治疗手术切除肿瘤病介入治疗

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The r.sults and p.ognosis of differ.nt tr.atment modalities for.solitar. metastatic lung tumor.fr.m nasop.ar.ngeal car.inoma:a r.tr.sp.ctive study of 105 cases

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Chinese Jour.al of cancer 2010年第9期29卷 787-795页

作者： Jun Ma1,2, Zhe-Sheng Wen1,2, p.ng Lin1,2, Xin Wang1,2, Fang-Yun Xie1,3 1 State Key Labor.tor. of oncology in South china, guangzhou, guangdong 510060, p.r.china 2 department of Thor.cic oncology, sun yat-sen university cancer center, guangzhou, guangdong 510060, p.r.china 3 department of r.diation oncology, sun yat-sen university cancer center, guangzhou, guangdong 510060, p.r.china department of Thor.cic Sur.er., Shanxi p.ovincial p.op.e’s Hosp.tal, Taiyuan, Shanxi 030012, p.r.china department of Thor.cic oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060 department of r.diation oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Backgr.und and Objective:Nasop.ar.ngeal car.inoma (Np.) is known for.its p.op.nsity for.distant *** metastasis is one of the most imp.r.ant causes of death for.p.tients with *** metastatic lung tumor.fr.m Np. is a distinctive gr.up.associated with a better.*** study was to find a mor. effective tr.atment modality and p.ognostic factor. for.the ***:Clinical data of 105 cases of solitar. metastatic lung tumor.fr.m Np. wer. r.tr.sp.ctively *** r.te was calculated by the Kap.an-Meier.*** differ.nce of sur.ival between the p.tients tr.ated by differ.nt modalities was evaluated by the log-r.nk *** Cox univar.ate and multivar.ate analyses of gender. age, p.thologic typ., stage, adjuvant chemother.p., evaluation of tr.atment for.Np., disease-fr.e inter.al, size of metastatic tumor. p.lmonar. hilar.and/or.mediastinal lymp. node metastasis, tr.atment modalities, r.cur.ent distant metastases and/or.r.lap.e of Np. wer. ***:The local contr.l r.te was 53.8% in chemother.p. gr.up. 88.0% in r.diother.p. +/-chemother.p. gr.up. and 96.4% in op.r.tion +/-chemother.p. gr.up.(p.0.01).The most p.omising p.ogr.ssion-fr.e sur.ival (p.S) and over.ll sur.ival (OS) wer. obtained with op.r.tion +/-chemother.p. and followed by r.diother.p. +/-*** of them showed much better.efficacy than chemother.p. (p.0.001).The Cox multivar.ate analysis showed that r.cur.ent distant metastases and/or.r.lap.e of Np. affected the sur.ival (Or.2.087, 95% CI=1.277-3.410, p.0.003).The T stage of Np., size of metastatic tumor. hilar.and/or.mediastinal lymp. node metastasis, and the tr.atment modality wer. indep.ndent p.ognostic ***:Op.r.tion +/-chemother.p. and r.diother.p. +/-chemother.p. ar. better.tr.atment of solitar. metastatic lung tumor.fr.m Np., which could imp.ove the local contr.l and p.olong the p.S and *** is r.commended for.p.tients with higher.T stage of Np., size of metastatic tu

关键词：治疗方式鼻咽癌预后孤立全国人民代表大会肺疗效评价多因素分析

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Inter.er.n-α enhances sensitivity of human osteosar.oma U2OS cells to doxor.bicin by p.3-dep.ndent ap.p.osis

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Acta p.ar.acologica Sinica 2007年第11期28卷 1835-1841页

作者： Xiang-wei YUAN~2,Xiao-feng ZHU~(3,5),Xiu-fang HUANG~4,p.-yi SHENG~2,Ai-shan HE~2,Zi-bo YANG~2,r.ng DENG~3,Gong-kanFENG~3,Wei-ming LIAO~(2,5)~2 department of Or.hop.dic Sur.er.,The Fir.t Affiliated Hosp.tal,sun yat-sen university,guangzhou 510080,china ~3 State Key Labor.tor.of oncology in South china,cancer center,sun yat-sen university,guangzhou 510060,china ~4 department of p.thology,The AffiliatedJiangmen Hosp.tal,sun yat-sen university,Jiangmen 529030,china department of Or.hop.dic Sur.er. The First Affiliated Hospital Sun Yat-sen University Guangzhou China State Key Labor.tor. of oncology in South china Cancer Center Sun Yat-sen University Guangzhou China department of p.thology The Affiliated Jiangmen Hospital Sun Yat-sen University Jiangmen China

Aim:To deter.ine whether.inter.er.n-α(IFNα) can enhance doxor.bicinsensitivity in osteosar.oma cells and its molecular.***:Cellviability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-dip.enyltetr.zoliumbr.mide *** was studied using Flow cytometr. analysis,Hoechst33258 staining,DNA fr.gmentation assay,as well as the activation ofcasp.se-3 and p.ly (ADp.r.bose) *** exp.ession was detectedby Wester. *** dep.ndence of p.3 was deter.ined using ***:IFNα incr.ased doxor.bicin-induced cytotoxicity to a muchgr.ater.degr.e thr.ugh ap.p.osis in human osteosar.oma p.3-wild U2OS cells,but not p.3-mutant MG63 ***α mar.edly up.egulated p.3,Bax,Mdm2,andp.1,downr.gulated Bcl-2,and activated casp.se-3 and p.r.1}cleavage in r.-sp.nse to doxor.bicin in U2OS ***,the sir.A-mediated silencing ofp.3 significantly r.duced the IFNα/doxor.bicin combination-induced cytotoxic-ity and p.r.1}***:IFNα enhances the sensitivity of humanosteosar.oma U2OS cells to doxor.bicin by p.3-dep.ndent *** p.op.r.ombination with IFNα and conventional chemother.p.utic agents may be a r.-tional str.tegy for.imp.oving the tr.atment of osteosar.oma with functional p.3.

关键词： Inter.er.n-α doxor.bicin ap.p.osis p.3 osteosar.oma

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Imp.ct of Kr.S mutation and p.EN exp.ession on cetuximab-tr.ated color.ctal cancer

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Wor.d Jour.al of Gastr.enter.logy 2010年第46期16卷 5881-5888页

作者： Fang-Hua Li,Zhuang-Hua Li,Hui-Yan Luo,Miao-Zhen Qiu,Yu-Hong Li,r.i-Hua Xu,State Key Labor.tor. of oncology in Souther. china,department of medical oncology,sun yatsen university cancer center,guangzhou 510060,guangdong p.ovince,china Fang-Hua Li,department of medical oncology,Shengli Oil Field Centr.l Hosp.tal,Dongying 257034,Shandong p.ovince,china Lin Shen,department of GI oncology,p.king university School of oncology,Beijing cancer Hosp.tal and Institute,Beijing 100142,china Hui-Zhong Zhang,State Key Labor.tor. of oncology in Souther. china,department of p.thology,sun yat-sen university cancer center,guangzhou 510060,guangdong p.ovince,china State Key Labor.tor. of oncology in Souther. china Department of Medical Oncology Sun Yat-Sen University Cancer Center Guangzhou 510060 Guangdong Province China.

AIM:To investigate the p.ognostic value of Kr.S mutation,and p.osp.atase and tensin (p.EN) exp.ession in Chinese metastatic color.ctal cancer metastatic color.ctal cancer (mCr.) p.tients tr.ated with ***:Ninety Chinese mCr. p.tients tr.ated with cetuximab wer. evaluated for.Kr.S mutation and p.EN p.otein exp.ession by DNA sequencing of codons 12 and 13 and immunohistochemistr.,*** then selected 61 p.tients tr.ated with cetuximab,either.in combination with chemother.p.,or.alone as a second-line or.thir.-line r.gimen to assess whether.Kr.S mutation or.p.EN p.otein exp.ession is associated with the r.sp.nse and the sur.ival time of mCr. p.tients tr.ated with ***:Kr.S mutation was found in 30 (33.3%) tumor.samp.es fr.m the 90 p.tients,and p.sitive p.EN exp.ession was detected in 58 (64.4%) of the 90 *** the 61 p.tients who wer. tr.ated with cetuximab as a second-line or.thir.-line r.gimen,the r.sistance to cetuximab was found in 22 p.tients with Kr.S mutation and in 39 p.tients without Kr.S mutation,with a r.sp.nse r.te of 4.5% and 46.1% r.sp.ctively (p.0.001),a shor.er.median p.ogr.ssion-fr.e sur.ival (p.S) time of 14 ± 1.3 wk and 32 ± 2.5 wk r.sp.ctively (p.r.ll sur.ival (OS) time of 11 ± 1.2 mo and 19 ± 1.8 mo r.sp.ctively (p.24 p.tients with negative p.EN exp.ession and in 37 p.tients with p.sitive p.EN exp.ession r.sp.ctively (p.r.sp.nsive r.te of 4.2% and 48.6% r.sp.ctively,a shor.er.median p.S sur.ival time of 17 ± 2.0 wk and 28 ± 1.9 wk r.sp.ctively (p.0.07),and a median OS time of 11 ± 1.3 mo and 18 ± 1.9 mo r.sp.ctively (p.0.004).Combined Kr.S mutation and p.EN exp.ession analysis showed that the p.S and OS time of p.tients with two favor.ble p.ognostic factor. wer. longer.than those of p.tients with one favor.ble p.ognostic factor.or.no favor.ble p.ognostic factor.(p.r.S mutation and p.EN p.otein exp.ession ar. significantly cor.

关键词： Cetuximab Metastatic color.ctal cancer Kr.S mutation p.osp.atase and tensin p.otein exp.ession

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